Dr Stephen Barrett
Biography
2024 - Assistant Lecturer, Dept. of Chemistry, Maynooth University.
2022 - 2024 - Irish Research Council Post Doctoral Research Fellow, Dept. of Chemistry, Royal College Of Surgeons Ireland.
2021 - 2022 - Assistant Lecturer, Dept. of Chemistry Maynooth University
2021 - PhD. in Chemistry, Dept. of Chemistry, Maynooth University, Ireland
2020 - Visiting Lecturer, Dept. of Chemistry, CCZU, Changzhou University, China
Research Interests
The Barrett research groups primary interest is in metal based anti - cancer therapeutics and metal based complexes which display anti - microbial activities. Our research falls under the large umbrella of Bio-Inorganic Chemistry and is at the interface of Chemistry & Biology.
We are specifically interested in metal based complexes as targeted anti - cancer and anti - microbial therapeutics.
In particular:
1) Self-immolative Pt(IV) complexes as potential chemotherapy drugs.
2) Targeted Cu(II) small molecule drugs which interact with DNA & RNA.
3) Targeted Cu(II) complexes with anti microbial and anti- cancer properties .
4) Pt(II) anti - cancer complexes which are activated in the cell via bioorthogonal pathways.
5) Lipophillic Pt(IV) complexes with potential anti - microbial properties.
Peer Reviewed Journal
| Year | Publication | |
|---|---|---|
| 2025 | Darren F. Beirne , Sean O'Neill , Eithne Dempsey , Kevin Kavanagh , Diego Seamus Montagner , Stephen Barrett (2025) 'Electrochemical behaviour and DNA intercalation studies of novel antimicrobial Bis - Cu(II) substituted Dipyridophenazine complexes'. Inorganica Chimica Acta, 587 . [Link] https://www.sciencedirect.com/science/article/abs/pii/S0020169325002956?via%3Dihub [Full-Text] | |
| 2023 | Barrett, S.; De Franco, M.; Donati, C.; Marzano, C.; Gandin, V.; Montagner, D. (2023) 'Novel Biotinylated Cu(II)-Phenanthroline Complexes: 2D and 3D Cytotoxic Activity and Mechanistic Insight'. Molecules (Basel, Switzerland), 28 . [Link] [DOI] [Full-Text] | |
| 2019 | Barrett, S; De Franco, M; Kellett, A; Dempsey, E; Marzano, C; Erxleben, A; Gandin, V; Montagner, D (2019) 'Anticancer activity, DNA binding and cell mechanistic studies of estrogen-functionalised Cu(II) complexes'. Journal of Biological Inorganic Chemistry, . [DOI] [Full-Text] | |
| 2018 | Barrett S.; Delaney S.; Kavanagh K.; Montagner D. (2018) 'Evaluation of in vitro and in vivo antibacterial activity of novel Cu(II)-steroid complexes'. Inorganica Chimica Acta, 479 :261-265. [DOI] [Full-Text] |
Book Chapter
Committees
Teaching Interests
CH405C - ADVANCED ORGANIC CHEMISTRY (Alkaloid chemistry)
CH301C - ORGANIC CHEMISTRY
CH202 - SPECTROSCOPY & ANALYTICAL CHEMISTRY
CH101 - GENERAL CHEMISTRY