Prof Bernard Mahon

Biology, Hamilton Institute

Professor

Biosciences & Electronic Engineering Facility
1st
B2.15
(01) 708 3835

Biography

My scientific work is based on hypothesis-driven, fundamental studies of murine and human immunology. Two major topics are addressed:
  1. How do adult mesenchymal stem cells modulate immunity (a question with implications for stem cell therapy, transplantation and tolerance).  This work finds application is the design of new cell based therapies;
  2. The immunology of early life, particularly at the mucosal surface of the airways. This has led me to examine early life infections with the pathogens B. pertussis, poliovirus and B19V, work which has implications for vaccine design, immunisation protocols and diagnostics.
When appropriate, my work has been commercialised or translated to clinical settings. Key recent advances: a) Overcoming the technical problems of adult stem cell therapy; b) a clinical trial of a new whooping cough vaccine with EU partners. I previously served as Faculty dean and VP Research.     

Research Interests

Key Words: Immunology, adult stem cells, cell therapy, vaccines, GvHD, infants, adverse events.My scientific work is based on hypothesis-driven, fundamental studies of murine and human immunology. Two major topics are addressed:
  1. How do adult mesenchymal stem cells modulate immunity? (a question with implications for stem cell therapy, transplantation and tolerance).  This work finds application is the design of new cell based therapies; 
  2. The immunology of early life, particularly at the mucosal surface of the airways. This has led me to examine early life infections with the pathogens B. pertussis, poliovirus and B19V, work which has implications for vaccine design, immunisation protocols and diagnostics.
When appropriate, my work has been commercialised or translated to clinical settings. Key recent advances: a) Overcoming the technical problems of adult stem cell therapy; b) a clinical trial of a new whooping cough vaccine with EU partners.

Peer Reviewed Journals

  Year Publication
2016 'Human mesenchymal stromal cells exert HGF dependent cytoprotective effects in a human relevant pre-clinical model of COPD'
Kennelly, H;Mahon, BP;English, K (2016) 'Human mesenchymal stromal cells exert HGF dependent cytoprotective effects in a human relevant pre-clinical model of COPD'. Scientific Reports, 6 [DOI] [Details]
2016 'Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis-Associated Pathogen Burkholderia cepacia Complex to Lung Epithelial Cells and Protect Mice against Infection'
McClean S;Healy ME;Collins C;Carberry S;O'Shaughnessy L;Dennehy R;Adams Á;Kennelly H;Corbett JM;Carty F;Cahill LA;Callaghan M;English K;Mahon BP;Doyle S;Shinoy M; (2016) 'Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis-Associated Pathogen Burkholderia cepacia Complex to Lung Epithelial Cells and Protect Mice against Infection'. Infection and Immunity, 84 (5) [DOI] [IR Link] [Details]
2016 'Hepatocyte Growth Factor Is Required for Mesenchymal Stromal Cell Protection Against Bleomycin-Induced Pulmonary Fibrosis'
Cahill EF;Kennelly H;Carty F;Mahon BP;English K; (2016) 'Hepatocyte Growth Factor Is Required for Mesenchymal Stromal Cell Protection Against Bleomycin-Induced Pulmonary Fibrosis'. Stem cells translational medicine, 5 (10) [DOI] [Details]
2011 'Allogeneic mesenchymal stem cells: Agents of immune modulation'
English K.;Mahon B. (2011) 'Allogeneic mesenchymal stem cells: Agents of immune modulation'. Journal of Cellular Biochemistry, 112 (8):1963-1968 [DOI] [IR Link] [Details]
2009 'A Live Attenuated Bordetella pertussis Candidate Vaccine Does Not Cause Disseminating Infection in Gamma Interferon Receptor Knockout Mice'
Skerry, CM;Cassidy, JP;English, K;Feunou-Feunou, P;Locht, C;Mahon, BP (2009) 'A Live Attenuated Bordetella pertussis Candidate Vaccine Does Not Cause Disseminating Infection in Gamma Interferon Receptor Knockout Mice'. CLINICAL AND VACCINE IMMUNOLOGY, 16 :1344-1351 [DOI] [Details]
2005 'Mesenchymal stem cells avoid allogeneic rejection'
Ryan J.;Barry F.;Murphy J.;Mahon B. (2005) 'Mesenchymal stem cells avoid allogeneic rejection'. JOURNAL OF INFLAMMATION, 2 [DOI] [Details]
2015 'Mesenchymal Stromal Cells Protect Against Caspase 3-Mediated Apoptosis of CD19(+) Peripheral B Cells Through Contact-Dependent Upregulation of VEGF'
Healy, ME;Bergin, R;Mahon, BP;English, K (2015) 'Mesenchymal Stromal Cells Protect Against Caspase 3-Mediated Apoptosis of CD19(+) Peripheral B Cells Through Contact-Dependent Upregulation of VEGF'. Stem Cells and Development, 24 :2391-2402 [DOI] [Details]
2015 'Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells'
Cahill E.;Tobin L.;Carty F.;Mahon B.;English K. (2015) 'Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells'. Stem Cell Research and Therapy, 6 (1) [DOI] [IR Link] [Details]
2014 'Mesenchymal stromal cells; role in tissue repair, drug discovery and immune modulation'
English K;Mahon BP;Wood KJ; (2014) 'Mesenchymal stromal cells; role in tissue repair, drug discovery and immune modulation'. Current Drug Delivery, 11 (5) [IR Link] [Details]
2013 'Human mesenchymal stem cells suppress donor CD4+T cell proliferation and reduce pathology in a humanized mouse model of acute graft-versus-host disease'
Tobin, LM., Healy, ME., English, K., Mahon, BP. (2013) 'Human mesenchymal stem cells suppress donor CD4+T cell proliferation and reduce pathology in a humanized mouse model of acute graft-versus-host disease'. Clinical and Experimental Immunology, 174 :333-348 [IR Link] [Details]
2013 'IFN-gamma stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro'
Noone C.;Kihm A.;English K.;O'Dea S.;Mahon B. (2013) 'IFN-gamma stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro'. Stem Cells and Development, 22 (22):3003-3014 [DOI] [IR Link] [Details]
2013 'Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: Lessons Learned from First Clinical Trials'
Franquesa, M;Hoogduijn, MJ;Reinders, ME;Eggenhofer, E;Engela, AU;Mensah, FK;Torras, J;Pileggi, A;van Kooten, C;Mahon, B;Detry, O;Popp, FC;Benseler, V;Casiraghi, F;Johnson, C;Ancans, J;Fillenberg, B;delaRosa, O;Aran, JM;Roemeling-vanRhijn, M;Pinxteren, J;Perico, N;Gotti, E;Christ, B;Reading, J;Introna, M;Deans, R;Shagidulin, M;Farre, R;Rambaldi, A;Sanchez-Fueyo, A;Obermajer, N;Pulin, A;Dor, FJMF;Portero-Sanchez, I;Baan, CC;Rabelink, TJ;Remuzzi, G;Betjes, MGH;Dahlke, MH;Grinyo, JM (2013) 'Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: Lessons Learned from First Clinical Trials'. Transplantation, 96 :234-238 [DOI] [IR Link] [Details]
2012 'Fabrication of CaO-NaO-SiO2/TiO2 scaffolds for surgical applications'
Wren, AW., Coughlan, A., Smale, KE., Misture, ST., Mahon, BP., Clarkin, OM., Towler, MR. (2012) 'Fabrication of CaO-NaO-SiO2/TiO2 scaffolds for surgical applications'. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 23 :2881-2891 [IR Link] [Details]
2012 'Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3-and viral-induced expression of type I interferons'
Siednienko, J., Jackson, R., Mellett, M., Delagic, N., Yang, S., Wang, BW., Tang, LS., Callanan, JJ., Mahon, BP., Moynagh, PN. (2012) 'Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3-and viral-induced expression of type I interferons'. NATURE IMMUNOLOGY, 13 :1055-1062 [IR Link] [Details]
2011 'Mesenchymal stem cell inhibition of T-helper 17 cell-differentiation is triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor'
Duffy, MM., Pindjakova, J., Hanley, SA., McCarthy, C., Weidhofer, GA., Sweeney, EM., English, K., Shaw, G., Murphy, JM., Barry, FP., Mahon, BP., Belton, O., Ceredig, R., Griffin, MD. (2011) 'Mesenchymal stem cell inhibition of T-helper 17 cell-differentiation is triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor'. EUROPEAN JOURNAL OF IMMUNOLOGY, 41 :2840-2851 [IR Link] [Details]
2011 'Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells'
Kavanagh H.;Mahon B. (2011) 'Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells'. Allergy: European Journal of Allergy and Clinical Immunology, 66 (4):523-531 [DOI] [IR Link] [Details]
2011 'A live attenuated Bordetella pertussis vaccine provides long term protection against virulent challenge in a murine model'
Skerry CM, and B.P. Mahon. (2011) 'A live attenuated Bordetella pertussis vaccine provides long term protection against virulent challenge in a murine model'. CLINICAL AND VACCINE IMMUNOLOGY, 18 :187-193 [DOI] [IR Link] [Details]
2011 'Allogeneic Mesenchymal Stem Cells: Agents of Immune Modulation'
English, K;Mahon, BP (2011) 'Allogeneic Mesenchymal Stem Cells: Agents of Immune Modulation'. Journal of Cellular Biochemistry, 112 :1963-1968 [DOI] [IR Link] [Details]
2010 'Adult Mesenchymal Stem Cells - Intelligent therapies for immune reprogramming'
Kavanagh H., and B.P. Mahon. (2010) 'Adult Mesenchymal Stem Cells - Intelligent therapies for immune reprogramming'. INTERNATIONAL DRUG DISCOVERY, 5 :46-51 [Details]
2010 'Immunological Aspects of Allogeneic Mesenchymal Stem Cell Therapies'
Griffin MD, Ritter T, and B.P. Mahon (2010) 'Immunological Aspects of Allogeneic Mesenchymal Stem Cell Therapies'. HUMAN GENE THERAPY, 21 :1641-1655 [DOI] [IR Link] [Details]
2010 'The attenuated Bordetella pertussis vaccine strain BPZE1 prevents exacerbated allergic pathology in a murine model'
Kavanagh H, English K, Locht C, and B.P. Mahon. (2010) 'The attenuated Bordetella pertussis vaccine strain BPZE1 prevents exacerbated allergic pathology in a murine model'. CLINICAL AND EXPERIMENTAL ALLERGY, 40 :933-941 [IR Link] [Details]
2010 'Zinc and Silver Glass Polyalkenoate Cement Solutions: An Evaluation of their Antibacterial Nature Through in vitro and in vivo Testing'
Coughlan, A., K. Scanlon, B.P. Mahon & M.R. Towler. (2010) 'Zinc and Silver Glass Polyalkenoate Cement Solutions: An Evaluation of their Antibacterial Nature Through in vitro and in vivo Testing'. BIO-MEDICAL MATERIALS AND ENGINEERING, 20 :99-106 [IR Link] [Details]
2009 'Cell Contact, Prostaglandin E2 and Transforming growth factor beta 1 play non redundant roles in Human Mesenchymal Stem Cell Induction of CD4+CD25HighFoxp3+ Regulatory T cells'
English, K., J.R. Ryan, L. Tobin, M.J. Murphy, F.P. Barry and B.P. Mahon. (2009) 'Cell Contact, Prostaglandin E2 and Transforming growth factor beta 1 play non redundant roles in Human Mesenchymal Stem Cell Induction of CD4+CD25HighFoxp3+ Regulatory T cells'. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 156 :149-160 [DOI] [IR Link] [Details]
2009 'Adeno-associated virus serotype 2 induces cell-mediated immune responses directed against multiple epitopes of the capsid protein VP1'
Madsen, D., E.R. Cantwell, T. O'Brien, P.A. Johnson and B.P. Mahon. (2009) 'Adeno-associated virus serotype 2 induces cell-mediated immune responses directed against multiple epitopes of the capsid protein VP1'. JOURNAL OF GENERAL VIROLOGY, 90 :2622-2633 [DOI] [IR Link] [Details]
2008 'Murine mesenchymal stem cells suppress dendritic cell migration, maturation and function'
K.  English, F. P. Barry and B.  P.  Mahon.  (2008) 'Murine mesenchymal stem cells suppress dendritic cell migration, maturation and function'. IMMUNOLOGY LETTERS, 115 :50-58 [IR Link] [Details]
2008 'BMP4 induces an epithelial-mesenchymal transition-like response in adult airway epithelial cells'
Molloy, E.L., Adams, A., Moore, J.B., Masterson, J.C., Madrigal-Estebas, L., Mahon, B.P. and O’Dea, S. (2008) 'BMP4 induces an epithelial-mesenchymal transition-like response in adult airway epithelial cells'. Growth Factors, 26 :12-22 [IR Link] [Details]
2008 'A possible role for protein synthesis, ERK and BDNF in long-term spatial memory retention in the water maze'
McGauran, A.T., J.B. Moore, D. Madsen, D. Barry, S. O’Dea, B.P. Mahon and S. Commins (2008) 'A possible role for protein synthesis, ERK and BDNF in long-term spatial memory retention in the water maze'. BEHAVIORAL NEUROSCIENCE, 122 :805-815 [IR Link] [Details]
2007 'IFN-g and TNF-a differentially regulate immunomodulation by murine mesenchymal stem cells'
English K.;Barry F.;Field-Corbett C.;Mahon B. (2007) 'IFN-g and TNF-a differentially regulate immunomodulation by murine mesenchymal stem cells'. Immunology Letters, 110 (2):91-100 [DOI] [IR Link] [Details]
2007 'Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells'
Ryan J.;Barry F.;Murphy J.;Mahon B. (2007) 'Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells'. Clinical and Experimental Immunology, 149 (2):353-363 [DOI] [IR Link] [Details]
2006 'Inflammation of the respiratory tract is associated with CCL28 and CCR10 expression in a murine model of allergic asthma'
K. English, C. M. Brady, P. Corcoran, J. P. Cassidy and B. P. Mahon.  (2006) 'Inflammation of the respiratory tract is associated with CCL28 and CCR10 expression in a murine model of allergic asthma'. IMMUNOLOGY LETTERS, 103 :92-100 [IR Link] [Details]
2006 'Interleukin-10 (IL-10) but not Lipopolysaccharide (LPS) produces increased motor activity and abnormal exploratory patterns while impairing spatial learning in Balb/c mice'
Harvey, D;Smith, R;English, K;Mahon, B;Commins, S (2006) 'Interleukin-10 (IL-10) but not Lipopolysaccharide (LPS) produces increased motor activity and abnormal exploratory patterns while impairing spatial learning in Balb/c mice'. Physiology and Behavior, 87 :842-847 [DOI] [IR Link] [Details]
2006 'gamma-delta T cells regulate the early inflammatory response to Bordetella pertussis infection in the murine respiratory tract'
Zachariadis O.;Cassidy J.;Brady J.;Mahon B. (2006) 'gamma-delta T cells regulate the early inflammatory response to Bordetella pertussis infection in the murine respiratory tract'. Infection and Immunity, 74 (3):1837-1845 [DOI] [IR Link] [Details]
2005 'Whole cell pertussis vaccine protects against Bordetella pertussis exacerbation of allergic asthma:  Pw immunization reduces IL-13 and IL-10'
D.P. Ennis, J.P. Cassidy, and B.P. Mahon.  (2005) 'Whole cell pertussis vaccine protects against Bordetella pertussis exacerbation of allergic asthma:  Pw immunization reduces IL-13 and IL-10'. Immunology Letters, 97 :91-100 [IR Link] [Details]
2005 'IL-1beta and TNF-alpha induce increased expression of CCL28 by airway epithelial cells via an NFκB-dependent pathway'
O'Gorman M.;Jatoi N.;Lane S.;Mahon B. (2005) 'IL-1beta and TNF-alpha induce increased expression of CCL28 by airway epithelial cells via an NFκB-dependent pathway'. Cellular Immunology, 238 (2):87-96 [DOI] [IR Link] [Details]
2005 'Mesenchymal Stem Cell Transplantation for Tissue Repair'
F. P. Barry, J. M. Murphy, T. O’Brien and B. P. Mahon (2005) 'Mesenchymal Stem Cell Transplantation for Tissue Repair'. SEMINARS IN PLASTIC SURGERY, 19 :229-240 [IR Link] [Details]
2005 'Immunogenicity of adult mesenchymal stem cells: lessons from the fetal allograft. '
F.P. Barry, J.M. Murphy, K. English and B.P. Mahon. (2005) 'Immunogenicity of adult mesenchymal stem cells: lessons from the fetal allograft. '. Stem Cells and Development, 14 :252-265 [Details]
2005 'Mesenchymal stem cells avoid allogeneic rejection'
J. Ryan, F.P. Barry, J.M. Murphy and B.P. Mahon.  (2005) 'Mesenchymal stem cells avoid allogeneic rejection'. JOURNAL OF INFLAMMATION, 2 :1-11 [IR Link] [Details]
2005 'Novel mechanism of immunosuppression by influenza virus haemagglutinin:  selective suppression of IL-12p35 transcription'
C.M. Noone, A.B. Frawely, M.F. Doyle, B.P. Mahon, K.H.G. Mills and. P.A. Johnson.  (2005) 'Novel mechanism of immunosuppression by influenza virus haemagglutinin:  selective suppression of IL-12p35 transcription'. JOURNAL OF GENERAL VIROLOGY, 86 :1885-1890 [IR Link] [Details]
2005 'Acellular pertussis vaccine protects against Bordetella pertussis exacerbation of allergic asthma but in the absence of infection potentiates airway IL-10 and IL-13'
D. P. Ennis, J. P. Cassidy, and B. P. Mahon. (2005) 'Acellular pertussis vaccine protects against Bordetella pertussis exacerbation of allergic asthma but in the absence of infection potentiates airway IL-10 and IL-13'. Clinical and Diagnostic Laboratory Immunology, 12 :409-417 [IR Link] [Details]
2004 'Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo'
Flynn M.;Casey D.;Todryk S.;Mahon B. (2004) 'Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo'. Journal of Inflammation, 1 [DOI] [IR Link] [Details]
2004 'B cell memory is directed towards conformational epitopes of parvovirus B19 capsid proteins and the VP1-unique region. Journal of Infectious Diseases. 189:1873-1880'
A. Corcoran, B. P. Mahon and S. Doyle. (2004) 'B cell memory is directed towards conformational epitopes of parvovirus B19 capsid proteins and the VP1-unique region. Journal of Infectious Diseases. 189:1873-1880'. JOURNAL OF INFECTIOUS DISEASES, 183 :1873-1880 [IR Link] [Details]
2004 'Prior Bordetella pertussis infection influences allergen priming and the severity of airway pathology in a murine model of allergic asthma'
D. P. Ennis, J. P. Cassidy, and B. P. Mahon. (2004) 'Prior Bordetella pertussis infection influences allergen priming and the severity of airway pathology in a murine model of allergic asthma'. CLINICAL AND EXPERIMENTAL ALLERGY, 34 :1488-1497 [IR Link] [Details]
2004 'Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo. '
M. Flynn, D. Casey. S. Todryk, and B. P. Mahon (2004) 'Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo. '. JOURNAL OF INFLAMMATION, 1 :1-12 [IR Link] [Details]
2003 'Ex vivo cytokine responses against parvovirus B19 antigens in previously infected pregnant women'
Corcoran, A., Mahon, B. P., McParland, P., Davoren, A. and Doyle, S (2003) 'Ex vivo cytokine responses against parvovirus B19 antigens in previously infected pregnant women'. JOURNAL OF MEDICAL VIROLOGY, 70 :475-480 [IR Link] [Details]
2002 'High-sensitivity PCR detection of parvovirus B19 in plasma'
Daly P.;Corcoran A.;Mahon B.;Doyle S. (2002) 'High-sensitivity PCR detection of parvovirus B19 in plasma'. Journal of Clinical Microbiology, 40 (6):1958-1962 [DOI] [IR Link] [Details]
2001 'The immunological role of respiratory tract epithelium'
R. Cunningham and B. P. Mahon (2001) 'The immunological role of respiratory tract epithelium'. Modern Aspects of Immunobiology, 1 :204-208 [Details]
2001 'Baculovirus expression of parvovirus B19 (B19V) NS1: Utility in confirming recent infection'
O. Ennis, A. Corcoran, K. Kavanagh, B.P. Mahon & S. Doyle (2001) 'Baculovirus expression of parvovirus B19 (B19V) NS1: Utility in confirming recent infection'. JOURNAL OF CLINICAL VIROLOGY, 22 :55-60 [IR Link] [Details]
2001 'The rational design of vaccine adjuvants for mucosal and neonatal immunization'
Mahon B. (2001) 'The rational design of vaccine adjuvants for mucosal and neonatal immunization'. Current Medicinal Chemistry, 8 (9):1057-1075 [Details]
2000 'Protection against Bordetella pertussis in mice in the absence of circulating antibody: Implications for long term immunity in children'
B. P. Mahon, M. T. Brady and K. H. G. Mills. (2000) 'Protection against Bordetella pertussis in mice in the absence of circulating antibody: Implications for long term immunity in children'. JOURNAL OF INFECTIOUS DISEASES, 181 :2087-2091 [IR Link] [Details]
2000 'Impaired interferon-g responses against Parvovirus B19 by recently infected children'
A. Corcoran, S. Doyle, D. Waldron, A. Nicholson, and B. P. Mahon. (2000) 'Impaired interferon-g responses against Parvovirus B19 by recently infected children'. JOURNAL OF VIROLOGY, 74 :9903-9910 [IR Link] [Details]
2000 'Protection against Bordetella pertussis in mice in the absence of detectable circulating antibody: Implications for long-term immunity in children'
Mahon B.;Brady M.;Mills K. (2000) 'Protection against Bordetella pertussis in mice in the absence of detectable circulating antibody: Implications for long-term immunity in children'. Journal of Infectious Diseases, 181 (6):2087-2091 [DOI] [IR Link] [Details]
1999 'Pertussis infection and vaccination induce Th1 cells and does not enhance allergy'
M. Brady, B. P. Mahon, and K. H. G. Mills. (1999) 'Pertussis infection and vaccination induce Th1 cells and does not enhance allergy'. Trends in Immunology, 19 :534-534 [Details]
1999 'Interferon-g mediated immune effector mechanisms against Bordetella pertussis'
B. P. Mahon, and K. H. G. Mills. (1999) 'Interferon-g mediated immune effector mechanisms against Bordetella pertussis'. IMMUNOLOGY LETTERS, 68 :213-217 [IR Link] [Details]
1999 'The immunology of Bordetella pertussis infection'
Mills, KHG;Ryan, M;McGuirk, P;Griffin, F;Murphy, G;Mahon, B (1999) 'The immunology of Bordetella pertussis infection'. Biologicals, 27 :77-77 [IR Link] [Details]
1998 'Compartmentalization of T cell responses following respiratory infection with Bordetella pertussis: hypo responsiveness of lung T cells is associated with modulated expression of the costimulatory molecule CD28'
P. McGuirk, B. P. Mahon, F. Griffin, and K. H. G. Mills. (1998) 'Compartmentalization of T cell responses following respiratory infection with Bordetella pertussis: hypo responsiveness of lung T cells is associated with modulated expression of the costimulatory molecule CD28'. European Journal of Immunology, 28 :153-163 [Details]
1998 'PT potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28'
M. Ryan, L. McCarthy, B. P. Mahon, R. Rappuoli, and K. H. G. Mills. (1998) 'PT potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28'. International Immunology, 10 :651-662 [IR Link] [Details]
1998 'A respiratory challenge model for infection with Bordetella pertussis: application in the assessment of pertussis vaccine potency and in the definition of the mechanism of protective immunity'
K. H. G. Mills, M. Brady, E. J. Ryan, and B. P. Mahon. (1998) 'A respiratory challenge model for infection with Bordetella pertussis: application in the assessment of pertussis vaccine potency and in the definition of the mechanism of protective immunity'. DEVELOPMENTS IN BIOLOGICAL STANDARDISATION, 95 :31-41 [Details]
1998 'A murine model in which protection correlates with pertussis vaccine efficacy in children reveals complementary roles for humoral and cell mediated immunity in protection against Bordetella pertussis'
K. H. G. Mills, M. Ryan, E. Ryan and B. P. Mahon. (1998) 'A murine model in which protection correlates with pertussis vaccine efficacy in children reveals complementary roles for humoral and cell mediated immunity in protection against Bordetella pertussis'. Infection and Immunity, 66 :594-602 [IR Link] [Details]
1997 'Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions of interferon-γ receptor or imnaunoglobulin μ chain genes'
Mahon B.;Sheahan B.;Griffin F.;Murphy G.;Mills K. (1997) 'Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions of interferon-γ receptor or imnaunoglobulin μ chain genes'. Journal of Experimental Medicine, 186 (11):1843-1851 [DOI] [IR Link] [Details]
1996 'IL-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting the induction of Th1 cells'
B. P. Mahon, M. Ryan, F. Griffin, P. McGuirk and K. H. G. Mills. (1996) 'IL-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting the induction of Th1 cells'. Infection and Immunity, 64 :5295-5301 [IR Link] [Details]
1996 'Th1/Th2 cell dichotomy in acquired immunity to Bordetella pertussis: variables in the in vivo priming and in vitro cytokine detection techniques affect the classification of T-cell subsets as Th1, Th2 or Th0'
Barnard A;Mahon BP;Watkins J;Redhead K;Mills KH; (1996) 'Th1/Th2 cell dichotomy in acquired immunity to Bordetella pertussis: variables in the in vivo priming and in vitro cytokine detection techniques affect the classification of T-cell subsets as Th1, Th2 or Th0'. Journal of Immunology, 87 (3) [IR Link] [Details]
1995 'Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor'
B. P. Mahon, K. Katrak, A. Nomoto, A. J. Macadam, P. D. Minor and K. H. G. Mills. (1995) 'Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor'. Journal of Experimental Medicine, 181 :1285-1292 [IR Link] [Details]
1994 'Immunochemical estimation of haemoglobin types in red blood cells by FACS analysis'
S.J. Thorpe, S. L. Thein, M. Sampietro, J.E. Craig, B. P. Mahon and E. R. Huehns. (1994) 'Immunochemical estimation of haemoglobin types in red blood cells by FACS analysis'. British Journal of Haematology, 87 :125-131 [Details]
1992 'Preparative separation of foreign antigens for highly efficient presentation to T cells in vitro'
K. Katrak, B. P. Mahon, W. C. Jones, S. Brautigam and K. H. G. Mills. (1992) 'Preparative separation of foreign antigens for highly efficient presentation to T cells in vitro'. Journal of Immunological Methods, 156 :247-254 [IR Link] [Details]
1992 'Antigenic sequences of poliovirus recognized by T cells: serotype-specific epitopes on VP1 and VP3 and cross-reactive epitopes on VP4 defined by using CD4+ T-cell clones'
Mahon BP;Katrak K;Mills KH; (1992) 'Antigenic sequences of poliovirus recognized by T cells: serotype-specific epitopes on VP1 and VP3 and cross-reactive epitopes on VP4 defined by using CD4+ T-cell clones'. Virology, 66 (12) [IR Link] [Details]
1992 'Mechanisms of inhibition of T cell IL-2 secretion by factor VIII concentrates'
M. Wadwha, P. D. Dilger, J. Tubbs, T. Barrowcliffe, B. P. Mahon and R. Thorpe. (1992) 'Mechanisms of inhibition of T cell IL-2 secretion by factor VIII concentrates'. British Journal of Haematology, 82 :575-583 [Details]
1991 'Cellular and humoral immune responses to poliovirus in mice: a role for helper T cells in heterotypic immunity to poliovirus'
K. Katrak, B. P. Mahon, P.D. Minor and K. H. G. Mills. (1991) 'Cellular and humoral immune responses to poliovirus in mice: a role for helper T cells in heterotypic immunity to poliovirus'. Journal of General Virology, 72 :1093-1098 [IR Link] [Details]
1990 'HIV p24-specific helper T cell clones from immunised primates recognise highly conserved regions of HIV-1'
K. H. G. Mills, P. A. Kitchin, B. P. Mahon, A. L. Barnard, S. E. Adams, M. Kingsman and A. J. Kingsman. (1990) 'HIV p24-specific helper T cell clones from immunised primates recognise highly conserved regions of HIV-1'. Journal of Immunology, 144 :1677-1683 [IR Link] [Details]
1988 'A sensitive and specific immunoradiometric assay (IRMA) for human interleukin-1'
R. Thorpe, M. Wadwha, A. J. H. Gearing, B. P. Mahon and S. Poole. (1988) 'A sensitive and specific immunoradiometric assay (IRMA) for human interleukin-1'. Lymphokine Research, 7 :119-127 [Details]
1987 'Preparation and characterisation of monoclonal antibodies directed against antigenic determinants of recombinant human tumour necrosis factor (rTNF)'
A. Meager, S. Parti, H. Leung, E. Peil and B. P. Mahon. (1987) 'Preparation and characterisation of monoclonal antibodies directed against antigenic determinants of recombinant human tumour necrosis factor (rTNF)'. Hybridoma, 6 :305-311 [IR Link] [Details]

Book Chapters

  Year Publication
2009 'Tissue Engineering and Regenerative Medicine using Mesenchymal Stem Cells'
Barry, F.P., Duffy, G., Rooney, G., Mahon, B.P. and Murphy, J.M. (2009) 'Tissue Engineering and Regenerative Medicine using Mesenchymal Stem Cells' In: Regenerative therapy for the musculoskeletal system using recombinant adeno-associated viral vectors. [Details]
2003 'Cell mediated and humoral immune responses to mumps virus: recent developments'
M.A. Flynn & B.P. Mahon (2003) 'Cell mediated and humoral immune responses to mumps virus: recent developments' In: Recent research developments in Virology. International: TGN. [IR Link] [Details]
1993 'Cellular and humoral immune responses to poliovirus and tetanus following primary immunisation of SIV-infected Macaques'
K. H. G. Mills, W. C. Jones, B. P. Mahon, K. Katrak, F. Taffs, E. J. Stott and M. Page. (1993) 'Cellular and humoral immune responses to poliovirus and tetanus following primary immunisation of SIV-infected Macaques' In: Animal models of HIV and other retroviral infections. Basel, Switzerland: Karger. [Details]
1990 'Titration of SIVmac251 (32H) isolate in cynomolgus macaques for use as a challenge in vaccination studies'
P.A. Kitchin, M.P. Cranage, N. Almond, A. Barnard, A. Baskerville, T. Corcoran, C. Fromholc, P. Greenaway, C Grief, A. Jenkins, K. Kent, C. Ling, B. P. Mahon, K. Mills, M. Page, P. Silvera, Z. Szotyori, F. Taffs, and E.J. Stott. (1990) 'Titration of SIVmac251 (32H) isolate in cynomolgus macaques for use as a challenge in vaccination studies' In: Animal models in AIDS. Amsterdam: Elsevier Science Publishers B.V.. [Details]
1990 'Induction of HIV-specific immune responses in primates: fine specificity of antibody and helper T cell recognition of the HIV-p24 protein'
K. H.G. Mills, A. L. Barnard, B. P. Mahon, P. A. Kitchin, S. E. Adams, M. Kingsman and A. J. Kingsman. (1990) 'Induction of HIV-specific immune responses in primates: fine specificity of antibody and helper T cell recognition of the HIV-p24 protein' In: Vaccines 90: Modern approaches to new vaccines including the prevention of AIDS. New York: Cold Spring Harbor Laboratory. [Details]
1988 'Monoclonal antibodies to fibrin cross-linked degradation products: comparison of specificities of IgM and IgG classes'
P. J. Gaffney, L. J. Creighton, A. Curry, B. P. Mahon and R. Thorpe. (1988) 'Monoclonal antibodies to fibrin cross-linked degradation products: comparison of specificities of IgM and IgG classes' In: In Fibrinogen 2. Biochemistry, Physiology and Clinical relevance. Exerpta Medica. Amsterdam: Elsevier. [Details]

Honours and Awards

  Year Title Awarding Body
2010 Priz Servier Scholar (Ireland Fund of France)
1998 Wellcome Trust/HRB New Blood Award

Committees

  Committee Function From / To
Research Committee Chair /
Academic Council Member /
IUA VP Research Committee Representative /
Ethics Committee Chair /

Teaching Interests

All aspects of Biomedical education at BSc, MSc and PhD level.

External Collaborators

  Name Role / Description Country
Prof. Frank Barry. REMEDI, NUI Galway SFI CSET IRELAND
Prof. Ken Cooke. Cleveland Clinic International U.S.A.
Prof. Camille Locht. Institut Pasteur de Lille, France Child Innovac FP7 FRANCE