Dr Ozgur Bayram

    Biology

    Associate Professor

    Callan
    2.31
    (01) 708 6879

    Biography

    2020-Curr Associate Professor in Biology (Maynooth University, Ireland)
    2014    -2020 Assistant Professor in Biology (Maynooth University, Ireland)
    2011-2014: Project leader & Dozent (Genetics, Georg-August University, Goettingen, Germany)                
    2012: Associate Professor Degree in Biology (Turkish Higher Education Council, Ankara, Turkey)
    2008-2011: Postdoctoral fellow (Georg-August University, Goettingen, Germany) 
    2003-2007: PhD in Microbiology, Genetics and Biochemistry (Georg-August University, Goettingen, Germany)
    2001-2003: MSc in Molecular Biology (Yeast genetics) (Uludag University, Bursa, Turkey)
    1996-2000: BSc in Biology (Uludag University, Bursa, Turkey)

    Research Interests

    Fungi play an important role as integral part of our ecosystem. They are source of food as raw material as well as fermentation products and enzymes. Furthermore, they produce bioactive secondary metabolites including food contaminating mycotoxins (e.g. aflatoxin, sterigmatocystin, fumonisins), antibiotics (e.g. penicillin, cephalosporin) and many other pharmaceuticals have great impact on human activities on earth. Our research focuses on detrimental and beneficial features of fungi. We try to prevent detrimental features of fungi such as mycotoxin production and contaminating food sources while we try to enhance beneficial features such as enzyme production, pollutant degradation using our expertise of molecular biology and fungal physiology. We have been working with a number of fungal organisms including model filamentous fungus Aspergillus nidulans, opportunistic human pathogen Aspergillus fumigatus, plant pathogen and aflaxotin producer Aspergillus flavus, model organism Neurospora crass, model system yeast Saccharomyces cerevisiae. In addition to these filamentous fungi and yeast, we have also established expertise for mushrooms to cultivate these organisms for enzyme and biomass production.

    Our research has got more than 5,000 citations according to the Google Scholar, and many of our papers are available as open access and in platforms like Researchgate. We have been collaborating with leading researchers from countries, Macau, Brazil, USA, Austria, Germany, Japan and Korea. We are expert in discovering protein complexes that regulate fungal secondary metabolite production. We have published landmark papers in regulation of mycotoxins. Transcriptional regulatory complexes, velvet complex (Science) (Genetics), Epigenetic Methyltransferase Complex, (Developmental Cell), COP9 complex (PNAS), the MAPK complex, the STRIPAK complex, F-box proteins and SCF complexes (PLoS Genetics), Fbx15 complex (PLoS Pathogens) the chromatin binding KERS complex (Nucleic Acids Research) are few to name. Our major research interest include:

    • Understanding mycotoxin production of fungi using molecular biology and epigenetic tools.
    • Reducing mycotoxins in food and feed sources for food safety and security.
    • Use of fungal enzymes for bioremediation of pollution.
    • Use of fungal biomass for feeding.
    • Using fungi and fungal enyzmes for circular economy. 

    We will be organising Europes largest Fungal Genetics Conference, 17th European Conference on Fungal Genetics (ECFG) in Dublin, Ireland in March 2025. We encourage all fungal researchers and plant pathologists working with fungi to participate in 17th ECFG.

    Research Projects

    Title Role Description Start date End date Amount
    Molecular analysis of chromatin-regulated gene expression in mycotoxigenic fungi for improved agricultural outputs and food security PI 01/12/2022 30/11/2026 615266
    NURoFE_MSCA IF EF ST_LEANDROASSIS PI The dependence of mankind on petroleum- and oil-based fuels as the main energy source is widely recognised as being accompanied by several problems that impact the global economy and environmental health. In recent years, the conversion of plant biomass to biofuels, in a process called 1st- (1G) and 2nd-generation (2G) biofuel-production, has gained significant interest as an environmentally friendly and naturally abundant alternative, renewable energy source. The EU (European Union) legislation implements that by 2020, 20% of energy must be derived from renewable sources, showing the importance that renewable energy source production will play in the future. Saprobic microorganisms, such as filamentous fungi of the genus Aspergillus, are of particular interest for this process as they secrete a vast array of plant biomass hydrolyzing enzymes. A major drawback in the production of renewable biofuels is built-up of glucose during enzymatic hydrolysis of plant biomass, resulting in the transcriptional repression of fungal enzyme-encoding genes and subsequent secretion. The here described fellowship is proposing to uncover novel proteins involved in the regulation of hydrolytic enzymes and secondary metabolites production in the filamentous fungus Aspergillus nidulans that can be explored for biotechnological processes. To implement this project, the candidate will be hosted at the National University of Ireland in Maynooth in the laboratory of Fungal Genetics and Secondary Metabolism, under the supervision of Dr. Ozgur Bayram. 26/05/2021 25/05/2023 196590.72
    Role of scaffold proteins in the control of fungal development and secondary metabolism PI 01/09/2014 01/10/2018 62000
    GOI Scholarship for Dean Frawley: Analysis of the scaffolding roles of HamE and it's homologs in fungal MAP kinase modules PI 01/10/2018 30/09/2020 48000
    Epigenetic networks of histone demethylase complexes in coordination of fungal morphogenesis and secondary metabolite production PI 01/10/2014 30/09/2018 597630
    External collaborator access to Mass Spectrometry facility in Biology Department PI 12/06/2023 30/06/2023 2500

    Peer Reviewed Journal

    Year Publication
    2023 Borges, BM; Ramos, RBC; Preite, NW; Kaminski, VL; Alves de Castro, P; Camacho, M; Maximo, MF; Fill, TP; Calich, VLG; Traynor, AM; Sarikaya-Bayram, Ö; Doyle, S; Bayram, Ö; de Campos, CBL; Zelanis, A; Goldman, GH; Loures, FV (2023) 'Transcriptional profiling of a fungal granuloma reveals a low metabolic activity of Paracoccidioides brasiliensis yeasts and an actively regulated host immune response'. Frontiers in Cellular and Infection Microbiology, 13 . [DOI]
    2023 Luciano-Rosario, D; Barda, O; Tannous, J; Frawley, D; Bayram, Ö; Prusky, D; Sionov, E; Keller, NP (2023) 'The histone demethylase KdmB is part of a trimeric protein complex and mediates virulence and mycotoxin production in Penicillium expansum'. Fungal genetics and biology : FG & B, . [DOI]
    2023 Bauer, I; Sarikaya Bayram, Ö; Bayram, Ö (2023) 'The use of immunoaffinity purification approaches coupled with LC-MS/MS offers a powerful strategy to identify protein complexes in filamentous fungi'. Essays in Biochemistry, 67 (5). [DOI]
    2023 Karahoda, B; Pfannenstiel, BT; Sarikaya-Bayram, Ö; Dong, Z; Ho Wong, K; Fleming, AB; Keller, NP; Bayram, Ö (2023) 'The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus'. Fungal genetics and biology : FG & B, 169 . [DOI]
    2023 Traynor, A.M., Sarikaya-Bayram, Ö., Bayram, Ö., Calera J.A., and Doyle, S. (2023) 'Proteomic dissection of role of GliZ in gliotoxin biosynthesis in Aspergillus fumigatus'. Fungal Genetics and Biology, 166 (103795). [Link] [DOI]
    2023 Sarikaya Bayram, Ö; Bayram, Ö (2023) 'An Anatomy of Fungal Eye: Fungal Photoreceptors and Signalling Mechanisms'. Journal Of Fungi, 5 (9):1-22. [DOI]
    2022 Sarikaya Bayram Ö; Bayram Ö; Karahoda B; Meister C; Köhler AM; Thieme S; Elramli N; Frawley D; McGowan J; Fitzpatrick DA; Schmitt K; de Assis LJ; Valerius O; Goldman GH; Braus GH; (2022) 'F-box receptor mediated control of substrate stability and subcellular location organizes cellular development of Aspergillus nidulans'. PLoS Genetics, 18 (12). [DOI] [Full-Text]
    2022 Karahoda B; Pardeshi L; Ulas M; Dong Z; Shirgaonkar N; Guo S; Wang F; Tan K; Sarikaya-Bayram Ö; Bauer I; Dowling P; Fleming AB; Pfannenstiel BT; Luciano-Rosario D; Berger H; Graessle S; Alhussain MM; Strauss J; Keller NP; Wong KH; Bayram Ö; (2022) 'The KdmB-EcoA-RpdA-SntB chromatin complex binds regulatory genes and coordinates fungal development with mycotoxin synthesis'. Nucleic Acids Research, . [DOI] [Full-Text]
    2021 Katayama, T; Bayram, Ö; Mo, T; Karahoda, B; Valerius, O; Takemoto, D; Braus, GH, 4 , Kitamoto, K; Maruyama, J.I (2021) 'Novel Fus3- and Ste12-interacting protein FsiA activates cell fusion-related genes in both Ste12-dependent and -independent manners in Ascomycete filamentous fungi'. Molecular Microbiology, . [DOI] [Full-Text]
    2021 Hofer, AM; Harting, R; Assmann, NF; Gerke, J; Schmitt, K; Starke, J; Bayram, O; Tran, VT; Valerius, O; Braus-Stromeyer, SA; Braus, GH (2021) 'The velvet protein Vel1 controls initial plant root colonization and conidia formation for xylem distribution in Verticillium wilt'. PLoS Genetics, 17 . [DOI] [Full-Text]
    2021 José de Assis, L; Silva LP; Bayram, Ö; Dowling, P; Kniemeyer, O; Krüger, T; Brakhage, AA; Chen, Y; Dong, L; Tan, K; Wong, KH; Ries, LRA; Goldman, GH (2021) 'Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA'. mBio, . [DOI] [Full-Text]
    2020 Frawley, D; Greco, C; Oakley, B; Alhussain, MM; Fleming, AB; Keller, NP; Bayram, O (2020) 'The tetrameric pheromone module SteC-MkkB-MpkB-SteD regulates asexual sporulation, sclerotia formation and aflatoxin production in Aspergillus flavus'. Cellular Microbiology, . [DOI] [Full-Text]
    2020 Frawley D.; Stroe M.C.; Oakley B.R.; Heinekamp T.; Straßburger M.; Fleming A.B.; Brakhage A.A.; Bayram Ö. (2020) 'The Pheromone Module SteC-MkkB-MpkB-SteD-HamE Regulates Development, Stress Responses and Secondary Metabolism in Aspergillus fumigatus'. Frontiers in Microbiology, 11 . [DOI] [Full-Text]
    2020 Frawley D.; Bayram Ö. (2020) 'Identification of SkpA-CulA-F-box E3 ligase complexes in pathogenic Aspergilli'. Fungal Genetics and Biology, 140 . [DOI]
    2020 Bauer I.; Gross S.; Merschak P.; Kremser L.; Karahoda B.; Bayram Ö.S.; Abt B.; Binder U.; Gsaller F.; Lindner H.; Bayram Ö.; Brosch G.; Graessle S. (2020) 'RcLS2F – A Novel Fungal Class 1 KDAC Co-repressor Complex in Aspergillus nidulans'. Frontiers in Microbiology, 11 . [DOI] [Full-Text]
    2020 Frawley, D; Bayram, O (2020) 'The pheromone response module, a mitogen-activated protein kinase pathway implicated in the regulation of fungal development, secondary metabolism and pathogenicity'. Fungal Genetics and Biology, 144 . [DOI]
    2020 Silva. L; Frawley. D; de Assis. L; Tierney. C; Fleming. A; Bayram. O; Goldma. G (2020) 'Putative membrane receptors contribute to activation and efficient signaling of Mitogen-Activated Protein Kinase cascades during adaptation of Aspergillus fumigatus to different stressors and carbon sources'. Msphere, . [DOI] [Full-Text]
    2019 Ribeiro L.; Chelius C.; Boppidi K.; Naik N.; Hossain S.; Ramsey J.; Kumar J.; Ribeiro L.; Ostermeier M.; Tran B.; Goo Y.; Assis L.; Ulas M.; Bayram O.; Goldman G.; Lincoln S.; Srivastava R.; Harris S.; Martena M. (2019) 'Comprehensive analysis of aspergillus nidulans PKA phosphorylome identifies a novel mode of CreA regulation'. mBio, 10 (2). [DOI] [Full-Text]
    2019 Sarikaya Bayram Ö; Dettmann A; Karahoda B; Moloney NM; Ormsby T; McGowan J; Cea-Sánchez S; Miralles-Durán A; Brancini GTP; Luque EM; Fitzpatrick DA; Cánovas D; Corrochano LM; Doyle S; Selker EU; Seiler S; Bayram Ö (2019) 'Control of development, secondary metabolism and light-dependent carotenoid biosynthesis by the velvet complex of Neurospora crassa'. GENETICS, . https://doi.org/10.1534/genetics.119.302277 [Full-Text]
    2019 Bauer I.; Pidroni A.; Bayram Ö.; Brosch G.; Graessle S. (2019) 'Single-Step Enrichment of a TAP-Tagged Histone Deacetylase of the Filamentous Fungus Aspergillus nidulans for Enzymatic Activity Assay'. Journal of visualized experiments : JoVE, (147). [DOI] [Full-Text]
    2019 Elramli N; Karahoda B; Sarikaya-Bayram Ö; Frawley D; Ulas M; Oakley CE; Oakley BR; Seiler S; Bayram Ö; (2019) 'Assembly of a heptameric STRIPAK complex is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans'. PLoS Genetics, 15 (3). [DOI] [Full-Text]
    2019 Manfiolli OA; Mattos EC; de Assis LJ; Silva LP; Ulaş M; Brown NA; Bayram Ö; Goldman GH (2019) 'Aspergillus fumigatus high osmolarity glycerol mitogen activated protein kinases SakA and MpkC physically interact during osmotic and cell wall stresses'. Frontiers in Microbiology, . [DOI] [Full-Text]
    2018 Frawley D.; Karahoda B.; Sarikaya Bayram Ö.; Bayram Ö. (2018) 'The HamE scaffold positively regulates MpkB phosphorylation to promote development and secondary metabolism in Aspergillus nidulans'. Scientific Reports, 8 (1). [DOI] [Full-Text]
    2018 de Assis L.; Ulas M.; Ries L.; El Ramli N.; Sarikaya-Bayram O.; Braus G.; Bayram O.; Goldman G. (2018) 'Regulation of Aspergillus nidulans CreA-mediated catabolite repression by the F-Box proteins Fbx23 and Fbx47'. mBio, 9 (3). [DOI] [Full-Text]
    2018 Ries L.; de Assis L.; Rodrigues F.; Caldana C.; Rocha M.; Malavazi I.; Bayram Ö.; Goldman G. (2018) 'The Aspergillus nidulans pyruvate dehydrogenase kinases are essential to integrate carbon source metabolism'. G3 (Bethesda, Md.), 8 (7):2445-2463. [DOI] [Full-Text]
    2017 Sarikaya Bayram Ö; Latgé JP; Bayram Ö; (2017) 'MybA, a new player driving survival of the conidium of the human pathogen Aspergillus fumigatus'. Current Genetics, . [DOI] [Full-Text]
    2017 Manfiolli AO; de Castro PA; Dos Reis TF; Dolan S; Doyle S; Jones G; Riaño Pachón DM; Ulaş M; Noble LM; Mattern DJ; Brakhage AA; Valiante V; Silva-Rocha R; Bayram O; Goldman GH; (2017) 'Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence'. Cellular Microbiology, . [DOI] [Full-Text]
    2017 Valsecchi I; Sarikaya-Bayram Ö; Wong Sak Hoi J; Muszkieta L; Gibbons J; Prevost MC; Mallet A; Krijnse-Locker J; Ibrahim-Granet O; Mouyna I; Carr P; Bromley M; Aimanianda V; Yu JH; Rokas A; Braus GH; Saveanu C; Bayram Ö; Latgé JP; (2017) 'MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen Aspergillus fumigatus'. Molecular Microbiology, . [DOI] [Full-Text]
    2017 de Vries RP; Riley R; Wiebenga A; Aguilar-Osorio G; Amillis S; Uchima CA; Anderluh G; Asadollahi M; Askin M; Barry K; Battaglia E; Bayram Ö; Benocci T; Braus-Stromeyer SA; Caldana C; Cánovas D; Cerqueira GC; Chen F; Chen W; Choi C; Clum A; Dos Santos RA et al (2017) 'Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus'. Genome Biology, 18 (1):1-45. [Link] [DOI] [Full-Text]
    2016 Bayram Ö.; Feussner K.; Dumkow M.; Herrfurth C.; Feussner I.; Braus G. (2016) 'Changes of global gene expression and secondary metabolite accumulation during light-dependent Aspergillus nidulans development'. Fungal Genetics and Biology, 87 :30-53. [DOI] [Full-Text]
    2016 Jöhnk B; Bayram O; Abelmann A; Heinekamp T; Mattern DJ; Brakhage AA; Jacobsen ID; Valerius O; Braus GH; (2016) 'SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus'. PLoS Pathogens, 12 (9). [Link] [DOI] [Full-Text]
    2016 Manzanares-Miralles L, Sarikaya-Bayram Ö, Smith EB, Dolan SK, Bayram Ö, Jones GW, Doyle S. (2016) 'Quantitative proteomics reveals the mechanism and consequence of gliotoxin-mediated dysregulation of the methionine cycle in Aspergillus niger'. Proteomics, NA . [DOI] [Full-Text]
    2015 Sarikaya-Bayram , Palmer JM, Keller N, Braus GH, Bayram (2015) 'One Juliet and four Romeos: VeA and its methyltransferases'. Frontiers in Microbiology, 20 . [DOI] [Full-Text]
    2015 Jaimes-Arroyo, R; Lara-Rojas, F; Bayram, O; Valerius, O; Braus, GH; Aguirre, J (2015) 'The SrkA Kinase Is Part of the SakA Mitogen-Activated Protein Kinase Interactome and Regulates Stress Responses and Development in Aspergillus nidulans'. Eukaryotic Cell, 14 :495-510. [DOI] [Full-Text]
    2015 Fajardo-Somera R.; Jöhnk B.; Bayram Ö.; Valerius O.; Braus G.; Riquelme M. (2015) 'Dissecting the function of the different chitin synthases in vegetative growth and sexual development in Neurospora crassa'. Fungal Genetics and Biology, 75 :30-45. [DOI] [Full-Text]
    2014 Sarikaya-Bayram O.; Bayram O.; Feussner K.; Kim J.; Kim H.; Kaever A.; Feussner I.; Chae K.; Han D.; Han K.; Braus G. (2014) 'Membrane-bound methyltransferase complex VapA-VipC-VapB guides epigenetic control of fungal development'. Developmental Cell, 29 (4):406-420. [DOI] [Full-Text]
    2013 Ahmed YL, Gerke J, Park HS, Bayram O, Neumann P, Ni M, Dickmanns A, Kim S.C, Yu J.H, Braus G.H, Ficner R. (2013) 'The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-κB'. PLoS Biology, 11 . [DOI] [Full-Text]
    2013 Christmann M, Schmaler T, Gordon C, Huang X, Bayram O, Schinke J, Stumpf S, Dubiel W, Braus G.H. (2013) 'Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome'. PLoS Genetics, 9 . [DOI] [Full-Text]
    2013 Harting R, Bayram O, Laubinger K, Valerius O, Braus G.H. (2013) 'Interplay of the fungal sumoylation network for control of multicellular development'. Molecular Microbiology, 90 :1125-1145. [DOI] [Full-Text]
    2013 Suzuki S; Sarikaya Bayram Ö; Bayram Ö; Braus GH; (2013) 'conF and conJ contribute to conidia germination and stress response in the filamentous fungus Aspergillus nidulans'. Fungal Genetics and Biology, 56 . [DOI] [Full-Text]
    2012 Gerke J, Bayram O, Braus G.H. (2012) 'Fungal S-adenosylmethionine synthetase and the control of development and secondary metabolism in Aspergillus nidulans'. Fungal Genetics and Biology, 49 :443-454. [DOI] [Full-Text]
    2012 Park HS, Bayram O, Braus G.H, Kim S.C, Yu J.H. (2012) 'Characterization of the velvet regulators in Aspergillus fumigatus'. Molecular Microbiology, 86 :937-953. [DOI] [Full-Text]
    2012 Kress M.R, Harting R, Bayram O, Christmann M, Irmer H, Valerius O, Schinke J, Goldman GH, Braus G.H. (2012) 'The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development'. Molecular Microbiology, 83 :1162-1177. [DOI] [Full-Text]
    2012 Colabardini A.C, Humanes AC, Gouvea P.F, Savoldi M, Goldman M.H, Kress M.R, Bayram O, Oliveira J.V, Gomes M.D, Braus G.H, Goldman G.H. (2012) 'Molecular characterization of the Aspergillus nidulans fbxA encoding an F-box protein involved in xylanase induction'. Fungal Genetics and Biology, 49 :130-140. [DOI] [Full-Text]
    2012 Bayram Ö; Bayram ÖS; Ahmed YL; Maruyama J; Valerius O; Rizzoli SO; Ficner R; Irniger S; Braus GH; (2012) 'The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism'. PLoS Genetics, 8 (7). [DOI] [Full-Text]
    2012 Bayram O, Braus G.H. (2012) 'Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins'. FEMS Microbiology Reviews, 36 :1-24. [DOI] [Full-Text]
    2012 Gerke J, Bayram O, Feussner K, Landesfeind M, Shelest E, Feussner I, Braus G.H. (2012) 'Breaking the silence: protein stabilization uncovers silenced biosynthetic gene clusters in the fungus Aspergillus nidulans'. Applied And Environmental Microbiology, 78 :8234-8244. [DOI] [Full-Text]
    2010 Sarikaya Bayram O; Bayram O; Valerius O; Park HS; Irniger S; Gerke J; Ni M; Han KH; Yu JH; Braus GH; (2010) 'LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity'. PLoS Genetics, 6 (12). [DOI] [Full-Text]
    2010 Braus G.H, Irniger S, Bayram O. (2010) 'Fungal development and the COP9 signalosome'. Current Opinion in Microbiology, 13 :672-676. [DOI] [Full-Text]
    2010 Bayram O, Braus GH, Fischer R, Rodriguez-Romero J (2010) 'Spotlight on Aspergillus nidulans photosensory systems'. Fungal Genetics and Biology, 47 :900-908. [DOI] [Full-Text]
    2010 Kuczera T, Bayram O, Sari F, Braus G.H, Irniger S. (2010) 'Dissection of mitotic functions of the yeast cyclin Clb2'. Cell Cycle, 9 :2611-2619. [DOI] [Full-Text]
    2010 Nahlik K, Dumkow M, Bayram O, Helmstaedt K, Busch S, Valerius O, Gerke J, Hoppert M, Schwier E, Opitz L, Westermann M, Grond S, et al. (2010) 'The COP9 signalosome mediates transcriptional and metabolic response to hormones, oxidative stress protection and cell wall rearrangement during fungal development'. Molecular Microbiology, 78 :964-979. [DOI] [Full-Text]
    2009 Bayram O, Sari F, Braus G.H, Irniger S. (2009) 'The protein kinase ImeB is required for light-mediated inhibition of sexual development and for mycotoxin production in Aspergillus nidulans'. Molecular Microbiology, 71 :1278-1295. [DOI] [Full-Text]
    2009 Turkel S, Bayram O, Arik E. (2009) 'Glucose signaling pathway and growth conditions regulate gene expression in retrotransposon Ty2'. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF C, 64 :526-532. [Full-Text]
    2008 Bayram O, Krappmann S, Seiler S, Vogt N, Braus GH (2008) 'Neurospora crassa ve-1 affects asexual conidiation'. Fungal Genetics and Biology, 45 :127-138. [DOI] [Full-Text]
    2008 Bayram O, Krappmann S, Ni M, Bok JW, Helmstaedt K, Valerius O, Braus-Stromeyer S, Kwon NJ, Keller NP, Yu JH, Braus GH (2008) 'VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism'. Science, 320 :1504-1506. [DOI] [Full-Text]
    2008 Helmstaedt K, Laubinger K, Vosskuhl K, Bayram O, Busch S, Hoppert M, Valerius O, Seiler S, Braus GH. (2008) 'The nuclear migration protein NUDF/LIS1 forms a complex with NUDC and BNFA at spindle pole bodies'. Eukaryotic Cell, 7 :1041-1052. [DOI] [Full-Text]
    2008 Bayram O, Biesemann C, Krappmann S, Galland P, Braus GH (2008) 'More than a repair enzyme: Aspergillus nidulans photolyase-like CryA is a regulator of sexual development'. Molecular Biology of the Cell, 19 :3254-3262. [DOI] [Full-Text]
    2007 Busch S, Schwier EU, Nahlik K, Bayram O, Helmstaedt K, Draht OW, Krappmann S, Valerius O, Lipscomb WN, Braus G.H (2007) 'An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, 8 :8089-8094. [DOI] [Full-Text]
    2005 Krappmann S, Bayram O, Braus G.H. (2005) 'Deletion and allelic exchange of the Aspergillus fumigatus veA locus via a novel recyclable marker module'. Eukaryotic Cell, 4 :1298-1307. [DOI] [Full-Text]

    Book Chapter

    Year Publication
    2016 Irniger S, Sarikaya-Bayram O, Bayram O (2016) 'Fungal MAP-Kinase-Mediated Regulatory Pathways' In: D. Hoffmeister(Eds.). Biochemistry and Molecular Biology, 3rd Edition The Mycota III. Switzerland : Springer.
    2012 Bayram O, Bayram OS, Valerius O, Jöhnk B, Braus G.H (2012) 'Identification of protein complexes from filamentous fungi with tandem affinity purification' In: Keller, N.P, Turner, G(Eds.). Methods in Molecular Biology. : Humana Press. [DOI]

    Edited Book

    Year Publication
    2017 Keller NP, Palmer J, Bayram O (Ed.). (2017) Fungal Jewels: Secondary Metabolites. Lausanne: Frontiers Media, [Link] [DOI]

    Conference Contribution

    Year Publication
    2022 Bayram, Ö; Wong K, H; Sarikaya Bayram, Ö (2022) How Evolution Learnt to Learn: Epigenetics of Experienced Context Epigenetic regulation of fungal secondary metabolite gene clusters: are we seeing the tip of the iceberg? Salzburg, Austria, 06/07/2022-10/07/2022.
    2020 Frawley D; Oakley BR; Karahoda B, Sarikaya-Bayram Ö; Bayram Ö (2020) Regulation of development and secondary metabolism in Aspergillus nidulans, A. flavus and A. fumigatus via the pheromone module 15th European Conference on Fungal Genetics Rome, Italy, 17/02/2020-20/06/2020.
    2019 Frawley D, Karahoda B, Sarikaya-Bayram O, Bayram O (2019) HamE scaffold positively regulates MAP kinase signal transduction to promote development and secondary metabolism in Aspergillus nidulans 30th Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 12/03/2019-17/03/2019.
    2019 Elramli N, Karahoda B, Sarikaya-Bayram O, Frawley D, Ulas M, Oakley CE, Oakley B, Seiler S, Bayram, O. (2019) Assembly of a heptameric STRIPAK complex at the nuclear envelope is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans 30th Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 12/03/2019-17/03/2019.
    2018 Karahoda B, Bayram O, Sarikaya Bayram O, Elramli N, Thieme S, Assis LJ, Goldman GH, Braus GH (2018) Global analysis of the molecular roles, localizations and interactomes of F-box proteins during fungal development 14th European Conference on Fungal Genetics Haifa, Israel, 25/02/2018-28/02/2018.
    2018 Özgür Bayram (2018) Building up scaffolds : Control of signal influx into development and secondary metabolism 8th Irish Fungal Society Meeting Maynooth University, 18/06/2018-19/06/2018.
    2018 Assis LJ, Ulas M, Ries LN, Elramli N, Sarikaya Bayram O, Braus GH, Bayram O, Goldman G (2018) Regulation of Aspergillus nidulans CreA-mediated catabolite repression by the F-box proteins Fbx23 and Fbx47 14th European Conference on Fungal Genetics Haifa, Israel, 25/02/2018-28/02/2018.
    2018 Ries LN, Assis LJ, Rodrigues FJS, Caldana C, Rocha MC, Malavazi I, Bayram O, Goldman GH (2018) The Aspergillus nidulans pyruvate dehydrogenase kinases are essential to integrate carbon source metabolism 14th European Conference on Fungal Genetics Haifa, Israel, 25/02/2018-28/02/2018.
    2015 Bayram O, Sarikaya-Bayram O, Reen S, Goldman G and Braus G (2015) Global examination of the molecular roles, localizations and interactomes of F-box proteins in fungal development 28th Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 17/03/2015-22/03/2015.
    2015 Gerke J, Luqman YA, Park HS, Bayram O, Neumann P, Ni M, Dickmanns A, Kim CS, Yu JH, Ficner R, Braus G (2015) The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-KB 28th Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 17/03/2015-22/03/2015.
    2015 Dhingra S, Chung D, Bayram O, Buckey JC, Cramer RA (2015) Regulation of SrbA in Aspergillus fumigatus 28th Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 17/03/2015-22/03/2015.
    2015 Özgür Bayram (2015) Control of sexual and asexual development in Aspergillus nidulans by two different modules: MAPK (SteC-SteD-MkkB-MpkB) and heterotrimeric VapA-VipC-VapB methyltransferase complex 28th Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 17/03/2015-22/03/2015.
    2014 Özgür Bayram (2014) Membrane-bound methyltransferase complex VapA-VipC-VapB guides epigenetic control of fungal development 4th Irish Fungal Society Meeting NUIG, Galway, 19/06/2014-20/06/2014.
    2013 Jöhnk B, Bayram O, Valerius O, Heinekamp T, Jacobsen ID, Brakhage AA, Braus GH (2013) F-box protein 15 (Fbx15) links virulence of Aspergillus fumigatus to protein degradation and stress response 27th Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 12/03/2013-17/03/2013.
    2013 Sarikaya Bayram O, Bayram O, Kim JH, Chae KS, Han DM, Han KH, Braus GH (2013) Two methyltransferase protein complexes control fungal development and secondary metabolite production 27th Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 12/03/2013-17/03/2013.
    2013 Schinke J, Christmann M, Schmaler T, Gordon C, Huang X, Bayram O, Stumpf S, Dubiel W, Braus G (2013) Control of Multicellular Development by the Physically Interacting Deneddylases DEN1/DenA and COP9 Signalosome 27th Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 12/03/2013-17/03/2013.
    2013 Fajardo R, Roberson R, Jöhnk B, Bayram O, Braus GH, Riquelme M (2013) The role and traffic of chitin syntheses in Neurospora crassa 27th Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 12/03/2013-17/03/2013.
    2013 Özgür Bayram (2013) New insights into the MAPK modules in filamentous fungi: Aspergillus nidulans MAPK module has an exceptional mobility 27th Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 12/03/2013-17/03/2013.
    2013 Bayram O, Sarikaya Bayram O, Luqman Ahmed Y, Maruyama JI, Valerius O, Rizzoli O, Ficner R, Irniger S, Braus G (2013) The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism 27th Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 12/03/2013-17/03/2013.
    2012 Özgür Bayram (2012) Shuttling of entire MAPK module from membrane to nuclear envelope links fungal development to secondary metabolism The 9th International Aspergillus Meeting Marburg, Germany, 29/03/2012-30/03/2012.
    2012 Gerke J, Bayram O, Feussner K, Feussner I, Landesfeind M and Braus GH (2012) Breaking the silence: protein stabilization uncovers silenced biosynthetic gene clusters in the fungus Aspergillus nidulans 11th European Conference on Fungal Genetics Marburg, Germany, 30/03/2012-02/04/2012.
    2012 Sarikaya Bayram O, Bayram O, Ahmed Luqman Y, Maruyama JI, Valerius O, Ficner R, Irniger S, Braus G.H. (2012) Shuttling of entire MAPK module from membrane to nuclear envelope links fungal development to secondary metabolism 11th European Conference on Fungal Genetics Marburg, Germany, 30/03/2012-02/04/2012.
    2011 Christmann M, Harting R, Bayram O, Braus G.H. (2011) DenA is a deneddylating protein involved in A. nidulans development 26th Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 15/03/2011-20/03/2011.
    2011 Jöhnk B, Bayram O, Heinekamp T, Brakhage A.A, Braus G.H (2011) Analysis of the F-box protein encoding genes of the opportunistic human pathogen Aspergillus fumigatus 4th FEBS Advanced Lecture Course, Human Fungal Pathogens- Molecular Mechanisms of Host-Pathogen Interactions and Virulence La Colle sur Loup, France, 07/05/2011-13/05/2011.
    2011 Jöhnk B, Bayram O, Heinekamp T, Brakhage A.A, Braus G.H (2011) Interplay between degradation, oxidative stress response, polar growth and virulence in the pathogen Aspergillus fumigatus Tagungsband zur VAAM-Jahrestagung 2011 Karlsruhe, Germany, 03/04/2011-06/04/2011.
    2011 Sarikaya Bayram O, Bayram O, Valerius O, Park H.S, Irniger S, Gerke J, Ni M, Han K.H, Yu J.H and Braus G.H. (2011) LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity 26th Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 15/03/2011-20/03/2011.
    2010 Özgür Bayram (2010) Dynamic and functional interactions between the components of the trimeric velvet complex in the filamentous fungus Aspergillus nidulans The 7th International Aspergillus Meeting NH Conference Centre Leeuwenhorst, The Netherlands, 29/03/2010-01/04/2010.
    2010 Sarikaya Bayram O, Bayram O, Valerius O, Gerke J, Irniger S, Han K.H, and Braus G.H (2010) Dynamic and functional interactions between the components of the trimeric velvet complex in the filamentous fungus Aspergillus nidulans 10th European Conference on Fungal Genetics NH Conference Centre Leeuwenhorst, The Netherlands, 29/03/2010-01/04/2010.
    2009 Irniger S, Bayram O, Sari F, and Braus G.H (2009) The protein kinase ImeB is involved in the coordination of sexual development and mycotoxin production in Aspergillus nidulans 25th Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 17/03/2009-22/03/2009.
    2009 Christmann M, Harting R, Kress M, Bayram O, Sarikaya Bayram O, Jöhnk B, Helmstaedt K, Braus G.H (2009) Fungal development requires the deneddylating proteins Den1 (DenA) and CSN 9 th VAAM Symposium, Molecular Biology of Fungi Munster, Germany, 27/09/2009-30/09/2009.
    2008 Özgür Bayram (2008) Light signaling governing fungal development and secondary metabolism Final Eurofungbase Meeting Girona, Spain, 23/10/2008-.
    2008 Bayram O, Krappmann S, Ni M, Helmstaedt K, Valerius O, Braus-Stromeyer S, Kwon N.J, Bok J.W, Keller N.P, Yu J.H, and Braus G.H (2008) The velvet complex coordinates light, fungal development and secondary metabolism 9th European Conference on Fungal Genetics University of Edinburgh, Edinburgh, Scotland, 05/04/2008-08/04/2008.
    2008 Helmstaedt K, Laubinger K, Voßkuhl K, Bayram O, Busch S, Hoppert M, Valerius O, Seiler S, Braus G.H (2008) The nuclear migration protein NUDF/LIS1 forms a complex with NUDC and BNFA at spindle pole bodies 9th European Conference on Fungal Genetics University of Edinburgh, Edinburgh, Scotland, 05/04/2008-08/04/2008.
    2008 Özgür Bayram (2008) The velvet complex coordinates light, fungal development and secondary metabolism The 5th International Aspergillus Meeting University of Edinburgh, Edinburgh, Scotland, 04/04/2008-05/04/2008.
    2007 Sari F, Bayram O, Braus G.H, and Irniger S (2007) The protein kinase ImeB acts as a potential inhibitor of sexual development in Aspergillus nidulans Tagungsband zur VAAM-Jahrestagung 2007 Osnabruck, Germany, 01/04/2007-04/04/2007.
    2007 Helmstaedt K, Meng K, Busch S, Bayram O, Valerius O, and Braus G.H (2007) The Nuclear Migration Protein NUDF Associates with BNFA and NUDC at Spindle Pole Bodies in Aspergillus nidulans 24th Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 20/03/2007-25/03/2007.
    2007 Bayram O, Rupprecht H.S, Dumkow M, R. v. Z. Kress M, Linger T, Sarikaya Bayram O, Goldman G.H (2007) The Aspergillus nidulans F-box Protein Project 24th Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 20/03/2007-25/03/2007.
    2007 Özgür Bayram (2007) The Aspergillus nidulans F-box Protein Project The 4th Aspergillus Meeting Asilomar, Pacific Grove California, USA, 18/03/2007-20/03/2007.
    2006 Helmstaedt K, Voßkuhl K, Busch S, Bayram O, and Braus G.H (2006) The nuclear migration protein NUDF associates with NUDC and BNFA in Aspergillus nidulans 8th European Conference on Fungal Genetics Vienna, Austria, 08/04/2006-11/04/2006.
    2006 Sari F, Bayram O, Braus G.H, Irniger S (2006) Analysis of the protein kinase ImeB in Aspergillus nidulans 8th European Conference on Fungal Genetics Vienna, Austria, 08/04/2006-11/04/2006.
    2006 Busch S, Schwier E, Bayram O, Draht O, Grube V, Helmstaedt K, Krappmann S, Valerius O, and Braus G.H (2006) The COP9 signalosome is essential for development and oxidative stress response 8th European Conference on Fungal Genetics Vienna, Austria, 08/04/2006-11/04/2006.
    2006 Bayram O, Biesemann C, Krappmann S, and Braus G.H (2006) Characterization of the Aspergillus nidulans putative blue light receptor gene cryA encoding a cryptochrome 8th European Conference on Fungal Genetics Vienna, Austria, 08/04/2006-11/04/2006.
    2005 Bayram O, Helmstaedt K, Krappmann S, and Braus G.H (2005) Adaptation of the tap tag method to decipher protein complexes in filamentous fungi 23rd Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 15/03/2005-11/03/2005.
    2005 Özgür Bayram (2005) TAP tagging in Aspergillus nidulans The 2nd Aspergillus Meeting Asilomar, Pacific Grove California, USA, 13/03/2005-15/03/2005.
    2005 Busch S, Helmstaedt K, Bayram O, and Braus G.H (2005) Analysis of the regulatory multprotein complex COP9 Signalosome in Aspergillus nidulans 23rd Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 15/03/2005-11/03/2005.
    2005 Helmstaedt K, Busch S, Bayram O, and Braus G.H (2005) Analysis of dynein regulatory complexes using a tandem affinity purification tag for filamentous fungi 23rd Fungal Genetics Conference Asilomar, Pacific Grove California, USA, 15/03/2005-20/03/2005.
    2004 Krappmann S, Bignell E.M, Reichard U, Bayram O, Haynes K, and Braus G.H (2004) The cross-pathway control system contributes to pathogenicity of Aspergillus fumigatus 7th European Conference on Fungal Genetics Cophenagen, Denmark, 17/04/2004-20/04/2004.
    Certain data included herein are derived from the © Web of Science (2023) of Clarivate. All rights reserved.

    Professional Associations

    Description Function From / To
    American Society For Microbiology ASM Ambassador for Ireland 01/01/2021 -
    American Society For Microbiology Member 01/08/2018 -
    Irish Fungal Society (IFS) Member 01/06/2014 -
    Association for General and Applied Microbiology Member 01/10/2011 -
    Irish Fungal Society (IFS) Treasurer 01/01/2017 -
    Genetics Society of America (GSA) Member 01/07/2011 -

    Honors and Awards

    Date Title Awarding Body
    01/05/2019 Early Career Research Achievement Award, Faculty of Science and Engineering Maynooth University, Ireland
    01/05/2014 Science Foundation Ireland (SFI) Career Development Award (CDA) Science Foundation Ireland
    01/11/2012 Associate Professorship of Biology Higher Education and Science Council, Turkey
    01/09/2011 Listed among the top 50 Turkish academicians in Germany in the book entitled „In Bester Gesellschaft“ German Standards Institute, Berlin, Germany
    01/12/2009 Outstanding Publication as Young Investigator Board of Trustees of Georg August University, Germany
    01/06/2008 GZMB outstanding doctoral thesis Award Goettingen Center for Molecular Biosciences (GZMB)
    01/11/2008 PhD Graduation (summa cum laude) Georg August University
    01/04/2008 Excellence award for poster presentation Aspergillus Genomes Research Policy Committee

    Committees

    Committee Function From / To
    Departmental Research Committee Member 01/02/2018 - 01/09/2023
    Graduate Education Committee Member 18/10/2022 -
    University of Sanctuary Member 02/11/2018 - 01/09/2023

    Employment

    Employer Position From / To
    Maynooth University Lecturer in Biology 18/01/2014 - 01/10/2020
    Maynooth University Associate Professor 01/09/2020 -
    Georg August University Project Leader 01/01/2011 - 31/12/2013
    Georg August University Postdoctoral Fellow 01/01/2008 - 31/12/2011

    Education

    Start date Institution Qualification Subject
    01/10/2020 Maynooth University Postgraduate Diploma in Higher Education Teaching, Learning and Assessment Teaching and Learning
    13/07/2003 Georg August University PhD (Dr.rer.nat) Molecular Microbiology, Genetics, Biochemistry
    01/09/2001 Uludag University MSc Molecular Biology (yeast genetics)
    01/09/1996 Uludag University BSc Biology

    Languages

    Language Reading Writing Speaking
    English Fluent Fluent Fluent
    German Functional Functional Functional
    Turkish Fluent Fluent Fluent

    Consultancy

    Client Description
    Niskus Biotech Circular Economy, Zero Waste

    Editorial / Academic Reviews

    Amount Role From / To
    PLOS GENETICS Associate Editor 15/06/2023 -
    Genes Editor 07/05/2021 -
    Fungal Genetics and Biology Associate Editor 03/04/2023 -
    Frontiers in Microbiology Editor 01/01/2018 -
    Frontiers in Fungal Biology Associate Editor 01/04/2020 -
    Scientific Reports Reviewer -
    Proceedings of the National Academy of Sciences of the United States of America Reviewer -
    Applied Microbiology and Biotechnology Reviewer -
    Biochima Et Biophysica Acta - Molecular Cell Research Reviewer -
    Biochimie Reviewer -
    PLoS Genetics Reviewer -
    Microbial Genomics Reviewer -
    Eukaryotic Cell Reviewer -
    Current Genetics Reviewer -
    Clinical Microbiology Reviews Reviewer -
    Virulence Reviewer -
    mBio Reviewer -
    Toxins Reviewer -
    Molecular Genetics and Genomics Reviewer -
    Molecules Reviewer -
    Fungal Genetics and Biology Reviewer -
    PLoS ONE Reviewer -
    Frontiers in Microbiology Reviewer -
    PLoS Pathogens Reviewer -
    Molecular Microbiology Reviewer -
    International Journal of Food Microbiology Reviewer -
    Communications Biology Reviewer -

    Outreach Activities

    Organisation Type Description
    Science Week 2015 Civic Society Science Week 2015
    Science Week 2016 Civic Society
    Science Week 2017 Civic Society [Link]
    Science Week 2018 Civic Society
    Science Week 2022 Civic Society [Link]

    Teaching Interests

    I currently teach
    • BI441 (Fungal and Bacterial Secondary Metabolism)
    • BI416 (Genomics and Proteomics)
    • BI423 (Literature project 1)
    • BI424 (Literature project 2)
    • BI427 (Laboratory research project)
    • BI421 (Research methodology)
    • BI431 (Biological science research project)
    • BI312 (Scientific Writing)
    • BI308 (Proteomics)
    • BI305 (Dissertation)
    • BI103 (Human Biology)

    Recent Students

    Graduation date Name Degree
    2020 Dean Frawley PhD
    2018 Betim Karahoda PhD
    2018 Mevlüt Ulaş PhD
    2018 Nadia Elramli PhD
    2016 Bastian Joehnk PhD
    2014 Özlem Sarikaya Bayram PhD
    2013 Rebekka Harting PhD
    2013 Sabine Reen MSc
    2013 Marc Dumkow PhD
    2012 Jennifer Gerke PhD
    2009 Bastian Joehnk Diplom
    2009 Hani Kaba Diplom
    2008 Oliver Voigt Diplom
    2009 Özlem Sarikaya Bayram Diplom

    Internal Collaborators

    Name Company Role Country
    David Fitzpatrick Dr David Fitzpatrick / Bioinformatics Analysis Bioinformatics analysis / RNA Sequencing and DNA Sequencing analysis Ireland
    Sean Doyle Biology Department Secondary Metabolism / Kit Development for protein purification and gene cloning Ireland
    Kevin Kavanagh Maynooth University Research development / Enzyme Discovery Ireland

    External Collaborators

    Name Role Country
    Dr Satoshi Suzuki / NARO Food biotechnology Japan
    Prof. Eric Selker / University of Oregon RNA sequencing United States
    Prof. Dr. Joseph Strauss / University of Vienna Chromatin Biology Austria
    Prof. Gerhard Braus/ Georg August University Protein degradation Germany
    Dr. Stephan Seiler/ University of Freiburg Fungal Genetics Germany
    Prof. Dr. Jean Paul Latge / Institut Pasteur Fungal pathogens France
    Prof. Dr. Koonho Wong / University of Macao Chromatin immunoprecipitation Hong Kong
    Prof. Dr. Jun-Ichi Maruyama / University of Tokyo Fungal Genetics/Biotechnology Japan
    Prof. Dr. Berl Oakley / University of Kansas Cell biology imaging of fungal cells United States
    Prof. Dr. Nancy P Keller / University of Wisconsin Fungal secondary metabolism United States
    Prof. Alastair Fleming / Trinity College Dublin Chromatin Biology Ireland
    Prof. Dr. Luis Corrochano / University of Sevilla Fungal light repsonses Spain
    Dr Ingo Bauer / University of Innsbruck Fungal Chromatin Complex Analysis Austria
    Prof. Dr. Gustavo Goldman / University Sao Paolo Fungal Pathogenicity Brazil