Dr Trinidad Velasco-Torrijos

Chemistry, Human Health Institute

Lecturer

Science Building
2.69
(01) 7083747

Biography

  • 2007-Present: Lecturer in Pharmaceutical Chemistry, Maynooth University (Ireland) 
  • 2003-2006: Postdoctoral researcher (Marie Curie Fellow 2003-2005), University College Dublin (Ireland)
  • 2002-2003: Postdoctoral researcher, Ghent University (Belgium)
  • 1999-2002: PhD. Synthetic and Supramolecular Chemistry- Trinity College Dublin (Ireland)/University of Bristol (UK)
  • 1993-1998: BSc. Chemistry (Organic Chemistry)-Universidad Autonoma de Madrid (Spain)













Research Interests

Synthetic and Carbohydrate Chemistry
Glycoconjugates as antimicrobials and soft materials
Supramolecular Chemistry

CURRENT PROJECTS:
- Anti-Microbial and anti-parasitic Therapies: Carbohydrate recognition is key in processes like pathogen infection, regulation of protein function and cellular communication. Using Synthetic and Carbohydrate Chemistry, we aim to design bioactive glycoconjugates as novel anti-infection agents to overcome emerging drug resistance to conventional antibiotics. Projects include:
- Glycosylated prodrugs as anti-parasitic agents
- Anti-adhesion glycoconjugates to prevent
Candida albicans fungal infection.

-Supramolecular Chemistry and Soft Materials:  Synthetic molecules based on carbohydrates can be designed to self-assemble and soft materials, such as Low Molecular Weight Gelators. We are developing these soft materials as novel electrospun biocompatible materials for drug-delivery and tissue engineering.




Book Chapters

  Year Publication
2008 'Monosaccharides as Scaffolds for the Synthesis of Novel Compounds'
Trinidad Velasco-Torrijos, Paul V. Murphy (2008) 'Monosaccharides as Scaffolds for the Synthesis of Novel Compounds' In: Glycoscience: Chemistry and Chemical Biology, 2nd edition. Springer. [Details]

Peer Reviewed Journals

  Year Publication
2017 'Glycosylated metal chelators as anti-parasitic agents with tunable selectivity'
Reddy A;Sangenito LS;Guedes AA;Branquinha MH;Kavanagh K;McGinley J;Dos Santos ALS;Velasco-Torrijos T; (2017) 'Glycosylated metal chelators as anti-parasitic agents with tunable selectivity'. Dalton Transactions, 46 (16) [DOI] [Details]
2016 'Formulation factors affecting the isomerization rate of betamethasone-17-valerate in a developmental hydrophilic cream – a HPLC and microscopy based stability study'
Byrne J, Wyraz A, Velasco-Torrijos T, Reinhardt R (2016) 'Formulation factors affecting the isomerization rate of betamethasone-17-valerate in a developmental hydrophilic cream – a HPLC and microscopy based stability study'. Pharmaceutical Development and Technology, 21 :1-8 [DOI] [IR Link] [Details]
2015 'An RP-HPLC Method for the Stability-Indicating Analysis of Impurities of Both Fusidic Acid and Betamethasone-17-Valerate in a Semi-Solid Pharmaceutical Dosage Form'
Byrne, J;Velasco-Torrijos, T;Reinhardt, R (2015) 'An RP-HPLC Method for the Stability-Indicating Analysis of Impurities of Both Fusidic Acid and Betamethasone-17-Valerate in a Semi-Solid Pharmaceutical Dosage Form'. Journal of Chromatographic Science, 53 :1498-1503 [DOI] [IR Link] [Details]
2014 'Development and validation of a novel stability-indicating HPLC method for the simultaneous assay of betamethasone-17-valerate, fusidic acid, potassium sorbate, methylparaben and propylparaben in a topical cream preparation'
Byrne, J;Velasco-Torrijos, T;Reinhardt, R (2014) 'Development and validation of a novel stability-indicating HPLC method for the simultaneous assay of betamethasone-17-valerate, fusidic acid, potassium sorbate, methylparaben and propylparaben in a topical cream preparation'. Journal of Pharmaceutical and Biomedical Analysis, 96 :111-117 [DOI] [IR Link] [Details]
2014 'Adding glycolipid functionality to model membranes - phase behaviour of a synthetic glycolipid in a phospholipid membrane'
Migas, UM;Abbey, L;Velasco-Torrijos, T;McManus, JJ (2014) 'Adding glycolipid functionality to model membranes - phase behaviour of a synthetic glycolipid in a phospholipid membrane'. Soft Matter, 10 :3978-3983 [DOI] [IR Link] [Details]
2013 'Multivalent glycoconjugates as anti-pathogenic agents '
Bernardi Anna, Jesus Jimnez-Barbero , Alessandro Casnati , Cristina De Castro , Tamis Darbre , Franck Fieschi , Jukka Finne , Horst Funken , Karl-Erich Jaeger , Martina Lahmann , Thisbe K. Lindhorst , Marco Marradi , Paul Messner , Antonio Molinaro , Paul V. Murphy , Cristina Nativi , Stefan Oscarson , Soledad Penads , Francesco Peri , Roland J. Pieters , Olivier Renaudet , Jean-Louis Reymond , Barbara Richichi , Javier Rojo , Francesco Sansone , Christina Schffer , W. Bruce Turnbull , Velasco-Torrijos Trinidad, Sbastien Vidal , Stphane Vincent , Tom Wennekes , Han Zuilhof and Anne Imberty (2013) 'Multivalent glycoconjugates as anti-pathogenic agents '. CHEMICAL SOCIETY REVIEWS, 1 [DOI] [IR Link] [Details]
2012 'A concise synthesis of glycolipids based on aspartic acid building blocks'
Velasco-Torrijos, Trinidad; Abbey, Lorna; O'Flaherty, Roisin (2012) 'A concise synthesis of glycolipids based on aspartic acid building blocks'. MOLECULES, 17 :11346-11362 [DOI] [IR Link] [Details]
2012 'Inhibition of Burkholderia multivorans adhesion to lung epithelial cells by bivalent lactosides '
Wright, Ciara; Leyden, Rosaria; Murphy, Paul V.; Callaghan, Maire; Velasco-Torrijos, Trinidad; McClean, Siobhan. (2012) 'Inhibition of Burkholderia multivorans adhesion to lung epithelial cells by bivalent lactosides '. MOLECULES, 17 :10065-1007 [DOI] [IR Link] [Details]
2009 'Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles'
Andre S, Velasco-Torrijos T, Leyden R, Gouin S, Tosin M, Murphy PV, Gabius HJ. (2009) 'Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles'. ORGANIC AND BIOMOLECULAR CHEMISTRY, 7 :4715-4725 [IR Link] [Details]
2009 'Synthesis of Bivalent Lactosides Based on Terephthalamide, N,N'-Diglucosylterephthalamide, and Glycophane Scaffolds and Assessment of Their Inhibitory Capacity on Medically Relevant Lectins'
Leyden R, Velasco-Torrijos T, Andre S, Gouin S, Gabius HJ, MurphyPV, (2009) 'Synthesis of Bivalent Lactosides Based on Terephthalamide, N,N'-Diglucosylterephthalamide, and Glycophane Scaffolds and Assessment of Their Inhibitory Capacity on Medically Relevant Lectins'. JOURNAL OF ORGANIC CHEMISTRY, 74 :9010-9026 [IR Link] [Details]
2005 'The crystal structure of a cyclic glycolipid reveals a carbohydrate-carbohydrate interaction interface'
Müller-Bunz H, Velasco-Torrijos T, Murphy PV, (2005) 'The crystal structure of a cyclic glycolipid reveals a carbohydrate-carbohydrate interaction interface'. CARBOHYDRATE RESEARCH, 340 :1437-1440 [Details]
2005 'Fine-tuning furan toxicity: fast and quantitative DNA interchain cross-link formation upon selective oxidation of a furan containing oligonucleotide'
Halila S, Velasco T, De Clercq P, Madder A (2005) 'Fine-tuning furan toxicity: fast and quantitative DNA interchain cross-link formation upon selective oxidation of a furan containing oligonucleotide'. CHEMICAL COMMUNICATIONS, :936-938 [Details]
2005 'Synthesis and conformational analysis of novel water soluble macrocycles incorporating carbohydrates, including a beta-cyclodextrin mimic'
Velasco-Torrijos T, Murphy, PV (2005) 'Synthesis and conformational analysis of novel water soluble macrocycles incorporating carbohydrates, including a beta-cyclodextrin mimic'. TETRAHEDRON ASYMMETRY, 16 :261-272 [Details]
2004 'Metathesis of structurally preorganised bivalent carbohydrates. Synthesis of macrocyclic and oligomeric scaffolds'
Velasco-Torrijos T, Murphy PV (2004) 'Metathesis of structurally preorganised bivalent carbohydrates. Synthesis of macrocyclic and oligomeric scaffolds'. ORGANIC LETTERS, 5 :3961-3964 [Details]
2004 'Tuning selectivity in macrotricyclic carbohydrate receptors; CH to N mutations in aromatic spacers'
Velasco T, Lecollinet G, Ryan T Davis AP (2004) 'Tuning selectivity in macrotricyclic carbohydrate receptors; CH to N mutations in aromatic spacers'. ORGANIC AND BIOMOLECULAR CHEMISTRY, 2 :645-647 [Details]
2002 'Phase transfer of monosaccharides through noncovalent interactions: selective extraction of glucose by a lipophilic cage receptor'
Ryan TJ, Lecollinet G, Velasco T, Davis AP (2002) 'Phase transfer of monosaccharides through noncovalent interactions: selective extraction of glucose by a lipophilic cage receptor'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, 99 :4863-4866 [Details]
2002 'Highly selective disaccharide recognition by a tricyclic octaamide cage'
Lecollinet G, Dominey AP, Velasco T, Davis AP (2002) 'Highly selective disaccharide recognition by a tricyclic octaamide cage'. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 41 :4093-4096 [Details]

Reviews

  Year Publication
2013 Multivalent glycoconjugates as anti-pathogenic agents.
Bernardi, A;Jimenez-Barbero, J;Casnati, A;De Castro, C;Darbre, T;Fieschi, F;Finne, J;Funken, H;Jaeger, KE;Lahmann, M;Lindhorst, TK;Marradi, M;Messner, P;Molinaro, A;Murphy, PV;Nativi, C;Oscarson, S;Penades, S;Peri, F;Pieters, RJ;Renaudet, O;Reymond, JL;Richichi, B;Rojo, J;Sansone, F;Schaffer, C;Turnbull, WB;Velasco-Torrijos, T;Vidal, S;Vincent, S;Wennekes, T;Zuilhof, H;Imberty, A (2013) Multivalent glycoconjugates as anti-pathogenic agents. CAMBRIDGE: Reviews [DOI] [IR Link] [Details]

Reviews

  Journal Role
Molecules Series Editor