Dr Ozgur Bayram

    Biology, Human Health Institute

    Lecturer
    Assistant Professor

    Callan
    2.31
    (01) 708 6879

    Biography

    2000: BSc in Biology (Uludag University, Bursa, Turkey); 2003: MSc in Molecular Biology (yeast genetics) (Uludag University, Bursa, Turkey); 2007: PhD in Microbiology, Genetics and Biochemistry (Fungal genetics and Secondary metabolism) (Institute of Microbiology and Genetics, Georg-August University, Goettingen, Germany); 2008-2011: Postdoctoral fellow (Institute of Microbiology and Genetics, Georg-August University, Goettingen, Germany); 2012: Docent degree (Associate Professor) in Biology (Turkish Higher Education Council, Ankara, Turkey); 2012-2014: Project leader and Dozent (Institute of Microbiology and Genetics, Georg-August University, Goettingen, Germany); From 2014: Lecturer in Biology (National University of Ireland Maynooth)

    Research Interests

    Fungal secondary metabolites (SM), including food contaminating mycotoxins (e.g. aflatoxin, sterigmatocystin, fumonisins), antibiotics (e.g. penicillin, cephalosporin) and many other pharmaceuticals have great impact on human activities on earth. SM genes are mostly clustered in the subtelomeric regions of fungal chromosomes. Many SM gene clusters are silenced by facultative heterochromatin and activated upon environmental signals, including light, pH, temperature, organismic interactions, and nutritional conditions during development of the fungus. Our laboratory focuses on understanding of the molecular control mechanisms of SM production and development in the model system Aspergillus nidulans, aflatoxin production and development in Aspergillus flavus and SM-based virulence factors in opportunistic human pathogen A. fumigatus. Fungal development and SM production is coordinated by the regulatory protein complexes. In this context, we are interested in two questions: (I) How are the gene clusters turned on and off at the epigenetic level by the regulatory proteins? (II) What kind of signals are important for the activation of gene clusters and fungal development? While approaching to these questions, we use genetic, biochemical, cell biological methods, including gene disruption, epitope tagging, overexpression, protein enrichment, protein-protein interactions, time-lapse imaging and confocal imaging.

    Research Projects

      Project Role Funding Body / Program Description Start Date End Date Award (€)
    Role of scaffold proteins in the control of fungal development and secondary metabolism PI / Libyan Government Postgraduate Award

    Book Chapters

      Year Publication
    2016 'Fungal MAP-Kinase-Mediated Regulatory Pathways'
    Irniger S, Sarikaya-Bayram O, Bayram O (2016) 'Fungal MAP-Kinase-Mediated Regulatory Pathways' In: Biochemistry and Molecular Biology, 3rd Edition The Mycota III. Switzerland: Springer. [Details]
    2012 'Identification of protein complexes from filamentous fungi with tandem affinity purification'
    Bayram O, Bayram OS, Valerius O, Jöhnk B, Braus G.H (2012) 'Identification of protein complexes from filamentous fungi with tandem affinity purification' In: Methods in Molecular Biology. Humana Press. [DOI] [Details]

    Edited Books

      Year Publication
    2017 Fungal Jewels: Secondary Metabolites
    Keller NP, Palmer J, Bayram O (Ed.). (2017) Fungal Jewels: Secondary Metabolites Lausanne: Frontiers Media. [DOI] [Details]

    Peer Reviewed Journals

      Year Publication
    2020 'The tetrameric pheromone module SteC-MkkB-MpkB-SteD regulates asexual sporulation, sclerotia formation and aflatoxin production in Aspergillus flavus'
    Frawley D, Greco C, Oakley B, Alhussain MM, Fleming AB, Keller NP, Bayram Ö (2020) 'The tetrameric pheromone module SteC-MkkB-MpkB-SteD regulates asexual sporulation, sclerotia formation and aflatoxin production in Aspergillus flavus'. Cellular Microbiology, [Details]
    2020 'RcLS2F – a Novel Fungal Class 1 KDAC Co-Repressor Complex in Aspergillus nidulans'
    Bauer I, Gross, Merschak P, Kremser L, Karahoda B, Sarikaya-Bayram Ö, Abt B, Binder U, Gsaller F, Lindner H, Bayram Ö, Brosch G, Graessle S (2020) 'RcLS2F – a Novel Fungal Class 1 KDAC Co-Repressor Complex in Aspergillus nidulans'. Frontiers in Microbiology, [Details]
    2019 'Control of development, secondary metabolism and light-dependent carotenoid biosynthesis by the velvet complex of Neurospora crassa'
    Sarikaya Bayram Ö; Dettmann A; Karahoda B; Moloney NM; Ormsby T; McGowan J; Cea-Sánchez S; Miralles-Durán A; Brancini GTP; Luque EM; Fitzpatrick DA; Cánovas D; Corrochano LM; Doyle S; Selker EU; Seiler S; Bayram Ö (2019) 'Control of development, secondary metabolism and light-dependent carotenoid biosynthesis by the velvet complex of Neurospora crassa'. GENETICS, [DOI] [Details]
    2019 'Comprehensive analysis of aspergillus nidulans PKA phosphorylome identifies a novel mode of CreA regulation'
    Ribeiro L.;Chelius C.;Boppidi K.;Naik N.;Hossain S.;Ramsey J.;Kumar J.;Ribeiro L.;Ostermeier M.;Tran B.;Goo Y.;Assis L.;Ulas M.;Bayram O.;Goldman G.;Lincoln S.;Srivastava R.;Harris S.;Martena M. (2019) 'Comprehensive analysis of aspergillus nidulans PKA phosphorylome identifies a novel mode of CreA regulation'. mBio, 10 (2) [DOI] [Details]
    2019 'Assembly of a heptameric STRIPAK complex is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans'
    Elramli N;Karahoda B;Sarikaya-Bayram Ö;Frawley D;Ulas M;Oakley CE;Oakley BR;Seiler S;Bayram Ö; (2019) 'Assembly of a heptameric STRIPAK complex is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans'. PLoS Genetics, 15 (3) [DOI] [IR Link] [Details]
    2019 'Aspergillus fumigatus high osmolarity glycerol mitogen activated protein kinases SakA and MpkC physically interact during osmotic and cell wall stresses'
    Manfiolli OA; Mattos EC; de Assis LJ; Silva LP; Ulaş M; Brown NA; Bayram Ö; Goldman GH (2019) 'Aspergillus fumigatus high osmolarity glycerol mitogen activated protein kinases SakA and MpkC physically interact during osmotic and cell wall stresses'. Frontiers in Microbiology, [DOI] [IR Link] [Details]
    2019 'Single-Step Enrichment of a TAP-Tagged Histone Deacetylase of the Filamentous Fungus Aspergillus nidulans for Enzymatic Activity Assay'
    Bauer I; Pidroni A; Bayram O; Brosch G; Graessle S (2019) 'Single-Step Enrichment of a TAP-Tagged Histone Deacetylase of the Filamentous Fungus Aspergillus nidulans for Enzymatic Activity Assay'. Journal of visualized experiments : JoVE, [DOI] [IR Link] [Details]
    2018 'The HamE scaffold positively regulates MpkB phosphorylation to promote development and secondary metabolism in Aspergillus nidulans'
    Frawley D.;Karahoda B.;Sarikaya Bayram Ö.;Bayram Ö. (2018) 'The HamE scaffold positively regulates MpkB phosphorylation to promote development and secondary metabolism in Aspergillus nidulans'. Scientific Reports, 8 (1) [DOI] [IR Link] [Details]
    2018 'Regulation of Aspergillus nidulans CreA-mediated catabolite repression by the F-Box proteins Fbx23 and Fbx47'
    de Assis L.;Ulas M.;Ries L.;El Ramli N.;Sarikaya-Bayram O.;Braus G.;Bayram O.;Goldman G. (2018) 'Regulation of Aspergillus nidulans CreA-mediated catabolite repression by the F-Box proteins Fbx23 and Fbx47'. mBio, 9 (3) [DOI] [IR Link] [Details]
    2018 'The Aspergillus nidulans pyruvate dehydrogenase kinases are essential to integrate carbon source metabolism'
    Ries L.;de Assis L.;Rodrigues F.;Caldana C.;Rocha M.;Malavazi I.;Bayram Ö.;Goldman G. (2018) 'The Aspergillus nidulans pyruvate dehydrogenase kinases are essential to integrate carbon source metabolism'. G3 (Bethesda, Md.), 8 (7):2445-2463 [DOI] [IR Link] [Details]
    2017 'MybA, a new player driving survival of the conidium of the human pathogen Aspergillus fumigatus'
    Sarikaya Bayram Ö;Latgé JP;Bayram Ö; (2017) 'MybA, a new player driving survival of the conidium of the human pathogen Aspergillus fumigatus'. Current Genetics, [DOI] [IR Link] [Details]
    2017 'Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence'
    Manfiolli AO;de Castro PA;Dos Reis TF;Dolan S;Doyle S;Jones G;Riaño Pachón DM;Ulaş M;Noble LM;Mattern DJ;Brakhage AA;Valiante V;Silva-Rocha R;Bayram O;Goldman GH; (2017) 'Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence'. Cellular Microbiology, [DOI] [IR Link] [Details]
    2017 'MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen Aspergillus fumigatus'
    Valsecchi I;Sarikaya-Bayram Ö;Wong Sak Hoi J;Muszkieta L;Gibbons J;Prevost MC;Mallet A;Krijnse-Locker J;Ibrahim-Granet O;Mouyna I;Carr P;Bromley M;Aimanianda V;Yu JH;Rokas A;Braus GH;Saveanu C;Bayram Ö;Latgé JP; (2017) 'MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen Aspergillus fumigatus'. Molecular Microbiology, [DOI] [IR Link] [Details]
    2017 'Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus'
    de Vries RP;Riley R;Wiebenga A;Aguilar-Osorio G;Amillis S;Uchima CA;Anderluh G;Asadollahi M;Askin M;Barry K;Battaglia E;Bayram Ö;Benocci T;Braus-Stromeyer SA;Caldana C;Cánovas D;Cerqueira GC;Chen F;Chen W;Choi C;Clum A;Dos Santos RA et al (2017) 'Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus'. Genome Biology, 18 (1):1-45 [DOI] [IR Link] [Details]
    2016 'Changes of global gene expression and secondary metabolite accumulation during light-dependent Aspergillus nidulans development'
    Bayram Ö.;Feussner K.;Dumkow M.;Herrfurth C.;Feussner I.;Braus G. (2016) 'Changes of global gene expression and secondary metabolite accumulation during light-dependent Aspergillus nidulans development'. Fungal Genetics and Biology, 87 :30-53 [DOI] [IR Link] [Details]
    2016 'SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus'
    Jöhnk B;Bayram O;Abelmann A;Heinekamp T;Mattern DJ;Brakhage AA;Jacobsen ID;Valerius O;Braus GH; (2016) 'SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus'. PLoS Pathogens, 12 (9) [DOI] [IR Link] [Details]
    2016 'Quantitative proteomics reveals the mechanism and consequence of gliotoxin-mediated dysregulation of the methionine cycle in Aspergillus niger'
    Manzanares-Miralles L, Sarikaya-Bayram Ö, Smith EB, Dolan SK, Bayram Ö, Jones GW, Doyle S. (2016) 'Quantitative proteomics reveals the mechanism and consequence of gliotoxin-mediated dysregulation of the methionine cycle in Aspergillus niger'. Proteomics, NA [DOI] [IR Link] [Details]
    2015 'One Juliet and four Romeos: VeA and its methyltransferases'
    Sarikaya-Bayram , Palmer JM, Keller N, Braus GH, Bayram (2015) 'One Juliet and four Romeos: VeA and its methyltransferases'. Frontiers in Microbiology, 20 [DOI] [IR Link] [Details]
    2015 'Dissecting the function of the different chitin synthases in vegetative growth and sexual development in Neurospora crassa'
    Fajardo-Somera R.;Jöhnk B.;Bayram Ö.;Valerius O.;Braus G.;Riquelme M. (2015) 'Dissecting the function of the different chitin synthases in vegetative growth and sexual development in Neurospora crassa'. Fungal Genetics and Biology, 75 :30-45 [DOI] [IR Link] [Details]
    2015 'The SrkA Kinase Is Part of the SakA Mitogen-Activated Protein Kinase Interactome and Regulates Stress Responses and Development in Aspergillus nidulans'
    Jaimes-Arroyo R, Lara-Rojas F, Bayram , Valerius O, Braus GH, Aguirre J (2015) 'The SrkA Kinase Is Part of the SakA Mitogen-Activated Protein Kinase Interactome and Regulates Stress Responses and Development in Aspergillus nidulans'. EUKARYOTIC CELL, 14 :495-510 [DOI] [IR Link] [Details]
    2014 'Membrane-Bound Methyltransferase Complex VapA-VipC-VapB Guides Epigenetic Control of Fungal Development'
    Sarikaya-Bayram O, Bayram O, Feussner K, Kim J.H, Kim H.S, Kaever A, Feussner I, Chae K.S, Han D.M, Han K.H, Braus G.H (2014) 'Membrane-Bound Methyltransferase Complex VapA-VipC-VapB Guides Epigenetic Control of Fungal Development'. Developmental Cell, 29 :406-420 [DOI] [IR Link] [Details]
    2013 'The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-κB'
    Ahmed YL, Gerke J, Park HS, Bayram O, Neumann P, Ni M, Dickmanns A, Kim S.C, Yu J.H, Braus G.H, Ficner R. (2013) 'The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-κB'. PLOS Biology, 11 [DOI] [IR Link] [Details]
    2013 'Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome'
    Christmann M, Schmaler T, Gordon C, Huang X, Bayram O, Schinke J, Stumpf S, Dubiel W, Braus G.H. (2013) 'Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome'. PLOS Genetics, 9 [DOI] [IR Link] [Details]
    2013 'Interplay of the fungal sumoylation network for control of multicellular development'
    Harting R, Bayram O, Laubinger K, Valerius O, Braus G.H. (2013) 'Interplay of the fungal sumoylation network for control of multicellular development'. MOLECULAR MICROBIOLOGY, 90 :1125-1145 [DOI] [IR Link] [Details]
    2013 'conF and conJ contribute to conidia germination and stress response in the filamentous fungus Aspergillus nidulans'
    Suzuki S, Sarikaya Bayram O, Bayram O, Braus G.H. (2013) 'conF and conJ contribute to conidia germination and stress response in the filamentous fungus Aspergillus nidulans'. FUNGAL GENETICS AND BIOLOGY, 56 :42-53 [DOI] [IR Link] [Details]
    2012 'Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins'
    Bayram O, Braus G.H. (2012) 'Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins'. FEMS Microbiology Reviews, 36 :1-24 [DOI] [IR Link] [Details]
    2012 'Breaking the silence: protein stabilization uncovers silenced biosynthetic gene clusters in the fungus Aspergillus nidulans'
    Gerke J, Bayram O, Feussner K, Landesfeind M, Shelest E, Feussner I, Braus G.H. (2012) 'Breaking the silence: protein stabilization uncovers silenced biosynthetic gene clusters in the fungus Aspergillus nidulans'. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 78 :8234-8244 [DOI] [IR Link] [Details]
    2012 'Fungal S-adenosylmethionine synthetase and the control of development and secondary metabolism in Aspergillus nidulans'
    Gerke J, Bayram O, Braus G.H. (2012) 'Fungal S-adenosylmethionine synthetase and the control of development and secondary metabolism in Aspergillus nidulans'. FUNGAL GENETICS AND BIOLOGY, 49 :443-454 [DOI] [IR Link] [Details]
    2012 'The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism'
    Bayram O, Bayram OS, Ahmed Y.L, Maruyama J, Valerius O, Rizzoli S.O, Ficner R, Irniger S, Braus G.H (2012) 'The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism'. PLOS Genetics, 8 [DOI] [IR Link] [Details]
    2012 'Characterization of the velvet regulators in Aspergillus fumigatus'
    Park HS, Bayram O, Braus G.H, Kim S.C, Yu J.H. (2012) 'Characterization of the velvet regulators in Aspergillus fumigatus'. Molecular Microbiology, 86 :937-953 [DOI] [IR Link] [Details]
    2012 'The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development'
    Kress M.R, Harting R, Bayram O, Christmann M, Irmer H, Valerius O, Schinke J, Goldman GH, Braus G.H. (2012) 'The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development'. Molecular Microbiology, 83 :1162-1177 [DOI] [IR Link] [Details]
    2012 'Molecular characterization of the Aspergillus nidulans fbxA encoding an F-box protein involved in xylanase induction'
    Colabardini A.C, Humanes AC, Gouvea P.F, Savoldi M, Goldman M.H, Kress M.R, Bayram O, Oliveira J.V, Gomes M.D, Braus G.H, Goldman G.H. (2012) 'Molecular characterization of the Aspergillus nidulans fbxA encoding an F-box protein involved in xylanase induction'. FUNGAL GENETICS AND BIOLOGY, 49 :130-140 [DOI] [IR Link] [Details]
    2010 'Fungal development and the COP9 signalosome'
    Braus G.H, Irniger S, Bayram O. (2010) 'Fungal development and the COP9 signalosome'. Current Opinion in Microbiology, 13 :672-676 [DOI] [IR Link] [Details]
    2010 'Spotlight on Aspergillus nidulans photosensory systems'
    Bayram O, Braus GH, Fischer R, Rodriguez-Romero J (2010) 'Spotlight on Aspergillus nidulans photosensory systems'. Fungal Genetics and Biology, 47 :900-908 [DOI] [IR Link] [Details]
    2010 'Dissection of mitotic functions of the yeast cyclin Clb2'
    Kuczera T, Bayram O, Sari F, Braus G.H, Irniger S. (2010) 'Dissection of mitotic functions of the yeast cyclin Clb2'. Cell Cycle, 9 :2611-2619 [DOI] [IR Link] [Details]
    2010 'LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity'
    Sarikaya Bayram O, Bayram O, Valerius O, Park H.S, Irniger S, Gerke J, Ni M, Han K.H, Yu J.H, Braus G.H. (2010) 'LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity'. PLOS Genetics, 6 [DOI] [IR Link] [Details]
    2010 'The COP9 signalosome mediates transcriptional and metabolic response to hormones, oxidative stress protection and cell wall rearrangement during fungal development'
    Nahlik K, Dumkow M, Bayram O, Helmstaedt K, Busch S, Valerius O, Gerke J, Hoppert M, Schwier E, Opitz L, Westermann M, Grond S, et al. (2010) 'The COP9 signalosome mediates transcriptional and metabolic response to hormones, oxidative stress protection and cell wall rearrangement during fungal development'. Molecular Microbiology, 78 :964-979 [DOI] [IR Link] [Details]
    2009 'The protein kinase ImeB is required for light-mediated inhibition of sexual development and for mycotoxin production in Aspergillus nidulans'
    Bayram O, Sari F, Braus G.H, Irniger S. (2009) 'The protein kinase ImeB is required for light-mediated inhibition of sexual development and for mycotoxin production in Aspergillus nidulans'. Molecular Microbiology, 71 :1278-1295 [DOI] [IR Link] [Details]
    2009 'Glucose signaling pathway and growth conditions regulate gene expression in retrotransposon Ty2'
    Turkel S, Bayram O, Arik E. (2009) 'Glucose signaling pathway and growth conditions regulate gene expression in retrotransposon Ty2'. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF C, 64 :526-532 [IR Link] [Details]
    2008 'Neurospora crassa ve-1 affects asexual conidiation'
    Bayram O, Krappmann S, Seiler S, Vogt N, Braus GH (2008) 'Neurospora crassa ve-1 affects asexual conidiation'. Fungal Genetics and Biology, 45 :127-138 [DOI] [IR Link] [Details]
    2008 'More than a repair enzyme: Aspergillus nidulans photolyase-like CryA is a regulator of sexual development'
    Bayram O, Biesemann C, Krappmann S, Galland P, Braus GH (2008) 'More than a repair enzyme: Aspergillus nidulans photolyase-like CryA is a regulator of sexual development'. Molecular Biology of the Cell, 19 :3254-3262 [DOI] [IR Link] [Details]
    2008 'The nuclear migration protein NUDF/LIS1 forms a complex with NUDC and BNFA at spindle pole bodies'
    Helmstaedt K, Laubinger K, Vosskuhl K, Bayram O, Busch S, Hoppert M, Valerius O, Seiler S, Braus GH. (2008) 'The nuclear migration protein NUDF/LIS1 forms a complex with NUDC and BNFA at spindle pole bodies'. EUKARYOTIC CELL, 7 :1041-1052 [DOI] [IR Link] [Details]
    2008 'VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism'
    Bayram O, Krappmann S, Ni M, Bok JW, Helmstaedt K, Valerius O, Braus-Stromeyer S, Kwon NJ, Keller NP, Yu JH, Braus GH (2008) 'VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism'. Science, 320 :1504-1506 [DOI] [IR Link] [Details]
    2007 'An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation'
    Busch S, Schwier EU, Nahlik K, Bayram O, Helmstaedt K, Draht OW, Krappmann S, Valerius O, Lipscomb WN, Braus G.H (2007) 'An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, 8 :8089-8094 [DOI] [IR Link] [Details]
    2005 'Deletion and allelic exchange of the Aspergillus fumigatus veA locus via a novel recyclable marker module'
    Krappmann S, Bayram O, Braus G.H. (2005) 'Deletion and allelic exchange of the Aspergillus fumigatus veA locus via a novel recyclable marker module'. EUKARYOTIC CELL, 4 :1298-1307 [DOI] [IR Link] [Details]

    Conference Contributions

      Year Publication
    2019 30th Fungal Genetics Conference.
    Frawley D, Karahoda B, Sarikaya-Bayram O, Bayram O (2019) 30th Fungal Genetics Conference. [Poster Presentation], HamE scaffold positively regulates MAP kinase signal transduction to promote development and secondary metabolism in Aspergillus nidulans, Asilomar, Pacific Grove California, USA , 12-MAR-19 - 17-MAR-19 [Details]
    2019 30th Fungal Genetics Conference.
    Elramli N, Karahoda B, Sarikaya-Bayram O, Frawley D, Ulas M, Oakley CE, Oakley B, Seiler S, Bayram, O. (2019) 30th Fungal Genetics Conference. [Poster Presentation], Assembly of a heptameric STRIPAK complex at the nuclear envelope is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans, Asilomar, Pacific Grove California, USA , 12-MAR-19 - 17-MAR-19 [Details]
    2018 14th European Conference on Fungal Genetics.
    Karahoda B, Bayram O, Sarikaya Bayram O, Elramli N, Thieme S, Assis LJ, Goldman GH, Braus GH (2018) 14th European Conference on Fungal Genetics. [Poster Presentation], Global analysis of the molecular roles, localizations and interactomes of F-box proteins during fungal development, Haifa, Israel , 25-FEB-18 - 28-FEB-18 [Details]
    2018 8th Irish Fungal Society Meeting.
    Özgür Bayram (2018) 8th Irish Fungal Society Meeting. [Oral Presentation], Building up scaffolds : Control of signal influx into development and secondary metabolism, Maynooth University , 18-JUN-18 - 19-JUN-18 [Details]
    2018 14th European Conference on Fungal Genetics.
    Assis LJ, Ulas M, Ries LN, Elramli N, Sarikaya Bayram O, Braus GH, Bayram O, Goldman G (2018) 14th European Conference on Fungal Genetics. [Poster Presentation], Regulation of Aspergillus nidulans CreA-mediated catabolite repression by the F-box proteins Fbx23 and Fbx47, Haifa, Israel , 25-FEB-18 - 28-FEB-18 [Details]
    2018 14th European Conference on Fungal Genetics.
    Ries LN, Assis LJ, Rodrigues FJS, Caldana C, Rocha MC, Malavazi I, Bayram O, Goldman GH (2018) 14th European Conference on Fungal Genetics. [Poster Presentation], The Aspergillus nidulans pyruvate dehydrogenase kinases are essential to integrate carbon source metabolism, Haifa, Israel , 25-FEB-18 - 28-FEB-18 [Details]
    2015 28th Fungal Genetics Conference.
    Bayram O, Sarikaya-Bayram O, Reen S, Goldman G and Braus G (2015) 28th Fungal Genetics Conference. [Poster Presentation], Global examination of the molecular roles, localizations and interactomes of F-box proteins in fungal development, Asilomar, Pacific Grove California, USA , 17-MAR-15 - 22-MAR-15 [Details]
    2015 28th Fungal Genetics Conference.
    Gerke J, Luqman YA, Park HS, Bayram O, Neumann P, Ni M, Dickmanns A, Kim CS, Yu JH, Ficner R, Braus G (2015) 28th Fungal Genetics Conference. [Poster Presentation], The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-KB, Asilomar, Pacific Grove California, USA , 17-MAR-15 - 22-MAR-15 [Details]
    2015 28th Fungal Genetics Conference.
    Dhingra S, Chung D, Bayram O, Buckey JC, Cramer RA (2015) 28th Fungal Genetics Conference. [Poster Presentation], Regulation of SrbA in Aspergillus fumigatus, Asilomar, Pacific Grove California, USA , 17-MAR-15 - 22-MAR-15 [Details]
    2015 28th Fungal Genetics Conference.
    Özgür Bayram (2015) 28th Fungal Genetics Conference. [Oral Presentation], Control of sexual and asexual development in Aspergillus nidulans by two different modules: MAPK (SteC-SteD-MkkB-MpkB) and heterotrimeric VapA-VipC-VapB methyltransferase complex, Asilomar, Pacific Grove California, USA , 17-MAR-15 - 22-MAR-15 [Details]
    2014 4th Irish Fungal Society Meeting.
    Özgür Bayram (2014) 4th Irish Fungal Society Meeting. [Oral Presentation], Membrane-bound methyltransferase complex VapA-VipC-VapB guides epigenetic control of fungal development, NUIG, Galway , 19-JUN-14 - 20-JUN-14 [Details]
    2013 27th Fungal Genetics Conference.
    Jöhnk B, Bayram O, Valerius O, Heinekamp T, Jacobsen ID, Brakhage AA, Braus GH (2013) 27th Fungal Genetics Conference. [Oral Presentation], F-box protein 15 (Fbx15) links virulence of Aspergillus fumigatus to protein degradation and stress response, Asilomar, Pacific Grove California, USA , 12-MAR-13 - 17-MAR-13 [Details]
    2013 27th Fungal Genetics Conference.
    Sarikaya Bayram O, Bayram O, Kim JH, Chae KS, Han DM, Han KH, Braus GH (2013) 27th Fungal Genetics Conference. [Poster Presentation], Two methyltransferase protein complexes control fungal development and secondary metabolite production, Asilomar, Pacific Grove California, USA , 12-MAR-13 - 17-MAR-13 [Details]
    2013 27th Fungal Genetics Conference.
    Schinke J, Christmann M, Schmaler T, Gordon C, Huang X, Bayram O, Stumpf S, Dubiel W, Braus G (2013) 27th Fungal Genetics Conference. [Poster Presentation], Control of Multicellular Development by the Physically Interacting Deneddylases DEN1/DenA and COP9 Signalosome, Asilomar, Pacific Grove California, USA , 12-MAR-13 - 17-MAR-13 [Details]
    2013 27th Fungal Genetics Conference.
    Fajardo R, Roberson R, Jöhnk B, Bayram O, Braus GH, Riquelme M (2013) 27th Fungal Genetics Conference. [Poster Presentation], The role and traffic of chitin syntheses in Neurospora crassa, Asilomar, Pacific Grove California, USA , 12-MAR-13 - 17-MAR-13 [Details]
    2013 27th Fungal Genetics Conference.
    Özgür Bayram (2013) 27th Fungal Genetics Conference. [Oral Presentation], New insights into the MAPK modules in filamentous fungi: Aspergillus nidulans MAPK module has an exceptional mobility, Asilomar, Pacific Grove California, USA , 12-MAR-13 - 17-MAR-13 [Details]
    2013 27th Fungal Genetics Conference.
    Bayram O, Sarikaya Bayram O, Luqman Ahmed Y, Maruyama JI, Valerius O, Rizzoli O, Ficner R, Irniger S, Braus G (2013) 27th Fungal Genetics Conference. [Poster Presentation], The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism, Asilomar, Pacific Grove California, USA , 12-MAR-13 - 17-MAR-13 [Details]
    2012 The 9th International Aspergillus Meeting.
    Özgür Bayram (2012) The 9th International Aspergillus Meeting. [Oral Presentation], Shuttling of entire MAPK module from membrane to nuclear envelope links fungal development to secondary metabolism, Marburg, Germany , 29-MAR-12 - 30-MAR-12 [Details]
    2012 11th European Conference on Fungal Genetics.
    Gerke J, Bayram O, Feussner K, Feussner I, Landesfeind M and Braus GH (2012) 11th European Conference on Fungal Genetics. [Oral Presentation], Breaking the silence: protein stabilization uncovers silenced biosynthetic gene clusters in the fungus Aspergillus nidulans, Marburg, Germany , 30-MAR-12 - 02-APR-12 [Details]
    2012 11th European Conference on Fungal Genetics.
    Sarikaya Bayram O, Bayram O, Ahmed Luqman Y, Maruyama JI, Valerius O, Ficner R, Irniger S, Braus G.H. (2012) 11th European Conference on Fungal Genetics. [Poster Presentation], Shuttling of entire MAPK module from membrane to nuclear envelope links fungal development to secondary metabolism, Marburg, Germany , 30-MAR-12 - 02-APR-12 [Details]
    2011 26th Fungal Genetics Conference.
    Christmann M, Harting R, Bayram O, Braus G.H. (2011) 26th Fungal Genetics Conference. [Poster Presentation], DenA is a deneddylating protein involved in A. nidulans development, Asilomar, Pacific Grove California, USA , 15-MAR-11 - 20-MAR-11 [Details]
    2011 4th FEBS Advanced Lecture Course, Human Fungal Pathogens- Molecular Mechanisms of Host-Pathogen Interactions and Virulence.
    Jöhnk B, Bayram O, Heinekamp T, Brakhage A.A, Braus G.H (2011) 4th FEBS Advanced Lecture Course, Human Fungal Pathogens- Molecular Mechanisms of Host-Pathogen Interactions and Virulence. [Poster Presentation], Analysis of the F-box protein encoding genes of the opportunistic human pathogen Aspergillus fumigatus, La Colle sur Loup, France , 07-MAY-11 - 13-MAY-11 [Details]
    2011 Tagungsband zur VAAM-Jahrestagung 2011.
    Jöhnk B, Bayram O, Heinekamp T, Brakhage A.A, Braus G.H (2011) Tagungsband zur VAAM-Jahrestagung 2011. [Poster Presentation], Interplay between degradation, oxidative stress response, polar growth and virulence in the pathogen Aspergillus fumigatus, Karlsruhe, Germany , 03-APR-11 - 06-APR-11 [Details]
    2011 26th Fungal Genetics Conference.
    Sarikaya Bayram O, Bayram O, Valerius O, Park H.S, Irniger S, Gerke J, Ni M, Han K.H, Yu J.H and Braus G.H. (2011) 26th Fungal Genetics Conference. [Poster Presentation], LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity, Asilomar, Pacific Grove California, USA , 15-MAR-11 - 20-MAR-11 [Details]
    2010 The 7th International Aspergillus Meeting.
    Özgür Bayram (2010) The 7th International Aspergillus Meeting. [Oral Presentation], Dynamic and functional interactions between the components of the trimeric velvet complex in the filamentous fungus Aspergillus nidulans, NH Conference Centre Leeuwenhorst, The Netherlands , 29-MAR-10 - 01-APR-10 [Details]
    2010 10th European Conference on Fungal Genetics.
    Sarikaya Bayram O, Bayram O, Valerius O, Gerke J, Irniger S, Han K.H, and Braus G.H (2010) 10th European Conference on Fungal Genetics. [Poster Presentation], Dynamic and functional interactions between the components of the trimeric velvet complex in the filamentous fungus Aspergillus nidulans, NH Conference Centre Leeuwenhorst, The Netherlands , 29-MAR-10 - 01-APR-10 [Details]
    2009 25th Fungal Genetics Conference.
    Irniger S, Bayram O, Sari F, and Braus G.H (2009) 25th Fungal Genetics Conference. [Poster Presentation], The protein kinase ImeB is involved in the coordination of sexual development and mycotoxin production in Aspergillus nidulans, Asilomar, Pacific Grove California, USA , 17-MAR-09 - 22-MAR-09 [Details]
    2009 9 th VAAM Symposium, Molecular Biology of Fungi.
    Christmann M, Harting R, Kress M, Bayram O, Sarikaya Bayram O, Jöhnk B, Helmstaedt K, Braus G.H (2009) 9 th VAAM Symposium, Molecular Biology of Fungi. [Poster Presentation], Fungal development requires the deneddylating proteins Den1 (DenA) and CSN, Munster, Germany , 27-SEP-09 - 30-SEP-09 [Details]
    2008 Final Eurofungbase Meeting.
    Özgür Bayram (2008) Final Eurofungbase Meeting. [Oral Presentation], Light signaling governing fungal development and secondary metabolism, Girona, Spain , 23-OCT-08 [Details]
    2008 9th European Conference on Fungal Genetics.
    Bayram O, Krappmann S, Ni M, Helmstaedt K, Valerius O, Braus-Stromeyer S, Kwon N.J, Bok J.W, Keller N.P, Yu J.H, and Braus G.H (2008) 9th European Conference on Fungal Genetics. [Poster Presentation], The velvet complex coordinates light, fungal development and secondary metabolism, University of Edinburgh, Edinburgh, Scotland , 05-APR-08 - 08-APR-08 [Details]
    2008 9th European Conference on Fungal Genetics.
    Helmstaedt K, Laubinger K, Voßkuhl K, Bayram O, Busch S, Hoppert M, Valerius O, Seiler S, Braus G.H (2008) 9th European Conference on Fungal Genetics. [Poster Presentation], The nuclear migration protein NUDF/LIS1 forms a complex with NUDC and BNFA at spindle pole bodies, University of Edinburgh, Edinburgh, Scotland , 05-APR-08 - 08-APR-08 [Details]
    2008 The 5th International Aspergillus Meeting.
    Özgür Bayram (2008) The 5th International Aspergillus Meeting. [Oral Presentation], The velvet complex coordinates light, fungal development and secondary metabolism, University of Edinburgh, Edinburgh, Scotland , 04-APR-08 - 05-APR-08 [Details]
    2007 Tagungsband zur VAAM-Jahrestagung 2007.
    Sari F, Bayram O, Braus G.H, and Irniger S (2007) Tagungsband zur VAAM-Jahrestagung 2007. [Poster Presentation], The protein kinase ImeB acts as a potential inhibitor of sexual development in Aspergillus nidulans, Osnabruck, Germany , 01-APR-07 - 04-APR-07 [Details]
    2007 24th Fungal Genetics Conference.
    Helmstaedt K, Meng K, Busch S, Bayram O, Valerius O, and Braus G.H (2007) 24th Fungal Genetics Conference. [Poster Presentation], The Nuclear Migration Protein NUDF Associates with BNFA and NUDC at Spindle Pole Bodies in Aspergillus nidulans, Asilomar, Pacific Grove California, USA , 20-MAR-07 - 25-MAR-07 [Details]
    2007 24th Fungal Genetics Conference.
    Bayram O, Rupprecht H.S, Dumkow M, R. v. Z. Kress M, Linger T, Sarikaya Bayram O, Goldman G.H (2007) 24th Fungal Genetics Conference. [Poster Presentation], The Aspergillus nidulans F-box Protein Project, Asilomar, Pacific Grove California, USA , 20-MAR-07 - 25-MAR-07 [Details]
    2007 The 4th Aspergillus Meeting.
    Özgür Bayram (2007) The 4th Aspergillus Meeting. [Oral Presentation], The Aspergillus nidulans F-box Protein Project, Asilomar, Pacific Grove California, USA , 18-MAR-07 - 20-MAR-07 [Details]
    2006 8th European Conference on Fungal Genetics.
    Helmstaedt K, Voßkuhl K, Busch S, Bayram O, and Braus G.H (2006) 8th European Conference on Fungal Genetics. [Poster Presentation], The nuclear migration protein NUDF associates with NUDC and BNFA in Aspergillus nidulans, Vienna, Austria , 08-APR-06 - 11-APR-06 [Details]
    2006 8th European Conference on Fungal Genetics.
    Sari F, Bayram O, Braus G.H, Irniger S (2006) 8th European Conference on Fungal Genetics. [Poster Presentation], Analysis of the protein kinase ImeB in Aspergillus nidulans, Vienna, Austria , 08-APR-06 - 11-APR-06 [Details]
    2006 8th European Conference on Fungal Genetics.
    Busch S, Schwier E, Bayram O, Draht O, Grube V, Helmstaedt K, Krappmann S, Valerius O, and Braus G.H (2006) 8th European Conference on Fungal Genetics. [Poster Presentation], The COP9 signalosome is essential for development and oxidative stress response, Vienna, Austria , 08-APR-06 - 11-APR-06 [Details]
    2006 8th European Conference on Fungal Genetics.
    Bayram O, Biesemann C, Krappmann S, and Braus G.H (2006) 8th European Conference on Fungal Genetics. [Poster Presentation], Characterization of the Aspergillus nidulans putative blue light receptor gene cryA encoding a cryptochrome, Vienna, Austria , 08-APR-06 - 11-APR-06 [Details]
    2005 23rd Fungal Genetics Conference.
    Bayram O, Helmstaedt K, Krappmann S, and Braus G.H (2005) 23rd Fungal Genetics Conference. [Poster Presentation], Adaptation of the tap tag method to decipher protein complexes in filamentous fungi, Asilomar, Pacific Grove California, USA , 15-MAR-05 - 11-MAR-05 [Details]
    2005 The 2nd Aspergillus Meeting.
    Özgür Bayram (2005) The 2nd Aspergillus Meeting. [Oral Presentation], TAP tagging in Aspergillus nidulans, Asilomar, Pacific Grove California, USA , 13-MAR-05 - 15-MAR-05 [Details]
    2005 23rd Fungal Genetics Conference.
    Busch S, Helmstaedt K, Bayram O, and Braus G.H (2005) 23rd Fungal Genetics Conference. [Poster Presentation], Analysis of the regulatory multprotein complex COP9 Signalosome in Aspergillus nidulans, Asilomar, Pacific Grove California, USA , 15-MAR-05 - 11-MAR-05 [Details]
    2005 23rd Fungal Genetics Conference.
    Helmstaedt K, Busch S, Bayram O, and Braus G.H (2005) 23rd Fungal Genetics Conference. [Poster Presentation], Analysis of dynein regulatory complexes using a tandem affinity purification tag for filamentous fungi, Asilomar, Pacific Grove California, USA , 15-MAR-05 - 20-MAR-05 [Details]
    2004 7th European Conference on Fungal Genetics.
    Krappmann S, Bignell E.M, Reichard U, Bayram O, Haynes K, and Braus G.H (2004) 7th European Conference on Fungal Genetics. [Poster Presentation], The cross-pathway control system contributes to pathogenicity of Aspergillus fumigatus, Cophenagen, Denmark , 17-APR-04 - 20-APR-04 [Details]

    Honours and Awards

      Year Title Awarding Body
    2019 Early Career Research Achievement Award, Faculty of Science and Engineering Maynooth University, Ireland
    2014 Science Foundation Ireland (SFI) Career Development Award (CDA) Science Foundation Ireland
    2012 Associate Professorship of Biology Higher Education and Science Council, Turkey
    2011 Listed among the top 50 Turkish academicians in Germany in the book entitled „In Bester Gesellschaft“ German Standards Institute, Berlin, Germany
    2010 Distinctive publication prize Board of Trustees of Georg August University, Germany
    2008 GZMB outstanding doctoral thesis Award Goettingen Center for Molecular Biosciences (GZMB)
    2008 PhD Graduation (summa cum laude) Georg August University
    2008 Excellence award for poster presentation Aspergillus Genomes Research Policy Committee

    Professional Associations

      Association Function From / To
    Irish Fungal Society (IFS) Member 01-JUN-14 /
    Association for General and Applied Microbiology Member 01-OCT-11 /
    Irish Fungal Society (IFS) Treasurer 01-JAN-17 /
    American Society For Microbiology Member 01-AUG-18 /
    Genetics Society of America (GSA) Member 01-JUL-11 /

    Committees

      Committee Function From / To
    University of Sanctuary Member 2018 /

    Employment

      Employer Position From / To
    Maynooth University Lecturer in Biology 18-JAN-14 /
    Georg August University Project Leader 01-JAN-11 / 31-DEC-13
    Georg August University Postdoctoral Fellow 01-JAN-08 / 31-DEC-11

    Education

      Year Institution Qualification Subject
    2007 Georg August University PhD (Dr.rer.nat) Molecular Microbiology, Genetics, Biochemistry
    2003 Uludag University MSc Molecular Biology (yeast genetics)
    2000 Uludag University BSc Biology

    Languages

      Language Reading Writing Speaking
    English Fluent Fluent Fluent
    German Functional Functional Functional

    Reviews

      Journal Role
    Eukaryotic Cell Reviewer
    Plos Pathogens Reviewer
    Clinical Microbiology Reviews Reviewer
    Scientific Reports Reviewer
    Plos One Reviewer
    Plos Genetics Reviewer
    Frontiers In Microbiology Editor
    Applied Microbiology And Biotechnology Reviewer
    Fungal Genetics And Biology Reviewer
    Frontiers In Microbiology Reviewer
    Current Genetics Reviewer
    Molecular Genetics And Genomics Reviewer
    Molecular Microbiology Reviewer

    Teaching Interests

    I currently teach
    • BI441 (Fungal and Bacterial Secondary Metabolism)
    • BI416 (Genomics and Proteomics)
    • BI423 (Literature project 1)
    • BI424 (Literature project 2)
    • BI427 (Laboratory research project)
    • BI421 (Research methodology)
    • BI431 (Biological science research project)
    • BI312 (Scientific Writing)
    • BI308 (Proteomics)
    • BI305 (Dissertation)
    • BI103 (Human Biology)

    Recent Postgraduates

      Graduation Student Name University Degree Thesis
    2020 Dean Frawley Maynooth University PhD Role of MAPK pheromone modules in pathogenic Aspergilli
    2018 Mevlüt Ulaş Maynooth University PhD Molecular Functions of Histone Demethylase MERCK complex on Fungal Development and Secondary Metabolism
    2018 Betim Karahoda Maynooth University PhD The role of the novel demethylase KERS complex in fungal development and secondary metabolism
    2018 Nadia Elramli Maynooth University PhD Role of Striatin Complexes in the Control of Development and Secondary Metabolism of the Filamentous Fungus Aspergillus nidulans
    2016 Bastian Joehnk Georg-August-Universitat Gottingen PhD Stress Response SCF Ubiquitin Ligase F box Protein Fbx15 Controls Nuclear Co repressor Localization and Virulence of the Opportunistic Human Fungal Pathogen Aspergillus fumigatus
    2014 Özlem Sarikaya Bayram Georg-August-Universitat Gottingen PhD Role of methyltransferases in fungal development and secondary metabolite production
    2013 Marc Dumkow Georg-August-Universitat Gottingen PhD Alterations in gene expression and secondary metabolite production during development of Aspergillus nidulans
    2013 Rebekka Harting Georg-August-Universitat Gottingen PhD The sumoylation and neddylation networks in Aspergillus nidulans development
    2013 Sabine Reen Georg-August-Universitat Gottingen MSc Interaction partners of 49 high-scoring F-box proteins in Aspergillus nidulans
    2012 Jennifer Gerke Georg-August-Universitat Gottingen PhD Secondary metabolism and development in the filamentous fungus Aspergillus nidulans - Activation of silent gene clusters and characterization of the SAM synthetase SasA
    2009 Bastian Joehnk Georg-August-Universitat Gottingen Diplom Comparison of the model organism Aspergillus nidulans and opportunistic pathogen Aspergillus fumigatus F-box protein encoding genes
    2009 Hani Kaba Georg-August-Universitat Gottingen Diplom F-box proteins important for development in the filamentous fungus Aspergillus nidulans
    2009 Özlem Sarikaya Bayram Georg-August-Universitat Gottingen Diplom Role of methyltransferases in development and coordinated secondary metabolism in the filamentous fungus Aspergillus nidulans
    2008 Oliver Voigt Georg-August-Universitat Gottingen Diplom Characterization of the f-box genes 32, 58 and 62 in the filamentous fungus Aspergillus nidulans

    Internal Collaborators

      Name Institute Country
    David Fitzpatrick Dr David Fitzpatrick / Bioinformatics Analysis IRELAND
    Sean Doyle Biology Department IRELAND

    External Collaborators

      Name Role / Description Country
    Prof. Dr. Jean Paul Latge / Institut Pasteur Fungal pathogens FRANCE
    University of Innsbruck AUSTRIA
    Prof. Dr. Nancy P Keller / University of Wisconsin Fungal secondary metabolism U.S.A.
    Prof. Dr. Luis Corrochano / University of Sevilla Fungal light repsonses SPAIN
    Prof. Dr. Koonho Wong / University of Macao Chromatin immunoprecipitation HONG KONG
    Dr Satoshi Suzuki / NARO Food biotechnology JAPAN
    Prof. Dr. Joseph Strauss / University of Vienna Chromatin Biology AUSTRIA
    Prof. Dr. Berl Oakley / University of Kansas Cell biology imaging of fungal cells U.S.A.
    Prof. Dr. Jun-Ichi Maruyama / University of Tokyo Fungal Genetics/Biotechnology JAPAN
    Prof. Dr. Gustavo Goldman / University Sao Paolo Fungal Pathogenicity BRAZIL