Dr Sinead Miggin
Biography
Research Interests
Peer Reviewed Journals
Year | Publication | |
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2017 | 'Analysis of Inflammatory Cytokines in Pre-diabetic subjects'
Gupta, S., Maratha, A, Natarajan, A, Miggin, S and Hoashi, S (2017) 'Analysis of Inflammatory Cytokines in Pre-diabetic subjects'. Current Research in Diabetes and Obesity Journal, 4 (5) [DOI] [IR Link] [Details] |
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2017 | 'Analysis of inflammatory cytokine and TLR expression levels in Type 2 Diabetes with complications'
Gupta S;Maratha A;Siednienko J;Natarajan A;Gajanayake T;Hoashi S;Miggin S; (2017) 'Analysis of inflammatory cytokine and TLR expression levels in Type 2 Diabetes with complications'. Scientific Reports, 7 (1) [DOI] [IR Link] [Details] |
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2017 | 'Long non-coding RNA AGER-1 functionally upregulates the innate immunity gene AGER and approximates its anti-tumor effect in lung cancer'
Pan Z;Liu L;Nie W;Miggin S;Qiu F;Cao Y;Chen J;Yang B;Zhou Y;Lu J;Yang L; (2017) 'Long non-coding RNA AGER-1 functionally upregulates the innate immunity gene AGER and approximates its anti-tumor effect in lung cancer'. Molecular Carcinogenesis, [DOI] [IR Link] [Details] |
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2015 | 'Acute serum amyloid A is an endogenous TLR2 ligand that mediates inflammatory and angiogenic mechanisms'
Connolly M.;Rooney P.;McGarry T.;Maratha A.;McCormick J.;Miggin S.;Veale D.;Fearon U. (2015) 'Acute serum amyloid A is an endogenous TLR2 ligand that mediates inflammatory and angiogenic mechanisms'. ANNALS OF THE RHEUMATIC DISEASES, [DOI] [IR Link] [Details] |
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2014 | 'The TIR-Domain Containing Adaptor TRAM Is Required for TLR7 Mediated RANTES Production'
Shevlin, E;Miggin, SM (2014) 'The TIR-Domain Containing Adaptor TRAM Is Required for TLR7 Mediated RANTES Production'. PLoS ONE, 9 [DOI] [IR Link] [Details] |
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2013 | 'TRIF-Mediated TLR3 and TLR4 Signaling Is Negatively Regulated by ADAM15'
Ahmed, S;Maratha, A;Butt, AQ;Shevlin, E;Miggin, SM (2013) 'TRIF-Mediated TLR3 and TLR4 Signaling Is Negatively Regulated by ADAM15'. Journal of Immunology, 190 :2217-2228 [DOI] [Details] |
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2011 | 'Absence of MyD88 Results in Enhanced TLR3-Dependent Phosphorylation of IRF3 and Increased IFN-beta and RANTES Production'
Siednienko, J;Gajanayake, T;Fitzgerald, KA;Moynagh, P;Miggin, SM (2011) 'Absence of MyD88 Results in Enhanced TLR3-Dependent Phosphorylation of IRF3 and Increased IFN-beta and RANTES Production'. Journal of Immunology, 186 :2514-2522 [DOI] [IR Link] [Details] |
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2011 | 'Targeted Disruption of Nonribosomal Peptide Synthetase pes3 Augments the Virulence of Aspergillus fumigatus'
O'Hanlon, KA;Cairns, T;Stack, D;Schrettl, M;Bignell, EM;Kavanagh, K;Miggin, SM;O'Keeffe, G;Larsen, TO;Doyle, S (2011) 'Targeted Disruption of Nonribosomal Peptide Synthetase pes3 Augments the Virulence of Aspergillus fumigatus'. Infection and Immunity, 79 :3978-3992 [DOI] [IR Link] [Details] |
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2011 | 'Nuclear Factor kappa B Subunits RelB and cRel Negatively Regulate Toll-like Receptor 3-mediated beta-Interferon Production via Induction of Transcriptional Repressor Protein YY1'
Siednienko, J;Maratha, A;Yang, S;Mitkiewicz, M;Miggin, SM;Moynagh, PN (2011) 'Nuclear Factor kappa B Subunits RelB and cRel Negatively Regulate Toll-like Receptor 3-mediated beta-Interferon Production via Induction of Transcriptional Repressor Protein YY1'. Journal of Biological Chemistry, 286 :44750-44763 [DOI] [Details] |
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2010 | 'Cytokine profiling of pre-diabetic patients'
Gupta, S;Maratha, A;Gajanayake, T;Siednienko, J;Natarajan, A;Hoashi, S;Miggin, S (2010) 'Cytokine profiling of pre-diabetic patients'. IRISH JOURNAL OF MEDICAL SCIENCE, 179 :513-513 [Details] |
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2010 | 'TLR3-mediated IFN-beta gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like'
Siednienko, J;Halle, A;Nagpal, K;Golenbock, DT;Miggin, SM (2010) 'TLR3-mediated IFN-beta gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like'. European Journal of Immunology, 40 :3150-3160 [DOI] [IR Link] [Details] |
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2007 | 'NF-kappa B activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1'
Miggin, SM;Palsson-McDermott, E;Dunne, A;Jefferies, C;Pinteaux, E;Banahan, K;Murphy, C;Moynagh, P;Yamamoto, M;Akira, S;Rothwelll, N;Golenbock, D;Fitzgerald, KA;O'Neill, LAJ (2007) 'NF-kappa B activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1'. Proceedings of the National Academy of Sciences of the United States of America, 104 :3372-3377 [DOI] [IR Link] [Details] |
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2006 | 'New insights into the regulation of TLR signaling'
Miggin SM, O'Neill LA (2006) 'New insights into the regulation of TLR signaling'. Journal Of Leukocyte Biology, 80 :220-226 [IR Link] [Details] |
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2003 | 'Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa'
Wietek, C., Miggin, S. M., Jefferies, C. A. and O’Neill, L.A. (2003) 'Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa'. JOURNAL OF BIOLOGICAL CHEMISTRY, 278 :50923-50931 [IR Link] [Details] |
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2002 | 'Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor'
Miggin, S. M., Lawler, O. A. and Kinsella, B. T. (2002) 'Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor'. EUROPEAN JOURNAL OF BIOCHEMISTRY, 269 :1714-1725 [Details] |
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2002 | 'Regulation of the extracellular signal regulated protein kinase cascades by the a and b isoforms of the human thromboxane A2 receptor'
Miggin, S. M. and Kinsella, B. T. (2002) 'Regulation of the extracellular signal regulated protein kinase cascades by the a and b isoforms of the human thromboxane A2 receptor'. MOLECULAR PHARMACOLOGY, 61 :817-831 [Details] |
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2002 | 'Characterization of the 5' untranslated region of alpha and beta isoforms of the human thromboxane A2 receptor (TP). Differential promoter utilization by the TP isoforms'
Coyle, AT., Miggin, SM. and Kinsella BT. (2002) 'Characterization of the 5' untranslated region of alpha and beta isoforms of the human thromboxane A2 receptor (TP). Differential promoter utilization by the TP isoforms'. EUROPEAN JOURNAL OF BIOCHEMISTRY, 269 :4058-4073 [IR Link] [Details] |
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2001 | 'Protein kinase A dependent phosphorylation of serine 357 of the mouse prostacyclin receptor regulated its coupling to Gs-, Gi- and to Gq- coupled effector signalling'
Lawler, O. A., Miggin, S. M. and Kinsella, B. T. (2001) 'Protein kinase A dependent phosphorylation of serine 357 of the mouse prostacyclin receptor regulated its coupling to Gs-, Gi- and to Gq- coupled effector signalling'. JOURNAL OF BIOLOGICAL CHEMISTRY, 276 :33596-33607 [IR Link] [Details] |
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2001 | 'The effects of the statins lovastatin and cerivastatin on signalling by the prostanoid IP-receptor'
Lawler, O. A., Miggin, S. M. and Kinsella, B. T. (2001) 'The effects of the statins lovastatin and cerivastatin on signalling by the prostanoid IP-receptor'. BRITISH JOURNAL OF PHARMACOLOGY, 132 :1639-1649 [IR Link] [Details] |
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2001 | 'Thromboxane A(2) receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells'
Miggin, S.M. and Kinsella, BT. (2001) 'Thromboxane A(2) receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells'. BIOCHIMICA ET BIOPHYSICA ACTA, 1539 :147-162 [IR Link] [Details] |
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1998 | 'Expression and tissue distribution of the mRNAs encoding the human thromboxane A2 receptor (TP) alpha and beta isoforms'
Miggin, SM and Kinsella, BT. (1998) 'Expression and tissue distribution of the mRNAs encoding the human thromboxane A2 receptor (TP) alpha and beta isoforms'. BIOCHIMICA ET BIOPHYSICA ACTA, 1425 :543-59 [IR Link] [Details] |
Book Chapters
Year | Publication | |
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2011 | 'Toll-like receptor adaptor proteins'
Shevlin, Enda and Miggin, Sinéad M. (2011) 'Toll-like receptor adaptor proteins' In: Encyclopedia of Signaling Molecules. Springer. [Details] |
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2011 | 'Toll-like receptor 3'
Butt, Aisha Qasim and Miggin, Sinéad M. (2011) 'Toll-like receptor 3' In: Encyclopedia of Signaling Molecules. Springer. [Details] |
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2009 | 'Expression Analysis of the Toll-Like Receptors in Human Peripheral Blood Mononuclear Cells'
Siednienko, J. and Miggin, S.M. (2009) 'Expression Analysis of the Toll-Like Receptors in Human Peripheral Blood Mononuclear Cells' In: Methods in Molecular Biology, Vol. 517. New Jersey: Humana Press Inc. [Details] |
Conference Contributions
Year | Publication | |
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2010 | Congress on Trauma, Shock, Inflammation and Sepsis.
(2010) Congress on Trauma, Shock, Inflammation and Sepsis. [Oral Presentation], Comparative Analysis of Cytokine Production by Synoviocytes in Response to Toll-Like Receptor Ligan, TSIS 2010 [Details] |
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2009 | Irish Society of Immunology.
(2009) Irish Society of Immunology. [Poster Presentation], TLR3 signalling in synoviocytes is negatively regulated by ATP through inhibition of NF-kB, St James Hospital, Dublin [Details] |
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2009 | Tri-Society Annual Conference.
(2009) Tri-Society Annual Conference. [Poster Presentation], TLR3 signalling in synoviocytes is negatively regulated by extracellular ATP, Lisbon, Portugal [Details] |
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2007 | Biochemical Society, Pattern-recognition receptors in human disease.
(2007) Biochemical Society, Pattern-recognition receptors in human disease. [Poster Presentation], NF-kB activation by MyD88 adapter-like is regulated by Caspase-1’, Cambridge, UK [Details] |
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2007 | International Cytokine Society, Cytokines in health and disease.
(2007) International Cytokine Society, Cytokines in health and disease. [Poster Presentation], NF-kB activation by MyD88 adapter-like is regulated by Caspase-1, San Francisco, CA, USA [Details] |
Magazine Article
Year | Publication | |
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2014 | Burnt out Diabetes: Cytokines, Adipokines and TLRs Modulation in Type 2 Diabetes.
Gupta, S;Maratha, A;Natarajan, A;Gajanayake, T;Siednienko, J;Hoashi, S;Miggin, S (2014) Burnt out Diabetes: Cytokines, Adipokines and TLRs Modulation in Type 2 Diabetes. WASHINGTON: Magazine Article [Details] |
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2013 | Acute serum amyloid A is an endogenous TLR2 ligand that mediates inflammation and angiogenesis in rheumatoid arthritis.
Connolly, MC;Rooney, PR;Maratha, AX;Miggin, SM;Veale, DJ;Fearon, UM (2013) Acute serum amyloid A is an endogenous TLR2 ligand that mediates inflammation and angiogenesis in rheumatoid arthritis. LONDON: Magazine Article [Details] |
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2013 | Association Between Type 2 Diabetes & Inflammation.
Gupta, S;Maratha, A;Natarajan, A;Gajanayake, V;Siednienko, J;Hoashi, S;Miggin, S (2013) Association Between Type 2 Diabetes & Inflammation. LONDON: Magazine Article [Details] |