Dr Trinidad Velasco-Torrijos

Chemistry, Human Health Institute

Associate Professor

Science Building
2.69
(01) 708 3747

Biography

  • 2007-Present: Lecturer in Pharmaceutical Chemistry, Maynooth University (Ireland). Pharmaceutical and Biomedical Chemistry MH210 Program Coordinator.
  • 2003-2006: Postdoctoral researcher (Marie Curie Fellow 2003-2005), University College Dublin (Ireland)
  • 2002-2003: Postdoctoral researcher, Ghent University (Belgium)
  • 1999-2002: PhD. Synthetic and Supramolecular Chemistry- Trinity College Dublin (Ireland)/University of Bristol (UK)
  • 1993-1998: BSc. Chemistry (Organic Chemistry)-Universidad Autonoma de Madrid (Spain)













Research Interests

Synthetic and Carbohydrate Chemistry
Glycoconjugates as antimicrobials and soft materials
Supramolecular Chemistry

CURRENT PROJECTS:
- Anti-Microbial and anti-parasitic Therapies: Carbohydrate recognition is key in processes like pathogen infection, regulation of protein function and cellular communication. Using Synthetic and Carbohydrate Chemistry, we aim to design bioactive glycoconjugates as novel anti-infection agents to overcome emerging drug resistance to conventional antibiotics. Projects include:
- Glycosylated prodrugs as anti-parasitic agents
- Anti-adhesion glycoconjugates to prevent
Candida albicans fungal infection.

-Supramolecular Chemistry and Soft Materials:  Synthetic molecules based on carbohydrates can be designed to self-assemble and soft materials, such as Low Molecular Weight Gelators. We are developing these soft materials as novel electrospun biocompatible materials for drug-delivery and tissue engineering.




Research Projects

  Project Role Funding Body / Program Description Start Date End Date Award (€)
Ulysses PI Irish Research Council (IRC) / Ulysses The increasing number of pathogens becoming resistant to conventional anti-microbial therapies has been highlighted by the World Health Organization as a serious global threat to public health. Thus, investigation into novel and effective treatments to combat microbial infections is urgently required. The anti-adhesion approach is an emerging alternative to antimicrobial therapies that rely solely on killing on the pathogen, therefore decreasing the risk of developing resistance. For infection to occur, the pathogen must first adhere to the host cell using proteins that recognize carbohydrates on the host cell surface. Anti-adhesion antimicrobials prevent infections by blocking these proteins so that adhesion, and subsequent infection, cannot take place. Recent research conducted in Dr Velasco-Torrijos' lab has identified synthetic carbohydrates (glycoconjugates) capable of inhibiting the adhesion of pathogenic yeast Candida albicans to epithelial cells. The activity of anti-adhesion glycoconjugates increases when several of them are displayed simultaneously. This is known as the multivalent effect. In the proposed collaboration, the glycoconjugates will be attached to RAFT macrocyclic scaffolds developed in Prof Renaudet's group. The scaffolds are specifically designed to allow for the optimal multivalent presentation of bioactive groups. This synergistic approach will enhance the glycoconjugate’s ability to inhibit pathogen adhesion. 01-MAR-19 01-APR-19 2500
Supramolecular gels: Biocompatible Materials for Drug Delivery and Tissue Engineering PI /
Novel Anti-Microbial therapies: Anti-Adhesion Glycoconjugates and Metal Chelators PI /
Smart Delivery Technology for Infectious Disease PI Enterprise Ireland / Commerical Case Feasibility Fund 01-NOV-13 31-JAN-14

Book Chapters

  Year Publication
2017 '2-Chloroethyl and 2-Azidoethyl 2,3,4,6-tetra-O-acetyl-beta-D-gluco- and beta-D-galactopyranosides'
Reddy, A;Ramos-Ondono, J;Abbey, L;Velasco-Torrijos, T;Ziegler, T (2017) '2-Chloroethyl and 2-Azidoethyl 2,3,4,6-tetra-O-acetyl-beta-D-gluco- and beta-D-galactopyranosides' In: CARBOHYDRATE CHEMISTRY: PROVEN SYNTHETIC METHODS, VOL 4. BOCA RATON: CRC PRESS-TAYLOR & FRANCIS GROUP. [Details]
2008 'Monosaccharides as Scaffolds for the Synthesis of Novel Compounds'
Trinidad Velasco-Torrijos, Paul V. Murphy (2008) 'Monosaccharides as Scaffolds for the Synthesis of Novel Compounds' In: Glycoscience: Chemistry and Chemical Biology, 2nd edition. Springer. [Details]

Peer Reviewed Journals

  Year Publication
2018 'Glycosylated α-Azido Amino Acids: Versatile Intermediates in the Synthesis of Neoglycoconjugates'
O'Flaherty R.;Velasco-Torrijos T. (2018) 'Glycosylated α-Azido Amino Acids: Versatile Intermediates in the Synthesis of Neoglycoconjugates'. Synlett, 29 (7):904-907 [DOI] [Details]
2018 'Inhibition of adherence of the yeast Candida albicans to buccal epithelial cells by synthetic aromatic glycoconjugates'
Martin H;Govern MM;Abbey L;Gilroy A;Mullins S;Howell S;Kavanagh K;Velasco-Torrijos T; (2018) 'Inhibition of adherence of the yeast Candida albicans to buccal epithelial cells by synthetic aromatic glycoconjugates'. European Journal of Medicinal Chemistry, 160 [DOI] [full-text] [Details]
2017 'The Selective Electrochemical Detection of Dopamine Using a Sulfated beta-Cyclodextrin Carbon Paste Electrode'
Gnahore, GT;Velasco-Torrijos, T;Colleran, J (2017) 'The Selective Electrochemical Detection of Dopamine Using a Sulfated beta-Cyclodextrin Carbon Paste Electrode'. Electrocatalysis, 8 :459-471 [DOI] [full-text] [Details]
2017 'Polymorphism in Commercial Sources of Fusidic Acid: A Comparative Study of the In Vitro Release Characteristics of Forms I and III from a Marketed Pharmaceutical Cream'
Byrne, J;Reinhardt, R;Velasco-Torrijos, T (2017) 'Polymorphism in Commercial Sources of Fusidic Acid: A Comparative Study of the In Vitro Release Characteristics of Forms I and III from a Marketed Pharmaceutical Cream'. Journal of Analytical Methods in Chemistry, [DOI] [full-text] [Details]
2017 'Glycosylated metal chelators as anti-parasitic agents with tunable selectivity'
Reddy A;Sangenito LS;Guedes AA;Branquinha MH;Kavanagh K;McGinley J;Dos Santos ALS;Velasco-Torrijos T; (2017) 'Glycosylated metal chelators as anti-parasitic agents with tunable selectivity'. Dalton Transactions, 46 (16) [DOI] [full-text] [Details]
2016 'Selective aliphatic/aromatic organogelation controlled by the side chain of serine amphiphiles'
Ramos J.;Arufe S.;O'Flaherty R.;Rooney D.;Moreira R.;Velasco-Torrijos T. (2016) 'Selective aliphatic/aromatic organogelation controlled by the side chain of serine amphiphiles'. RSC Advances, 6 (109):108093-108104 [DOI] [full-text] [Details]
2016 'Formulation factors affecting the isomerization rate of betamethasone-17-valerate in a developmental hydrophilic cream – a HPLC and microscopy based stability study'
Byrne J, Wyraz A, Velasco-Torrijos T, Reinhardt R (2016) 'Formulation factors affecting the isomerization rate of betamethasone-17-valerate in a developmental hydrophilic cream – a HPLC and microscopy based stability study'. Pharmaceutical Development and Technology, 21 :1-8 [DOI] [full-text] [Details]
2015 'An RP-HPLC Method for the Stability-Indicating Analysis of Impurities of Both Fusidic Acid and Betamethasone-17-Valerate in a Semi-Solid Pharmaceutical Dosage Form'
Byrne, J;Velasco-Torrijos, T;Reinhardt, R (2015) 'An RP-HPLC Method for the Stability-Indicating Analysis of Impurities of Both Fusidic Acid and Betamethasone-17-Valerate in a Semi-Solid Pharmaceutical Dosage Form'. Journal of Chromatographic Science, 53 :1498-1503 [DOI] [full-text] [Details]
2014 'Development and validation of a novel stability-indicating HPLC method for the simultaneous assay of betamethasone-17-valerate, fusidic acid, potassium sorbate, methylparaben and propylparaben in a topical cream preparation'
Byrne, J;Velasco-Torrijos, T;Reinhardt, R (2014) 'Development and validation of a novel stability-indicating HPLC method for the simultaneous assay of betamethasone-17-valerate, fusidic acid, potassium sorbate, methylparaben and propylparaben in a topical cream preparation'. Journal of Pharmaceutical and Biomedical Analysis, 96 :111-117 [DOI] [full-text] [Details]
2014 'Adding glycolipid functionality to model membranes - phase behaviour of a synthetic glycolipid in a phospholipid membrane'
Migas, UM;Abbey, L;Velasco-Torrijos, T;McManus, JJ (2014) 'Adding glycolipid functionality to model membranes - phase behaviour of a synthetic glycolipid in a phospholipid membrane'. Soft Matter, 10 :3978-3983 [DOI] [full-text] [Details]
2013 'Multivalent glycoconjugates as anti-pathogenic agents '
Bernardi Anna, Jesus Jimnez-Barbero , Alessandro Casnati , Cristina De Castro , Tamis Darbre , Franck Fieschi , Jukka Finne , Horst Funken , Karl-Erich Jaeger , Martina Lahmann , Thisbe K. Lindhorst , Marco Marradi , Paul Messner , Antonio Molinaro , Paul V. Murphy , Cristina Nativi , Stefan Oscarson , Soledad Penads , Francesco Peri , Roland J. Pieters , Olivier Renaudet , Jean-Louis Reymond , Barbara Richichi , Javier Rojo , Francesco Sansone , Christina Schffer , W. Bruce Turnbull , Velasco-Torrijos Trinidad, Sbastien Vidal , Stphane Vincent , Tom Wennekes , Han Zuilhof and Anne Imberty (2013) 'Multivalent glycoconjugates as anti-pathogenic agents '. CHEMICAL SOCIETY REVIEWS, 1 [DOI] [full-text] [Details]
2012 'Inhibition of Burkholderia multivorans adhesion to lung epithelial cells by bivalent lactosides '
Wright, Ciara; Leyden, Rosaria; Murphy, Paul V.; Callaghan, Maire; Velasco-Torrijos, Trinidad; McClean, Siobhan. (2012) 'Inhibition of Burkholderia multivorans adhesion to lung epithelial cells by bivalent lactosides '. MOLECULES, 17 :10065-1007 [DOI] [full-text] [Details]
2009 'Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles'
Andre S, Velasco-Torrijos T, Leyden R, Gouin S, Tosin M, Murphy PV, Gabius HJ. (2009) 'Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles'. ORGANIC AND BIOMOLECULAR CHEMISTRY, 7 :4715-4725 [full-text] [Details]
2009 'Synthesis of Bivalent Lactosides Based on Terephthalamide, N,N'-Diglucosylterephthalamide, and Glycophane Scaffolds and Assessment of Their Inhibitory Capacity on Medically Relevant Lectins'
Leyden R, Velasco-Torrijos T, Andre S, Gouin S, Gabius HJ, MurphyPV, (2009) 'Synthesis of Bivalent Lactosides Based on Terephthalamide, N,N'-Diglucosylterephthalamide, and Glycophane Scaffolds and Assessment of Their Inhibitory Capacity on Medically Relevant Lectins'. JOURNAL OF ORGANIC CHEMISTRY, 74 :9010-9026 [full-text] [Details]
2005 'The crystal structure of a cyclic glycolipid reveals a carbohydrate-carbohydrate interaction interface'
Müller-Bunz H, Velasco-Torrijos T, Murphy PV, (2005) 'The crystal structure of a cyclic glycolipid reveals a carbohydrate-carbohydrate interaction interface'. CARBOHYDRATE RESEARCH, 340 :1437-1440 [Details]
2005 'Fine-tuning furan toxicity: fast and quantitative DNA interchain cross-link formation upon selective oxidation of a furan containing oligonucleotide'
Halila S, Velasco T, De Clercq P, Madder A (2005) 'Fine-tuning furan toxicity: fast and quantitative DNA interchain cross-link formation upon selective oxidation of a furan containing oligonucleotide'. CHEMICAL COMMUNICATIONS, :936-938 [Details]
2005 'Synthesis and conformational analysis of novel water soluble macrocycles incorporating carbohydrates, including a beta-cyclodextrin mimic'
Velasco-Torrijos T, Murphy, PV (2005) 'Synthesis and conformational analysis of novel water soluble macrocycles incorporating carbohydrates, including a beta-cyclodextrin mimic'. TETRAHEDRON ASYMMETRY, 16 :261-272 [Details]
2004 'Metathesis of structurally preorganised bivalent carbohydrates. Synthesis of macrocyclic and oligomeric scaffolds'
Velasco-Torrijos T, Murphy PV (2004) 'Metathesis of structurally preorganised bivalent carbohydrates. Synthesis of macrocyclic and oligomeric scaffolds'. ORGANIC LETTERS, 5 :3961-3964 [Details]
2004 'Tuning selectivity in macrotricyclic carbohydrate receptors; CH to N mutations in aromatic spacers'
Velasco T, Lecollinet G, Ryan T Davis AP (2004) 'Tuning selectivity in macrotricyclic carbohydrate receptors; CH to N mutations in aromatic spacers'. ORGANIC AND BIOMOLECULAR CHEMISTRY, 2 :645-647 [Details]
2002 'Phase transfer of monosaccharides through noncovalent interactions: selective extraction of glucose by a lipophilic cage receptor'
Ryan TJ, Lecollinet G, Velasco T, Davis AP (2002) 'Phase transfer of monosaccharides through noncovalent interactions: selective extraction of glucose by a lipophilic cage receptor'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, 99 :4863-4866 [Details]
2002 'Highly selective disaccharide recognition by a tricyclic octaamide cage'
Lecollinet G, Dominey AP, Velasco T, Davis AP (2002) 'Highly selective disaccharide recognition by a tricyclic octaamide cage'. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 41 :4093-4096 [Details]

Conference Contributions

  Year Publication
2009 15th European Carbohydrate Symposium.
(2009) 15th European Carbohydrate Symposium. [Poster Presentation], O-Serine Glycosides as Versatile Building Blocks i, Vienna [Details]
2009 Royal Society of Chemistry Regional Symposium.
Trinidad Velasco-Torrijos (2009) Royal Society of Chemistry Regional Symposium. [Oral Presentation], O-Serine Glycosides: Building Blocks in Glycomimetic synthesis, Belfast [Details]

Reviews

  Year Publication
2013 Multivalent glycoconjugates as anti-pathogenic agents.
Bernardi, A;Jimenez-Barbero, J;Casnati, A;De Castro, C;Darbre, T;Fieschi, F;Finne, J;Funken, H;Jaeger, KE;Lahmann, M;Lindhorst, TK;Marradi, M;Messner, P;Molinaro, A;Murphy, PV;Nativi, C;Oscarson, S;Penades, S;Peri, F;Pieters, RJ;Renaudet, O;Reymond, JL;Richichi, B;Rojo, J;Sansone, F;Schaffer, C;Turnbull, WB;Velasco-Torrijos, T;Vidal, S;Vincent, S;Wennekes, T;Zuilhof, H;Imberty, A (2013) Multivalent glycoconjugates as anti-pathogenic agents. CAMBRIDGE: Reviews [DOI] [full-text] [Details]

Thesis

  Year Publication
2002 Towards a Second Generation of Macrocyclic Receptors for Carbohydrate Recognition.
Dr Trinidad Velasco-Torrijos (2002) Towards a Second Generation of Macrocyclic Receptors for Carbohydrate Recognition. University of Bristol: Thesis [Details]

Reviews

  Journal Role
Molecules Series Editor