Dr John Stephens

Chemistry, Human Health Institute

Associate Professor

Science Building
2.60
(01) 708 6942

Biography

NUI Galway, BSc, 1999
NUI Galway, PhD, 2004
University of Nottingham, Postdoctoral Fellowship with Prof Simon Woodward, 2004-2005
University of Nottingham, Junior Lecturer, 2004
Maynooth University
, Assistant Professor/Lecturer, 2005-2012
Maynooth University, Head of Department 2012-2017
Maynooth University, Associate Professor/Senior Lecturer, 2016-
 

Research Interests

Research in the Stephens Group is focused on the discovery and application of new technologies such as continuous flow, new reactions, and new catalysts in organic synthesis, as well as applications of organic chemistry at the interface of chemistry & biology. Many of our research targets have potential as molecules of biological significance. We focus on projects with medicinal endpoints, including diabetes, cancer, and bacterial/fungal infections, as well as projects at the intersection between chemistry & food science. Our research has been supported by several funding agencies (EI, SFI, IRC, EU) and partnering with industry is an important aspect of our work (AF Chempharm, Dual Systems, others confidentially). Through a structured PhD programme we provide an excellent in-depth training in organic synthesis and in the interdisciplinary space between chemistry & biology.  ‘Hot’ project areas where we have enjoyed significant successes include: asymmetric catalysis, synthetic methodology development, antidiabetic agent discovery, and antimicrobial agent discovery.


Peer Reviewed Journals

  Year Publication
2019 'Characterization of an aryl piperazine/ 2-hydroxypropyl-β-cyclodextrin association, a complex with antidiabetic potential'
R. Devine, D. S. D. Martin, G. K. Kinsella, J. B. C. Findlay, J. C. Stephens (2019) 'Characterization of an aryl piperazine/ 2-hydroxypropyl-β-cyclodextrin association, a complex with antidiabetic potential'. Results in Chemistry, in press [Details]
2019 'A review of cinnamaldehyde and its derivatives as antibacterial agents'
Doyle AA;Stephens JC; (2019) 'A review of cinnamaldehyde and its derivatives as antibacterial agents'. Fitoterapia, 139 [DOI] [Details]
2019 'Cinnamaldehydes: Synthesis, antibacterial evaluation, and the effect of molecular structure on antibacterial activity'
Amanda A. Doyle, John C. Stephens (2019) 'Cinnamaldehydes: Synthesis, antibacterial evaluation, and the effect of molecular structure on antibacterial activity'. Results in Chemistry, 1 [DOI] [Details]
2019 'Oosporein, an abundant metabolite in Beauveria caledonica, with a feedback induction mechanism and a role in insect virulence'
Mc Namara L.;Dolan S.;Walsh J.;Stephens J.;Glare T.;Kavanagh K.;Griffin C. (2019) 'Oosporein, an abundant metabolite in Beauveria caledonica, with a feedback induction mechanism and a role in insect virulence'. Fungal Biology, 123 (8):601-610 [DOI] [Details]
2019 'The Versatility of Squaramides: From Supramolecular Chemistry to Chemical Biology'
Marchetti L.;Kumawat L.;Mao N.;Stephens J.;Elmes R. (2019) 'The Versatility of Squaramides: From Supramolecular Chemistry to Chemical Biology'. Chem, 5 (6):1398-1485 [DOI] [Details]
2018 'Synthesis of pyrazolopyrimidinones using a “one-pot” approach and microwave irradiation'
Mark Kelada, John M. D. Walsh, Robert W. Devine, Patrick McArdle, and John C. Stephens (2018) 'Synthesis of pyrazolopyrimidinones using a “one-pot” approach and microwave irradiation'. Beilstein Journal of Organic Chemistry, 14 :1222-1228 [DOI] [IR Link] [Details]
2016 'Synthesis, antibacterial and anti-MRSA activity, in vivo toxicity and a structure-activity relationship study of a quinoline thiourea'
Dolan, N;Gavin, DP;Eshwika, A;Kavanagh, K;McGinley, J;Stephens, JC (2016) 'Synthesis, antibacterial and anti-MRSA activity, in vivo toxicity and a structure-activity relationship study of a quinoline thiourea'. Bioorganic and Medicinal Chemistry Letters, 26 :630-635 [DOI] [IR Link] [Details]
2016 'Novel mitochondrial complex I inhibitors restore glucose-handling abilities of high-fat fed mice'
Martin DS;Leonard S;Devine R;Redondo C;Kinsella GK;Breen CJ;McEneaney V;Rooney MF;Munsey TS;Porter RK;Sivaprasadarao A;Stephens JC;Findlay J; (2016) 'Novel mitochondrial complex I inhibitors restore glucose-handling abilities of high-fat fed mice'. Molecular Endocrinology, [DOI] [IR Link] [Details]
2016 'Synthesis of an Imidazolidinone Organocatalyst and Its Application in a Diels–Alder Cycloaddition: A Multistep Experiment for the Organic Teaching Laboratory'
Murphy, John J.; Driver, Ross B.; Walsh, Ria ; Stephens; John C (2016) 'Synthesis of an Imidazolidinone Organocatalyst and Its Application in a Diels–Alder Cycloaddition: A Multistep Experiment for the Organic Teaching Laboratory'. Journal of Chemical Education, [DOI] [IR Link] [Details]
2015 'Computational Development of Selective nNOS Inhibitors: Binding Modes and Pharmacokinetic Considerations'
Curtin, AM;Kinsella, GK;Stephens, JC (2015) 'Computational Development of Selective nNOS Inhibitors: Binding Modes and Pharmacokinetic Considerations'. Current Medicinal Chemistry, 22 :2558-2579 [IR Link] [Details]
2014 'Synthesis, characterisation and antimicrobial studies of organotin(IV) complexes with 1,10-phenanthroline derivatives'
Dolan, N;McGinley, J;Stephens, JC;Kavanagh, K;Hurley, D;Maher, NJ (2014) 'Synthesis, characterisation and antimicrobial studies of organotin(IV) complexes with 1,10-phenanthroline derivatives'. Inorganica Chimica Acta, 409 :276-284 [DOI] [IR Link] [Details]
2013 'Selective Michael additions to alkylidenemalonates using thiourea-based Bifunctional organocatalysts'
Gavin D.;Stephens J. (2013) 'Selective Michael additions to alkylidenemalonates using thiourea-based Bifunctional organocatalysts'. Arkivoc, 2013 (4):76-87 [IR Link] [Details]
2013 'Organocatalytic Asymmetric Annulation of 1,3-Bis(alkoxycarbonyl)buta-1,3-dienes and Aldehydes'
Pezzati, B;Chellat, MF;Murphy, JJ;Besnard, C;Reginato, G;Stephens, JC;Alexakis, A (2013) 'Organocatalytic Asymmetric Annulation of 1,3-Bis(alkoxycarbonyl)buta-1,3-dienes and Aldehydes'. Organic Letters, 15 :2950-2953 [DOI] [IR Link] [Details]
2011 'Organocatalytic enantioselective Michael addition of β-diketones to β-nitrostyrene: The first Michael addition of dipivaloylmethane to an activated olefin'
Gavin D.;Stephens J. (2011) 'Organocatalytic enantioselective Michael addition of β-diketones to β-nitrostyrene: The first Michael addition of dipivaloylmethane to an activated olefin'. Arkivoc, 2011 (9):407-421 [IR Link] [Details]
2011 'Asymmetric Organocatalytic 1,6-Conjugate Addition of Aldehydes to Dienic Sulfones'
Murphy, JJ;Quintard, A;McArdle, P;Alexakis, A;Stephens, JC (2011) 'Asymmetric Organocatalytic 1,6-Conjugate Addition of Aldehydes to Dienic Sulfones'. Angewandte Chemie - International Edition, 50 :5095-5098 [DOI] [IR Link] [Details]
2011 'The Role of Glutathione S-Transferase GliG in Gliotoxin Biosynthesis in Aspergillus fumigatus'
Davis, C;Carberry, S;Schrettl, M;Singh, I;Stephens, JC;Barry, SM;Kavanagh, K;Challis, GL;Brougham, D;Doyle, S (2011) 'The Role of Glutathione S-Transferase GliG in Gliotoxin Biosynthesis in Aspergillus fumigatus'. Chemistry and Biology, 18 :542-552 [DOI] [IR Link] [Details]
2010 'Self-Protection against Gliotoxin-A Component of the Gliotoxin Biosynthetic Cluster, GliT, Completely Protects Aspergillus fumigatus Against Exogenous Gliotoxin'
Schrettl, M;Carberry, S;Kavanagh, K;Haas, H;Jones, GW;O'Brien, J;Nolan, A;Stephens, J;Fenelon, O;Doyle, S (2010) 'Self-Protection against Gliotoxin-A Component of the Gliotoxin Biosynthetic Cluster, GliT, Completely Protects Aspergillus fumigatus Against Exogenous Gliotoxin'. PLoS Pathogens, 6 [DOI] [IR Link] [Details]
2008 'A ceric ammonium nitrate (CAN) N-dearylation of N-p-anisylazoles applied to pyrazole, triazole, tetrazole and pentazole rings: Release of parent azoles. Generation of unstable pentazole, HN5/N5-, in solution'
Stephens J.C., Butler R.N., Hanniffy J.M., Burke L.A. (2008) 'A ceric ammonium nitrate (CAN) N-dearylation of N-p-anisylazoles applied to pyrazole, triazole, tetrazole and pentazole rings: Release of parent azoles. Generation of unstable pentazole, HN5/N5-, in solution'. JOURNAL OF ORGANIC CHEMISTRY, 73 :1354-1364 [DOI] [IR Link] [Details]
2007 'Demonstration of promoted zinc Schlenk equilibria, their equilibrium values and derived reactivity'
Stephens J.C., Blake A.J., Shannon J., Woodward S. (2007) 'Demonstration of promoted zinc Schlenk equilibria, their equilibrium values and derived reactivity'. CHEMISTRY-A EUROPEAN JOURNAL, 13 :2462-2472 [DOI] [IR Link] [Details]
2006 'One-​Pot Synthesis of Fluorescent 2,​5-​Dihydro-​1,​2,​3-​triazine Derivatives from a Cascade Rearrangement Sequence in the Reactions of 1,​2,​3-​Triazolium-​1-​aminide 1,​3-​Dipoles with Propiolate Esters'
Butler, Richard N.; Fahy, Aoife M.; Fox, Anthony; Stephens, John C.; McArdle, P.; Cunningham, D.; Ryder, A. (2006) 'One-​Pot Synthesis of Fluorescent 2,​5-​Dihydro-​1,​2,​3-​triazine Derivatives from a Cascade Rearrangement Sequence in the Reactions of 1,​2,​3-​Triazolium-​1-​aminide 1,​3-​Dipoles with Propiolate Esters'. Journal of Organic Chemistry, 71 :5679-5687 [DOI] [IR Link] [Details]
2006 'New reactive fluorophores in the 1,2,3-triazine series'
Stephens J. C., Butler R. N., Fahy A. M., Fox A., McArdle P., Cunningham D. and Ryder A. G. (2006) 'New reactive fluorophores in the 1,2,3-triazine series'. TETRAHEDRON LETTERS, 47 :1721-1724 [DOI] [IR Link] [Details]
2005 'Investigations into the utility of high-​surface area silica pellets as potential solid-​phase synthesis supports'
Timofte, Roxana S.; Titman, Jeremy J.; Shao, Limin; Stephens, John C.; Woodward, Simon (2005) 'Investigations into the utility of high-​surface area silica pellets as potential solid-​phase synthesis supports'. Tetrahedron, 65 :51-59 [DOI] [Details]
2004 'Sulfonic acid libraries attained through opening of 2-​sulfobenzoic acid anhydride'
Robinson, Richard I.; Stephens, John C.; Worden, Steve M.; Blake, Alexander J.; Wilson, Claire; Woodward, Simon (2004) 'Sulfonic acid libraries attained through opening of 2-​sulfobenzoic acid anhydride'. European Journal of Organic Chemistry, 22 :4596-4605 [DOI] [IR Link] [Details]
2004 'First reversible protonation of the all-​nitrogen 1-​aryl pentazole ring'
Butler, R. N.; Stephens, John C.; Hanniffy, John M. (2004) 'First reversible protonation of the all-​nitrogen 1-​aryl pentazole ring'. Tetrahedron Letters, 45 :1977-1979 [DOI] [IR Link] [Details]
2003 'First generation of pentazole (HN5, pentazolic acid)​, the final azole, and a zinc pentazolate salt in solution: A new N-​dearylation of 1-​(p-​methoxyphenyl) pyrazoles, a 2-​(p-​methoxyphenyl) tetrazole and application of the methodology to 1-​(p-​methoxyphenyl) pentazole'
Butler, R. N.; Stephens, John C.; Burke, Luke A. (2003) 'First generation of pentazole (HN5, pentazolic acid)​, the final azole, and a zinc pentazolate salt in solution: A new N-​dearylation of 1-​(p-​methoxyphenyl) pyrazoles, a 2-​(p-​methoxyphenyl) tetrazole and application of the methodology to 1-​(p-​methoxyphenyl) pentazole'. Chemical Communications, 8 :1016-1017 [DOI] [IR Link] [Details]
2001 'Theoretical characterization of pentazole anion with metal counter ions. Calculated and experimental 15N shifts of aryldiazonium, -​azide and -​pentazole systems'
Burke, Luke A.; Butler, Richard N.; Stephens, John C. (2001) 'Theoretical characterization of pentazole anion with metal counter ions. Calculated and experimental 15N shifts of aryldiazonium, -​azide and -​pentazole systems'. Journal of the Chemical Society, Perkin Transactions 2, 9 :1679-1684 [DOI] [IR Link] [Details]

Newspaper Articles

  Year Publication
2019 Science matters: Exercise induced pulmonary haemorrhage.
John C Stephens (2019) Science matters: Exercise induced pulmonary haemorrhage. Newspaper Articles [Details]
2019 Science matters: No foot, no horse.
John C Stephens (2019) Science matters: No foot, no horse. Newspaper Articles [Details]
2019 Science matters: Hair to stay?.
John C Stephens (2019) Science matters: Hair to stay?. Newspaper Articles [Details]
2019 Science matters: You can bring a horse to water.
John C Stephens (2019) Science matters: You can bring a horse to water. Newspaper Articles [Details]
2019 Science matters: Go with your gut.
John C Stephens (2019) Science matters: Go with your gut. Newspaper Articles [Details]