Dr Martina Schroeder

Biology, Human Health Institute

Lecturer
Postgraduate Coordinator

Biosciences
B2.18
(01) 7086853

Biography

2007-2008: Research Lecturer, School of Biochemistry and Immunology, Trinity College Dublin 2003-2007: Postdoctoral Research Fellow, School of Biochemistry and Immunology, Trinity College Dublin (with Prof Andrew Bowie) 1999-2003: PhD Research, Institute of Medical Immunology, Humboldt-University (Charite) Berlin, Germany (with Prof Hans-Dieter Volk).

Research Interests

The Host-Pathogen interaction lab is interested in the recognition of pathogens by the innate immune system, as well as strategies employed by pathogens to evade recognition or to manipulate the ensuing immune response for its own benefit. Viral recognition by the innate immune system is mainly mediated by two classes of pattern recognition receptors: endosomal Toll-like receptors (TLRs) and cytoplasmic RIG-like helicases (RLHs). Both classes detect viral nucleic acids and lead to the induction of type I interferons, which are potent anti-viral mediators. Signalling pathways connecting the anti-viral PRRs to transcription factor activation and interferon induction are beginning to be elucidated, and the lab hopes to contribute to their understanding. A lot of viruses have developed sophisticated mechanism to evade detection by PRRs and/or to actively inhibit the resulting signalling pathways in order to prevent transcription factor activation and the induction of pro-inflammatory and anti-viral mediators. Viral strategies for immune evasion or subversion are optimised during evolution; therefore they tend to target key aspects of the host anti-viral response. Studying the modulation of the host protein by the virus can provide information for the design of anti-viral therapeutics and give us an edge in the evolutionary battle against the virus. Current work in the lab focuses on the human protein DDX3, as three different viruses that pose major global health threats, poxviruses, HIV and HCV, have been shown to manipulate DDX3 function. HIV and HCV seem to require DDX3 for their replication, and it has therefore been proposed as a potential drug target. However, we have recently identified an anti-viral role for DDX3 in type I interferon induction; and DDX3 is also involved in cell growth control. Therefore, we believe that DDX3 function needs to be investigated in more detail before informed strategies for its therapeutic manipulation can be designed.

Peer Reviewed Journals

  Year Publication
2018 'Investigating nucleo-cytoplasmic shuttling of the human DEAD-box helicase DDX3'
Brennan R.;Haap-Hoff A.;Gu L.;Gautier V.;Long A.;Schröder M. (2018) 'Investigating nucleo-cytoplasmic shuttling of the human DEAD-box helicase DDX3'. European Journal of Cell Biology, [DOI] [Details]
2018 'DDX3 directly facilitates IKKα activation and regulates downstream signalling pathways'
Fullam A;Gu L;Höhn Y;Schröder M; (2018) 'DDX3 directly facilitates IKKα activation and regulates downstream signalling pathways'. Biochemical Journal, 475 (22) [DOI] [Details]
2016 'DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS'
Gu L, Fullam A, McCormack N, Höhn Y, Schröder M. (2016) 'DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS'. Biochemical Journal, 474 (4):571-587 [DOI] [IR Link] [Details]
2013 'DExD/H-box RNA helicases as mediators of anti-viral innate immunity and essential host factors for viral replication'
Fullam A, Schroder M (2013) 'DExD/H-box RNA helicases as mediators of anti-viral innate immunity and essential host factors for viral replication'. Biochimica et biophysica acta, 1829 :854-865 [DOI] [IR Link] [Details]
2011 'Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation?'
Schroder, Martina (2011) 'Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation?'. Biochemical Society Transactions, 39 :679-683 [IR Link] [Details]
2010 'Human DEAD-box protein 3 has multiple functions in gene regulation and cell cycle control and is a prime target for viral manipulation'
Schroder, Martina (2010) 'Human DEAD-box protein 3 has multiple functions in gene regulation and cell cycle control and is a prime target for viral manipulation'. Biochemical Pharmacology, 79 :297-306 [IR Link] [Details]
2015 'TCAIM decreases T cell priming capacity of dendritic cells by inhibiting TLR-induced Ca2+ influx and IL-2 production'
Vogel SZ(1), Schlickeiser S(1), Jürchott K(2), Akyuez L(3), Schumann J(1), Appelt C(1), Vogt K(1), Schröder M(4), Vaeth M(5), Berberich-Siebelt F(5), Lutz MB(6), Grütz G(1), Sawitzki B(7) (2015) 'TCAIM decreases T cell priming capacity of dendritic cells by inhibiting TLR-induced Ca2+ influx and IL-2 production'. Journal of Immunology, 194 (7):3136-3146 [DOI] [IR Link] [Details]
2014 'Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-α responses'
Collins AS, Ahmed S, Napoletano S, Schroeder M, Johnston JA, Hegarty JE, O'Farrelly C, Stevenson NJ (2014) 'Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-α responses'. JOURNAL OF LEUKOCYTE BIOLOGY, epub [IR Link] [Details]
2013 'Human DEAD box helicase 3 couples IκB kinase ε to interferon regulatory factor 3 activation'
Gu L, Fullam A, Brennan R and Schroder M (2013) 'Human DEAD box helicase 3 couples IκB kinase ε to interferon regulatory factor 3 activation'. MOLECULAR AND CELLULAR BIOLOGY, 33 :2004-2015 [DOI] [IR Link] [Details]
2013 'A novel IRAK1-IKKε signaling axis limits the activation of TAK1-IKKβ downstream of TLR3'
Bruni D, Sebastia J, Dunne S, Schroder M, Butler MP (2013) 'A novel IRAK1-IKKε signaling axis limits the activation of TAK1-IKKβ downstream of TLR3'. Journal of Immunology, 190 :2844-2856 [DOI] [IR Link] [Details]
2009 'Poxvirus K7 protein adopts a Bcl-2 fold: Biochemical mapping of its interactions with human DEAD-box RNA helicase DDX3'
Kalverda AP, Thompson GS, Vogel A, Schröder M, Bowie AG, Khan AR and Homans SW (2009) 'Poxvirus K7 protein adopts a Bcl-2 fold: Biochemical mapping of its interactions with human DEAD-box RNA helicase DDX3'. JOURNAL OF MOLECULAR BIOLOGY, 385 :843-853 [Details]
2009 'Structural basis for targeting of human RNA helicase DDX3 by poxvirus protein K7'
Oda S, Schroder M and Khan A.R. (2009) 'Structural basis for targeting of human RNA helicase DDX3 by poxvirus protein K7'. STRUCTURE, 17 :1528-1537 [IR Link] [Details]
2009 'IL-10 interferes directly with TCR-induced IFN-gamma but not IL-17 production in memory T cells'
Naundorf S, Schröder M, Hoflich C, Suman N, Volk HD and Grutz G (2009) 'IL-10 interferes directly with TCR-induced IFN-gamma but not IL-17 production in memory T cells'. EUROPEAN JOURNAL OF IMMUNOLOGY, 39 :1066-1077 [Details]
2008 'Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKe-mediated IRF activation'
Schröder M, Baran M and Bowie AG (2008) 'Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKe-mediated IRF activation'. EMBO JOURNAL, 27 :2147-2157 [Details]
2007 'An arms race: Innate antiviral immune responses and counteracting viral strategies'
Schröder M and Bowie AG (2007) 'An arms race: Innate antiviral immune responses and counteracting viral strategies'. Biochemical Society Transactions, 35 :1512-1514 [Details]
2006 'The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signalling'
Carty M, Goodbody R, Schröder M, Stack J, Moynagh PN and Bowie AG (2006) 'The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signalling'. NATURE IMMUNOLOGY, 7 :1074-1081 [IR Link] [Details]
2005 'TLR3 in anti-viral immunity: key player or bystander?'
Schröder M and Bowie AG (2005) 'TLR3 in anti-viral immunity: key player or bystander?'. Trends in Immunology, 26 :462-468 [Details]
2005 'Vaccinia Virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence'
Stack J, Haga IR, Schröder M, Bartlett NW, Maloney G, Reading PC, Fitzgerald KA, Smith GL, Bowie AG (2005) 'Vaccinia Virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence'. JOURNAL OF EXPERIMENTAL MEDICINE, 201 :1007-1018 [Details]
2005 'Vaccinia Virus protein A52R activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10'
Maloney G, Schroder M, Bowie AG (2005) 'Vaccinia Virus protein A52R activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10'. JOURNAL OF BIOLOGICAL CHEMISTRY, 280 :30838-30844 [Details]
2004 'Preassociation of nonactivated STAT3 molecules demonstrated in living cells using Bioluminescence Resonance Energy Transfer : a new model of STAT activation'
Schröder M, Kroeger KM, Volk HD, Eidne KA and Grütz G (2004) 'Preassociation of nonactivated STAT3 molecules demonstrated in living cells using Bioluminescence Resonance Energy Transfer : a new model of STAT activation'. JOURNAL OF LEUKOCYTE BIOLOGY, 75 :792-797 [Details]
2003 'Different modes of IL-10 and TGF-beta to inhibit cytokine-dependent IFN gamma production: nconsequences for reversal of lipopolysaccharide desensitization'
Schröder M, Meisel C, Buhl K, Profanter N, Sievert N, Volk HD and Grütz G (2003) 'Different modes of IL-10 and TGF-beta to inhibit cytokine-dependent IFN gamma production: nconsequences for reversal of lipopolysaccharide desensitization'. Journal of Immunology, 170 :5260-5267 [Details]

Conference Contributions

  Year Publication
2011  3rd UK and Ireland NF-kB workshop.
(2011)  3rd UK and Ireland NF-kB workshop. [Oral Presentation], The innate immune function of the, Maynooth [Details]
2010 Biochemical Society Workshop: Human Disease and Signalling.
(2010) Biochemical Society Workshop: Human Disease and Signalling. [Oral Presentation], Learning from viruses: 'The role of human DEAD-box helicase 3 in innate immune signalling', Belfast, NI [Details]
2010 EMBO workshop ‘Viruses and Innate Immunity’.
(2010) EMBO workshop ‘Viruses and Innate Immunity’. [Oral Presentation], The human DEAD-box protein DDX3 is targeted by vaccinia virus to interfere with type I interferon in, Dublin [Details]
2009 European Congress of Immunology.
(2009) European Congress of Immunology. [Oral Presentation], Viral targeting of Human Dead-box protein 3, Berlin, Germany [Details]
2009 ISI Annual Conference.
(2009) ISI Annual Conference. [Poster Presentation], Human Dead-box protein 3 enhances IFN-b production, Dublin [Details]
2009 Tri-Society Annual Conference (ICS, ISICR, SLB).
(2009) Tri-Society Annual Conference (ICS, ISICR, SLB). [Poster Presentation], Human DEAD-box protein 3 enhances IFNb production, Lisbon, Portugal [Details]

Honours and Awards

  Year Title Awarding Body
2012 ISICR Milstein Travel award
2007 HRB Postdoctoral Career Development Fellowship
2009 ISICR Milstein Travel award
2008 ICS Postdoctoral Investigator award

Professional Associations

  Association Function From / To
Irish Society of Immunology Committee member /