Dr Ozgur Bayram
Biography
Research Interests
Research Projects
| Project | Role | Description | Start Date | End Date | |
|---|---|---|---|---|---|
| Role of MAPK pathways in pathogenicity of Aspergilli | PI | 01-OCT-18 | 31-OCT-20 | ||
| Role of scaffold proteins in the control of fungal development and secondary metabolism | PI | ||||
| Roles of histone demethylase complexes in the control of fungal development and secondary metabolite production | PI |
Book Chapters
| Year | Publication | |
|---|---|---|
| 2016 | 'Fungal MAP-Kinase-Mediated Regulatory Pathways'
Irniger S, Sarikaya-Bayram O, Bayram O (2016) 'Fungal MAP-Kinase-Mediated Regulatory Pathways' In: Biochemistry and Molecular Biology, 3rd Edition The Mycota III. Switzerland: Springer. [Details] |
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| 2012 | 'Identification of protein complexes from filamentous fungi with tandem affinity purification'
Bayram O, Bayram OS, Valerius O, Jöhnk B, Braus G.H (2012) 'Identification of protein complexes from filamentous fungi with tandem affinity purification' In: Methods in Molecular Biology. Humana Press. [DOI] [Details] |
Edited Books
| Year | Publication | |
|---|---|---|
| 2017 | Fungal Jewels: Secondary Metabolites
Keller NP, Palmer J, Bayram O (Ed.). (2017) Fungal Jewels: Secondary Metabolites Lausanne: Frontiers Media. [DOI] [Details] |
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| 2019 | 'Assembly of a heptameric STRIPAK complex is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans'
Elramli N;Karahoda B;Sarikaya-Bayram Ö;Frawley D;Ulas M;Oakley CE;Oakley BR;Seiler S;Bayram Ö; (2019) 'Assembly of a heptameric STRIPAK complex is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans'. PLoS Genetics, 15 (3) [DOI] [Details] |
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| 2019 | 'Aspergillus fumigatus high osmolarity glycerol mitogen activated protein kinases SakA and MpkC physically interact during osmotic and cell wall stresses'
Manfiolli OA; Mattos EC; de Assis LJ; Silva LP; Ulaş M; Brown NA; Bayram Ö; Goldman GH (2019) 'Aspergillus fumigatus high osmolarity glycerol mitogen activated protein kinases SakA and MpkC physically interact during osmotic and cell wall stresses'. Frontiers in Microbiology, [Details] |
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| 2019 | 'Comprehensive analysis of A. nidulans PKA phosphorylome identifies a novel mode of CreA regulation'
Ribeiro LFC , Chelius C ,Boppidi K, Naik N, Hossain S, Ramsey JJL, Kumar J, Ribeiro LF , Ostermeier M , Tran B , Goo YA , deAssis LJ , Ulas M , Bayram O , Goldman GH , Lincoln S, Srivastava R ,Harris SD , Marten MR (2019) 'Comprehensive analysis of A. nidulans PKA phosphorylome identifies a novel mode of CreA regulation'. mBio, [Details] |
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| 2019 | 'Single-Step Enrichment of a TAP-Tagged Histone Deacetylase of the Filamentous Fungus Aspergillus nidulans for Enzymatic Activity Assay'
Bauer I; Pidroni A; Bayram O; Brosch G; Graessle S (2019) 'Single-Step Enrichment of a TAP-Tagged Histone Deacetylase of the Filamentous Fungus Aspergillus nidulans for Enzymatic Activity Assay'. Journal of visualized experiments : JoVE, [Details] |
|
| 2018 | 'The HamE scaffold positively regulates MpkB phosphorylation to promote development and secondary metabolism in Aspergillus nidulans'
Frawley D.;Karahoda B.;Sarikaya Bayram Ö.;Bayram Ö. (2018) 'The HamE scaffold positively regulates MpkB phosphorylation to promote development and secondary metabolism in Aspergillus nidulans'. Scientific Reports, 8 (1) [DOI] [Details] |
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| 2018 | 'Regulation of Aspergillus nidulans CreA-mediated catabolite repression by the F-Box proteins Fbx23 and Fbx47'
de Assis L.;Ulas M.;Ries L.;El Ramli N.;Sarikaya-Bayram O.;Braus G.;Bayram O.;Goldman G. (2018) 'Regulation of Aspergillus nidulans CreA-mediated catabolite repression by the F-Box proteins Fbx23 and Fbx47'. mBio, 9 (3) [DOI] [Details] |
|
| 2018 | 'The Aspergillus nidulans pyruvate dehydrogenase kinases are essential to integrate carbon source metabolism'
Ries L.;de Assis L.;Rodrigues F.;Caldana C.;Rocha M.;Malavazi I.;Bayram Ö.;Goldman G. (2018) 'The Aspergillus nidulans pyruvate dehydrogenase kinases are essential to integrate carbon source metabolism'. G3 (Bethesda, Md.), 8 (7):2445-2463 [DOI] [IR Link] [Details] |
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| 2017 | 'MybA, a new player driving survival of the conidium of the human pathogen Aspergillus fumigatus'
Sarikaya Bayram Ö;Latgé JP;Bayram Ö; (2017) 'MybA, a new player driving survival of the conidium of the human pathogen Aspergillus fumigatus'. Current Genetics, [DOI] [Details] |
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| 2017 | 'Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence'
Manfiolli AO;de Castro PA;Dos Reis TF;Dolan S;Doyle S;Jones G;Riaño Pachón DM;Ulaş M;Noble LM;Mattern DJ;Brakhage AA;Valiante V;Silva-Rocha R;Bayram O;Goldman GH; (2017) 'Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence'. Cellular Microbiology, [DOI] [Details] |
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| 2017 | 'MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen Aspergillus fumigatus'
Valsecchi I;Sarikaya-Bayram Ö;Wong Sak Hoi J;Muszkieta L;Gibbons J;Prevost MC;Mallet A;Krijnse-Locker J;Ibrahim-Granet O;Mouyna I;Carr P;Bromley M;Aimanianda V;Yu JH;Rokas A;Braus GH;Saveanu C;Bayram Ö;Latgé JP; (2017) 'MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen Aspergillus fumigatus'. Molecular Microbiology, [DOI] [Details] |
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| 2017 | 'Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus'
de Vries RP;Riley R;Wiebenga A;Aguilar-Osorio G;Amillis S;Uchima CA;Anderluh G;Asadollahi M;Askin M;Barry K;Battaglia E;Bayram Ö;Benocci T;Braus-Stromeyer SA;Caldana C;Cánovas D;Cerqueira GC;Chen F;Chen W;Choi C;Clum A;Dos Santos RA et al (2017) 'Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus'. Genome Biology, 18 (1):1-45 [DOI] [IR Link] [Details] |
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| 2016 | 'Changes of global gene expression and secondary metabolite accumulation during light-dependent Aspergillus nidulans development'
Bayram Ö.;Feussner K.;Dumkow M.;Herrfurth C.;Feussner I.;Braus G. (2016) 'Changes of global gene expression and secondary metabolite accumulation during light-dependent Aspergillus nidulans development'. Fungal Genetics and Biology, 87 :30-53 [DOI] [Details] |
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| 2016 | 'SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus'
Jöhnk B;Bayram O;Abelmann A;Heinekamp T;Mattern DJ;Brakhage AA;Jacobsen ID;Valerius O;Braus GH; (2016) 'SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus'. PLoS Pathogens, 12 (9) [DOI] [IR Link] [Details] |
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| 2016 | 'Quantitative proteomics reveals the mechanism and consequence of gliotoxin-mediated dysregulation of the methionine cycle in Aspergillus niger'
Manzanares-Miralles L, Sarikaya-Bayram Ö, Smith EB, Dolan SK, Bayram Ö, Jones GW, Doyle S. (2016) 'Quantitative proteomics reveals the mechanism and consequence of gliotoxin-mediated dysregulation of the methionine cycle in Aspergillus niger'. Proteomics, NA [DOI] [IR Link] [Details] |
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| 2015 | 'One Juliet and four Romeos: VeA and its methyltransferases'
Sarikaya-Bayram , Palmer JM, Keller N, Braus GH, Bayram (2015) 'One Juliet and four Romeos: VeA and its methyltransferases'. Frontiers in Microbiology, 20 [DOI] [IR Link] [Details] |
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| 2015 | 'Dissecting the function of the different chitin synthases in vegetative growth and sexual development in Neurospora crassa'
Fajardo-Somera R.;Jöhnk B.;Bayram Ö.;Valerius O.;Braus G.;Riquelme M. (2015) 'Dissecting the function of the different chitin synthases in vegetative growth and sexual development in Neurospora crassa'. Fungal Genetics and Biology, 75 :30-45 [DOI] [IR Link] [Details] |
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| 2015 | 'The SrkA Kinase Is Part of the SakA Mitogen-Activated Protein Kinase Interactome and Regulates Stress Responses and Development in Aspergillus nidulans'
Jaimes-Arroyo R, Lara-Rojas F, Bayram , Valerius O, Braus GH, Aguirre J (2015) 'The SrkA Kinase Is Part of the SakA Mitogen-Activated Protein Kinase Interactome and Regulates Stress Responses and Development in Aspergillus nidulans'. EUKARYOTIC CELL, 14 :495-510 [DOI] [IR Link] [Details] |
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| 2014 | 'Membrane-Bound Methyltransferase Complex VapA-VipC-VapB Guides Epigenetic Control of Fungal Development'
Sarikaya-Bayram O, Bayram O, Feussner K, Kim J.H, Kim H.S, Kaever A, Feussner I, Chae K.S, Han D.M, Han K.H, Braus G.H (2014) 'Membrane-Bound Methyltransferase Complex VapA-VipC-VapB Guides Epigenetic Control of Fungal Development'. Developmental Cell, 29 :406-420 [DOI] [IR Link] [Details] |
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| 2013 | 'The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-κB'
Ahmed YL, Gerke J, Park HS, Bayram O, Neumann P, Ni M, Dickmanns A, Kim S.C, Yu J.H, Braus G.H, Ficner R. (2013) 'The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-κB'. PLOS Biology, 11 [DOI] [IR Link] [Details] |
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| 2013 | 'Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome'
Christmann M, Schmaler T, Gordon C, Huang X, Bayram O, Schinke J, Stumpf S, Dubiel W, Braus G.H. (2013) 'Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome'. PLOS Genetics, 9 [DOI] [IR Link] [Details] |
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| 2013 | 'Interplay of the fungal sumoylation network for control of multicellular development'
Harting R, Bayram O, Laubinger K, Valerius O, Braus G.H. (2013) 'Interplay of the fungal sumoylation network for control of multicellular development'. MOLECULAR MICROBIOLOGY, 90 :1125-1145 [DOI] [IR Link] [Details] |
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| 2013 | 'conF and conJ contribute to conidia germination and stress response in the filamentous fungus Aspergillus nidulans'
Suzuki S, Sarikaya Bayram O, Bayram O, Braus G.H. (2013) 'conF and conJ contribute to conidia germination and stress response in the filamentous fungus Aspergillus nidulans'. FUNGAL GENETICS AND BIOLOGY, 56 :42-53 [DOI] [IR Link] [Details] |
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| 2012 | 'Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins'
Bayram O, Braus G.H. (2012) 'Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins'. FEMS Microbiology Reviews, 36 :1-24 [DOI] [IR Link] [Details] |
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| 2012 | 'Breaking the silence: protein stabilization uncovers silenced biosynthetic gene clusters in the fungus Aspergillus nidulans'
Gerke J, Bayram O, Feussner K, Landesfeind M, Shelest E, Feussner I, Braus G.H. (2012) 'Breaking the silence: protein stabilization uncovers silenced biosynthetic gene clusters in the fungus Aspergillus nidulans'. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 78 :8234-8244 [DOI] [IR Link] [Details] |
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| 2012 | 'Fungal S-adenosylmethionine synthetase and the control of development and secondary metabolism in Aspergillus nidulans'
Gerke J, Bayram O, Braus G.H. (2012) 'Fungal S-adenosylmethionine synthetase and the control of development and secondary metabolism in Aspergillus nidulans'. FUNGAL GENETICS AND BIOLOGY, 49 :443-454 [DOI] [IR Link] [Details] |
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| 2012 | 'The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism'
Bayram O, Bayram OS, Ahmed Y.L, Maruyama J, Valerius O, Rizzoli S.O, Ficner R, Irniger S, Braus G.H (2012) 'The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism'. PLOS Genetics, 8 [DOI] [IR Link] [Details] |
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| 2012 | 'Characterization of the velvet regulators in Aspergillus fumigatus'
Park HS, Bayram O, Braus G.H, Kim S.C, Yu J.H. (2012) 'Characterization of the velvet regulators in Aspergillus fumigatus'. Molecular Microbiology, 86 :937-953 [DOI] [IR Link] [Details] |
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| 2012 | 'The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development'
Kress M.R, Harting R, Bayram O, Christmann M, Irmer H, Valerius O, Schinke J, Goldman GH, Braus G.H. (2012) 'The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development'. Molecular Microbiology, 83 :1162-1177 [DOI] [IR Link] [Details] |
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| 2012 | 'Molecular characterization of the Aspergillus nidulans fbxA encoding an F-box protein involved in xylanase induction'
Colabardini A.C, Humanes AC, Gouvea P.F, Savoldi M, Goldman M.H, Kress M.R, Bayram O, Oliveira J.V, Gomes M.D, Braus G.H, Goldman G.H. (2012) 'Molecular characterization of the Aspergillus nidulans fbxA encoding an F-box protein involved in xylanase induction'. FUNGAL GENETICS AND BIOLOGY, 49 :130-140 [DOI] [IR Link] [Details] |
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| 2010 | 'Fungal development and the COP9 signalosome'
Braus G.H, Irniger S, Bayram O. (2010) 'Fungal development and the COP9 signalosome'. Current Opinion in Microbiology, 13 :672-676 [DOI] [IR Link] [Details] |
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| 2010 | 'Spotlight on Aspergillus nidulans photosensory systems'
Bayram O, Braus GH, Fischer R, Rodriguez-Romero J (2010) 'Spotlight on Aspergillus nidulans photosensory systems'. Fungal Genetics and Biology, 47 :900-908 [DOI] [IR Link] [Details] |
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| 2010 | 'Dissection of mitotic functions of the yeast cyclin Clb2'
Kuczera T, Bayram O, Sari F, Braus G.H, Irniger S. (2010) 'Dissection of mitotic functions of the yeast cyclin Clb2'. Cell Cycle, 9 :2611-2619 [DOI] [IR Link] [Details] |
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| 2010 | 'LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity'
Sarikaya Bayram O, Bayram O, Valerius O, Park H.S, Irniger S, Gerke J, Ni M, Han K.H, Yu J.H, Braus G.H. (2010) 'LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity'. PLOS Genetics, 6 [DOI] [IR Link] [Details] |
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| 2010 | 'The COP9 signalosome mediates transcriptional and metabolic response to hormones, oxidative stress protection and cell wall rearrangement during fungal development'
Nahlik K, Dumkow M, Bayram O, Helmstaedt K, Busch S, Valerius O, Gerke J, Hoppert M, Schwier E, Opitz L, Westermann M, Grond S, et al. (2010) 'The COP9 signalosome mediates transcriptional and metabolic response to hormones, oxidative stress protection and cell wall rearrangement during fungal development'. Molecular Microbiology, 78 :964-979 [DOI] [IR Link] [Details] |
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| 2009 | 'The protein kinase ImeB is required for light-mediated inhibition of sexual development and for mycotoxin production in Aspergillus nidulans'
Bayram O, Sari F, Braus G.H, Irniger S. (2009) 'The protein kinase ImeB is required for light-mediated inhibition of sexual development and for mycotoxin production in Aspergillus nidulans'. Molecular Microbiology, 71 :1278-1295 [DOI] [IR Link] [Details] |
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| 2009 | 'Glucose signaling pathway and growth conditions regulate gene expression in retrotransposon Ty2'
Turkel S, Bayram O, Arik E. (2009) 'Glucose signaling pathway and growth conditions regulate gene expression in retrotransposon Ty2'. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF C, 64 :526-532 [IR Link] [Details] |
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| 2008 | 'Neurospora crassa ve-1 affects asexual conidiation'
Bayram O, Krappmann S, Seiler S, Vogt N, Braus GH (2008) 'Neurospora crassa ve-1 affects asexual conidiation'. Fungal Genetics and Biology, 45 :127-138 [DOI] [IR Link] [Details] |
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| 2008 | 'More than a repair enzyme: Aspergillus nidulans photolyase-like CryA is a regulator of sexual development'
Bayram O, Biesemann C, Krappmann S, Galland P, Braus GH (2008) 'More than a repair enzyme: Aspergillus nidulans photolyase-like CryA is a regulator of sexual development'. Molecular Biology of the Cell, 19 :3254-3262 [DOI] [IR Link] [Details] |
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| 2008 | 'The nuclear migration protein NUDF/LIS1 forms a complex with NUDC and BNFA at spindle pole bodies'
Helmstaedt K, Laubinger K, Vosskuhl K, Bayram O, Busch S, Hoppert M, Valerius O, Seiler S, Braus GH. (2008) 'The nuclear migration protein NUDF/LIS1 forms a complex with NUDC and BNFA at spindle pole bodies'. EUKARYOTIC CELL, 7 :1041-1052 [DOI] [IR Link] [Details] |
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| 2008 | 'VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism'
Bayram O, Krappmann S, Ni M, Bok JW, Helmstaedt K, Valerius O, Braus-Stromeyer S, Kwon NJ, Keller NP, Yu JH, Braus GH (2008) 'VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism'. Science, 320 :1504-1506 [DOI] [IR Link] [Details] |
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| 2007 | 'An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation'
Busch S, Schwier EU, Nahlik K, Bayram O, Helmstaedt K, Draht OW, Krappmann S, Valerius O, Lipscomb WN, Braus G.H (2007) 'An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, 8 :8089-8094 [DOI] [IR Link] [Details] |
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| 2005 | 'Deletion and allelic exchange of the Aspergillus fumigatus veA locus via a novel recyclable marker module'
Krappmann S, Bayram O, Braus G.H. (2005) 'Deletion and allelic exchange of the Aspergillus fumigatus veA locus via a novel recyclable marker module'. EUKARYOTIC CELL, 4 :1298-1307 [DOI] [IR Link] [Details] |
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 2014 | Science Foundation Ireland (SFI) Career Development Award (CDA) | SFI | |
| 2012 | Associate Professorship of Biology | Higher Education and Science Council, Turkey | |
| 2011 | Listed among the top 50 Turkish academicians in Germany in the book entitled „In Bester Gesellschaft“ | German Standards Institute, Berlin, Germany | |
| 2010 | Distinctive publication prize | Board of Trustees of Georg August University, Germany | |
| 2008 | GZMB outstanding doctoral thesis Award | Goettingen Center for Molecular Biosciences (GZMB) | |
| 2008 | PhD Graduation (summa cum laude) | Georg August University | |
| 2008 | Excellence award for poster presentation | Aspergillus Genomes Research Policy Committee |
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| Irish Fungal Society (IFS) | Member | 01-JUN-14 / | |
| Irish Fungal Society (IFS) | Treasurer | 01-JAN-17 / | |
| American Society For Microbiology | Member | 01-AUG-18 / | |
| Genetics Society of America (GSA) | Member | 01-JUL-11 / |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| University of Sanctuary | Member | 2018 / |
Employment
| Employer | Position | From / To | |
|---|---|---|---|
| Maynooth University | Lecturer in Biology | 18-JAN-14 / | |
| Georg August University | Project Leader | 01-JAN-12 / 31-DEC-13 | |
| Georg August University | Postdoctoral Fellow | 01-JAN-08 / 31-DEC-11 |
Education
| Year | Institution | Qualification | Subject | |
|---|---|---|---|---|
| 2007 | Georg August University | PhD (Dr.rer.nat) | Molecular Microbiology, Genetics, Biochemistry | |
| 2003 | Uludag University | MSc | Molecular Biology (yeast genetics) | |
| 2000 | Uludag University | BSc | Biology |
Languages
| Language | Reading | Writing | Speaking | |
|---|---|---|---|---|
| English | Fluent | Fluent | Fluent | |
| German | Functional | Functional | Functional |
Reviews
| Journal | Role | |
|---|---|---|
| Eukaryotic Cell | Reviewer | |
| Plos Pathogens | Reviewer | |
| Clinical Microbiology Reviews | Reviewer | |
| Scientific Reports | Reviewer | |
| Plos One | Reviewer | |
| Plos Genetics | Reviewer | |
| Frontiers In Microbiology | Editor | |
| Applied Microbiology And Biotechnology | Reviewer | |
| Fungal Genetics And Biology | Reviewer | |
| Frontiers In Microbiology | Reviewer | |
| Current Genetics | Reviewer | |
| Molecular Genetics And Genomics | Reviewer | |
| Molecular Microbiology | Reviewer |
Teaching Interests
Recent Postgraduates
| Graduation | Student Name | University | Degree | Thesis | |
|---|---|---|---|---|---|
| 2018 | Nadia Elramli | Maynooth University | PhD | ||
| 2019 | Betim Karahoda | Maynooth University | PhD | ||
| 2019 | Mevlut Ulas | Maynooth University | PhD | ||
| 2020 | Dean Frawley | Maynooth University | PhD |
Internal Collaborators
| Name | Institute | Country | |
|---|---|---|---|
| Sean Doyle | IRELAND |
External Collaborators
| Name | Role / Description | Country | |
|---|---|---|---|
| Prof. Dr. Jean Paul Latge | Fungal pathogens | FRANCE | |
| Prof. Dr. Joseph Strauss | Chromatin Biology | AUSTRIA | |
| Prof. Dr. Berl Oakley | Cell Biology | U.S.A. | |
| Prof. Dr. Jun-Ichi Maruyama | Fungal Genetics/Biotechnology | JAPAN | |
| Prof. Dr. Gustavo Goldman | Fungal Pathogenicity | BRAZIL |