Dr Eoin McNamee

Biography
Research Interests
Peer Reviewed Journals
Year | Publication | |
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2020 | 'Muc5ac Expression Protects the Colonic Barrier in Experimental Colitis'
Olli K.E.;Rapp C.;O'Connell L.;Collins C.B.;McNamee E.N.;Jensen O.;Jedlicka P.;Allison K.C.;Goldberg M.S.;Gerich M.E.;Frank D.N.;Ir D.;Robertson C.E.;Evans C.M.;Aherne C.M. (2020) 'Muc5ac Expression Protects the Colonic Barrier in Experimental Colitis'. Inflammatory Bowel Diseases, 26 (9):1353-1367 [DOI] [full-text] [Details] |
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2019 | 'Epithelial HIF-1α/claudin-1 axis regulates barrier dysfunction in eosinophilic esophagitis'
Masterson JC;Biette KA;Hammer JA;Nguyen N;Capocelli KE;Saeedi BJ;Harris RF;Fernando SD;Hosford LB;Kelly CJ;Campbell EL;Ehrentraut SF;Ahmed FN;Nakagawa H;Lee JJ;McNamee EN;Glover LE;Colgan SP;Furuta GT; (2019) 'Epithelial HIF-1α/claudin-1 axis regulates barrier dysfunction in eosinophilic esophagitis'. Journal of Clinical Investigation, 129 (8) [DOI] [full-text] [Details] |
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2017 | 'Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome'
Neudecker, V;Haneklaus, M;Jensen, O;Khailova, L;Masterson, JC;Tye, H;Biette, K;Jedlicka, P;Brodsky, KS;Gerich, ME;Mack, M;Robertson, AAB;Cooper, MA;Furuta, GT;Dinarello, CA;O'Neill, LA;Eltzschig, HK;Masters, SL;McNamee, EN (2017) 'Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome'. Journal of Experimental Medicine, 214 :1737-1752 [DOI] [full-text] [Details] |
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2019 | 'Neutrophil-derived microRNAs put the (DNA) breaks of intestinal mucosal healing'
Eoin N. McNamee (2019) 'Neutrophil-derived microRNAs put the (DNA) breaks of intestinal mucosal healing'. Journal of Clinical Investigation, 129 (2):xxxx-yyyy [DOI] [full-text] [Details] |
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2018 | 'Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury'
Jennifer C. Jones , Constance D. Brindley , Nicholas H. Elder , Martin G. Myers Jr. , Michael W. Rajala , Christopher M. Dekaney , Eoin N. McNamee , Mark R. Frey , Noah F. Shroyer , Peter J. Dempsey (2018) 'Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury'. American Journal of Gastroenterology, [DOI] [full-text] [Details] |
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2017 | 'NK cells regulate CXCR2+ neutrophil recruitment during acute lung injury'
Hoegl S;Ehrentraut H;Brodsky KS;Victorino F;Golden-Mason L;Eltzschig HK;McNamee EN; (2017) 'NK cells regulate CXCR2+ neutrophil recruitment during acute lung injury'. Journal Of Leukocyte Biology, 101 (2) [DOI] [full-text] [Details] |
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2017 | 'Defective Lymphatics in Crohn's Disease: Tertiary Lymphoid Follicles Plug the Gap'
McNamee EN;Rivera-Nieves J; (2017) 'Defective Lymphatics in Crohn's Disease: Tertiary Lymphoid Follicles Plug the Gap'. Journal of Gastroenterology, 152 (4) [DOI] [full-text] [Details] |
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2016 | 'Ectopic Tertiary Lymphoid Tissue in Inflammatory Bowel Disease: Protective or Provocateur?'
McNamee EN;Rivera-Nieves J; (2016) 'Ectopic Tertiary Lymphoid Tissue in Inflammatory Bowel Disease: Protective or Provocateur?'. Frontiers in Immunology, 7 [DOI] [full-text] [Details] |
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2016 | 'Clenbuterol activates the central IL-1 system via the β2-adrenoceptor without provoking inflammatory response related behaviours in rats'
Ryan KM;Griffin ÉW;Ryan KJ;Tanveer R;Vanattou-Saifoudine N;McNamee EN;Fallon E;Heffernan S;Harkin A;Connor TJ; (2016) 'Clenbuterol activates the central IL-1 system via the β2-adrenoceptor without provoking inflammatory response related behaviours in rats'. Brain, Behavior, and Immunity, 56 [DOI] [full-text] [Details] |
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2016 | 'G2A Signaling Dampens Colitic Inflammation via Production of IFN-γ'
Frasch SC;McNamee EN;Kominsky D;Jedlicka P;Jakubzick C;Zemski Berry K;Mack M;Furuta GT;Lee JJ;Henson PM;Colgan SP;Bratton DL; (2016) 'G2A Signaling Dampens Colitic Inflammation via Production of IFN-γ'. Journal of Immunology, 197 (4) [DOI] [full-text] [Details] |
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2016 | 'Purinergic Signaling During Immune Cell Trafficking'
Ferrari D;McNamee EN;Idzko M;Gambari R;Eltzschig HK; (2016) 'Purinergic Signaling During Immune Cell Trafficking'. Trends in Immunology, 37 (6) [DOI] [full-text] [Details] |
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2015 | 'Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors'
Henry CJ;Casás-Selves M;Kim J;Zaberezhnyy V;Aghili L;Daniel AE;Jimenez L;Azam T;McNamee EN;Clambey ET;Klawitter J;Serkova NJ;Tan AC;Dinarello CA;DeGregori J; (2015) 'Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors'. Journal of Clinical Investigation, 125 (12) [DOI] [full-text] [Details] |
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2015 | 'Chemokine receptor CCR7 regulates the intestinal TH1/TH17/Treg balance during Crohn's-like murine ileitis'
McNamee EN;Masterson JC;Veny M;Collins CB;Jedlicka P;Byrne FR;Ng GY;Rivera-Nieves J; (2015) 'Chemokine receptor CCR7 regulates the intestinal TH1/TH17/Treg balance during Crohn's-like murine ileitis'. Journal Of Leukocyte Biology, 97 (6) [DOI] [full-text] [Details] |
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2015 | 'Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis'
Masterson JC;Capocelli KE;Hosford L;Biette K;McNamee EN;de Zoeten EF;Harris R;Fernando SD;Jedlicka P;Protheroe C;Lee JJ;Furuta GT; (2015) 'Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis'. Inflammatory Bowel Diseases, 21 (10) [DOI] [full-text] [Details] |
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2015 | 'Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti-Asialo-GM1 Antibody'
Victorino F;Sojka DK;Brodsky KS;McNamee EN;Masterson JC;Homann D;Yokoyama WM;Eltzschig HK;Clambey ET; (2015) 'Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti-Asialo-GM1 Antibody'. Journal of Immunology, 195 (10) [DOI] [full-text] [Details] |
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2015 | 'Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis'
Aherne CM;Saeedi B;Collins CB;Masterson JC;McNamee EN;Perrenoud L;Rapp CR;Curtis VF;Bayless A;Fletcher A;Glover LE;Evans CM;Jedlicka P;Furuta GT;de Zoeten EF;Colgan SP;Eltzschig HK; (2015) 'Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis'. Mucosal Immunology, 8 (6) [DOI] [full-text] [Details] |
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2015 | 'Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis'
Masterson JC;McNamee EN;Fillon SA;Hosford L;Harris R;Fernando SD;Jedlicka P;Iwamoto R;Jacobsen E;Protheroe C;Eltzschig HK;Colgan SP;Arita M;Lee JJ;Furuta GT; (2015) 'Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis'. Gut, 64 (8) [DOI] [full-text] [Details] |
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2014 | 'Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis'
Masterson JC;McNamee EN;Hosford L;Capocelli KE;Ruybal J;Fillon SA;Doyle AD;Eltzschig HK;Rustgi AK;Protheroe CA;Lee NA;Lee JJ;Furuta GT; (2014) 'Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis'. Gut, 63 (1) [DOI] [full-text] [Details] |
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2014 | 'Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis'
Keely S;Campbell EL;Baird AW;Hansbro PM;Shalwitz RA;Kotsakis A;McNamee EN;Eltzschig HK;Kominsky DJ;Colgan SP; (2014) 'Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis'. Mucosal Immunology, 7 (1) [DOI] [full-text] [Details] |
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2014 | 'Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation'
Campbell EL;Bruyninckx WJ;Kelly CJ;Glover LE;McNamee EN;Bowers BE;Bayless AJ;Scully M;Saeedi BJ;Golden-Mason L;Ehrentraut SF;Curtis VF;Burgess A;Garvey JF;Sorensen A;Nemenoff R;Jedlicka P;Taylor CT;Kominsky DJ;Colgan SP; (2014) 'Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation'. Immunity, 40 (1) [DOI] [full-text] [Details] |
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2013 | 'CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury'
Ehrentraut H;Clambey ET;McNamee EN;Brodsky KS;Ehrentraut SF;Poth JM;Riegel AK;Westrich JA;Colgan SP;Eltzschig HK; (2013) 'CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury'. FASEB Journal, 27 (6) [DOI] [full-text] [Details] |
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2013 | 'Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function'
McNamee EN;Korns Johnson D;Homann D;Clambey ET; (2013) 'Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function'. Immunologic Research, 55 (1-3) [DOI] [full-text] [Details] |
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2013 | 'Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury'
Koeppen M;McNamee EN;Brodsky KS;Aherne CM;Faigle M;Downey GP;Colgan SP;Evans CM;Schwartz DA;Eltzschig HK; (2013) 'Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury'. Mucosal Immunology, 6 (4) [DOI] [full-text] [Details] |
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2013 | 'Stimulation of central β2-adrenoceptors suppresses NFκB activity in rat brain: a role for IκB'
Ryan KJ;Griffin É;Yssel JD;Ryan KM;McNamee EN;Harkin A;Connor TJ; (2013) 'Stimulation of central β2-adrenoceptors suppresses NFκB activity in rat brain: a role for IκB'. Neurochemistry International, 63 (5) [DOI] [full-text] [Details] |
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2013 | 'Lactobacillus rhamnosus GG improves outcome in experimental pseudomonas aeruginosa pneumonia: potential role of regulatory T cells'
Khailova L;Baird CH;Rush AA;McNamee EN;Wischmeyer PE; (2013) 'Lactobacillus rhamnosus GG improves outcome in experimental pseudomonas aeruginosa pneumonia: potential role of regulatory T cells'. Shock (Augusta, Ga.), 40 (6) [DOI] [full-text] [Details] |
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2013 | 'Ectopic lymphoid tissue alters the chemokine gradient, increases lymphocyte retention and exacerbates murine ileitis'
McNamee EN;Masterson JC;Jedlicka P;Collins CB;Williams IR;Rivera-Nieves J; (2013) 'Ectopic lymphoid tissue alters the chemokine gradient, increases lymphocyte retention and exacerbates murine ileitis'. Gut, 62 (1) [DOI] [full-text] [Details] |
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2013 | 'Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis'
Collins CB;Aherne CM;Ehrentraut SF;Gerich ME;McNamee EN;McManus MC;Lebsack MD;Jedlicka P;Azam T;de Zoeten EF;Dinarello CA;Rivera-Nieves J; (2013) 'Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis'. Inflammatory Bowel Diseases, 19 (9) [DOI] [full-text] [Details] |
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2012 | 'Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa'
Clambey ET;McNamee EN;Westrich JA;Glover LE;Campbell EL;Jedlicka P;de Zoeten EF;Cambier JC;Stenmark KR;Colgan SP;Eltzschig HK; (2012) 'Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa'. Proceedings of the National Academy of Sciences of the United States of America, 109 (41) [DOI] [full-text] [Details] |
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2012 | 'Flt3 ligand expands CD103⁺ dendritic cells and FoxP3⁺ T regulatory cells, and attenuates Crohn's-like murine ileitis'
Collins CB;Aherne CM;McNamee EN;Lebsack MD;Eltzschig H;Jedlicka P;Rivera-Nieves J; (2012) 'Flt3 ligand expands CD103⁺ dendritic cells and FoxP3⁺ T regulatory cells, and attenuates Crohn's-like murine ileitis'. Gut, 61 (8) [DOI] [full-text] [Details] |
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2011 | 'CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling'
Masterson JC;McNamee EN;Jedlicka P;Fillon S;Ruybal J;Hosford L;Rivera-Nieves J;Lee JJ;Furuta GT; (2011) 'CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling'. American Journal of Pathology, 179 (5) [DOI] [full-text] [Details] |
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2011 | 'The chemokine receptor CCR9 is required for the T-cell-mediated regulation of chronic ileitis in mice'
Wermers JD;McNamee EN;Wurbel MA;Jedlicka P;Rivera-Nieves J; (2011) 'The chemokine receptor CCR9 is required for the T-cell-mediated regulation of chronic ileitis in mice'. Journal of Gastroenterology, 140 (5) [DOI] [full-text] [Details] |
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2011 | 'Interleukin 37 expression protects mice from colitis'
McNamee EN;Masterson JC;Jedlicka P;McManus M;Grenz A;Collins CB;Nold MF;Nold-Petry C;Bufler P;Dinarello CA;Rivera-Nieves J; (2011) 'Interleukin 37 expression protects mice from colitis'. Proceedings of the National Academy of Sciences of the United States of America, 108 (40) [DOI] [full-text] [Details] |
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2010 | 'Novel model of TH2-polarized chronic ileitis: the SAMP1 mouse'
McNamee EN;Wermers JD;Masterson JC;Collins CB;Lebsack MD;Fillon S;Robinson ZD;Grenawalt J;Lee JJ;Jedlicka P;Furuta GT;Rivera-Nieves J; (2010) 'Novel model of TH2-polarized chronic ileitis: the SAMP1 mouse'. Inflammatory Bowel Diseases, 16 (5) [DOI] [full-text] [Details] |
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2010 | 'Cell-specific inhibition of p38alpha as a therapeutic strategy for inflammatory bowel disease'
McNamee EN;Collins CB;Lebsack MD;Rivera-Nieves J; (2010) 'Cell-specific inhibition of p38alpha as a therapeutic strategy for inflammatory bowel disease'. Journal of Gastroenterology, 138 (4) [DOI] [full-text] [Details] |
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2010 | 'Chemokine decoy receptor D6 in inflammatory bowel disease (IBD) and IBD-associated colon cancer'
Collins CB;McNamee EN;Wermers JD;Lebsack MD;Rivera-Nieves J; (2010) 'Chemokine decoy receptor D6 in inflammatory bowel disease (IBD) and IBD-associated colon cancer'. Gut, 59 (2) [DOI] [full-text] [Details] |
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2010 | 'Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex'
McNamee EN;Griffin EW;Ryan KM;Ryan KJ;Heffernan S;Harkin A;Connor TJ; (2010) 'Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex'. Neuropharmacology, 59 (1-2) [DOI] [full-text] [Details] |
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2010 | 'Noradrenaline induces IL-1ra and IL-1 type II receptor expression in primary glial cells and protects against IL-1beta-induced neurotoxicity'
McNamee EN;Ryan KM;Kilroy D;Connor TJ; (2010) 'Noradrenaline induces IL-1ra and IL-1 type II receptor expression in primary glial cells and protects against IL-1beta-induced neurotoxicity'. European Journal of Pharmacology, 626 (2-3) [DOI] [full-text] [Details] |
Honours and Awards
Year | Title | Awarding Body | |
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2019 | SFI President of Ireland Future Research Leader Award | Science Foundation Ireland | |
2017 | Principal Investigator Award (R01) | National Institutes of Health, USA (NIDDK) | |
2016 | Senior Research Award | Crohn’s & Colitis Foundation of America | |
2013 | Career Development Award | Crohn’s & Colitis Foundation of America | |
2011 | Research Fellowship Award | Crohn’s & Colitis Foundation of America - | |
2008 | scholar award (Travel) | PsychoNeuroImmunology Research Society (PNIRS) | |
2007 | Trinity College Trust postgraduate award | Trinity College Dublin |
Professional Associations
Association | Function | From / To | |
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American Association of Immunologists | Member | / | |
Society for Mucosal Immunology | Member | / | |
Irish Society for Immunology | Member | / |