Dr Marion Butler

    Biology, Human Health Institute

    Lecturer
    Lecturer/Assistant Professor in Immunology

    Biosciences
    B3.18
    (01) 708 3856

    Biography

    2008-present: Lecturer in Immunology, Dept of Biology, Maynooth University
    2007-2008: Senior Post-doctoral Scientist, Biology Dept, Maynooth University     
    2003-2007: Senior Post-doctoral Scientist, Conway Institute, University College Dublin 
    2000-2003: Conway Post-doctoral Research Fellow, University College Dublin. 
    1999: PhD in Medicine (University College Dublin) based in Columbia University, New York & U.C.D 

    Research Interests

    Cancer research with a focus on breast and ovarian cancer.
    Immunology based research with a focus on the mechanistic understanding to disease, specifically autoimmune diseases. 

    Post Doctoral Fellows/Research Team

      Researcher Name Project Role Funding Body
    Devlin Simon Wall - Coughlan Breast Cancer Project Postgraduate student Irish Research Council (IRC)
    Mario Rodriguez Pena Immunology project Post Doctorate Health Research Board / HRB
    Adam Dignam Immunology Postgraduate student Health Research Board / HRB

    Peer Reviewed Journals

      Year Publication
    2019 'Improved performance of near infrared excitation Raman spectroscopy using reflective thin-film gold on glass substrates for cytology samples'
    Barton, SJ;O'Dwyer, K;Butler, M;Dignam, A;Byrne, HJ;O'Neill, L;Hennelly, BM (2019) 'Improved performance of near infrared excitation Raman spectroscopy using reflective thin-film gold on glass substrates for cytology samples'. Analytical Methods, 11 :6023-6032 [DOI] [Details]
    2018 'IRAK1 Limits TLR3/4- and IFNAR-Driven IL-27 Production through a STAT1-Dependent Mechanism'
    Bruni D;Dignam A;Dunne S;Wall-Coughlan D;McCrudden A;O'Connell K;Lyons C;McGuigan C;Tubridy N;Butler MP; (2018) 'IRAK1 Limits TLR3/4- and IFNAR-Driven IL-27 Production through a STAT1-Dependent Mechanism'. Journal of Immunology, 201 (7) [DOI] [IR Link] [Details]
    2013 'A novel IRAK1 IKKe signalling axis limits the activation of TAK1 IKKbeta downstsream of TLR3'
    Bruni D., Sebastia J., Dunne S., Schroeder M., Butler M. (2013) 'A novel IRAK1 IKKe signalling axis limits the activation of TAK1 IKKbeta downstsream of TLR3'. THE JOURNAL OF IMMUNOLOGY, 190 :2844-2856 [IR Link] [Details]
    2007 'Kinase-active Interleukin-1 Receptor-associated Kinases Promote Polyubiquitination and Degradation of the Pellino Family:  Direct evidence for pellino proteins being ubiquitin-protein isopeptide ligases'
    Butler, M.P., J.A. Hanly and P.N. Moynagh (2007) 'Kinase-active Interleukin-1 Receptor-associated Kinases Promote Polyubiquitination and Degradation of the Pellino Family:  Direct evidence for pellino proteins being ubiquitin-protein isopeptide ligases'. JOURNAL OF BIOLOGICAL CHEMISTRY, 282 :29729-29737 [IR Link] [Details]
    2007 'Evidence for a role for the group I metabotropic glutamate receptor in the inhibitory effect of tumor necrosis factor-alpha on long-term potentiation'
    Cumiskey, D., M.P. Butler, P.N. Moynagh and J.J. O'Connor (2007) 'Evidence for a role for the group I metabotropic glutamate receptor in the inhibitory effect of tumor necrosis factor-alpha on long-term potentiation'. Journal of Brain Research, 1136 :13-19 [IR Link] [Details]
    2005 'Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner'
    Butler, M.P., Hanly, J.A. and Moynagh, P.N. (2005) 'Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner'. JOURNAL OF BIOLOGICAL CHEMISTRY, 280 :27759-27768 [IR Link] [Details]
    2004 'Dissection of tumor-necrosis factor-alpha inhibition of long-term potentiation (LTP) reveals a p38 mitogen-activated protein kinase-dependent mechanism which maps to early-but not late-phase LTP'
    Butler, M.P., O’Connor, J.J. and Moynagh, P.N. (2004) 'Dissection of tumor-necrosis factor-alpha inhibition of long-term potentiation (LTP) reveals a p38 mitogen-activated protein kinase-dependent mechanism which maps to early-but not late-phase LTP'. 124 :319-326 [IR Link] [Details]
    2002 'Alternative translocation breakpoint cluster region 5' to BCL-6 in B-cell non-Hodgkin's lymphoma'
    Butler, M. P., Iida, S., Capello, D., Rossi, D., Rao, P. H., Nallasivam, P., Louie, D. C., Chaganti, S., Au, T., Gascoyne, R. D., Gaidano, G., Chaganti, R. S. and Dalla-Favera, R (2002) 'Alternative translocation breakpoint cluster region 5' to BCL-6 in B-cell non-Hodgkin's lymphoma'. CANCER RESEARCH, 62 :4089-4094 [IR Link] [Details]
    2002 'Methods of detection of the transcription factor NF-kappaB in rat hippocampal slices'
    Butler, M., Moynagh, P.N. and O’Connor, J. (2002) 'Methods of detection of the transcription factor NF-kappaB in rat hippocampal slices'. Journal of Neuroscience Methods, 119 :185-189 [IR Link] [Details]
    1999 'Analysis of PTEN mutations and deletions in B-cell non-Hodgkin's lymphomas'
    Butler, M. P., Wang, S. I., Chaganti, R. S., Parsons, R. and Dalla-Favera, R., (1999) 'Analysis of PTEN mutations and deletions in B-cell non-Hodgkin's lymphomas'. GENES CHROMOSOMES & CANCER, 24 :322-327 [IR Link] [Details]
    1998 'The t(2;3)(q21;q27) translocation in non-Hodgkin's lymphoma displays BCL6 mutations in the 5' regulatory region and chromosomal breakpoints distant from the gene'
    Chen, W., Butler, M., Rao, P. H., Chaganti, S. R., Louie, D. C., Dalla-Favera, R. and Chaganti, R. S (1998) 'The t(2;3)(q21;q27) translocation in non-Hodgkin's lymphoma displays BCL6 mutations in the 5' regulatory region and chromosomal breakpoints distant from the gene'. ONCOGENE, 17 :1717-1722 [IR Link] [Details]
    1997 'BCL-6 and other genomic alterations in non-Hodgkin's lymphoma (NHL)'
    Butler, M., Corbally, N., Dervan, P. A. and Carney, D. N., (1997) 'BCL-6 and other genomic alterations in non-Hodgkin's lymphoma (NHL)'. BRITISH JOURNAL OF CANCER, 75 :1641-1645 [IR Link] [Details]
    1997 'Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma'
    Iida, S., Rao, P. H., Butler, M., Corradini, P., Boccadoro, M., Klein, B., Chaganti, R. S. and Dalla-Favera, R. (1997) 'Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma'. NATURE GENETICS, 17 :226-230 [IR Link] [Details]
    1996 'The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene'
    Iida, S., Rao, P. H., Nallasivam, P., Hibshoosh, H., Butler, M., Louie, D. C., Dyomin, V., Ohno, H., Chaganti, R. S. and Dalla-Favera, R., (1996) 'The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene'. BLOOD, 88 :4110-4117 [IR Link] [Details]

    Book Chapters

      Year Publication
    2001 '“Methods of detection of the transcription factor NF-kB in rat hippocampal slices.”'
    Butler M.P., Moynagh P.N. and O’Connor J.J. (2001) '“Methods of detection of the transcription factor NF-kB in rat hippocampal slices.”' In: [DOI] [Details]
    1998 '“Molecular pathogenesis of B cell malignancy: the role of BCL-6.”'
    Dalla-Favera, R., Migliazza, A., Chang, C. C., Niu, H., Pasqualucci, L., Butler, M., Shen, Q. and Cattoretti, G. (1998) '“Molecular pathogenesis of B cell malignancy: the role of BCL-6.”' In: In: Curr Top Microbiology and Immunology. [Details]

    Professional Associations

      Association Function From / To
    Irish Association for Cancer Research (IACR) IACR member /
    European Association for Cancer Research (EACR) Member /

    Teaching Interests

    Mechanisms of Human Disease (module coordinator)
    Introductory Immunology  
    Advanced Immunology  (module coordinator)
    Tumour Biology  (module coordinator)

    Recent Postgraduates

      Graduation Student Name University Degree Thesis
    2012 Dr Daniela Bruni Maynooth University PhD
    2016 Dr Susan Dunne Maynooth University PhD