MIT-Harvard CINCS / Hamilton Institute Seminar

Wednesday, April 7, 2021 - 15:00 to 16:00
Passcode: 779910

MIT-Harvard CINCS (Communications Information Networks Circuits and Signals) / Hamilton Institute Seminar

Speaker: Dr Leïla Perié, Curie Institute

Title: "A quantitative gaze at blood cell production"

Abstract: Hematopoiesis is the process by which hematopoietic stem and progenitor cells give rise to all blood cells. Hematopoietic cells can be divided into at least 13 cell types, corresponding to approximately tens of trillions of cells distributed among most tissues of the body.
As most hematopoietic cells are short-lived, hematopoiesis is a constantly regenerating process. Moreover, hematopoiesis flux can vary in response to changing demands for blood cells in peripheral tissues, for example during bleeding or infection. Hematopoiesis starts from a few hematopoietic stem and progenitor cells (HSPC) to finally produce many mature cells. Understanding the mechanisms that allow the small pool of HSPCs to meet changing requirements for such large blood cell numbers remains a challenge. In this talk, I will present some general quantitative consideration of hematopoiesis and recent results on quantifying cell dynamics in hematopoiesis.

Bio: Trained as an engineer, Leïla Perié did a PhD in experimental immunology at Institut Cochin in France. She then did a postdoc in the Netherlands in the lab of Ton Schumacher at the Netherland Cancer Institute and the lab of Rob de Boer at Utrecht University. She studied hematopoiesis and T cell at the single cell level, mixing experimental and theoretical work. Since 2015, Leïla Perié head a group the Curie Institute in France. Her lab is interested in understanding the hematopoietic tree at the single cell level and combines different experimental and mathematical/computational approaches of single cell lineage tracing to study blood cells production. Leïla is also the head of the single cell facility of her institute.