Dr Ozgur Bayram

Biology, Human Health Institute

Lecturer

Callan
2.31
(+353) 1 708 6879

Biography

2000: BSc in Biology (Uludag University, Bursa, Turkey); 2003: MSc in Molecular Biology (yeast genetics) (Uludag University, Bursa, Turkey); 2007: PhD in Microbiology, Genetics and Biochemistry (Fungal genetics and Secondary metabolism) (Institute of Microbiology and Genetics, Georg-August University, Goettingen, Germany); 2008-2011: Postdoctoral fellow (Institute of Microbiology and Genetics, Georg-August University, Goettingen, Germany); 2012: Docent degree in Biology (Ankara, Turkey); 2012-2014: Project leader and Dozent (Institute of Microbiology and Genetics, Georg-August University, Goettingen, Germany); From 2014: Lecturer in Biology (National University of Ireland Maynooth)

Research Interests

Fungal secondary metabolites (SM), including food contaminating mycotoxins (e.g. aflatoxin, sterigmatocystin, fumonisins), antibiotics (e.g. penicillin, cephalosporin) and many other pharmaceuticals have great impact on human activities on earth. SM genes are mostly clustered in the subtelomeric regions of fungal chromosomes. Many SM gene clusters are silenced by facultative heterochromatin and activated upon environmental signals, including light, pH, temperature, organismic interactions, and nutritional conditions during development of the fungus. Our laboratory focuses on understanding of the molecular control mechanisms of SM production and development in the model system Aspergillus nidulans, aflatoxin production and development in Aspergillus flavus and SM-based virulence factors in opportunistic human pathogen A. fumigatus. Fungal development and SM production is coordinated by the regulatory protein complexes. In this context, we are interested in two questions: (I) How are the gene clusters turned on and off at the epigenetic level by the regulatory proteins? (II) What kind of signals are important for the activation of gene clusters and fungal development? While approaching to these questions, we use genetic, biochemical, cell biological methods, including gene disruption, epitope tagging, overexpression, protein enrichment, protein-protein interactions, time-lapse imaging and confocal imaging.

Research Projects

  Project Role Description Start Date End Date
Role of scaffold proteins in the control of fungal development and secondary metabolism PI
Roles of histone demethylase complexes in the control of fungal development and secondary metabolite production PI

Book Chapters

  Year Publication
2016 'Fungal MAP-Kinase-Mediated Regulatory Pathways'
Irniger S, Sarikaya-Bayram O, Bayram O (2016) 'Fungal MAP-Kinase-Mediated Regulatory Pathways' In: Biochemistry and Molecular Biology, 3rd Edition The Mycota III. Switzerland: Springer. [Details]
2012 'Identification of protein complexes from filamentous fungi with tandem affinity purification'
Bayram O, Bayram OS, Valerius O, Jöhnk B, Braus G.H (2012) 'Identification of protein complexes from filamentous fungi with tandem affinity purification' In: Methods in Molecular Biology. Humana Press. [DOI] [Details]

Edited Books

  Year Publication
2017 Fungal Jewels: Secondary Metabolites
Keller NP, Palmer J, Bayram O (Ed.). (2017) Fungal Jewels: Secondary Metabolites Lausanne: Frontiers Media. [DOI] [Details]

Peer Reviewed Journals

  Year Publication
2018 'The HamE scaffold positively regulates MpkB phosphorylation to promote development and secondary metabolism in Aspergillus nidulans'
Frawley D.;Karahoda B.;Sarikaya Bayram Ö.;Bayram Ö. (2018) 'The HamE scaffold positively regulates MpkB phosphorylation to promote development and secondary metabolism in Aspergillus nidulans'. Scientific Reports, 8 (1) [DOI] [Details]
2018 'Regulation of Aspergillus nidulans CreA-mediated catabolite repression by the F-Box proteins Fbx23 and Fbx47'
de Assis L.;Ulas M.;Ries L.;El Ramli N.;Sarikaya-Bayram O.;Braus G.;Bayram O.;Goldman G. (2018) 'Regulation of Aspergillus nidulans CreA-mediated catabolite repression by the F-Box proteins Fbx23 and Fbx47'. mBio, 9 (3) [DOI] [Details]
2018 'The Aspergillus nidulans pyruvate dehydrogenase kinases are essential to integrate carbon source metabolism'
Ries L.;de Assis L.;Rodrigues F.;Caldana C.;Rocha M.;Malavazi I.;Bayram Ö.;Goldman G. (2018) 'The Aspergillus nidulans pyruvate dehydrogenase kinases are essential to integrate carbon source metabolism'. G3 (Bethesda, Md.), 8 (7):2445-2463 [DOI] [IR Link] [Details]
2017 'MybA, a new player driving survival of the conidium of the human pathogen Aspergillus fumigatus'
Sarikaya Bayram Ö;Latgé JP;Bayram Ö; (2017) 'MybA, a new player driving survival of the conidium of the human pathogen Aspergillus fumigatus'. Current Genetics, [DOI] [Details]
2017 'Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence'
Manfiolli AO;de Castro PA;Dos Reis TF;Dolan S;Doyle S;Jones G;Riaño Pachón DM;Ulaş M;Noble LM;Mattern DJ;Brakhage AA;Valiante V;Silva-Rocha R;Bayram O;Goldman GH; (2017) 'Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence'. Cellular Microbiology, [DOI] [Details]
2017 'MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen Aspergillus fumigatus'
Valsecchi I;Sarikaya-Bayram Ö;Wong Sak Hoi J;Muszkieta L;Gibbons J;Prevost MC;Mallet A;Krijnse-Locker J;Ibrahim-Granet O;Mouyna I;Carr P;Bromley M;Aimanianda V;Yu JH;Rokas A;Braus GH;Saveanu C;Bayram Ö;Latgé JP; (2017) 'MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen Aspergillus fumigatus'. Molecular Microbiology, [DOI] [Details]
2017 'Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus'
de Vries RP;Riley R;Wiebenga A;Aguilar-Osorio G;Amillis S;Uchima CA;Anderluh G;Asadollahi M;Askin M;Barry K;Battaglia E;Bayram Ö;Benocci T;Braus-Stromeyer SA;Caldana C;Cánovas D;Cerqueira GC;Chen F;Chen W;Choi C;Clum A;Dos Santos RA et al (2017) 'Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus'. Genome Biology, 18 (1):1-45 [DOI] [IR Link] [Details]
2016 'SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus'
Jöhnk B;Bayram O;Abelmann A;Heinekamp T;Mattern DJ;Brakhage AA;Jacobsen ID;Valerius O;Braus GH; (2016) 'SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus'. PLoS Pathogens, 12 (9) [DOI] [IR Link] [Details]
2016 'Changes of global gene expression and secondary metabolite accumulation during light-dependent Aspergillus nidulans development'
Bayram O, Feussner K, Dumkow M, Herrfurth C, Feussner I, Braus GH. (2016) 'Changes of global gene expression and secondary metabolite accumulation during light-dependent Aspergillus nidulans development'. Fungal Genetics and Biology, 87 :30-53 [DOI] [Details]
2015 'One Juliet and four Romeos: VeA and its methyltransferases'
Sarikaya-Bayram , Palmer JM, Keller N, Braus GH, Bayram (2015) 'One Juliet and four Romeos: VeA and its methyltransferases'. Frontiers in Microbiology, 20 [DOI] [IR Link] [Details]
2015 'Quantitative proteomics reveals the mechanism and consequence of gliotoxin-mediated dysregulation of the methionine cycle in Aspergillus niger'
Manzanares-Miralles L, Sarikaya-Bayram Ö, Smith EB, Dolan SK, Bayram Ö, Jones GW, Doyle S. (2015) 'Quantitative proteomics reveals the mechanism and consequence of gliotoxin-mediated dysregulation of the methionine cycle in Aspergillus niger'. Proteomics, NA [DOI] [IR Link] [Details]
2015 'Dissecting the function of the different chitin synthases in vegetative growth and sexual development in Neurospora crassa'
Fajardo-Somera RA, Jöhnk B, Bayram Ö, Valerius O, Braus GH, Riquelme M. (2015) 'Dissecting the function of the different chitin synthases in vegetative growth and sexual development in Neurospora crassa'. Fungal Genetics and Biology, 13 :30-45 [DOI] [IR Link] [Details]
2015 'The SrkA Kinase Is Part of the SakA Mitogen-Activated Protein Kinase Interactome and Regulates Stress Responses and Development in Aspergillus nidulans'
Jaimes-Arroyo R, Lara-Rojas F, Bayram , Valerius O, Braus GH, Aguirre J (2015) 'The SrkA Kinase Is Part of the SakA Mitogen-Activated Protein Kinase Interactome and Regulates Stress Responses and Development in Aspergillus nidulans'. EUKARYOTIC CELL, 14 :495-510 [DOI] [IR Link] [Details]
2014 'Membrane-Bound Methyltransferase Complex VapA-VipC-VapB Guides Epigenetic Control of Fungal Development'
Sarikaya-Bayram O, Bayram O, Feussner K, Kim J.H, Kim H.S, Kaever A, Feussner I, Chae K.S, Han D.M, Han K.H, Braus G.H (2014) 'Membrane-Bound Methyltransferase Complex VapA-VipC-VapB Guides Epigenetic Control of Fungal Development'. Developmental Cell, 29 :406-420 [DOI] [IR Link] [Details]
2013 'The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-κB'
Ahmed YL, Gerke J, Park HS, Bayram O, Neumann P, Ni M, Dickmanns A, Kim S.C, Yu J.H, Braus G.H, Ficner R. (2013) 'The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-κB'. PLOS Biology, 11 [DOI] [IR Link] [Details]
2013 'Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome'
Christmann M, Schmaler T, Gordon C, Huang X, Bayram O, Schinke J, Stumpf S, Dubiel W, Braus G.H. (2013) 'Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome'. PLOS Genetics, 9 [DOI] [IR Link] [Details]
2013 'Interplay of the fungal sumoylation network for control of multicellular development'
Harting R, Bayram O, Laubinger K, Valerius O, Braus G.H. (2013) 'Interplay of the fungal sumoylation network for control of multicellular development'. MOLECULAR MICROBIOLOGY, 90 :1125-1145 [DOI] [IR Link] [Details]
2013 'conF and conJ contribute to conidia germination and stress response in the filamentous fungus Aspergillus nidulans'
Suzuki S, Sarikaya Bayram O, Bayram O, Braus G.H. (2013) 'conF and conJ contribute to conidia germination and stress response in the filamentous fungus Aspergillus nidulans'. FUNGAL GENETICS AND BIOLOGY, 56 :42-53 [DOI] [IR Link] [Details]
2012 'Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins'
Bayram O, Braus G.H. (2012) 'Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins'. FEMS Microbiology Reviews, 36 :1-24 [DOI] [IR Link] [Details]
2012 'Breaking the silence: protein stabilization uncovers silenced biosynthetic gene clusters in the fungus Aspergillus nidulans'
Gerke J, Bayram O, Feussner K, Landesfeind M, Shelest E, Feussner I, Braus G.H. (2012) 'Breaking the silence: protein stabilization uncovers silenced biosynthetic gene clusters in the fungus Aspergillus nidulans'. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 78 :8234-8244 [DOI] [IR Link] [Details]
2012 'Fungal S-adenosylmethionine synthetase and the control of development and secondary metabolism in Aspergillus nidulans'
Gerke J, Bayram O, Braus G.H. (2012) 'Fungal S-adenosylmethionine synthetase and the control of development and secondary metabolism in Aspergillus nidulans'. FUNGAL GENETICS AND BIOLOGY, 49 :443-454 [DOI] [IR Link] [Details]
2012 'The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism'
Bayram O, Bayram OS, Ahmed Y.L, Maruyama J, Valerius O, Rizzoli S.O, Ficner R, Irniger S, Braus G.H (2012) 'The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism'. PLOS Genetics, 8 [DOI] [IR Link] [Details]
2012 'Characterization of the velvet regulators in Aspergillus fumigatus'
Park HS, Bayram O, Braus G.H, Kim S.C, Yu J.H. (2012) 'Characterization of the velvet regulators in Aspergillus fumigatus'. Molecular Microbiology, 86 :937-953 [DOI] [IR Link] [Details]
2012 'The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development'
Kress M.R, Harting R, Bayram O, Christmann M, Irmer H, Valerius O, Schinke J, Goldman GH, Braus G.H. (2012) 'The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development'. Molecular Microbiology, 83 :1162-1177 [DOI] [IR Link] [Details]
2012 'Molecular characterization of the Aspergillus nidulans fbxA encoding an F-box protein involved in xylanase induction'
Colabardini A.C, Humanes AC, Gouvea P.F, Savoldi M, Goldman M.H, Kress M.R, Bayram O, Oliveira J.V, Gomes M.D, Braus G.H, Goldman G.H. (2012) 'Molecular characterization of the Aspergillus nidulans fbxA encoding an F-box protein involved in xylanase induction'. FUNGAL GENETICS AND BIOLOGY, 49 :130-140 [DOI] [IR Link] [Details]
2010 'Fungal development and the COP9 signalosome'
Braus G.H, Irniger S, Bayram O. (2010) 'Fungal development and the COP9 signalosome'. Current Opinion in Microbiology, 13 :672-676 [DOI] [IR Link] [Details]
2010 'Spotlight on Aspergillus nidulans photosensory systems'
Bayram O, Braus GH, Fischer R, Rodriguez-Romero J (2010) 'Spotlight on Aspergillus nidulans photosensory systems'. Fungal Genetics and Biology, 47 :900-908 [DOI] [IR Link] [Details]
2010 'Dissection of mitotic functions of the yeast cyclin Clb2'
Kuczera T, Bayram O, Sari F, Braus G.H, Irniger S. (2010) 'Dissection of mitotic functions of the yeast cyclin Clb2'. Cell Cycle, 9 :2611-2619 [DOI] [IR Link] [Details]
2010 'LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity'
Sarikaya Bayram O, Bayram O, Valerius O, Park H.S, Irniger S, Gerke J, Ni M, Han K.H, Yu J.H, Braus G.H. (2010) 'LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity'. PLOS Genetics, 6 [DOI] [IR Link] [Details]
2010 'The COP9 signalosome mediates transcriptional and metabolic response to hormones, oxidative stress protection and cell wall rearrangement during fungal development'
Nahlik K, Dumkow M, Bayram O, Helmstaedt K, Busch S, Valerius O, Gerke J, Hoppert M, Schwier E, Opitz L, Westermann M, Grond S, et al. (2010) 'The COP9 signalosome mediates transcriptional and metabolic response to hormones, oxidative stress protection and cell wall rearrangement during fungal development'. Molecular Microbiology, 78 :964-979 [DOI] [IR Link] [Details]
2009 'The protein kinase ImeB is required for light-mediated inhibition of sexual development and for mycotoxin production in Aspergillus nidulans'
Bayram O, Sari F, Braus G.H, Irniger S. (2009) 'The protein kinase ImeB is required for light-mediated inhibition of sexual development and for mycotoxin production in Aspergillus nidulans'. Molecular Microbiology, 71 :1278-1295 [DOI] [IR Link] [Details]
2009 'Glucose signaling pathway and growth conditions regulate gene expression in retrotransposon Ty2'
Turkel S, Bayram O, Arik E. (2009) 'Glucose signaling pathway and growth conditions regulate gene expression in retrotransposon Ty2'. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF C, 64 :526-532 [IR Link] [Details]
2008 'Neurospora crassa ve-1 affects asexual conidiation'
Bayram O, Krappmann S, Seiler S, Vogt N, Braus GH (2008) 'Neurospora crassa ve-1 affects asexual conidiation'. Fungal Genetics and Biology, 45 :127-138 [DOI] [IR Link] [Details]
2008 'More than a repair enzyme: Aspergillus nidulans photolyase-like CryA is a regulator of sexual development'
Bayram O, Biesemann C, Krappmann S, Galland P, Braus GH (2008) 'More than a repair enzyme: Aspergillus nidulans photolyase-like CryA is a regulator of sexual development'. Molecular Biology of the Cell, 19 :3254-3262 [DOI] [IR Link] [Details]
2008 'The nuclear migration protein NUDF/LIS1 forms a complex with NUDC and BNFA at spindle pole bodies'
Helmstaedt K, Laubinger K, Vosskuhl K, Bayram O, Busch S, Hoppert M, Valerius O, Seiler S, Braus GH. (2008) 'The nuclear migration protein NUDF/LIS1 forms a complex with NUDC and BNFA at spindle pole bodies'. EUKARYOTIC CELL, 7 :1041-1052 [DOI] [IR Link] [Details]
2008 'VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism'
Bayram O, Krappmann S, Ni M, Bok JW, Helmstaedt K, Valerius O, Braus-Stromeyer S, Kwon NJ, Keller NP, Yu JH, Braus GH (2008) 'VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism'. Science, 320 :1504-1506 [DOI] [IR Link] [Details]
2007 'An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation'
Busch S, Schwier EU, Nahlik K, Bayram O, Helmstaedt K, Draht OW, Krappmann S, Valerius O, Lipscomb WN, Braus G.H (2007) 'An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, 8 :8089-8094 [DOI] [IR Link] [Details]
2005 'Deletion and allelic exchange of the Aspergillus fumigatus veA locus via a novel recyclable marker module'
Krappmann S, Bayram O, Braus G.H. (2005) 'Deletion and allelic exchange of the Aspergillus fumigatus veA locus via a novel recyclable marker module'. EUKARYOTIC CELL, 4 :1298-1307 [DOI] [IR Link] [Details]

Honours and Awards

  Year Title Awarding Body
2008 Excellence award for poster presentation Aspergillus Genomes Research Policy Committee
2010 Distinctive publication prize Board of Trustees of Georg August University, Germany
2014 Science Foundation Ireland (SFI) Career Development Award (CDA) SFI
2008 GZMB outstanding doctoral thesis Award Goettingen Center for Molecular Biosciences (GZMB)
2011 Listed among the top 50 Turkish academicians in Germany in the book entitled „In Bester Gesellschaft“ German Standards Institute, Berlin, Germany

Professional Associations

  Association Function From / To
Irish Fungal Society (IFS) Member /
Genetics Society of America (GSA) Meber /

Employment

  Employer Position From / To
Georg August University Postdoctoral Fellow 01-JAN-08 / 31-DEC-11
Georg August University Project Leader 01-JAN-12 / 31-DEC-13
Maynooth University Lecturer in Biology 18-JAN-14 /

Education

  Year Institution Qualification Subject
2007 Georg August University PhD (Dr.rer.nat) Molecular Microbiology, Genetics, Biochemistry
2003 Uludag University MSc Molecular Biology (yeast genetics)
2000 Uludag University BSc Biology

Languages

  Language Reading Writing Speaking
English Fluent Fluent Fluent
German Functional Functional Functional

Reviews

  Journal Role
Eukaryotic Cell Reviewer
Scientific Reports Reviewer
Plos One Reviewer
Plos Genetics Reviewer
Frontiers In Microbiology Editor
Applied Microbiology And Biotechnology Reviewer
Fungal Genetics And Biology Reviewer
Frontiers In Microbiology Reviewer
Current Genetics Reviewer
Molecular Genetics And Genomics Reviewer
Molecular Microbiology Reviewer

Teaching Interests

I currently teach
  • BI441 (Fungal and Bacterial Secondary Metabolism)
  • BI308 (Proteomics)
  • BI416 (Genomics and Proteomics)
  • BI312 (Scientific Writing)

Internal Collaborators

  Name Institute Country
Sean Doyle IRELAND

External Collaborators

  Name Role / Description Country
Prof. Dr. Jean Paul Latge Fungal pathogens FRANCE
Prof. Dr. Joseph Strauss Chromatin Biology AUSTRIA
Prof. Dr. Berl Oakley Cell Biology U.S.A.
Prof. Dr. Jun-Ichi Maruyama Fungal Genetics/Biotechnology JAPAN
Prof. Dr. Gustavo Goldman Fungal Pathogenicity BRAZIL