Dr Diego Montagner

Chemistry, Human Health Institute

Lecturer

Callan Building
2nd floor (ex Computer Science) office
2.112
(01) 474 7510

Biography

2016 Lecturer in Chemistry, Department of Chemistry, Maynooth University, Ireland
2015 Lecturer in Chemistry   School of Chemistry, National University of Ireland, Galway
2013- 2014 Marie Curie Post-Doctoral fellow School of Chemistry, National University of Ireland, Galway
2012-2013 Post-Doctoral Fellow Chemistry Department, National University of Singapore, Singapore
2011 Visiting Scientist School of Chemistry, National University of Ireland, Galway
2009-2010 Visiting Scientist Inorganic Chemistry Department, Dortmund University, Germany
2008 PhD in Chemistry University of Padua,  Italy

Research Interests

Our research is inserted in the big area of Bioinorganic Chemistry and it is placed at the interface between inorganic/medicinal chemistry and biology.
It is focused on the development of new metal based drugs
that could be selectively delivered and accumulated into the tumor cell and that interact with biologically-relevant macromolecules with different mechanism of action.

In particolar we are interested in:
1) Pt(IV) prodrug complexes with targeted axial ligands;
2) Cu(II) complexes that interact with the DNA via different pathways;
3) Au(I) carbene complexes as antimicrobial compunds;
4) metal based complexes (Cu(II), Zn(II), Fe(III)) that act as metallo-nuclease enzymes.

In our lab we design, synthetise and characterise with different spectroscopic techniques (multinuclear NMR, Mass, IR, UV, HPLC, AA) the metal based complexes.
In combination with our national and international collaborators we will study and speculate on the mode of action, interaction with biomolecules and cytotoxic activity of the new metal-based drugs.

Peer Reviewed Journals

  Year Publication
2019 'Synthesis, characterisation and in vitro antitumour potential of novel Pt(II) estrogen linked complexes'
E. Kitteringham, E. Andriollo, V. Gandin, D. Montagner, D. Griffith (2019) 'Synthesis, characterisation and in vitro antitumour potential of novel Pt(II) estrogen linked complexes'. Inorganica Chimica Acta, [DOI] [Details]
2019 'Anticancer activity, DNA binding and cell mechanistic studies of estrogen-functionalised Cu(II) complexes'
Barrett, S;De Franco, M;Kellett, A;Dempsey, E;Marzano, C;Erxleben, A;Gandin, V;Montagner, D (2019) 'Anticancer activity, DNA binding and cell mechanistic studies of estrogen-functionalised Cu(II) complexes'. Journal of Biological Inorganic Chemistry, [DOI] [Details]
2019 'Stability of antibacterial Te(IV) compounds: A combined experimental and computational study'
K. D'Arcy, A.P. Doyle, K. Kavanagh, L. Ronconi, B. Fresch, D. Montagner* (2019) 'Stability of antibacterial Te(IV) compounds: A combined experimental and computational study'. Journal of Inorganic Biochemistry, [DOI] [Details]
2019 'Cytotoxicity and ROS production of novel Pt(IV) oxaliplatin derivatives with indole propionic acid'
D. Tolan, A. Almoitairy, O. Howe, M. Devereaux, A. Erxleben, D. Montagner* (2019) 'Cytotoxicity and ROS production of novel Pt(IV) oxaliplatin derivatives with indole propionic acid'. Inorganica Chimica Acta, 492 :262-267 [DOI] [Details]
2018 'An innovative and efficient route to the synthesis of metal-based glycoconjugates: proof-of-concept and potential applications'
Pettenuzzo, Montagner, McArdle, Ronconi (2018) 'An innovative and efficient route to the synthesis of metal-based glycoconjugates: proof-of-concept and potential applications'. Dalton Transactions, [DOI] [Details]
2018 'Evaluation of in vitro and in vivo antibacterial activity of novel Cu(II)-steroid complexes'
Stephen Barrett , Stephen Delaney, Kevin Kavanagh, Diego Montagner* (2018) 'Evaluation of in vitro and in vivo antibacterial activity of novel Cu(II)-steroid complexes'. Inorganica Chimica Acta, 479 :261-265 [DOI] [Details]
2018 'A Pt(IV) prodrug combining Chlorambucil and cisplatin: a Dual Acting Weapon for targeting DNA in cancer cells'
Montagner*, Tolan, Andriollo, Gandin, Marzano (2018) 'A Pt(IV) prodrug combining Chlorambucil and cisplatin: a Dual Acting Weapon for targeting DNA in cancer cells'. International Journal of Molecular Sciences, 19 [DOI] [IR Link] [Details]
2018 'A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage'
Molphy Z;Montagner D;Bhat SS;Slator C;Long C;Erxleben A;Kellett A; (2018) 'A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage'. Nucleic Acids Research, [DOI] [IR Link] [Details]
2018 'Increased immune cell infiltration in patient-derived tumor explants treated with Traniplatin: an original Pt(IV) pro-drug based on Cisplatin and Tranilas'
Daniele Lo Re, Diego Montagner*, Dina Tolan, Di Sanza, Mar Iglesias, A. Calon, E. Giralt (2018) 'Increased immune cell infiltration in patient-derived tumor explants treated with Traniplatin: an original Pt(IV) pro-drug based on Cisplatin and Tranilas'. Chemical Communications, [DOI] [Details]
2018 'Development of an Efficient Dual‐action GST‐inhibiting Anticancer Platinum(IV) Prodrug'
Diego Montagner*, Keefe Guang Zhi Lee, Maria Babak, Andrea Weiss, Paul Dyson, Patrycja Novak-Slowinska, Wee han Ang (2018) 'Development of an Efficient Dual‐action GST‐inhibiting Anticancer Platinum(IV) Prodrug'. ChemMedChem, [DOI] [Details]
2017 'Estrogen functionalised metal complexes: selective anticancer and antibacterial activity'
Montagner Diego, A. Erxleben, P. Sanz Miguel, K. Kavanagh, A. Kellett (2017) 'Estrogen functionalised metal complexes: selective anticancer and antibacterial activity'. Journal of Biological Inorganic Chemistry, 22 (Suppl 1) [DOI] [Details]
2017 'Steroid-Au(I)-NHC Complexes: Synthesis and Antibacterial Activity'
Velle', Maguire, Kavanagh, Sanz Miguel, Montagner* (2017) 'Steroid-Au(I)-NHC Complexes: Synthesis and Antibacterial Activity'. ChemMedChem, 12 :841-844 [DOI] [IR Link] [Details]
2017 'Antitumor platinum(IV) derivatives of carboplatin and the histone deacetylase inhibitor 4-phenylbutyric acid'
Almotairy, Gandin, Morrison, Marzano, Erxleben and Montagner* (2017) 'Antitumor platinum(IV) derivatives of carboplatin and the histone deacetylase inhibitor 4-phenylbutyric acid'. JOURNAL OF INORGANIC BIOCHEMISTRY   , 177 :1-7 [DOI] [IR Link] [Details]
2017 'A Cu(II) Complex Targeting the Translocator Protein: In Vitro and In Vivo Antitumor Potential and Mechanistic Insights'
Montagner D, Fresch B, Browne K, Gandin V, Erxleben A (2017) 'A Cu(II) Complex Targeting the Translocator Protein: In Vitro and In Vivo Antitumor Potential and Mechanistic Insights'. Chemical Communications, 53 :134-137 [DOI] [IR Link] [Details]
2016 'Oxidative Stress Induced by Pt(IV) Pro-drugs Based on the Cisplatin Scaffold and Indole Carboxylic Acids in Axial Position'
Tolan, Gandin, Morrison, El-Nahas, Marzano, Erxleben, Montagner* (2016) 'Oxidative Stress Induced by Pt(IV) Pro-drugs Based on the Cisplatin Scaffold and Indole Carboxylic Acids in Axial Position'. Scientific Reports, 6 :29367-29373 [DOI] [IR Link] [Details]
2016 'DNA binding, cleavage and cytotoxicity of a novel dimetallic Fe(III) triaza-cyclononane complex'
Pinheiro Araujo, Gandin, Kavanagh, Braude, Nodari, Montagner,* Erxleben (2016) 'DNA binding, cleavage and cytotoxicity of a novel dimetallic Fe(III) triaza-cyclononane complex'. INORGANICA CHIMICA ACTA , 142 :170-175 [DOI] [Details]
2015 'DNA damage and induction of apoptosis in pancreatic cancer cells by a new dinuclear bis(triazacyclonane) copper complex'
Montagner, Gandin, Marzano, Erxleben (2015) 'DNA damage and induction of apoptosis in pancreatic cancer cells by a new dinuclear bis(triazacyclonane) copper complex'. JOURNAL OF INORGANIC BIOCHEMISTRY   , 145 :101-107 [DOI] [IR Link] [Details]
2014 'Phosphate Diester Cleavage, DNA Interaction and Cytotoxic Activity of a Bimetallic Bis(1,4,7-triazacyclononane) Zn Complex'
Montagner,* Gandin, Marzano, Erxleben (2014) 'Phosphate Diester Cleavage, DNA Interaction and Cytotoxic Activity of a Bimetallic Bis(1,4,7-triazacyclononane) Zn Complex'. European Journal of Inorganic Chemistry, :4084-4092 [DOI] [IR Link] [Details]
2014 'Investigating Cell Entry of Cisplatin and Anticancer Platinum(IV) Prodrugs Using Fluorescence Microscopy'
Ang, Montagner, Siew Qi (2014) 'Investigating Cell Entry of Cisplatin and Anticancer Platinum(IV) Prodrugs Using Fluorescence Microscopy'. Journal of Biological Inorganic Chemistry, 19 :194-194 [Details]
2014 'DNA cleavage ability and cytotoxicity of mono- and di-nuclear copper complexes'
Erxleben, Montagner, Gandin (2014) 'DNA cleavage ability and cytotoxicity of mono- and di-nuclear copper complexes'. Journal of Biological Inorganic Chemistry, 19 :733-733 [Details]
2013 'A Fluorescent Probe for Investigating the Activation of Anticancer Platinum(IV) Prodrugs Based on the Cisplatin Scaffold'
Montagner Diego, Yap Siew Qi, Wee Han Ang. (2013) 'A Fluorescent Probe for Investigating the Activation of Anticancer Platinum(IV) Prodrugs Based on the Cisplatin Scaffold'. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 52 :11785-11789 [IR Link] [Details]
2011 'Metal-promoted synthesis of amidines containing the model nucleobases 1-methylcytosine and 9-methyladenine'
Montagner,* Zangrando, Borsato, Lucchini, Longato (2011) 'Metal-promoted synthesis of amidines containing the model nucleobases 1-methylcytosine and 9-methyladenine'. Dalton Transactions, 40 :8664-8674 [DOI] [IR Link] [Details]
2011 'Pt(II) and Pd(II) Pyrrolidine-Dithiocarbamates Investigated by XPS'
Wenisch, Montagner, Helm, Tondello, Gross (2011) 'Pt(II) and Pd(II) Pyrrolidine-Dithiocarbamates Investigated by XPS'. Surface Science Spectra, 18 :82-90 [DOI] [Details]
2011 'Unique Pt5 metallacycle: [PtIICl(pyrrolidinedithiocarbamate)]5'
Montagner,* Sanz Miguel (2011) 'Unique Pt5 metallacycle: [PtIICl(pyrrolidinedithiocarbamate)]5'. Dalton Transactions, 40 :10809-10811 [DOI] [IR Link] [Details]
2011 'Synthesis, characterization and cytotoxic activity of palladium (II) dithiocarbamate complexes with ,-diamines'
Montagner,* Marzano, gandin (2011) 'Synthesis, characterization and cytotoxic activity of palladium (II) dithiocarbamate complexes with ,-diamines'. INORGANICA CHIMICA ACTA , 376 :574-580 [DOI] [IR Link] [Details]
2011 'Synthesis, characterization and cytotoxic properties of platinum(II) complexes containing the nucleosides adenosine and cytidine'
Montagner Diego, Gandin Valentina, Marzano Cristina, Longato Bruno (2011) 'Synthesis, characterization and cytotoxic properties of platinum(II) complexes containing the nucleosides adenosine and cytidine'. JOURNAL OF INORGANIC BIOCHEMISTRY   , 105 :919-926 [IR Link] [Details]
2010 'Irreversibile Insertion of Benzonitrile into Platinum(II)-Nitrogen Bonds of Nucleobase Complexes. Synthesis and Structural Characterization of Stable Azametallacycle Compounds'
Montagner, Venzi, Zangrando, Longato (2010) 'Irreversibile Insertion of Benzonitrile into Platinum(II)-Nitrogen Bonds of Nucleobase Complexes. Synthesis and Structural Characterization of Stable Azametallacycle Compounds'. Inorganic Chemistry, 49 :2013-2019 [DOI] [IR Link] [Details]
2009 'Role of the ancillary ligands on the stabilisation of the imino-oxo tautomer of 1-methylcytosine in PtII complexes'
Longato, Montagner, Zangrando (2009) 'Role of the ancillary ligands on the stabilisation of the imino-oxo tautomer of 1-methylcytosine in PtII complexes'. Dalton Transactions, :2400-2405 [DOI] [IR Link] [Details]
2009 'Stabilisation of the iminooxo tautomer of 1-Methylcytosine in PtII complexes: Role of the ancillary ligands'
Montagner, Zangrando, Longato (2009) 'Stabilisation of the iminooxo tautomer of 1-Methylcytosine in PtII complexes: Role of the ancillary ligands'. INORGANICA CHIMICA ACTA , 362 :725-732 [DOI] [IR Link] [Details]
2008 'Role of the Phosphine Ligands on the Stabilization of Monoadducts of the Model Nucleobases 1-Methylcytosine and 9-Methylguanine in Platinum(II) Complexes'
Montagner, Zangrando, Longato (2008) 'Role of the Phosphine Ligands on the Stabilization of Monoadducts of the Model Nucleobases 1-Methylcytosine and 9-Methylguanine in Platinum(II) Complexes'. Inorganic Chemistry, 47 :2588-2595 [DOI] [IR Link] [Details]
2008 'Synthesis and characterization of cis-[(PPh3)2Pt{9-MeAd(-H)N6N7}]X (X- = NO3, PF6): the first example of a Platinum(II) complex containing the N6,N7-chelated 9-methyladenine anion'
Montagner,* Longato (2008) 'Synthesis and characterization of cis-[(PPh3)2Pt{9-MeAd(-H)N6N7}]X (X- = NO3, PF6): the first example of a Platinum(II) complex containing the N6,N7-chelated 9-methyladenine anion'. INORGANICA CHIMICA ACTA , 361 :1676-1680 [DOI] [IR Link] [Details]
2006 'Platinum(II)-Mediated Coupling Reactions of Acetonitrile with the Exocyclic Nitrogen of 9-Methyladenine and 1-Methylcytosine. Synthesis, NMR Characterization and X-ray Structures of NewAzametallacycle Complexes'
Longato, Montagner, Bandoli, Zangrando (2006) 'Platinum(II)-Mediated Coupling Reactions of Acetonitrile with the Exocyclic Nitrogen of 9-Methyladenine and 1-Methylcytosine. Synthesis, NMR Characterization and X-ray Structures of NewAzametallacycle Complexes'. Inorganic Chemistry, 45 :1805-1814 [DOI] [IR Link] [Details]
2006 'Mono- and Polynuclear Complexes of the Model Nucleobase 1-Methylcytosine. Synthesis and Characterization of cis-[(PMe2Ph)2Pt{1-MeCy(- H)}]3(NO3)3 and cis-[(PPh3)2Pt{1-MeCy(-H)}(1-MeCy)]NO3'
Longato, Montagner, Zangrando (2006) 'Mono- and Polynuclear Complexes of the Model Nucleobase 1-Methylcytosine. Synthesis and Characterization of cis-[(PMe2Ph)2Pt{1-MeCy(- H)}]3(NO3)3 and cis-[(PPh3)2Pt{1-MeCy(-H)}(1-MeCy)]NO3'. Inorganic Chemistry, 45 :8179-8187 [DOI] [Details]
2005 'Pyrrolidine dithiocarbamates of Pd(II)'
Faraglia, Sitran, Montagner (2005) 'Pyrrolidine dithiocarbamates of Pd(II)'. INORGANICA CHIMICA ACTA , 358 :971-980 [DOI] [IR Link] [Details]

Professional Associations

  Association Function From / To
Royal Society of Chemistry member /
Italian Chemistry Society member /
CIRCMSB (Interuniversity Consortium for the Research in the Chemistry of Metals in Biological System) member /

Languages

  Language Reading Writing Speaking
Italian Fluent Fluent Fluent
German Functional Functional Functional
Spanish Fluent Fluent Fluent
English Fluent Fluent Fluent

Reviews

  Journal Role
Biophysical Chemistry Reviewer
Inorganica Chimica Acta Reviewer

Teaching Interests

CH204 s-block chemistry and principles of solid state chemistry
CH302C Inorganic Polymers
CH311 metal-carbonyl metallorganic complexes
CH406C Organic Polymers
CH407C Bioinorganic Chemsitry and Metals in Medicine

Internal Collaborators

  Name Institute Country
Kevin Kavanagh Biology department NUIM IRELAND

External Collaborators

  Name Role / Description Country
Andrew Kellett IRELAND
Barbara Fresch BELGIUM
Raffaele Ricco' AUSTRIA
Andrea Erxleben IRELAND
Valentina Gandin ITALY
Pablo Sanz Miguel SPAIN
Ang Wee Han SINGAPORE
Daniele Lo Re SPAIN