Dr Marion Butler

    Biology, Human Health Institute

    Lecturer
    Lecturer/Assistant Professor in Immunology

    Biosciences
    B3.18
    (01) 708 3856

    Biography

    2008-present: Lecturer in Immunology, Dept of Biology, Maynooth University
    2007-2008: Senior Post-doctoral Scientist, Biology Dept, Maynooth University     
    2003-2007: Senior Post-doctoral Scientist, Conway Institute, University College Dublin 
    2000-2003: Conway Post-doctoral Research Fellow, University College Dublin. 
    1999: PhD in Medicine (University College Dublin) based in Columbia University, New York & U.C.D 

    Research Interests

    Cancer research with a focus on breast and ovarian cancer.
    Immunology based research with a focus on the mechanistic understanding to disease, specifically autoimmune diseases. 

    Post Doctoral Fellows / Research Team

    Researcher Name Project Funding Body
    Devlin Simon Wall - Coughlan Ovarian Cancer Research
    Adam Dignam Immunology
    Mario Rodriguez Pena Immunology project

    Peer Reviewed Journal

    Year Publication
    2019 Barton, SJ; O' Dwyer, K; Butler, M; Dignam, A; Byrne, HJ; O' Neill, L; Hennelly, BM (2019) 'Improved performance of near infrared excitation Raman spectroscopy using reflective thin-film gold on glass substrates for cytology samples'. Analytical Methods, 11 :6023-6032. [DOI] [Full-Text]
    2018 Bruni D; Dignam A; Dunne S; Wall-Coughlan D; McCrudden A; O'Connell K; Lyons C; McGuigan C; Tubridy N; Butler MP; (2018) 'IRAK1 Limits TLR3/4- and IFNAR-Driven IL-27 Production through a STAT1-Dependent Mechanism'. Journal of Immunology, 201 (7). [DOI] [Full-Text]
    2013 Bruni D., Sebastia J., Dunne S., Schroeder M., Butler M. (2013) 'A novel IRAK1 IKKe signalling axis limits the activation of TAK1 IKKbeta downstsream of TLR3'. Journal of Immunology, 190 :2844-2856. [Full-Text]
    2007 Butler, M.P., J.A. Hanly and P.N. Moynagh (2007) 'Kinase-active Interleukin-1 Receptor-associated Kinases Promote Polyubiquitination and Degradation of the Pellino Family:  Direct evidence for pellino proteins being ubiquitin-protein isopeptide ligases'. JOURNAL OF BIOLOGICAL CHEMISTRY, 282 :29729-29737. [Full-Text]
    2007 Cumiskey, D., M.P. Butler, P.N. Moynagh and J.J. O'Connor (2007) 'Evidence for a role for the group I metabotropic glutamate receptor in the inhibitory effect of tumor necrosis factor-alpha on long-term potentiation'. Journal of Brain Research, 1136 :13-19. [Full-Text]
    2005 Butler, M.P., Hanly, J.A. and Moynagh, P.N. (2005) 'Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner'. JOURNAL OF BIOLOGICAL CHEMISTRY, 280 :27759-27768. [Full-Text]
    2004 Butler, M.P., O’Connor, J.J. and Moynagh, P.N. (2004) 'Dissection of tumor-necrosis factor-alpha inhibition of long-term potentiation (LTP) reveals a p38 mitogen-activated protein kinase-dependent mechanism which maps to early-but not late-phase LTP'. 124 :319-326. [Full-Text]
    2002 Butler, M. P., Iida, S., Capello, D., Rossi, D., Rao, P. H., Nallasivam, P., Louie, D. C., Chaganti, S., Au, T., Gascoyne, R. D., Gaidano, G., Chaganti, R. S. and Dalla-Favera, R (2002) 'Alternative translocation breakpoint cluster region 5' to BCL-6 in B-cell non-Hodgkin's lymphoma'. Cancer Research, 62 :4089-4094. [Full-Text]
    2002 Butler, M., Moynagh, P.N. and O’Connor, J. (2002) 'Methods of detection of the transcription factor NF-kappaB in rat hippocampal slices'. Journal of Neuroscience Methods, 119 :185-189. [Full-Text]
    1999 Butler, M. P., Wang, S. I., Chaganti, R. S., Parsons, R. and Dalla-Favera, R., (1999) 'Analysis of PTEN mutations and deletions in B-cell non-Hodgkin's lymphomas'. Genes Chromosomes and Cancer, 24 :322-327. [Full-Text]
    1998 Chen, W., Butler, M., Rao, P. H., Chaganti, S. R., Louie, D. C., Dalla-Favera, R. and Chaganti, R. S (1998) 'The t(2;3)(q21;q27) translocation in non-Hodgkin's lymphoma displays BCL6 mutations in the 5' regulatory region and chromosomal breakpoints distant from the gene'. Oncogene, 17 :1717-1722. [Full-Text]
    1997 Butler, M., Corbally, N., Dervan, P. A. and Carney, D. N., (1997) 'BCL-6 and other genomic alterations in non-Hodgkin's lymphoma (NHL)'. British Journal of Cancer, 75 :1641-1645. [Full-Text]
    1997 Iida, S., Rao, P. H., Butler, M., Corradini, P., Boccadoro, M., Klein, B., Chaganti, R. S. and Dalla-Favera, R. (1997) 'Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma'. Nature Genetics, 17 :226-230. [Full-Text]
    1996 Iida, S., Rao, P. H., Nallasivam, P., Hibshoosh, H., Butler, M., Louie, D. C., Dyomin, V., Ohno, H., Chaganti, R. S. and Dalla-Favera, R., (1996) 'The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene'. Blood, 88 :4110-4117. [Full-Text]

    Book Chapter

    Year Publication
    2001 Butler M.P., Moynagh P.N. and O’Connor J.J. (2001) '“Methods of detection of the transcription factor NF-kB in rat hippocampal slices.”' In: WT O’Connor, JP Lowry, JJ O’ Connor and RD O’Neill)(Eds.). [DOI]
    1998 Dalla-Favera, R., Migliazza, A., Chang, C. C., Niu, H., Pasqualucci, L., Butler, M., Shen, Q. and Cattoretti, G. (1998) '“Molecular pathogenesis of B cell malignancy: the role of BCL-6.”' In: In: Curr Top Microbiology and Immunology.
    Certain data included herein are derived from the © Web of Science (2023) of Clarivate. All rights reserved.

    Professional Associations

    Description Function From / To
    Irish Association for Cancer Research (IACR) IACR member -
    European Association for Cancer Research (EACR) Member -

    Teaching Interests

    Mechanisms of Human Disease (module coordinator)
    Introductory Immunology  
    Advanced Immunology  (module coordinator)
    Tumour Biology  (module coordinator)

    Recent Students

    Graduation date Name Degree
    2012 Dr Daniela Bruni PhD
    2021 Devlin Wall-Coughlan PhD
    2016 Dr Susan Dunne PhD