Prof Karen English

Biography
Research Interests
Research Projects
Project | Role | Funding Body / Program | Description | Start Date | End Date | Award (€) | |
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Investigating the influence of MIF on mesenchymal stream cell therapeutic efficacy in allergic asthma | PI | Irish Research Council (IRC) / Starting Laureate Award | Asthma is a debilitating chronic inflammatory disease causing up to 250,000 deaths (per year) and affecting 300 million people worldwide. Up to 15% of the asthma population have chronic steroid refractory severe asthma. Standard treatments (corticosteroids) are ineffective for severe asthmatics who suffer more frequent exacerbations and are susceptible to major respiratory failure and death. Therefore, there is an urgent unmet need for the development of new therapeutic approaches for treatment of severe asthmatics. Mesenchymal stromal cell (MSC) therapeutic efficacy has been demonstrated in pre-clinical models and allergic asthmatic patient samples but have not yet been tested in clinical trials. Evidence from clinical trials in other inflammatory diseases have suggested that MSC are differentially efficacious in heterogeneous patient populations suggesting the need to patient stratification to ensure MSC therapeutic efficacy. MSC licensing/activation (in addition to survival and migration) is important for therapeutic efficacy and is likely influenced by the microenvironment present in target organs/tissues. There is a strong correlation between severe asthma and the pro-inflammatory cytokine MIF (high (7-CATT) expression allele). Our preliminary data suggests that MIF enhances MSC migration, cytoprotective and immune modulatory functions. This proposal seeks to elucidate the influence of MIF on human MSC migration, survival and cytoprotective functions. These important outcomes will have far reaching implications and broad impact in advancing these themes in the MSC research field. The ultimate gain from this research programme will be the demonstration of the therapeutic efficacy of MSC or MIF licensed MSC in the treatment of 7-CATT MIF-high expression allele allergic asthma and the capacity to extrapolate these findings for the realisation of real clinical benefit for severe asthmatics. | 01-SEP-18 | 31-AUG-22 | 411931.18 | |
Investigating the capacity for multipotent adult progenitor cells to prolong graft survival through modulation of homeostatic proliferation | PI | Science Foundation Ireland / Starting Investigator Research Grant (SIRG) | 01-DEC-14 | 30-NOV-18 | 519996 | ||
In vivo imaging of cellular therapies a graft versus host disease model. | PI | Irish Research Council (IRC) / Enterprise Partnership Scheme Postgraduate Scholarship | 01-OCT-13 | 30-SEP-17 | |||
A novel humanised mouse model of aGVHD for the identification of Human Biomarkers | PI | Enterprise Ireland / Commerical Case Feasibility Fund | 01-JUL-13 | 31-AUG-13 | |||
BccVac: Development of a prophylactic vaccine against the cystic fibrosis-associated pathogen, Burkholderia cepacia complex. | PI | Enterprise Ireland / Commercialisation Fund | 01-JUN-13 | 30-NOV-14 | 17400 | ||
Food for Health Ireland FH 2 | PI | Enterprise Ireland / Technology centre | 01-JAN-13 | 01-JAN-17 | 177671 | ||
Enhancement of mesenchymal stem cell therapy for graft versus host disease | PI | EU Framework Programme 7 / PEOPLE - Marie Curie - Career Integration Grants (CIG) | 01-SEP-12 | 31-DEC-15 | 81250 | ||
Travel Support for Health Consortium meeting in Germany | PI | Enterprise Ireland / FP7 Travel Assistance | 20-AUG-12 | 22-AUG-12 |
Peer Reviewed Journals
Year | Publication | |
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2022 | 'Helminth antigens modulate human PBMCs, attenuating disease progression in a humanised mouse model of graft versus host disease'
Healy M;Aldridge A;Glasgow AMA;Mahon BP;English K;O'Neill SM; (2022) 'Helminth antigens modulate human PBMCs, attenuating disease progression in a humanised mouse model of graft versus host disease'. Experimental Parasitology, [DOI] [Details] |
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2022 | 'Mucosal associated invariant T cells are altered in patients with Hidradenitis Suppurativa and contribute to the inflammatory milieu'
Gallagher C;Mahon JM;OâNeill C;Cassidy FC;Dunbar H;De Barra C;Cadden C;Pisarska MM;Wood N;Masterson JC;McNamee EN;English K;OâShea D;Hogan AE; (2022) 'Mucosal associated invariant T cells are altered in patients with Hidradenitis Suppurativa and contribute to the inflammatory milieu'. Biorxiv : The Preprint Server For Biology, [DOI] [Details] |
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2021 | 'Cyclosporine A and IFNγ licencing enhances human mesenchymal stromal cell potency in a humanised mouse model of acute graft versus host disease'
Corbett J.M.;Hawthorne I.;Dunbar H.;Coulter I.;Chonghaile M.N.;Flynn C.M.;English K. (2021) 'Cyclosporine A and IFNγ licencing enhances human mesenchymal stromal cell potency in a humanised mouse model of acute graft versus host disease'. Stem Cell Research and Therapy, 12 (1) [DOI] [full-text] [Details] |
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2021 | 'Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges'
Masterson CH;Ceccato A;Artigas A;Dos Santos C;Rocco PR;Rolandsson Enes S;Weiss DJ;McAuley D;Matthay MA;English K;Curley GF;Laffey JG; (2021) 'Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges'. Intensive Care Medicine Experimental, 9 (1) [DOI] [full-text] [Details] |
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2021 | 'Healthy versus Inflamed Lung Environments Differentially Effect MSCs'
Enes S.R.;Hampton T.H.;Barua J.;McKenna D.H.;Dos Santos C.C.;Amiel E.;Ashare A.;Liu K.D.;Krasnodembskaya A.D.;English K.;Stanton B.A.;Rocco P.R.M.;Matthay M.A.;Weiss D.J. (2021) 'Healthy versus Inflamed Lung Environments Differentially Effect MSCs'. European Respiratory Journal, 58 (4) [DOI] [Details] |
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2021 | 'IFN-γ and PPARδ influence the efficacy and retention of multipotent adult progenitor cells in graft vs host disease'
Carty F.;Dunbar H.;Hawthorne I.J.;Ting A.E.;Stubblefield S.R.;Van't Hof W.;English K. (2021) 'IFN-γ and PPARδ influence the efficacy and retention of multipotent adult progenitor cells in graft vs host disease'. Stem cells translational medicine, [DOI] [full-text] [Details] |
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2021 | 'Drug delivery formulation impacts cyclosporine efficacy in a humanised mouse model of acute graft versus host disease'
Corbett, JM;Hawthorne, I;Coulter, IS;English, K (2021) 'Drug delivery formulation impacts cyclosporine efficacy in a humanised mouse model of acute graft versus host disease'. Transplant Immunology, 65 [DOI] [Details] |
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2021 | 'Research Progress on Strategies that can Enhance the Therapeutic Benefits of Mesenchymal Stromal Cells in Respiratory Diseases With a Specific Focus on Acute Respiratory Distress Syndrome and Other Inflammatory Lung Diseases'
Rolandsson Enes S;Krasnodembskaya AD;English K;Dos Santos CC;Weiss DJ; (2021) 'Research Progress on Strategies that can Enhance the Therapeutic Benefits of Mesenchymal Stromal Cells in Respiratory Diseases With a Specific Focus on Acute Respiratory Distress Syndrome and Other Inflammatory Lung Diseases'. Frontiers in Pharmacology, 12 [DOI] [full-text] [Details] |
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2020 | 'Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells'
Abreu, SC;Hampton, TH;Hoffman, E;Dearborn, J;Ashare, A;Sidhu, KS;Matthews, DE;McKenna, DH;Amiel, E;Barua, J;Krasnodembskaya, A;English, K;Mahon, B;Dos Santos, C;Cruz, FF;Chambers, DC;Liu, KD;Matthay, MA;Cramer, RA;Stanton, BA;Rocco, PRM;Wargo, MJ;Weiss, DJ;Enes, SR (2020) 'Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells'. American Journal of Physiology - Lung Cellular and Molecular Physiology, 319 :908-925 [DOI] [full-text] [Details] |
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2019 | 'The Necrobiology of Mesenchymal Stromal Cells Affects Therapeutic Efficacy'
Weiss DJ;English K;Krasnodembskaya A;Isaza-Correa JM;Hawthorne IJ;Mahon BP; (2019) 'The Necrobiology of Mesenchymal Stromal Cells Affects Therapeutic Efficacy'. Frontiers in Immunology, 10 [DOI] [full-text] [Details] |
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2018 | 'Multipotent Adult Progenitor Cells suppress T cell activation in in vivo models of homeostatic proliferation in a PGE2 dependant manner'
Fiona Carty, Jennifer Corbett, Joao Paulo Monteiro Carvalho Mori Cunha, James L. Reading, Timothy I. Tree, Anthony E. Ting, Samantha R. Stubblefield and Karen English1* (2018) 'Multipotent Adult Progenitor Cells suppress T cell activation in in vivo models of homeostatic proliferation in a PGE2 dependant manner'. Frontiers in Immunology, [DOI] [full-text] [Details] |
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2017 | 'The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents?'
Carty, F;Mahon, BP;English, K (2017) 'The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents?'. Clinical and Experimental Immunology, 188 :1-11 [DOI] [full-text] [Details] |
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2016 | 'Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis-Associated Pathogen Burkholderia cepacia Complex to Lung Epithelial Cells and Protect Mice against Infection'
McClean S;Healy ME;Collins C;Carberry S;O'Shaughnessy L;Dennehy R;Adams Á;Kennelly H;Corbett JM;Carty F;Cahill LA;Callaghan M;English K;Mahon BP;Doyle S;Shinoy M; (2016) 'Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis-Associated Pathogen Burkholderia cepacia Complex to Lung Epithelial Cells and Protect Mice against Infection'. Infection and Immunity, 84 (5) [DOI] [full-text] [Details] |
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2016 | 'Hepatocyte Growth Factor Is Required for Mesenchymal Stromal Cell Protection Against Bleomycin-Induced Pulmonary Fibrosis'
Cahill EF;Kennelly H;Carty F;Mahon BP;English K; (2016) 'Hepatocyte Growth Factor Is Required for Mesenchymal Stromal Cell Protection Against Bleomycin-Induced Pulmonary Fibrosis'. Stem cells translational medicine, 5 (10) [DOI] [full-text] [Details] |
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2016 | 'Human mesenchymal stromal cells exert HGF dependent cytoprotective effects in a human relevant pre-clinical model of COPD'
Kennelly, H;Mahon, BP;English, K (2016) 'Human mesenchymal stromal cells exert HGF dependent cytoprotective effects in a human relevant pre-clinical model of COPD'. Scientific Reports, 6 [DOI] [full-text] [Details] |
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2016 | 'Mesenchymal stem cells to promote islet transplant survival'
English K; (2016) 'Mesenchymal stem cells to promote islet transplant survival'. Current Opinion in Organ Transplantation, 21 (6) [DOI] [Details] |
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2015 | 'Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells'
Cahill E.;Tobin L.;Carty F.;Mahon B.;English K. (2015) 'Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells'. Stem Cell Research and Therapy, 6 (1) [DOI] [full-text] [Details] |
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2015 | 'Mesenchymal Stromal Cells Protect Against Caspase 3-Mediated Apoptosis of CD19(+) Peripheral B Cells Through Contact-Dependent Upregulation of VEGF'
Healy, ME;Bergin, R;Mahon, BP;English, K (2015) 'Mesenchymal Stromal Cells Protect Against Caspase 3-Mediated Apoptosis of CD19(+) Peripheral B Cells Through Contact-Dependent Upregulation of VEGF'. Stem Cells and Development, 24 :2391-2402 [DOI] [full-text] [Details] |
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2015 | 'Suppression of IL-7-dependent Effector T-cell Expansion by Multipotent Adult Progenitor Cells and PGE2'
Reading, JL;Vaes, B;Hull, C;Sabbah, S;Hayday, T;Wang, NS;DiPiero, A;Lehman, NA;Taggart, JM;Carty, F;English, K;Pinxteren, J;Deans, R;Ting, AE;Tree, TIM (2015) 'Suppression of IL-7-dependent Effector T-cell Expansion by Multipotent Adult Progenitor Cells and PGE2'. Molecular Therapy, 23 :1783-1793 [DOI] [full-text] [Details] |
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2014 | 'Stem cell transplantation for muscular dystrophy: the challenge of immune response'
Maffioletti SM;Noviello M;English K;Tedesco FS; (2014) 'Stem cell transplantation for muscular dystrophy: the challenge of immune response'. BioMed Research International, 2014 [DOI] [full-text] [Details] |
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2014 | 'Mesenchymal Stromal Cells; Role in Tissue Repair, Drug Discovery and Immune Modulation'
English, K;Mahon, BP;Wood, KJ (2014) 'Mesenchymal Stromal Cells; Role in Tissue Repair, Drug Discovery and Immune Modulation'. Current Drug Delivery, 11 :561-571 [full-text] [Details] |
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2013 | 'Mesenchymal Stromal Cells in Transplantation Rejection and Tolerance'
English, K;Wood, KJ (2013) 'Mesenchymal Stromal Cells in Transplantation Rejection and Tolerance'. Cold Spring Harbor perspectives in medicine, 3 [DOI] [full-text] [Details] |
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2013 | 'Mesoangioblasts suppress T cell proliferation through IDO and PGE-2-dependent pathways'
English K.;Tonlorenzi R.;Cossu G.;Wood K. (2013) 'Mesoangioblasts suppress T cell proliferation through IDO and PGE-2-dependent pathways'. Stem Cells and Development, 22 (3):512-523 [DOI] [full-text] [Details] |
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2013 | 'Human iPSC-derived mesoangioblasts, like their tissue-derived counterparts, suppress T cell proliferation through IDO- and PGE-2-dependent pathways'
Wood K.;Li O.;English K.;Tonlorenzi R.;Cossu G.;Saverio Tedesco F. (2013) 'Human iPSC-derived mesoangioblasts, like their tissue-derived counterparts, suppress T cell proliferation through IDO- and PGE-2-dependent pathways'. F1000 Research, 2 [DOI] [full-text] [Details] |
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2013 | 'IFN-gamma stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro'
Noone C.;Kihm A.;English K.;O'Dea S.;Mahon B. (2013) 'IFN-gamma stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro'. Stem Cells and Development, 22 (22):3003-3014 [DOI] [full-text] [Details] |
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2013 | 'Concise review: Adult mesenchymal stromal cell therapy for inflammatory diseases: How well are we joining the dots?'
Griffin, MD;Elliman, SJ;Cahill, E;English, K;Ceredig, R;Ritter, T (2013) 'Concise review: Adult mesenchymal stromal cell therapy for inflammatory diseases: How well are we joining the dots?'. Stem Cells, 31 :2033-2041 [DOI] [full-text] [Details] |
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2013 | 'Human mesenchymal stem cells suppress donor CD4+T cell proliferation and reduce pathology in a humanized mouse model of acute graft-versus-host disease'
Tobin, LM;Healy, ME;English, K;Mahon, BP (2013) 'Human mesenchymal stem cells suppress donor CD4+T cell proliferation and reduce pathology in a humanized mouse model of acute graft-versus-host disease'. Clinical and Experimental Immunology, 172 :333-348 [DOI] [full-text] [Details] |
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2013 | 'Mechanisms of mesenchymal stromal cell immunomodulation. Immunology and Cell Biology'
English, Dr Karen (2013) 'Mechanisms of mesenchymal stromal cell immunomodulation. Immunology and Cell Biology'. Immunology and Cell Biology, 91 :19-26 [DOI] [full-text] [Details] |
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2011 | 'Immunogenicity of embryonic stem cell-derived progenitors after transplantation'
English K;Wood KJ; (2011) 'Immunogenicity of embryonic stem cell-derived progenitors after transplantation'. Current Opinion in Organ Transplantation, 16 (1) [DOI] [Details] |
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2011 | 'Intervertebral disc repair: mesenchymal stem cells to the rescue?'
English K; (2011) 'Intervertebral disc repair: mesenchymal stem cells to the rescue?'. Transplantation, 92 (7) [DOI] [full-text] [Details] |
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2011 | 'Allogeneic Mesenchymal Stem Cells: Agents of Immune Modulation'
English, K;Mahon, BP (2011) 'Allogeneic Mesenchymal Stem Cells: Agents of Immune Modulation'. Journal of Cellular Biochemistry, 112 :1963-1968 [DOI] [full-text] [Details] |
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2011 | 'Mesenchymal stem cell inhibition of T-helper 17 cell-differentiation is triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor'
Duffy, MM;Pindjakova, J;Hanley, SA;McCarthy, C;Weidhofer, GA;Sweeney, EM;English, K;Shaw, G;Murphy, JM;Barry, FP;Mahon, BP;Belton, O;Ceredig, R;Griffin, MD (2011) 'Mesenchymal stem cell inhibition of T-helper 17 cell-differentiation is triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor'. European Journal of Immunology, 41 :2840-2851 [DOI] [full-text] [Details] |
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2010 | 'Mesenchymal stromal cells: facilitators of successful transplantation?'
English K;French A;Wood KJ; (2010) 'Mesenchymal stromal cells: facilitators of successful transplantation?'. Cell Stem Cell, 7 (4) [DOI] [full-text] [Details] |
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2010 | 'Attenuated Bordetella pertussis vaccine strain BPZE1 modulates allergen-induced immunity and prevents allergic pulmonary pathology in a murine model'
Kavanagh, H;Noone, C;Cahill, E;English, K;Locht, C;Mahon, BP (2010) 'Attenuated Bordetella pertussis vaccine strain BPZE1 modulates allergen-induced immunity and prevents allergic pulmonary pathology in a murine model'. Clinical and Experimental Allergy, 40 :933-941 [DOI] [full-text] [Details] |
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2009 | 'A Live Attenuated Bordetella pertussis Candidate Vaccine Does Not Cause Disseminating Infection in Gamma Interferon Receptor Knockout Mice'
Skerry, CM;Cassidy, JP;English, K;Feunou-Feunou, P;Locht, C;Mahon, BP (2009) 'A Live Attenuated Bordetella pertussis Candidate Vaccine Does Not Cause Disseminating Infection in Gamma Interferon Receptor Knockout Mice'. CLINICAL AND VACCINE IMMUNOLOGY, 16 :1344-1351 [DOI] [full-text] [Details] |
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2009 | 'Regulation of Surfactant Protein B Gene Expression in Bone Marrow-Derived Cells'
Field-Corbett, C;English, K;O'Dea, S (2009) 'Regulation of Surfactant Protein B Gene Expression in Bone Marrow-Derived Cells'. Stem Cells, 27 :662-669 [DOI] [full-text] [Details] |
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2009 | 'Cell contact, prostaglandin E-2 and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4(+)CD25(High)forkhead box P3(+) regulatory T cells'
English, K;Ryan, JM;Tobin, L;Murphy, MJ;Barry, FP;Mahon, BP (2009) 'Cell contact, prostaglandin E-2 and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4(+)CD25(High)forkhead box P3(+) regulatory T cells'. Clinical and Experimental Immunology, 156 :149-160 [DOI] [full-text] [Details] |
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2008 | 'Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation'
English, K;Barry, FP;Mahon, BP (2008) 'Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation'. Immunology Letters, 115 :50-58 [DOI] [full-text] [Details] |
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2007 | 'IFN-g and TNF-a differentially regulate immunomodulation by murine mesenchymal stem cells'
English K.;Barry F.;Field-Corbett C.;Mahon B. (2007) 'IFN-g and TNF-a differentially regulate immunomodulation by murine mesenchymal stem cells'. Immunology Letters, 110 (2):91-100 [DOI] [full-text] [Details] |
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2006 | 'Inflammation of the respiratory tract is associated with CCL28 and CCR10 expression in a murine model of allergic asthma'
English, K;Brady, C;Corcoran, P;Cassidy, JP;Mahon, BP (2006) 'Inflammation of the respiratory tract is associated with CCL28 and CCR10 expression in a murine model of allergic asthma'. Immunology Letters, 103 :92-100 [DOI] [full-text] [Details] |
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2006 | 'Interleukin-10 (IL-10) but not Lipopolysaccharide (LPS) produces increased motor activity and abnormal exploratory patterns while impairing spatial learning in Balb/c mice'
Harvey, D;Smith, R;English, K;Mahon, B;Commins, S (2006) 'Interleukin-10 (IL-10) but not Lipopolysaccharide (LPS) produces increased motor activity and abnormal exploratory patterns while impairing spatial learning in Balb/c mice'. Physiology and Behavior, 87 :842-847 [DOI] [full-text] [Details] |
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2005 | 'Immunogenicity of adult mesenchymal stem cells: lessons from the fetal allograft'
Barry FP;Murphy JM;English K;Mahon BP; (2005) 'Immunogenicity of adult mesenchymal stem cells: lessons from the fetal allograft'. Stem Cells and Development, 14 (3) [DOI] [full-text] [Details] |
Book Chapters
Year | Publication | |
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2017 | 'The Immune Response to the Allograft'
Carty F.;English K. (2017) 'The Immune Response to the Allograft' In: Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era. [DOI] [Details] |
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2014 | 'Stem Cell-Based Approach to Immunomodulation'
Wood K.;English K.;Li O. (2014) 'Stem Cell-Based Approach to Immunomodulation' In: Regenerative Medicine Applications in Organ Transplantation. [DOI] [Details] |
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2013 | 'Mesenchymal stromal cells in transplantation rejection and tolerance'
English K* and Wood K.J (2013) 'Mesenchymal stromal cells in transplantation rejection and tolerance' In: Transplantation. Cold Spring Harb Perspect Med. 1;3 (5). pii: a015560. [full-text] [Details] |
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2013 | 'Addressing the challenge of autoimmunity in the treatment of diabetes with stem cells'
English K* and Wood K.J (2013) 'Addressing the challenge of autoimmunity in the treatment of diabetes with stem cells' In: The immunological barriers to regenerative medicine. DOI: 10.1007/978-1-4614-5480-9_16. Springer Verlag In Press. [Details] |
Conference Contributions
Year | Publication | |
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2019 | Multipotent adult progenitor cells suppress T cell activation in vivo.
Karen English (2019) Multipotent adult progenitor cells suppress T cell activation in vivo. [Invited Lecture], 14th Annual Wisconsin Stem Cell Symposium 2019, University of Wisconsin, Madison, US [Details] |
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2018 | MSC therapy for Inflammatory Disease.
Karen English (2018) MSC therapy for Inflammatory Disease. [Invited Lecture], Molecular & Cellular Therapeutics Seminar Series, RCSI, RCSI, Ireland [Details] |
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2018 | MSC modulation of T cell homeostatic proliferation in vivo.
Karen English (2018) MSC modulation of T cell homeostatic proliferation in vivo. [Invited Lecture], Regenerative Medicine Institute (REMEDI) Seminar Series, NUI Galway, NUIG, Glaway, Ireland [Details] |
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2017 | The influence of MIF on Mesenchymal Stromal Cells.
Karen English (2017) The influence of MIF on Mesenchymal Stromal Cells. [Invited Lecture], 8th International MIF Conference, Wicklow, Ireland, Wicklow, Ireland [Details] |
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2017 | MSC therapy for chronic Lung Disease.
Karen English (2017) MSC therapy for chronic Lung Disease. [Invited Lecture], Matrix Biology Ireland, TCD, Dublin, Ireland [Details] |
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2016 | The influence of MIF on Mesenchymal Stromal Cells.
Karen English (2016) The influence of MIF on Mesenchymal Stromal Cells. [Invited Lecture], 21st NAT Congress: When Stem Cells Meet Immunology, Nante, France [Details] |
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2014 | MSC – Innovative mechanisms of action.
Karen English (2014) MSC – Innovative mechanisms of action. [Keynote Address], Mesenchymal Stem Cells in Solid Organ Transplantation (MISOT V 2014), Bergamo, Italy [Details] |
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2010 | The Oxford Stem Cell Institute Annual Symposium.
Karen English (2010) The Oxford Stem Cell Institute Annual Symposium. [Oral Presentation], Immunomodulation by mesenchymal stem cells, University of Oxford, June 2010 [Details] |
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2005 | Annual Congress of the British Society of Immunology.
Karen English (2005) Annual Congress of the British Society of Immunology. [Oral Presentation], (Comparative immunology of reproduction) - Allogeneic murine mesenchymal stem cells suppress mitogen induced proliferation of CD4+ T cells, lessons from the fetal allograft, Harrogate, UK Dec 2005 [Details] |
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2009 | Irish Stem Cell Meeting.
Karen English (2009) Irish Stem Cell Meeting. [Oral Presentation], Mesenchymal stem cells and rejection, Trinity College Dublin, March 2009 [Details] |
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2008 | Annual meetings of the Regenerative Medicine Institute (REMEDI).
Karen English (2008) Annual meetings of the Regenerative Medicine Institute (REMEDI). [Conference Organising Committee Member], Mesenchymal stem cell project collaborators, Galway, Ireland April 2005, 2006, 2007, 2008 [Details] |
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2008 | International Society for Cell Therapy – Europe.
Karen English (2008) International Society for Cell Therapy – Europe. [Oral Presentation], Human mesenchymal stem cells induce CD4+CD25HighFoxp3+ regulatory T cells through prostaglandin E2 and transforming growth factor beta 1, Antwerp, Belgium, September 2008 [Details] |
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2008 | RESCUE Society Meeting.
Karen English (2008) RESCUE Society Meeting. [Oral Presentation], Allogeneic human mesenchymal stem cells induce CD4+CD25HighFoxp3+ T cells with suppressor activity through production of prostaglandin E2, transforming growth factor beta 1 and by direct cell contact, Karolinska Institute, Stockholm, Sweeden, October 2008 [Details] |
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2009 | Optistem (EU consortium).
Karen English (2009) Optistem (EU consortium). [Oral Presentation], Mesenchymal stem cells prevent islet allograft rejection, Meeting, Hydra, Greece September 2009 [Details] |
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2007 | Irish Society for Immunology.
Karen English (2007) Irish Society for Immunology. [Oral Presentation], Murine mesenchymal stem cells interfere with dendritic cell migration, maturation and function, DCU, Ireland, September 2007 [Details] |
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2007 | International Immunology Postgraduate Master Class.
Karen English (2007) International Immunology Postgraduate Master Class. [Oral Presentation], Murine mesenchymal stem cells interfere with dendritic cell function and T cell proliferation, NUI Maynooth July 2007 [Details] |
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2007 | 2nd UK National Mesenchymal Stem Cell Meeting.
Karen English (2007) 2nd UK National Mesenchymal Stem Cell Meeting. [Oral Presentation], Murine mesenchymal stem cells interfere with dendritic cell migration, maturation and function, York, UK September 2007 [Details] |
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2007 | British Association of Lung Research.
Karen English (2007) British Association of Lung Research. [Oral Presentation], Murine mesenchymal stem cells reduce inflammation in a mouse model of allergic inflammation, NUI Maynooth September 2007 [Details] |
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2006 | Biology And Clinical Applications of Mesenchymal Stem CellsEHA Scientific workshop.
Karen English (2006) Biology And Clinical Applications of Mesenchymal Stem CellsEHA Scientific workshop. [Oral Presentation], Mesenchymal stem cell expression of immunomodulatory factors is regulated by the pro-inflammatory cytokine IFN-, Mandelieu, France October 2006 [Details] |
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2011 | Optistem (EU consortium) Annual Meeting April 2011.
Karen English (2011) Optistem (EU consortium) Annual Meeting April 2011. [Oral Presentation], Human Mesoangioblasts suppress T cell proliferation through IDO and PGE-2 dependent pathways, Loire France [Details] |
Book Review
Year | Publication | |
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2011 | Allogeneic Mesenchymal Stem Cells-Agents of Immune Deviation. J Cell Biochem.
English K and Mahon BP (2011) Allogeneic Mesenchymal Stem Cells-Agents of Immune Deviation. J Cell Biochem. Book Review [full-text] [Details] |
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2011 | Immunogenicity of embryonic stem cell-derived progenitors after transplantation.
English K and Wood KJ. (2011) Immunogenicity of embryonic stem cell-derived progenitors after transplantation. Book Review [Details] |
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2011 | Intervertebral Disc Repair: Mesenchymal Stem Cells to the Rescue?.
English, Dr Karen (2011) Intervertebral Disc Repair: Mesenchymal Stem Cells to the Rescue?. Book Review [full-text] [Details] |
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2010 | Mesenchymal stromal cells; facilitators of successful transplantation?.
English K, French A, Wood KJ. (2010) Mesenchymal stromal cells; facilitators of successful transplantation?. Book Review [full-text] [Details] |
Magazine Article
Year | Publication | |
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2021 | Mesenchymal stromal cells reduce house dust mite induced allergic airway inflammation in a humanised MIF expressing mouse model.
Dunbar, H;Hawthorne, IJ;Donnelly, S;English, K (2021) Mesenchymal stromal cells reduce house dust mite induced allergic airway inflammation in a humanised MIF expressing mouse model. HOBOKEN: Magazine Article [Details] |
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2021 | LSC-2021-Mesenchymal stromal cells reduce house dust mite induced allergic airway inflammation in a humanised MIF expressing mouse model.
Ian, H;Dunbar, H;Donnelly, S;English, K (2021) LSC-2021-Mesenchymal stromal cells reduce house dust mite induced allergic airway inflammation in a humanised MIF expressing mouse model. SHEFFIELD: Magazine Article [DOI] [Details] |
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2020 | Enhancing the potency of human mesenchymal stromal cells in acute Graft versus Host Disease; role for IFN-gamma and cyclosporine A.
English, K;Corbett, J (2020) Enhancing the potency of human mesenchymal stromal cells in acute Graft versus Host Disease; role for IFN-gamma and cyclosporine A. OXFORD: Magazine Article [Details] |
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2018 | MULTIPOTENT ADULT PROGENITOR CELLS SUPPRESS HOMEOSTATIC DRIVEN ACTIVATION OF T CELLS IN VIVO.
Carty, F;Corbett, J;Cunha, J;Reading, J;Tree, T;Ting, A;Stubblefield, S;English, K (2018) MULTIPOTENT ADULT PROGENITOR CELLS SUPPRESS HOMEOSTATIC DRIVEN ACTIVATION OF T CELLS IN VIVO. OXFORD: Magazine Article [Details] |
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2016 | Clinical grade multipotent adult progenitor cells suppress IL-7 driven stimulation of T cells in vivo.
Carty, F;Reading, J;Tree, T;Ting, A;Stubblefield, S;English, K (2016) Clinical grade multipotent adult progenitor cells suppress IL-7 driven stimulation of T cells in vivo. HOBOKEN: Magazine Article [Details] |
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2012 | Mesoangioblasts suppress T cell proliferation through IDO and PGE-2 dependent pathways.
English, K;Tonlorenzi, R;Cossu, G;Wood, KJ (2012) Mesoangioblasts suppress T cell proliferation through IDO and PGE-2 dependent pathways. HOBOKEN: Magazine Article [full-text] [Details] |
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2008 | Allogeneic mesenchymal stein cells induce CD4(+)CD25(high) Foxp3(+) T cells with suppressor activity through production of prostaglandin E2, transforming growth factor beta 1 and by direct cell contact.
English, K;Ryan, JM;Tobin, L;Barry, FP;Mahon, BP (2008) Allogeneic mesenchymal stein cells induce CD4(+)CD25(high) Foxp3(+) T cells with suppressor activity through production of prostaglandin E2, transforming growth factor beta 1 and by direct cell contact. MALDEN: Magazine Article [Details] |
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2008 | Mesenchymal stem cell therapy modulates allergic airway inflammation in syngeneic and allogeneic murine models.
Kavanagh, HM;English, K;Mahon, BM (2008) Mesenchymal stem cell therapy modulates allergic airway inflammation in syngeneic and allogeneic murine models. MALDEN: Magazine Article [Details] |
Reviews
Year | Publication | |
---|---|---|
2022 | Translating MSC Therapy in the Age of Obesity.
Boland L.;Bitterlich L.M.;Hogan A.E.;Ankrum J.A.;English K. (2022) Translating MSC Therapy in the Age of Obesity. Reviews [DOI] [Details] |
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2021 | Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges.
Masterson, CH;Ceccato, A;Artigas, A;dos Santos, C;Rocco, PR;Enes, SR;Weiss, DJ;McAuley, D;Matthay, MA;English, K;Curley, GF;Laffey, JG (2021) Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges. NEW YORK: Reviews [DOI] [full-text] [Details] |
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2021 | The inflammatory lung microenvironment; a key mediator in msc licensing.
Dunbar H.;Weiss D.J.;Enes S.R.;Laffey J.G.;English K. (2021) The inflammatory lung microenvironment; a key mediator in msc licensing. Reviews [DOI] [Details] |
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2021 | Research Progress on Strategies that can Enhance the Therapeutic Benefits of Mesenchymal Stromal Cells in Respiratory Diseases With a Specific Focus on Acute Respiratory Distress Syndrome and Other Inflammatory Lung Diseases.
Rolandsson Enes S.;Krasnodembskaya A.D.;English K.;Dos Santos C.C.;Weiss D.J. (2021) Research Progress on Strategies that can Enhance the Therapeutic Benefits of Mesenchymal Stromal Cells in Respiratory Diseases With a Specific Focus on Acute Respiratory Distress Syndrome and Other Inflammatory Lung Diseases. Reviews [DOI] [full-text] [Details] |
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2019 | The necrobiology of mesenchymal stromal cells affects therapeutic efficacy.
Weiss D.;English K.;Krasnodembskaya A.;Isaza-Correa J.;Hawthorne I.;Mahon B. (2019) The necrobiology of mesenchymal stromal cells affects therapeutic efficacy. Reviews [DOI] [Details] |
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2016 | Mesenchymal stem cells to promote islet transplant survival.
English K. (2016) Mesenchymal stem cells to promote islet transplant survival. Reviews [DOI] [Details] |
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2014 | Stem Cell Transplantation for Muscular Dystrophy: The Challenge of Immune Response.
Maffioletti, SM;Noviello, M;English, K;Tedesco, FS (2014) Stem Cell Transplantation for Muscular Dystrophy: The Challenge of Immune Response. NEW YORK: Reviews [DOI] [full-text] [Details] |
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2005 | Immunogenicity of adult mesenchymal stem cells: Lessons from the fetal allograft.
Barry, FP;Murphy, JM;English, K;Mahon, BP (2005) Immunogenicity of adult mesenchymal stem cells: Lessons from the fetal allograft. NEW ROCHELLE: Reviews [full-text] [Details] |
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2013 | Mesenchymal stromal cells in transplantation rejection and tolerance.
English K.;Wood K. (2013) Mesenchymal stromal cells in transplantation rejection and tolerance. Reviews [DOI] [full-text] [Details] |
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2013 | Mechanisms of mesenchymal stromal cell immunomodulation.
English K. (2013) Mechanisms of mesenchymal stromal cell immunomodulation. Reviews [DOI] [full-text] [Details] |
Note
Year | Publication | |
---|---|---|
2013 | Immunomodulation by adult stem cells.
English K. (2013) Immunomodulation by adult stem cells. Note [Details] |
Professional Associations
Association | Function | From / To | |
---|---|---|---|
British Society of Immunology | / | ||
European Respiratory Society | Member | 01-JAN-22 / | |
Irish Thoracic Society | Member | 01-JAN-22 / | |
International Society for Cell Therapy | Member | 01-JAN-13 / | |
Irish Society of Immunology | / |
Honours and Awards
Year | Title | Awarding Body | |
---|---|---|---|
2018 | IRC Early-Career Researcher of the Year | Irish Research Council | |
2006 | NUI Maynooth postgraduate travel grant | ||
2002 | Award for 1st in class, Third year B.Sc. NUI Maynooth | ||
2007 | Best Postgraduate Oral Presentation, Irish Society of Immu | ||
2018 | Maynooth University Early Career Researcher of the Year | Maynooth University | |
2017 | Maynooth University Enterprise Engagement Award | Maynooth University | |
2008 | Top 25 hottest articles” in Immunology Letters by Science Di | ||
2009 | Marie Curie Fellowship Intra-european Fellowship, Oxford. | ||
2007 | Dorothy Price Medal, International Postgraduate Master Class | ||
2011 | HRB Translational Medicine Postdoctoral Research Fellowship | ||
2012 | EFIS/IL Best cited paper award | ||
2012 | Marie Curie Career Integration Grant |
Committees
Committee | Function | From / To | |
---|---|---|---|
MU Athena SWAN Committee | Member | 2015 / 2020 | |
Research Coordinators Committee | Biology Postgrad Coordinator | 2017 / 2018 | |
Board of Food for Health Ireland | Maynooth University Representative | 2015 / 2018 | |
Irish Research Council International Engagement Strategy Committee | Maynooth University Representative | 2019 / 2020 | |
Biological Safety Committee | Biology Representative | 2015 / 2018 | |
National Biophotinics Imaging Platform Ireland | Maynooth University Representative | 2012 / 2014 | |
MU Communications Committee | FSE Representative | 2017 / 2020 | |
MU Biology Department Athena SWAN Committee | Chair | 2017 / 2020 | |
MU Academic Council | FSE Representative | 2018 / 2019 |
Employment
Employer | Position | From / To | |
---|---|---|---|
Nuffield Department of Surgical Sciences, University of Oxfo | Marie Curie Postdoctoral Fellow | 01-JAN-09 / 01-DEC-11 | |
Institute of Immunology, National University of Ireland, May | Postdoctoral Research Fellow | 01-JAN-08 / 31-DEC-08 | |
National University of Ireland, Maynooth, Maynooth, Co. Kild | Postdoctoral Research Fellow | 01-DEC-11 / 31-DEC-99 |
Education
Year | Institution | Qualification | Subject | |
---|---|---|---|---|
2003 | Maynooth University | Bachelor of Science | Biology and Experimental Physics | |
2008 | Maynooth University | Ph.D. | Immunology | |
2004 | Maynooth University | Masters by Research | Immunology |
Reviews
Journal | Role | |
---|---|---|
Stem Cell Research And Therapy | Associate Editor |
Teaching Interests
Recent Postgraduates
Graduation | Student Name | University | Degree | Thesis | |
---|---|---|---|---|---|
2016 | Laura Cahill | Maynooth University | PhD | An Investigation of The Effect of Hypoxic Culture on MSC Immunomodulation and Biodistribution in-vivo | |
2016 | Jennifer Corbett | Maynooth University | PhD | Investigation of the Efficacy of a Novel CsA Formulation Alone or in Combination with Cell Therapy in a Humanised Mouse Model of GvHD | |
2017 | Fiona Carty | Maynooth University | PhD | Biodistribution and modes of action of Multipoint Adult Progenitor Cell therapy in Murine models of Transplant Rejection | |
2015 | Marc E. Healy | Maynooth University | PhD | A Delineation of Mesenchymal Stromal Cell Therapeutic Action in New Models of Acute and Chronic Graft versus Host Disease | |
2018 | Aine Adams | Maynooth University | PhD | Development of a humanised mouse model of ovalbumin induced allergy and inflammation as a platform to test functional foods | |
2016 | Helen Kennelly | Maynooth University | PhD | Investigation of efficacy and mechanisms of action in mesenchymal stromal cell therapy for chronic lung diseases |
External Collaborators
Name | Role / Description | Country | |
---|---|---|---|
Prof. Claudia dos Santos, University of Toronto | Clinical Collaborator | CANADA | |
Prof. Daniel Weiss, University of Vermont | Clinical Collaborator | U.S.A. | |
Prof Ger Curley, RCSI | Clinical Collaborator | IRELAND | |
Prof John Laffey, Galway University | Co-PI | IRELAND | |
Bob Deans. Athersys Inc | Collaborative research project examining the Multistem cellular therapy in GvHD | ||
Ivan Coulter. Sigmoid Pharma | IRC EPS Joint Student PhD Scholar | ||
Catherine Flynn, Consultant Haematologist. St. James's Hospital | Clinical Collaborator | ||
Bart Vaes. ReGenesys | IRC EPS Joint PhD Student Scholar |