Prof Sean Doyle

Biology

Professor
Biotechnology Programme Coordinator

Callan
1.24
(01) 7083858

Biography

1985 BSc Biochemistry, UCC, Ireland.
1989 PhD Biochemistry, UCC, Ireland.
1989-90 Unilever Research, UK.
1990-93 Wellcome Diagnostics, UK.
1993-97 Biotrin, Dublin, Ireland.
1997- 2001 Lecturer, Maynooth University.
2001- 2008 Senior Lecturer, Maynooth University.
2009- date Professor, Maynooth University.


Research Interests

My molecular and applied proteomics work, which has resulted in over 100 peer-reviewed publications, is directed towards understanding microbial pathogenicity and identifying new biotechnological, therapeutic and diagnostic targets. https://scholar.google.com/citations?user=DJhTVdEAAAAJ&hl=en
I was also instrumental in securing competitive SFI funding for Departmental quantitative mass spectrometry facilities- now available to internal & external users. My group also has a number of academic and industrial collaborations and group members have been pro-active in the promotion of the public understanding of science through participation in such activities as the Maynooth University Chain Reaction Lecture Series and the National Science Week. Research work in the laboratory is funded by Science Foundation Ireland, The Irish Research Council (IRC), Enterprise Ireland and Industry (Alltech, Airmid, Sylvan and Accuplex Diagnostics).
Research area 1 Aspergillus fumigatus: We study the biology, diagnosis and molecular genetics of the human pathogenic fungus, Aspergillus fumigatus - a major cause of infection in immunocompromised individuals. Our group has identified a number of potential virulence factors (proteins) in the organism, which may contribute both to its pathogenicity and emerging resistance to conventional chemotherapies. We were the first to identify and characterise a novel self-protection mechanism against gliotoxin in Aspergillus fumigatus. We have also identified a number of non-ribosomal peptide synthetases and glutathione s-transferases in A. fumigatus. Interestingly, non-ribosomal peptide synthetases in fungi represent a novel source of bioactive metabolites and our published work is at the cutting-edge of this internationally competitive area. The primary research methods involved in this work comprise gene deletion studies, proteomics, NMR and LC-MS. Collaborators: Professor Gary Jones (Leeds-Beckett University, UK, Dr David Fitzpatrick, Professor Hubertus Haas (Innsbruck, Austria), Professor Gustavo Goldman (Sao Paulo, Brazil), Dr Siobhan McClean (UCD) & Dr Maire Callaghan (ITT Dublin).
Research area 2 Armillaria mellea: In the past, this plant pathogenic fungus has proven recalcitrant to detailed molecular analysis. However, we have undertaken genome sequencing of this organism and have established a robust proteomics pipeline to identify novel biocatalysts (enzymes) with biotechnological, pharmaceutical and biofuel applications. This work involves conventional individual protein mass spectrometry and shotgun proteomics. The primary research methods involved in this work comprise genome sequencing, bioinformatics, proteomics, HPLC and small molecule LC-MS. Collaborators: Dr David Fitzpatrick (NUI Maynooth), Dr Thomas Keane and Dr Dan Turner (UK).
Research area 3 Immunodiagnostics: Using a well-established recombinant protein expression systems (E. coli and baculovirus) we have expressed a number of A. fumigatus proteins in order to assess their diagnostic potential. In addition, we have developed novel immunoassays to detect fungal metabolites as disease indicators. Proteomic studies of a number of organisms, using Departmental protein mass spectrometry facilities, are also well underway and peer-reviewed publications are now emerging from these efforts. Research equipment infrastructure available for Industry-Academia Collaborations The Department of Biology possesses a range of modern molecular and proteomic instrumentation which is used for both PhD and Post-Doctoral Research projects. This equipment, much of which has been funded by competitive awards from the HEA, HRB, SFI and Enterprise Ireland, is also available for use by companies on a commercial basis. For further details see:

Book Chapters

  Year Publication
2017 'Fungal Proteomics'
Doyle S. and Owens R.A. (2017) 'Fungal Proteomics' In: K. Kavanagh (eds). Fungi: Biology and Applications, 3rd Edition. United Kingdom: Wiley Blackwell. [Details]
2014 'Virulence Characteristics of Aspergillus fumigatus'
Owens R.A., O’Keeffe G. O’Hanlon K.A., Gallagher L. and Doyle S. (2014) 'Virulence Characteristics of Aspergillus fumigatus' In: Human Pathogenic Fungi: Molecular Biology and Pathogenic Mechanisms. Norfolk, UK: Caister Academic Press. [Details]
2011 'Fungal Proteomics'
Doyle, S (2011) 'Fungal Proteomics' In: FUNGI: BIOLOGY AND APPLICATIONS, 2ND EDITION. OXFORD: BLACKWELL SCIENCE PUBL. [Details]
2011 'Purification of Proteins from Baculovirus-Infected Insect Cells'
O'Shaughnessy, L;Doyle, S (2011) 'Purification of Proteins from Baculovirus-Infected Insect Cells' In: PROTEIN CHROMATOGRAPHY: METHODS AND PROTOCOLS. TOTOWA: HUMANA PRESS INC. [DOI] [Details]
2011 'The Detection of Parvoviruses'
Doyle, S. (2011) 'The Detection of Parvoviruses' In: Methods in Molecular Biology- Diagnostic Virology Protocols. Humana Press. [DOI] [IR Link] [Details]
2010 'Nonribosomal Peptide Synthesis'
Doyle S. (2010) 'Nonribosomal Peptide Synthesis' In: Amino Acids, Peptides and Proteins in Organic Chemistry. [DOI] [Details]
2007 'Human Parvovirus B19: Molecular Virology, Clinical Features, Prevalence, Diagnosis and Control'
Corcoran, A;Doyle, S (2007) 'Human Parvovirus B19: Molecular Virology, Clinical Features, Prevalence, Diagnosis and Control' In: CONGENITAL AND OTHER RELATED INFECTIOUS DISEASES OF THE NEWBORN. AMSTERDAM: ELSEVIER SCIENCE BV. [DOI] [Details]
1996 'Alpha Glutathione s-transferases as biomarkers of organ viability and damage'
C.G. Kilty and S. Doyle (1996) 'Alpha Glutathione s-transferases as biomarkers of organ viability and damage' In: Glutathione s-Transferases: Structure, Function and Clinical Implications. London: Taylor & Francis Limited. [Details]

Peer Reviewed Journals

  Year Publication
2017 'Genome expansion and lineage-specific genetic innovations in the forest pathogenic fungi Armillaria'
Sipos G;Prasanna AN;Walter MC;O'Connor E;Bálint B;Krizsán K;Kiss B;Hess J;Varga T;Slot J;Riley R;Bóka B;Rigling D;Barry K;Lee J;Mihaltcheva S;LaButti K;Lipzen A;Waldron R;Moloney NM;Sperisen C;Kredics L;Vágvölgyi C;Patrignani A;Fitzpatrick D;Nagy I;Doyle S;Anderson JB;Grigoriev IV;Güldener U;Münsterkötter M;Nagy LG; (2017) 'Genome expansion and lineage-specific genetic innovations in the forest pathogenic fungi Armillaria'. Nature Ecology & Evolution, [DOI] [Details]
2017 'Functional Investigation of Iron-Responsive Microsomal Proteins, Including MirC, in Aspergillus fumigatus'
Mulvihill, E.D., Moloney, N.M., Owens, R.A., Dolan, S.K., Russell, L. and Doyle S. (2017) 'Functional Investigation of Iron-Responsive Microsomal Proteins, Including MirC, in Aspergillus fumigatus'. Frontiers in Microbiology, 8 (418):1-15 [DOI] [Details]
2017 'Draft Genome Sequence of Dermatophagoides pteronyssinus, the European House Dust Mite'
Waldron R;McGowan J;Gordon N;McCarthy C;Mitchell EB;Doyle S;Fitzpatrick DA; (2017) 'Draft Genome Sequence of Dermatophagoides pteronyssinus, the European House Dust Mite'. Genome Announcements, 5 (32) [DOI] [Details]
2017 'Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence'
Manfiolli AO;de Castro PA;Dos Reis TF;Dolan S;Doyle S;Jones G;Riaño Pachón DM;Ulaş M;Noble LM;Mattern DJ;Brakhage AA;Valiante V;Silva-Rocha R;Bayram O;Goldman GH; (2017) 'Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence'. Cellular Microbiology, [DOI] [Details]
2017 'Quantitative proteomics reveals new insights into calcium-mediated resistance mechanisms in Aspergillus flavus against the antifungal protein PgAFP in cheese'
Delgado, J., Owens, R.A., Doyle, S., Nunez, F., Asensio M.A. (2017) 'Quantitative proteomics reveals new insights into calcium-mediated resistance mechanisms in Aspergillus flavus against the antifungal protein PgAFP in cheese'. Food Microbiology, [DOI] [Details]
2017 'Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus'
Dolan S.K, Bock, T., Hering, V., Owens, R.A., Jones, G.W., Blankenfeldt W., Doyle S. (2017) 'Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus'. Open Biology, 7 [DOI] [Details]
2016 'Antifungal proteins from moulds: analytical tools and potential application to dry-ripened foods'
Delgado J;Owens RA;Doyle S;Asensio MA;Núñez F; (2016) 'Antifungal proteins from moulds: analytical tools and potential application to dry-ripened foods'. Applied Microbiology and Biotechnology, 100 (16):6991-6700 [DOI] [Details]
2016 'The Aspergillus fumigatus SchA(SCH9) kinase modulates SakA(HOG1) MAP kinase activity and it is essential for virulence'
de Castro PA;Dos Reis TF;Dolan SK;Manfiolli AO;Brown NA;Jones GW;Doyle S;Riaño-Pachón DM;Squina FM;Caldana C;Singh A;Del Poeta M;Hagiwara D;Silva-Rocha R;Goldman GH; (2016) 'The Aspergillus fumigatus SchA(SCH9) kinase modulates SakA(HOG1) MAP kinase activity and it is essential for virulence'. Molecular Microbiology, [DOI] [Details]
2016 'Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus'
Sheridan KJ;Lechner BE;Keeffe GO;Keller MA;Werner ER;Lindner H;Jones GW;Haas H;Doyle S; (2016) 'Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus'. Scientific Reports, 6 [DOI] [Details]
2016 'Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis-Associated Pathogen Burkholderia cepacia Complex to Lung Epithelial Cells and Protect Mice against Infection'
McClean S;Healy ME;Collins C;Carberry S;O'Shaughnessy L;Dennehy R;Adams Á;Kennelly H;Corbett JM;Carty F;Cahill LA;Callaghan M;English K;Mahon BP;Doyle S;Shinoy M; (2016) 'Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis-Associated Pathogen Burkholderia cepacia Complex to Lung Epithelial Cells and Protect Mice against Infection'. Infection and Immunity, 84 (5) [DOI] [IR Link] [Details]
2016 'Exploring sulfur assimilation of Aspergillus fumigatus reveals biosynthesis of sulfur-containing amino acids as a virulence determinant'
Amich, J., Dmig M., O'Keeffe, G., Binder, J., Doyle, S., Beilhack, A. and Krappmann, S. (2016) 'Exploring sulfur assimilation of Aspergillus fumigatus reveals biosynthesis of sulfur-containing amino acids as a virulence determinant'. INFECTION AND IMMUNITY, Accepted [DOI] [IR Link] [Details]
2016 'The iron-responsive microsomal proteome of Aspergillus fumigatus'
Moloney, NM*; Owens, RA*; Meleady, P; Henry, M; Dolan, SK; Mulvihill, E; Clynes, M; Doyle, S (2016) 'The iron-responsive microsomal proteome of Aspergillus fumigatus'. JOURNAL OF PROTEOMICS, 136 :99-111 [DOI] [Details]
2016 'Increased chitin biosynthesis contributes to the resistance of Penicillium polonicum against the antifungal protein PgAFP'
Delgado, J., Owens, R.A., Doyle, S., Asensio, M.A. and Núñez, F. (2016) 'Increased chitin biosynthesis contributes to the resistance of Penicillium polonicum against the antifungal protein PgAFP'. Applied Microbiology and Biotechnology, 100 :371-383 [DOI] [Details]
2016 'Towards understanding the gliotoxin detoxification mechanism: in vivo thiomethylation protects yeast from gliotoxin cytotoxicity'
Elizabeth B. Smith, Stephen K. Dolan, David A. Fitzpatrick, Sean Doyle and Gary W. Jones (2016) 'Towards understanding the gliotoxin detoxification mechanism: in vivo thiomethylation protects yeast from gliotoxin cytotoxicity'. Microbial Cell, 3 (3):120-125 [DOI] [Details]
2016 'Proteomic analysis of Aspergillus fumigatus - clinical implications'
Moloney NM;Owens RA;Doyle S; (2016) 'Proteomic analysis of Aspergillus fumigatus - clinical implications'. Expert Review of Proteomics, [DOI] [Details]
2016 'Quantitative proteomics reveals the mechanism and consequence of gliotoxin-mediated dysregulation of the methionine cycle in Aspergillus niger'
Manzanares-Miralles, L;Sarikaya-Bayram, O;Smith, EB;Dolan, SK;Bayram, O;Jones, GW;Doyle, S (2016) 'Quantitative proteomics reveals the mechanism and consequence of gliotoxin-mediated dysregulation of the methionine cycle in Aspergillus niger'. JOURNAL OF PROTEOMICS, 131 :149-162 [DOI] [IR Link] [Details]
2015 'Impact of the antifungal protein PgAFP from Penicillium chrysogenum on the protein profile in Aspergillus flavus'
Delgado, J;Owens, RA;Doyle, S;Asensio, MA;Nunez, F (2015) 'Impact of the antifungal protein PgAFP from Penicillium chrysogenum on the protein profile in Aspergillus flavus'. Applied Microbiology and Biotechnology, 99 :8701-8715 [DOI] [Details]
2015 'Filamentous fungi as a source of natural antioxidants'
Smith, H;Doyle, S;Murphy, R (2015) 'Filamentous fungi as a source of natural antioxidants'. Food Chemistry, 185 :389-397 [Details]
2015 'Endogenous cross-talk of fungal metabolites'
Sheridan, KJ;Dolan, SK;Doyle, S (2015) 'Endogenous cross-talk of fungal metabolites'. Frontiers in Microbiology, 5 [DOI] [IR Link] [Details]
2015 'A role for the Parkinson's disease protein DJ-1 as a chaperone and antioxidant in the anhydrobiotic nematode Panagrolaimus superbus'
Culleton, BA;Lall, P;Kinsella, GK;Doyle, S;McCaffrey, J;Fitzpatrick, DA;Burnell, AM (2015) 'A role for the Parkinson's disease protein DJ-1 as a chaperone and antioxidant in the anhydrobiotic nematode Panagrolaimus superbus'. Cell Stress and Chaperones, 20 :121-137 [DOI] [Details]
2015 'Systematic Global Analysis of Genes Encoding Protein Phosphatases in Aspergillus fumigatus'
Winkelstroter, LK;Dolan, SK;dos Reis, TF;Bom, VLP;de Castro, PA;Hagiwara, D;Alowni, R;Jones, GW;Doyle, S;Brown, NA;Goldman, GH (2015) 'Systematic Global Analysis of Genes Encoding Protein Phosphatases in Aspergillus fumigatus'. G3 (Bethesda, Md.), 5 :1525-1539 [DOI] [IR Link] [Details]
2015 'Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus'
Owens, RA;O'Keeffe, G;Smith, EB;Dolan, SK;Hammel, S;Sheridan, KJ;Fitzpatrick, DA;Keane, TM;Jones, GW;Doyle, S (2015) 'Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus'. Eukaryotic Cell, 14 :941-957 [DOI] [IR Link] [Details]
2015 'Minimum Information about a Biosynthetic Gene cluster'
Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO. (2015) 'Minimum Information about a Biosynthetic Gene cluster'. Nature Chemical Biology, 11 :625-631 [DOI] [Details]
2015 'Resistance is not futile: gliotoxin biosynthesis, functionality and utility'
Dolan, S.K., O’Keeffe, G., Jones, G.W. and Doyle S. (2015) 'Resistance is not futile: gliotoxin biosynthesis, functionality and utility'. Trends in Microbiology, 23 :419-428 [DOI] [Details]
2015 'Biochemical Comparison of Commercial Selenium Yeast Preparations'
Fagan S.;Owens R.;Ward P.;Connolly C.;Doyle S.;Murphy R. (2015) 'Biochemical Comparison of Commercial Selenium Yeast Preparations'. Biological Trace Element Research, [DOI] [Details]
2014 'Biomarker responses to weaning stress in beef calves'
O'Loughlin, A;McGee, M;Doyle, S;Earley, B (2014) 'Biomarker responses to weaning stress in beef calves'. Research in Veterinary Science, 97 :458-463 [DOI] [IR Link] [Details]
2014 'Regulation of Nonribosomal Peptide Synthesis: bis-Thiomethylation Attenuates Gliotoxin Biosynthesis in Aspergillus fumigatus'
Dolan, SK;Owens, RA;O'Keeffe, G;Hammel, S;Fitzpatrick, DA;Jones, GW;Doyle, S (2014) 'Regulation of Nonribosomal Peptide Synthesis: bis-Thiomethylation Attenuates Gliotoxin Biosynthesis in Aspergillus fumigatus'. Chemistry and Biology, 21 :999-1012 [DOI] [IR Link] [Details]
2014 'The evolutionary history of the genes involved in the biosynthesis of the antioxidant ergothioneine'
Jones, GW;Doyle, S;Fitzpatrick, DA (2014) 'The evolutionary history of the genes involved in the biosynthesis of the antioxidant ergothioneine'. Gene, 549 :161-170 [DOI] [IR Link] [Details]
2014 'A Proteomic Approach to Investigating Gene Cluster Expression and Secondary Metabolite Functionality in Aspergillus fumigatus'
Owens, RA;Hammel, S;Sheridan, KJ;Jones, GW;Doyle, S (2014) 'A Proteomic Approach to Investigating Gene Cluster Expression and Secondary Metabolite Functionality in Aspergillus fumigatus'. PLoS ONE, 9 [DOI] [IR Link] [Details]
2014 'RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus'
O'Keeffe, G;Hammel, S;Owens, RA;Keane, TM;Fitzpatrick, DA;Jones, GW;Doyle, S (2014) 'RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus'. BMC Genomics, 15 [DOI] [IR Link] [Details]
2014 'Biomarkers for Invasive Aspergillosis: the challenges continue'
Johnson G., Ferrini A., Dolan, S.K., Nolan T., Agrawal S., Doyle S. and Bustin S. (2014) 'Biomarkers for Invasive Aspergillosis: the challenges continue'. Biomarkers in Medicine, 8 :429-451 [DOI] [Details]
2013 'Genomic and Proteomic Dissection of the Ubiquitous Plant Pathogen, Armillaria mellea: Toward a New Infection Model System'
Collins, C;Keane, TM;Turner, DJ;O'Keeffe, G;Fitzpatrick, DA;Doyle, S (2013) 'Genomic and Proteomic Dissection of the Ubiquitous Plant Pathogen, Armillaria mellea: Toward a New Infection Model System'. Journal of Proteome Research, 12 :2552-2570 [DOI] [IR Link] [Details]
2013 'Proteomic profiling of bovine M-longissimus lumborum from Crossbred Aberdeen Angus and Belgian Blue sired steers varying in genetic merit for carcass weight'
Keady, SM;Kenny, DA;Ohlendieck, K;Doyle, S;Keane, MG;Waters, SM (2013) 'Proteomic profiling of bovine M-longissimus lumborum from Crossbred Aberdeen Angus and Belgian Blue sired steers varying in genetic merit for carcass weight'. Journal of Animal Science, 91 :654-665 [DOI] [IR Link] [Details]
2013 'Extensive proteomic remodeling is induced by eukaryotic translation elongation factor 1B gamma deletion in Aspergillus fumigatus'
O'Keeffe, G;Jochl, C;Kavanagh, K;Doyle, S (2013) 'Extensive proteomic remodeling is induced by eukaryotic translation elongation factor 1B gamma deletion in Aspergillus fumigatus'. Protein Science, 22 :1612-1622 [DOI] [IR Link] [Details]
2013 'Immunoproteomic Analysis of Proteins Expressed by Two Related Pathogens, Burkholderia multivorans and Burkholderia cenocepacia, during Human Infection'
Shinoy, M;Dennehy, R;Coleman, L;Carberry, S;Schaffer, K;Callaghan, M;Doyle, S;McClean, S (2013) 'Immunoproteomic Analysis of Proteins Expressed by Two Related Pathogens, Burkholderia multivorans and Burkholderia cenocepacia, during Human Infection'. PLoS ONE, 8 [DOI] [IR Link] [Details]
2012 'Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus'
O'Hanlon, KA;Margison, GP;Hatch, A;Fitzpatrick, DA;Owens, RA;Doyle, S;Jones, GW (2012) 'Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus'. Nucleic Acids Research, 40 :7806-7820 [DOI] [IR Link] [Details]
2012 'Transcriptomic analysis of the stress response to weaning at housing in bovine leukocytes using RNA-seq technology'
O'Loughlin, A;Lynn, DJ;Mcgee, M;Doyle, S;McCabe, M;Earley, B (2012) 'Transcriptomic analysis of the stress response to weaning at housing in bovine leukocytes using RNA-seq technology'. BMC Genomics, 13 [DOI] [IR Link] [Details]
2012 'Effect of pre-weaning concentrate supplementation on peripheral distribution of leukocytes, functional activity of neutrophils, acute phase protein and behavioural responses of abruptly weaned and housed beef calves'
Lynch, EM;McGee, M;Doyle, S;Earley, B (2012) 'Effect of pre-weaning concentrate supplementation on peripheral distribution of leukocytes, functional activity of neutrophils, acute phase protein and behavioural responses of abruptly weaned and housed beef calves'. BMC Veterinary Research, 8 [DOI] [IR Link] [Details]
2012 'The Aspergillus fumigatus Protein GliK Protects against Oxidative Stress and Is Essential for Gliotoxin Biosynthesis'
Gallagher, L;Owens, RA;Dolan, SK;O'Keeffe, G;Schrettl, M;Kavanagh, K;Jones, GW;Doyle, S (2012) 'The Aspergillus fumigatus Protein GliK Protects against Oxidative Stress and Is Essential for Gliotoxin Biosynthesis'. Eukaryotic Cell, 11 :1226-1238 [DOI] [IR Link] [Details]
2012 'Nonribosomal Peptide Synthetase Genes pesL and pes1 Are Essential for Fumigaclavine C Production in Aspergillus fumigatus'
O'Hanlon, KA;Gallagher, L;Schrettl, M;Jochl, C;Kavanagh, K;Larsen, TO;Doyle, S (2012) 'Nonribosomal Peptide Synthetase Genes pesL and pes1 Are Essential for Fumigaclavine C Production in Aspergillus fumigatus'. Applied And Environmental Microbiology, 78 :3166-3176 [DOI] [IR Link] [Details]
2012 'Gliotoxin effects on fungal growth: Mechanisms and exploitation'
Carberry, S;Molloy, E;Hammel, S;O'Keeffe, G;Jones, GW;Kavanagh, K;Doyle, S (2012) 'Gliotoxin effects on fungal growth: Mechanisms and exploitation'. Fungal Genetics and Biology, 49 :302-312 [DOI] [IR Link] [Details]
2012 'Anchoring high-throughput screening methods to scale-up bioproduction of siderophores'
Marques, MPC;Walshe, K;Doyle, S;Fernandes, P;de Carvalho, CCCR (2012) 'Anchoring high-throughput screening methods to scale-up bioproduction of siderophores'. Process Biochemistry, 47 :416-421 [DOI] [IR Link] [Details]
2011 'Recombinant expression and immunological characterisation of proteins derived from human metapneumovirus'
O'Shaughnessy, L;Carr, M;Crowley, B;Carberry, S;Doyle, S (2011) 'Recombinant expression and immunological characterisation of proteins derived from human metapneumovirus'. Journal of Clinical Virology, 52 :236-243 [DOI] [IR Link] [Details]
2011 'Targeted Disruption of Nonribosomal Peptide Synthetase pes3 Augments the Virulence of Aspergillus fumigatus'
O'Hanlon, KA;Cairns, T;Stack, D;Schrettl, M;Bignell, EM;Kavanagh, K;Miggin, SM;O'Keeffe, G;Larsen, TO;Doyle, S (2011) 'Targeted Disruption of Nonribosomal Peptide Synthetase pes3 Augments the Virulence of Aspergillus fumigatus'. Infection and Immunity, 79 :3978-3992 [DOI] [IR Link] [Details]
2011 'Effect of post-weaning management practices on physiological and immunological responses of weaned beef calves'
Lynch, EM;McGee, M;Doyle, S;Earley, B (2011) 'Effect of post-weaning management practices on physiological and immunological responses of weaned beef calves'. Irish Journal Of Agricultural And Food Research, 50 :161-174 [IR Link] [Details]
2011 'Single-pot derivatisation strategy for enhanced gliotoxin detection by HPLC and MALDI-ToF mass spectrometry'
Davis, C;Gordon, N;Murphy, S;Singh, I;Kavanagh, K;Carberry, S;Doyle, S (2011) 'Single-pot derivatisation strategy for enhanced gliotoxin detection by HPLC and MALDI-ToF mass spectrometry'. Analytical and Bioanalytical Chemistry, 401 :2519-2529 [DOI] [IR Link] [Details]
2011 'Purification of proteins from baculovirus-infected insect cells'
O'Shaughnessy L.;Doyle S. (2011) 'Purification of proteins from baculovirus-infected insect cells'. Methods in molecular biology (Clifton, N.J.), 681 :295-309 [Details]
2011 'The detection of parvoviruses'
Doyle S. (2011) 'The detection of parvoviruses'. Methods in molecular biology (Clifton, N.J.), 665 :213-231 [IR Link] [Details]
2011 'Examination of the bovine leukocyte environment using immunogenetic biomarkers to assess immunocompetence following exposure to weaning stress'
O'Loughlin, A;McGee, M;Waters, SM;Doyle, S;Earley, B (2011) 'Examination of the bovine leukocyte environment using immunogenetic biomarkers to assess immunocompetence following exposure to weaning stress'. BMC Veterinary Research, 7 [DOI] [IR Link] [Details]
2011 'The Role of Glutathione S-Transferase GliG in Gliotoxin Biosynthesis in Aspergillus fumigatus'
Davis, C;Carberry, S;Schrettl, M;Singh, I;Stephens, JC;Barry, SM;Kavanagh, K;Challis, GL;Brougham, D;Doyle, S (2011) 'The Role of Glutathione S-Transferase GliG in Gliotoxin Biosynthesis in Aspergillus fumigatus'. Chemistry and Biology, 18 :542-552 [DOI] [IR Link] [Details]
2010 'Self-Protection against Gliotoxin-A Component of the Gliotoxin Biosynthetic Cluster, GliT, Completely Protects Aspergillus fumigatus Against Exogenous Gliotoxin'
Schrettl, M;Carberry, S;Kavanagh, K;Haas, H;Jones, GW;O'Brien, J;Nolan, A;Stephens, J;Fenelon, O;Doyle, S (2010) 'Self-Protection against Gliotoxin-A Component of the Gliotoxin Biosynthetic Cluster, GliT, Completely Protects Aspergillus fumigatus Against Exogenous Gliotoxin'. PLoS Pathogens, 6 [DOI] [IR Link] [Details]
2010 'Characterisation of physiological and immunological responses in beef cows to abrupt weaning and subsequent housing'
Lynch E.;Earley B.;McGee M.;Doyle S. (2010) 'Characterisation of physiological and immunological responses in beef cows to abrupt weaning and subsequent housing'. BMC Veterinary Research, 6 [DOI] [IR Link] [Details]
2010 'Effect of abrupt weaning at housing on leukocyte distribution, functional activity of neutrophils, and acute phase protein response of beef calves'
Lynch, EM;Earley, B;McGee, M;Doyle, S (2010) 'Effect of abrupt weaning at housing on leukocyte distribution, functional activity of neutrophils, and acute phase protein response of beef calves'. BMC Veterinary Research, 6 [DOI] [IR Link] [Details]
2010 'Characterisation of physiological, haematological and immunological responses in beef cows to abrupt weaning and subsequent housing'
Lynch, E.M., Earley, B. McGee, M., Byrne, W. and Doyle, S. (2010) 'Characterisation of physiological, haematological and immunological responses in beef cows to abrupt weaning and subsequent housing'. BMC VETERINARY RESEARCH, 6 [DOI] [IR Link] [Details]
2009 'Optimization of Xylanase Production by Thermomyces lanuginosus in Solid State Fermentation'
Gaffney, M;Doyle, S;Murphy, R (2009) 'Optimization of Xylanase Production by Thermomyces lanuginosus in Solid State Fermentation'. Bioscience, Biotechnology and Biochemistry, 73 :2640-2644 [DOI] [IR Link] [Details]
2009 'Solid Phase 4 '-Phosphopantetheinylation: Fungal Thiolation Domains are Targets for Chemoenzymatic Modification'
Stack, D;Frizzell, A;Tomkins, K;Doyle, S (2009) 'Solid Phase 4 '-Phosphopantetheinylation: Fungal Thiolation Domains are Targets for Chemoenzymatic Modification'. Bioconjugate Chemistry, 20 :1514-1522 [DOI] [IR Link] [Details]
2009 'Purification and characterisation of a xylanase from Thermomyces lanuginosus and subsequent expression by Pichia pastoris'
Gaffney, M., Carberry, S., Doyle S and Murphy, R. (2009) 'Purification and characterisation of a xylanase from Thermomyces lanuginosus and subsequent expression by Pichia pastoris'. ENZYME AND MICROBIAL TECHNOLOGY, 45 :348-354 [IR Link] [Details]
2007 'Proteomic studies in biomedically and industrially relevant fungi'
Carberry, S. and S. Doyle (2007) 'Proteomic studies in biomedically and industrially relevant fungi'. Cytotechnology, 53 :95-100 [IR Link] [Details]
2007 'Improved detection of acute parvovirus B19 infection by IgM EIA in combination with a novel antigen EIA'
Corcoran, A., S. Kerr, M. Koppelman and S. Doyle (2007) 'Improved detection of acute parvovirus B19 infection by IgM EIA in combination with a novel antigen EIA'. Vox Sanguinis, 93 :216-222 [IR Link] [Details]
2007 'Nonribosomal Peptide Synthesis in the Human Pathogen Aspergillus fumigatus and other Fungi'
Stack D., Neville C.M. and Doyle S (2007) 'Nonribosomal Peptide Synthesis in the Human Pathogen Aspergillus fumigatus and other Fungi'. MICROBIOLOGY, 153 :1297-1306 [IR Link] [Details]
2007 'Isolation, activity and immunological characterisation of a secreted aspartic protease, CtsD, from Aspergillus fumigatus'
Vickers, I;Reeves, EP;Kavanagh, KA;Doyle, S (2007) 'Isolation, activity and immunological characterisation of a secreted aspartic protease, CtsD, from Aspergillus fumigatus'. Protein Expression and Purification, 53 :216-224 [DOI] [IR Link] [Details]
2006 'A nonribosomal peptide synthetase (Pes1) confers protection against oxidative stress in Aspergillus fumigatus'
Reeves, EP;Reiber, K;Neville, C;Scheibner, O;Kavanagh, K;Doyle, S (2006) 'A nonribosomal peptide synthetase (Pes1) confers protection against oxidative stress in Aspergillus fumigatus'. FEBS Journal, 273 :3038-3053 [DOI] [IR Link] [Details]
2006 'Establishment of functional B cell memory against parvovirus B19 capsid proteins may be associated with resolution of persistent infection'
Corcoran, A;Cromley, B;Dewhurst, C;Pizer, BL;Doyle, S (2006) 'Establishment of functional B cell memory against parvovirus B19 capsid proteins may be associated with resolution of persistent infection'. Journal of Medical Virology, 78 :125-128 [DOI] [IR Link] [Details]
2006 'The immune response to parvovirus B19 exposure in previously seronegative and seropositive individuals'
Doyle, S;Corcoran, A (2006) 'The immune response to parvovirus B19 exposure in previously seronegative and seropositive individuals'. Journal of Infectious Diseases, 194 :154-158 [IR Link] [Details]
2006 'Analysis of major intracellular proteins of Aspergillus fumigatus by MALDI mass spectrometry: Identification and characterisation of an elongation factor 1B protein with glutathione transferase activity'
Carberry, S;Neville, CM;Kavanagh, KA;Doyle, S (2006) 'Analysis of major intracellular proteins of Aspergillus fumigatus by MALDI mass spectrometry: Identification and characterisation of an elongation factor 1B protein with glutathione transferase activity'. Biochemical and Biophysical Research Communications, 341 :1096-1104 [DOI] [IR Link] [Details]
2005 'A 4 '-phosphopantetheinyl transferase mediates non-ribosomal peptide synthetase activation in Aspergillus fumigatus'
Neville, C;Murphy, A;Kavanagh, K;Doyle, S (2005) 'A 4 '-phosphopantetheinyl transferase mediates non-ribosomal peptide synthetase activation in Aspergillus fumigatus'. ChemBioChem, 6 :679-685 [DOI] [Details]
2005 'Identification, cloning, and functional expression of three glutathione transferase genes from Aspergillus fumigatus'
Burns, C;Geraghty, R;Neville, C;Murphy, A;Kavanagh, K;Doyle, S (2005) 'Identification, cloning, and functional expression of three glutathione transferase genes from Aspergillus fumigatus'. Fungal Genetics and Biology, 42 :319-327 [DOI] [IR Link] [Details]
2005 'Development of solution phase hybridisation PCR-ELISA for the detection and quantification of Enterococcus faecalis and Pediococcus pentosaceus in Nurmi-type cultures'
Waters, SM;Doyle, S;Murphy, RA;Power, RFG (2005) 'Development of solution phase hybridisation PCR-ELISA for the detection and quantification of Enterococcus faecalis and Pediococcus pentosaceus in Nurmi-type cultures'. Journal of Microbiological Methods, 63 :264-275 [DOI] [IR Link] [Details]
2005 'Targeting therapies for the treatment of liver fibrosis - Chemical conjugation of gliotoxin to a human small chain antibody selected for its affinity to a surface antigen on human hepatic stellate cells'
Wallace K, Elrick L, Leel V, Durward E, Doyle S, Kavanagh K, Porter A, Wright MC. (2005) 'Targeting therapies for the treatment of liver fibrosis - Chemical conjugation of gliotoxin to a human small chain antibody selected for its affinity to a surface antigen on human hepatic stellate cells'. Journal of Hepatology, 42 :601A-602A [Details]
2005 'The expression of selected non-ribosomal peptide synthetases in Aspergillus fumigatus is controlled by the availability of free iron'
Reiber K.;Reeves E.;Neville C.;Winkler R.;Gebhardt P.;Kavanagh K.;Doyle S. (2005) 'The expression of selected non-ribosomal peptide synthetases in Aspergillus fumigatus is controlled by the availability of free iron'. Fems Microbiology Letters, 248 (1):83-91 [DOI] [IR Link] [Details]
2005 'Evidence of serological cross-reactivity between genotype 1 and genotype 3 erythrovirus infections'
Corcoran, A. and Doyle, S. (2005) 'Evidence of serological cross-reactivity between genotype 1 and genotype 3 erythrovirus infections'. JOURNAL OF VIROLOGY, 79 :5238-5239 [IR Link] [Details]
2004 'Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence - Propeptide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells'
Collins, PR;Stack, CM;O'Neill, SM;Doyle, S;Ryan, T;Brennan, GP;Mousley, A;Stewart, M;Maule, AG;Dalton, JP;Donnelly, S (2004) 'Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence - Propeptide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells'. Journal of Biological Chemistry, 279 :17038-17046 [DOI] [IR Link] [Details]
2004 'B cell memory is directed towards conformational epitopes of parvovirus B19 capsid proteins and the VP1-unique region'
Corcoran, A., Mahon, B.P. and Doyle, S. (2004) 'B cell memory is directed towards conformational epitopes of parvovirus B19 capsid proteins and the VP1-unique region'. JOURNAL OF INFECTIOUS DISEASES, 189 :1873-1880 [IR Link] [Details]
2004 'Advances in the biology, diagnosis and host-pathogen interactions of parvovirus B19'
Corcoran, A. and Doyle, S. (2004) 'Advances in the biology, diagnosis and host-pathogen interactions of parvovirus B19'. JOURNAL OF MEDICAL MICROBIOLOGY, 53 :459-475 [IR Link] [Details]
2004 'Leucine aminopeptidase of the human blood fluke, Schistosoma mansoni'
McCarthy E., Stack, C., Donnelly, S.M., Doyle, S., Mann, V.H., Brindley, P.J., Brennan, G., Stewart, M., Maule, A.G., and Dalton, J.P. (2004) 'Leucine aminopeptidase of the human blood fluke, Schistosoma mansoni'. INTERNATIONAL JOURNAL FOR PARASITOLOGY, 34 :703-714 [IR Link] [Details]
2004 'Detection of Aspergillus fumigatus mycotoxins: immunogen synthesis and immunoassay development'
Fox, M;Gray, G;Kavanagh, K;Lewis, C;Doyle, S (2004) 'Detection of Aspergillus fumigatus mycotoxins: immunogen synthesis and immunoassay development'. Journal of Microbiological Methods, 56 :221-230 [DOI] [IR Link] [Details]
2004 'Leucine aminopeptidase of the human blood flukes, Schistosoma mansoni and Schistosoma japonicum'
McCarthy, E;Stack, C;Donnelly, SM;Doyle, S;Mann, VH;Brindley, PJ;Stewart, M;Day, TA;Maule, AG;Dalton, JP (2004) 'Leucine aminopeptidase of the human blood flukes, Schistosoma mansoni and Schistosoma japonicum'. International Journal For Parasitology, 34 :703-714 [DOI] [IR Link] [Details]
2004 'B cell memory is directed toward conformational epitopes of parvovirus B19 capsid proteins and the unique region of VP1'
Corcoran, A;Mahon, BP;Doyle, S (2004) 'B cell memory is directed toward conformational epitopes of parvovirus B19 capsid proteins and the unique region of VP1'. Journal of Infectious Diseases, 189 :1873-1880 [IR Link] [Details]
2004 'Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: Propeptide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells'
Collins P.R., Stack C.N., O'Neill S.M., Doyle S., Ryan T., Brennan G.P., Mousley A, Stewart M, Maule AG, Dalton JP, Donnelly S. (2004) 'Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: Propeptide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells'. JOURNAL OF BIOLOGICAL CHEMISTRY, 279 :17038-17046 [IR Link] [Details]
2004 'Detection of Aspergillus fumigatus mycotoxins: immunogen synthesis and immunoassay development'
Fox, M., Gray, G., Kavanagh, K., Lewis, C. and Doyle, S. (2004) 'Detection of Aspergillus fumigatus mycotoxins: immunogen synthesis and immunoassay development'. JOURNAL OF MICROBIOLOGICAL METHODS, 56 :221-230 [IR Link] [Details]
2004 'Correlation between gliotoxin production and virulence of Aspergillus fumigatus in Galleria mellonella'
Reeves, EP;Messina, CGM;Doyle, S;Kavanagh, K (2004) 'Correlation between gliotoxin production and virulence of Aspergillus fumigatus in Galleria mellonella'. Mycopathologia, 158 :73-79 [IR Link] [Details]
2003 'Quantitative detection of C-reactive protein using phosphocholine-labelled enzyme or microspheres'
Deegan, O;Walshe, K;Kavanagh, K;Doyle, S (2003) 'Quantitative detection of C-reactive protein using phosphocholine-labelled enzyme or microspheres'. Analytical Biochemistry, 312 :175-181 [IR Link] [Details]
2003 'The development of a competitive PCR-ELISA for the detection of equine herpesvirus-1'
Daly, P;Doyle, S (2003) 'The development of a competitive PCR-ELISA for the detection of equine herpesvirus-1'. Journal of Virological Methods, 107 :237-244 [IR Link] [Details]
2003 'Development of a Competitive PCR-ELISA for the detection of Equine Herpesvirus-1 (EHV-1)'
Daly P and Doyle S (2003) 'Development of a Competitive PCR-ELISA for the detection of Equine Herpesvirus-1 (EHV-1)'. JOURNAL OF VIROLOGICAL METHODS, 107 :237-244 [IR Link] [Details]
2003 'Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines'
Dalton, J.P., O'Neill, S.M., Stack, C., Collins, P., Walsh, A., Sekiya, M., Doyle, S., Mulcahy, G., Hoyle, D., Khaznadji, E., Moiré, N., Brennan, G.P., Mousley, A., Kreshchenko, N., Maule, A.G. and Donnelly, S.M. (2003) 'Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines'. International Journal For Parasitology, 33 :1173-1181 [IR Link] [Details]
2003 'Ex vivo cytokine responses against parvovirus B19 antigens in previously infected pregnant women'
Corcoran, A;Mahon, BP;McParland, P;Davoren, A;Doyle, S (2003) 'Ex vivo cytokine responses against parvovirus B19 antigens in previously infected pregnant women'. Journal of Medical Virology, 70 :475-480 [DOI] [IR Link] [Details]
2003 'Exposure of the yeast Candida albicans to the anti-neoplastic agent Adriamycin increases the tolerance to Amphotericin B'
O'Keeffe, J., Doyle, S. and Kavanagh, K. (2003) 'Exposure of the yeast Candida albicans to the anti-neoplastic agent Adriamycin increases the tolerance to Amphotericin B'. JOURNAL OF PHARMACY AND PHARMACOLOGY, 55 :1629-1633 [IR Link] [Details]
2002 'Establishment of the first World Health Organization International Standard for human parvovirus B19 DNA nucleic acid amplification techniques'
Saldanha J.;Lelie N.;Yu M.;Heath A.;Albrecht J.;Buhr S.;Roth W.;Chaput C.;Chudy ;Schmidt I.;Cohen B.;Defer C.;Lefebvre C.;Doyle S.;Daly P.;Echevarria J.;Erdman D.;Anderson B.;Fang R.;Johnstone D.;Gierman T.;Gross P.;Held I.;Jarvis L.;Cleland A.;Lazo A.;Gibaja V.;Murozuka T.;Okada Y.;Pedada L.;Lou A.;Pisani ;Gentili ;Saldanha ;Stolz M.;Thomas I.;Mathy E.;Weimer T.;Yu M.;Shen L.;Mason B.;York D.;Zhang H. (2002) 'Establishment of the first World Health Organization International Standard for human parvovirus B19 DNA nucleic acid amplification techniques'. Vox Sanguinis, 82 (1):24-31 [DOI] [IR Link] [Details]
2002 'PCR-ELISA detection of Escherichia coli in milk'
Daly, P;Collier, T;Doyle, S (2002) 'PCR-ELISA detection of Escherichia coli in milk'. Letters in Applied Microbiology, 34 :222-226 [IR Link] [Details]
2002 'NS1protein of Parvovims B19 interacts directly and via the transcription factors Spl/Sp3 with the p6 promoter'
Raab U, Beckenlehner K, Lowin T, Niller H-H, Doyle S and Modrow S (2002) 'NS1protein of Parvovims B19 interacts directly and via the transcription factors Spl/Sp3 with the p6 promoter'. 293 :86-93 [Details]
2002 'Establishment of the first World Health Organisation International Standard for human parvovirus B19 DNA nucleic acid amplification techniques'
Saldanda J, Lelie N, Yu MW and B19 Collaborative Study Group (incl. Doyle S and Daly P) (2002) 'Establishment of the first World Health Organisation International Standard for human parvovirus B19 DNA nucleic acid amplification techniques'. Vox Sanguinis, 82 :24-31 [IR Link] [Details]
2002 'High-sensitivity PCR detection of parvovirus B19 in plasma'
Daly P.;Corcoran A.;Mahon B.;Doyle S. (2002) 'High-sensitivity PCR detection of parvovirus B19 in plasma'. Journal of Clinical Microbiology, 40 (6):1958-1962 [DOI] [IR Link] [Details]
2002 'High Sensitivity PCR Detection of Parvovirus B19 in plasma'
Daly P, Corcoran A, Mahon BP and Doyle S (2002) 'High Sensitivity PCR Detection of Parvovirus B19 in plasma'. JOURNAL OF CLINICAL MICROBIOLOGY, 40 :1958-1962 [IR Link] [Details]
2002 'NS1 protein of parvovirus B19 interacts directly with DNA sequences of the P6 promoter and with the cellular transcription factors Sp1/Sp3'
Raab, U;Beckenlehner, K;Lowin, T;Niller, HH;Doyle, S;Modrow, S (2002) 'NS1 protein of parvovirus B19 interacts directly with DNA sequences of the P6 promoter and with the cellular transcription factors Sp1/Sp3'. Virology, 293 :86-93 [DOI] [IR Link] [Details]
2001 'Baculovirus expression of parvovirus B19 (B19V) NS1: utility in confirming recent infection'
Ennis, O;Corcoran, A;Kavanagh, K;Mahon, BP;Doyle, S (2001) 'Baculovirus expression of parvovirus B19 (B19V) NS1: utility in confirming recent infection'. Journal of Clinical Virology, 22 :55-60 [IR Link] [Details]
2001 'Baculovirus expression of parvovirus B19 (B19V) NS1: Utility in confirming recent infection'
Ennis O, Corcoran A, Kavanagh K, Mahon BP and Doyle S. (2001) 'Baculovirus expression of parvovirus B19 (B19V) NS1: Utility in confirming recent infection'. JOURNAL OF CLINICAL VIROLOGY, 22 :55-60 [IR Link] [Details]
2000 'Detection of parvovirus B19 IgM by antibody capture enzyme immunoassay: receiver operating characteristic analysis'
Doyle, S;Kerr, S;O'Keeffe, G;O'Carroll, D;Daly, P;Kilty, C (2000) 'Detection of parvovirus B19 IgM by antibody capture enzyme immunoassay: receiver operating characteristic analysis'. Journal of Virological Methods, 90 :143-152 [IR Link] [Details]
2000 'Recently infected children display impaired interferon-y responses against Parvovirus B19. 8th Annual Congress of the British Society for Immunology, Harrogate, UK, December 2000'
Corcoran A, Doyle S, Waldron D, Nicholson A and Mahon BP. (2000) 'Recently infected children display impaired interferon-y responses against Parvovirus B19. 8th Annual Congress of the British Society for Immunology, Harrogate, UK, December 2000'. 101 [Details]
2000 'Development of an insect model for the in vivo pathogenicity testing of yeasts'
Cotter, G;Doyle, S;Kavanagh, K (2000) 'Development of an insect model for the in vivo pathogenicity testing of yeasts'. FEMS Immunology and Medical Microbiology, 27 :163-169 [IR Link] [Details]
2000 'Detection of parvovirus B19 IgM by antibody capture enzyme immunoassay: Receiver Operating Characteristic analysis'
Doyle S, Kerr S, O'Keeffe G, O'Carroll D, Daly P and Kilty C. (2000) 'Detection of parvovirus B19 IgM by antibody capture enzyme immunoassay: Receiver Operating Characteristic analysis'. Journal of Virological Methods, 90 :143-152 [IR Link] [Details]
2000 'Development of an insect model for the in vivo pathogenicity testing of yeasts'
Cotter G, Doyle S and Kavanagh K. (2000) 'Development of an insect model for the in vivo pathogenicity testing of yeasts'. FEMS Immunology and Medical Microbiology, 1165 :1-7 [IR Link] [Details]
2000 'Impaired gamma interferon responses against parvovirus B19 by recently infected children'
Corcoran A;Doyle S;Waldron D;Nicholson A;Mahon BP; (2000) 'Impaired gamma interferon responses against parvovirus B19 by recently infected children'. Virology, 74 (21) [IR Link] [Details]
2000 'Impaired gamma interferon responses against parvovirus B19 by recently infected children'
Corcoran A;Doyle S;Waldron D;Nicholson A;Mahon BP; (2000) 'Impaired gamma interferon responses against parvovirus B19 by recently infected children'. Virology, 74 (21) [IR Link] [Details]
2000 'Impaired gamma interferon responses against parvovirus B19 by recently infected children'
Corcoran, A;Doyle, S;Waldron, D;Nicholson, A;Mahon, BP (2000) 'Impaired gamma interferon responses against parvovirus B19 by recently infected children'. Virology, 74 :9903-9910 [IR Link] [Details]
1999 'An automated biochemical assay for haptoglobin: Prevention of interference from albumin'
Eckersall P.;Duthie S.;Safi S.;Moffatt D.;Horadagoda N.;Doyle S.;Parton R.;Bennett D.;Fitzpatrick J. (1999) 'An automated biochemical assay for haptoglobin: Prevention of interference from albumin'. Comparative Clinical Pathology, 9 (3):117-124 [IR Link] [Details]
1999 'Undenatured parvovirus B19 antigens are essential for the accurate detection of parvovirus B19 IgG'
Kerr, S;O'Keeffe, G;Kilty, C;Doyle, S (1999) 'Undenatured parvovirus B19 antigens are essential for the accurate detection of parvovirus B19 IgG'. Journal of Medical Virology, 57 :179-185 [IR Link] [Details]
1999 'An automated biochemical assay for haptoglobin: prevention of interference from albumin'
Eckersall PD, Duthie S, Safi S, Moffatt D, Horadagoda NU, Doyle S, Parton R, Bennett D and Fitzpatrick JL. (1999) 'An automated biochemical assay for haptoglobin: prevention of interference from albumin'. Comparative Haematology International, 9 :117-124 [IR Link] [Details]
1999 'Evaluation of a novel design bioartificial liver in rats with complete liver ischemia: treatment efficacy and species-specific a-GST detection as a first attempt to monitor hepatocyte viability'
Flendrig L, Chamuleau RAFM, Maas MAW, Daalhuisen J, Hassett B, Kilty CJ, Doyle S, Ladiges NCJJ, Jorning GGA, la Soe JW, Sommeijer D and te Velde AA. (1999) 'Evaluation of a novel design bioartificial liver in rats with complete liver ischemia: treatment efficacy and species-specific a-GST detection as a first attempt to monitor hepatocyte viability'. 30 :311-321 [IR Link] [Details]
1998 'Glutathione s-transferases as biomarkers of organ damage: applications of rodent and canine GST enzyme immunoassays'
Kilty C, Doyle S, Hassett B. and Manning F. (1998) 'Glutathione s-transferases as biomarkers of organ damage: applications of rodent and canine GST enzyme immunoassays'. Chemico-Biological Interactions, 112 :123-135 [IR Link] [Details]
1997 'Alpha-glutathione s-transferase (alpha-GST) release, an early indicator of carbon tetrachloride hepatotoxicity in the rat'
Clarke, H, Egan, DA., Heffernan, M, Doyle, S, Byrne, C, Kilty, C and Ryan, MP (1997) 'Alpha-glutathione s-transferase (alpha-GST) release, an early indicator of carbon tetrachloride hepatotoxicity in the rat'. HUMAN EXPERIMENTAL TOXICOLOGY, 16 :154-157 [Details]
1996 'Generation of soluble recombinant human acute phase serum amyloid A2 protein and its use in the development of an A-SAA specific ELISA'
Hobson, AH, McCormack, C, Doyle, S, Jackson, J, Kilty, C and Whitehead, A (1996) 'Generation of soluble recombinant human acute phase serum amyloid A2 protein and its use in the development of an A-SAA specific ELISA'. Journal of Immunological Methods, 198 :101-110 [IR Link] [Details]
1995 'Evaluation of an enzyme-immunometric assay for serum glutathione s-transferase'
Rees, GW, Trull, AK and Doyle, S (1995) 'Evaluation of an enzyme-immunometric assay for serum glutathione s-transferase'. Annals of Clinical Biochemistry, 32 :575-583 [Details]
1990 'The amino-acid-sequence of cytosolic aspartate-aminotransferase from human liver'
Doyle JM, Schinina ME, Bossa F, Doonan S (1990) 'The amino-acid-sequence of cytosolic aspartate-aminotransferase from human liver'. Biochemical Journal, 270 :651-657 [IR Link] [Details]

Other Journals

  Year Publication
2010
Dr Gary W Jones, Research Support (2010) . [Details]
2009 'Abrupt weaning alters leukocyte subsets and functional activity of granulocytes in beef calves'
Lynch, E.M., B. Earley, M. McGee and S. Doyle (2009) 'Abrupt weaning alters leukocyte subsets and functional activity of granulocytes in beef calves' Journal of Dairy Science (ADSA/CSA/ASAS Meeting. Montreal, Quebec, Canada. Poster M36), 92 . [Details]
2009 'Abrupt weaning alters leukocyte subsets and functional activity of granulocytes in beef calves'
Lynch, E.M., B. Earley, M. McGee and S. Doyle (2009) 'Abrupt weaning alters leukocyte subsets and functional activity of granulocytes in beef calves' Journal of Animal Science (ADSA/CSA/ASAS Meeting. Montreal, Quebec, Canada. Poster M36), 87 . [Details]

Conference Publications

  Year Publication
2009 Effect of abrupt weaning and subsequent housing on leukocyte populations and acute phase proteins in beef suckler cows
Lynch, E.M., McGee, M., Doyle, S. & Earley, B. (2009) Effect of abrupt weaning and subsequent housing on leukocyte populations and acute phase proteins in beef suckler cows Proc. Agric. Res. Forum [Details]
2009 Effect of abrupt weaning on circulating leukocyte subsets and phagocytic activity of neutrophils in beef suckler calves
Lynch, E.M., McGee, M., Doyle, S. & Earley, B. (2009) Effect of abrupt weaning on circulating leukocyte subsets and phagocytic activity of neutrophils in beef suckler calves Proc. Agric. Res. Forum [IR Link] [Details]
2007 Proteomic studies in biomedically and industrially relevant fungi
Carberry, S;Doyle, S (2007) Proteomic studies in biomedically and industrially relevant fungi CYTOTECHNOLOGY , pp.95-100 [DOI] [IR Link] [Details]
2003 Fasciola hepatica cathepsin L-like proteases: Biology, function, and potential in the development of first generation liver fluke vaccines
Dalton J.;Neill S.;Stack C.;Collins P.;Walshe A.;Sekiya M.;Doyle S.;Mulcahy G.;Hoyle D.;Khaznadji E.;Moiré N.;Brennan G.;Mousley A.;Kreshchenko N.;Maule A.;Donnelly S. (2003) Fasciola hepatica cathepsin L-like proteases: Biology, function, and potential in the development of first generation liver fluke vaccines International Journal for Parasitology , pp.1173-1181 [DOI] [IR Link] [Details]
1998 Glutathione S-transferases as biomarkers of organ damage: applications of rodent and canine GST enzyme immunoassays
Kilty, C;Doyle, S;Hassett, B;Manning, F (1998) Glutathione S-transferases as biomarkers of organ damage: applications of rodent and canine GST enzyme immunoassays CHEMICO-BIOLOGICAL INTERACTIONS , pp.123-135 [IR Link] [Details]

Conference Contributions

  Year Publication
2015 Chronic Burkholderia cenocepacia infection in cystic fibrosis: an analysis of the adaptations in sequential isolates from two patients.
Cullen, L;Owens, R;Callaghan, M;Doyle, S;Schaffer, K;McClean, S (2015) Chronic Burkholderia cenocepacia infection in cystic fibrosis: an analysis of the adaptations in sequential isolates from two patients. [Published Abstract], The 29th Annual North American Cystic Fibrosis Conference, Phoenix, AZ [Details]
2009 Centre of Applied Science in Health Research Day.
(2009) Centre of Applied Science in Health Research Day. [Oral Presentation], A Gliotoxin Reductase in Aspergillus fumigatus?, Dublin, Ireland [Details]
2009 Diasorin 3rd International Meeting.
(2009) Diasorin 3rd International Meeting. [Oral Presentation], Parvovirus B19: clinical significance, serological diagnosis, and treatment, Turin, Italy [Details]
2009 National SFI Meeting.
(2009) National SFI Meeting. [Oral Presentation], Gliotoxin Biosynthesis in the Opportunistic Human Pathogen Aspergillus fumigatus, Kilkenny, Ireland [Details]
2009 25th Fungal Genetics Conference.
(2009) 25th Fungal Genetics Conference. [Oral Presentation], Absence of gliG disrupts gliotoxin biosynthesis in the human pathogen Aspergillus fumigatus, Asilomar, California, USA [Details]
2009 Dept of Clinical Microbiology, TCD.
(2009) Dept of Clinical Microbiology, TCD. [Oral Presentation], Functional proteomics investigation of gliotoxin biosynthesis in Aspergillus fumigatus...lessons, Dublin, Ireland [Details]
2009 3rd FEBS Adv. Lecture Course on Human Fungal Patho.
(2009) 3rd FEBS Adv. Lecture Course on Human Fungal Patho. [Oral Presentation], Dual-function protein: a putative translation elongation factor with glutathione ...str, La Colle sur Loup, France [Details]
2009 Biochemical Society Meeting-Irish Area Section.
(2009) Biochemical Society Meeting-Irish Area Section. [Oral Presentation], Absence of gliG Inhibits Gliotoxin Biosynthesis in Aspergillus fumigatus, Dublin, Ireland [Details]
2009 25th Fungal Genetics Conference.
(2009) 25th Fungal Genetics Conference. [Oral Presentation], GliT, a gliotoxin reductase, protects Aspergillus fumigatus against the harmful effects of gliotoxin, Asilomar, California, USA [Details]
2009 Irish Fungal Group Meeting.
(2009) Irish Fungal Group Meeting. [Oral Presentation], Multiple Effects of Non-Ribosomal Peptide Synthetase, Pes1, Deficiency in Aspergillus fumigatus, Dublin, Ireland [Details]
2009 Dept. of Chemistry, NUI Maynooth.
(2009) Dept. of Chemistry, NUI Maynooth. [Oral Presentation], Proteome mining of Aspergillus fumigatus - Smack at the interface of Chemistry and Genomics, Maynooth Ireland [Details]
2009 Agricultural Research Forum.
(2009) Agricultural Research Forum. [Oral Presentation], Effect of abrupt weaning on circulating leukocyte subsets and phagocytic activity of ...calves, Tullamore, Ireland [Details]
2009 Irish Fungal Group Meeting.
(2009) Irish Fungal Group Meeting. [Oral Presentation], Differential roles for Aspergillus fumigatus non-ribosomal peptides in protection against ...model, Dublin, Ireland [Details]
2009 AVTRW Annual Meeting.
(2009) AVTRW Annual Meeting. [Oral Presentation], Impact of weaning strategy on haematological variables of beef calves, Carlingford, Co. Louth, Ireland [Details]
2009 Irish Fungal Group Meeting.
(2009) Irish Fungal Group Meeting. [Oral Presentation], Absence of gliG disrupts gliotoxin biosynthesis in the human pathogen Aspergillus fumigatus, Dublin, Ireland [Details]
2009 Biomedical Sciences Meeting, RAMI.
(2009) Biomedical Sciences Meeting, RAMI. [Oral Presentation], Differential roles for Aspergillus fumigatus non-ribosomal peptides in protection against ...model, Maynooth, Ireland [Details]
2009 ADSA/CSA/ASAS Meeting.
(2009) ADSA/CSA/ASAS Meeting. [Poster Presentation], Abrupt weaning alters leukocyte subsets and functional activity of granulocytes in beef calves, Montreal, Canada [Details]
2009 Biomedical Sciences Meeting, RAMI.
(2009) Biomedical Sciences Meeting, RAMI. [Oral Presentation], Updating Genomics- New Insights into the Function of Gliotoxin in Aspergillus fumigatus, Maynooth, Ireland [Details]
2009 25th Fungal Genetics Conference.
(2009) 25th Fungal Genetics Conference. [Oral Presentation], Functional characterisation of a non-ribosomal peptide synthetase from the opportunistic...fumigatus, Asilomar, California, USA [Details]

Book Review

  Year Publication
2011 Purification of proteins from baculovirus-infected insect cells.
O'Shaughnessy, Luke and Doyle, Sean (2011) Purification of proteins from baculovirus-infected insect cells. Book Review [DOI] [Details]
2011 Fungal proteomics: from identification to function.
Doyle S (2011) Fungal proteomics: from identification to function. Book Review [DOI] [Details]

Editorial

  Year Publication
2015 Minimum Information about a Biosynthetic Gene cluster.
Medema, MH;Kottmann, R;Yilmaz, P;Cummings, M;Biggins, JB;Blin, K;de Bruijn, I;Chooi, YH;Claesen, J;Coates, RC;Cruz-Morales, P;Duddela, S;Dusterhus, S;Edwards, DJ;Fewer, DP;Garg, N;Geiger, C;Gomez-Escribano, JP;Greule, A;Hadjithomas, M;Haines, AS;Helfrich, EJN;Hillwig, ML;Ishida, K;Jones, AC;Jones, CS;Jungmann, K;Kegler, C;Kim, HU;Kotter, P;Krug, D;Masschelein, J;Melnik, AV;Mantovani, SM;Monroe, EA;Moore, M;Moss, N;Nutzmann, HW;Pan, GH;Pati, A;Petras, D;Reen, FJ;Rosconi, F;Rui, Z;Tian, ZH;Tobias, NJ;Tsunematsu, Y;Wiemann, P;Wyckoff, E;Yan, XH;Yim, G;Yu, FG;Xie, YC;Aigle, B;Apel, AK;Balibar, CJ;Balskus, EP;Barona-Gomez, F;Bechthold, A;Bode, HB;Borriss, R;Brady, SF;Brakhage, AA;Caffrey, P;Cheng, YQ;Clardy, J;Cox, RJ;De Mot, R;Donadio, S;Donia, MS;van der Donk, WA;Dorrestein, PC;Doyle, S;Driessen, AJM;Ehling-Schulz, M;Entian, KD;Fischbach, MA;Gerwick, L;Gerwick, WH;Gross, H;Gust, B;Hertweck, C;Hofte, M;Jensen, SE;Ju, JH;Katz, L;Kaysser, L;Klassen, JL;Keller, NP;Kormanec, J;Kuipers, OP;Kuzuyama, T;Kyrpides, NC;Kwon, HJ;Lautru, S;Lavigne, R;Lee, CY;Linquan, B;Liu, XY;Liu, W;Luzhetskyy, A;Mahmud, T;Mast, Y;Mendez, C;Metsa-Ketela, M;Micklefield, J;Mitchell, DA;Moore, BS;Moreira, LM;Muller, R;Neilan, BA;Nett, M;Nielsen, J;O'Gara, F;Oikawa, H;Osbourn, A;Osburne, MS;Ostash, B;Payne, SM;Pernodet, JL;Petricek, M;Piel, J;Ploux, O;Raaijmakers, JM;Salas, JA;Schmitt, EK;Scott, B;Seipke, RF;Shen, B;Sherman, DH;Sivonen, K;Smanski, MJ;Sosio, M;Stegmann, E;Sussmuth, RD;Tahlan, K;Thomas, CM;Tang, Y;Truman, AW;Viaud, M;Walton, JD;Walsh, CT;Weber, T;van Wezel, GP;Wilkinson, B;Willey, JM;Wohlleben, W;Wright, GD;Ziemert, N;Zhang, CS;Zotchev, SB;Breitling, R;Takano, E;Glockner, FO (2015) Minimum Information about a Biosynthetic Gene cluster. NEW YORK: Editorial [Details]

Magazine Article

  Year Publication
2015 O-linked beta-N-acetylglucosamine is exposed on the surface of B-lymphocytes in late apoptosis.
O'Connell, TM;Larragy, R;O'Keefe, G;Doyle, S;Walls, D;O'Connor, B (2015) O-linked beta-N-acetylglucosamine is exposed on the surface of B-lymphocytes in late apoptosis. CARY: Magazine Article [Details]
2005 Targeting therapies for the treatment of liver fibrosis - Chemical conjugation of gliotoxin to a human small chain antibody selected for its affinity to a surface antigen on human hepatic stellate cells.
Wallace, K;Elrick, L;Leel, V;Durward, E;Doyle, S;Kavanagh, K;Porter, A;Wright, MC (2005) Targeting therapies for the treatment of liver fibrosis - Chemical conjugation of gliotoxin to a human small chain antibody selected for its affinity to a surface antigen on human hepatic stellate cells. HOBOKEN: Magazine Article [Details]

Reviews

  Year Publication
2015 Endogenous cross-talk of fungal metabolites.
Sheridan K.;Dolan S.;Doyle S. (2015) Endogenous cross-talk of fungal metabolites. Reviews [DOI] [IR Link] [Details]
2015 Resistance is not futile: gliotoxin biosynthesis, functionality and utility.
Dolan, SK;O'Keeffe, G;Jones, GW;Doyle, S (2015) Resistance is not futile: gliotoxin biosynthesis, functionality and utility. OXFORD: Reviews [DOI] [Details]
2014 Biomarkers for invasive aspergillosis: the challenges continue.
Johnson, G;Ferrini, A;Dolan, SK;Nolan, T;Agrawal, S;Doyle, S;Bustin, SA (2014) Biomarkers for invasive aspergillosis: the challenges continue. LONDON: Reviews [DOI] [IR Link] [Details]
2011 Fungal proteomics: from identification to function.
Doyle, S (2011) Fungal proteomics: from identification to function. HOBOKEN: Reviews [DOI] [Details]
2007 Nonribosomal peptide synthesis in Aspergillus fumigatus and other fungi.
Stack, D;Neville, C;Doyle, S (2007) Nonribosomal peptide synthesis in Aspergillus fumigatus and other fungi. READING: Reviews [DOI] [Details]
2007 Nonribosomal peptide synthesis in Aspergillus fumigatus and other fungi.
Stack D.;Neville C.;Doyle S. (2007) Nonribosomal peptide synthesis in Aspergillus fumigatus and other fungi. Reviews [DOI] [Details]
2006 Human Parvovirus B19: Molecular Virology, Clinical Features, Prevalence, Diagnosis and Control.
Corcoran A.;Doyle S. (2006) Human Parvovirus B19: Molecular Virology, Clinical Features, Prevalence, Diagnosis and Control. Reviews [DOI] [Details]
2004 Advances in the biology, diagnosis and host-pathogen interactions of parvovirus B19.
Corcoran, A;Doyle, S (2004) Advances in the biology, diagnosis and host-pathogen interactions of parvovirus B19. READING: Reviews [DOI] [Details]
2003 Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines.
Dalton, JP;Neill, SO;Stack, C;Collins, P;Walshe, A;Sekiya, M;Doyle, S;Mulcahy, G;Hoyle, D;Khaznadji, E;Moire, N;Brennan, G;Mousley, A;Kreshchenko, N;Maule, AG;Donnelly, SM (2003) Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines. OXFORD: Reviews [DOI] [Details]

Thesis

  Year Publication
2001 *.
Thomas Tolfvenstam (2001) *. Karolinska Institute, Stockholm, Sweden: Thesis [Details]

Letters

  Year Publication
2005 Evidence of serological cross-reactivity between genotype 1 and genotype 3 erythrovirus infections (multiple letters).
Corcoran A.;Doyle S.;Allain J.;Candotti D.;Parsyan A. (2005) Evidence of serological cross-reactivity between genotype 1 and genotype 3 erythrovirus infections (multiple letters). Letters [DOI] [IR Link] [Details]