Dr Karen English

Biology

Lecturer, Postgraduate Coordinator

Biosciences & Electronic Engineering Facility
Room B3.17
(01) 7086290

Biography

Dr Karen English (B.Sc., M.Sc and Ph.D., (2008) Maynooth University) received a Marie Curie Fellowship to carry out her postdoctoral training at the University of Oxford (2009-2011) before returning to Maynooth University as a Health Research Board- Translational Medicine Research Fellow and later a Science Foundation Ireland –funded Starting Investigator. She was appointed Lecturer in the Maynooth University Biology Department in 2015.

Research Interests

Dr English leads the Cellular Immunology Laboratory in the Institute of Immunology at Maynooth University. The major focus of our research is the translation of cellular therapy for the treatment of inflammatory diseases. Mesenchymal stromal cells (MSC) are adult cells found in many tissues including bone marrow, adipose tissue and umbilical cord. MSC have potent anti-inflammatory and pro-reparative properties and for this reason are being tested as a cellular therapy for inflammatory disorders. The mechanisms of action used by MSC in protecting against inflammation and promoting repair and not well understood. To address this question, my lab utilises state of the art humanised mouse models of inflammatory disease including graft versus host disease and lung inflammation and fibrotic associated diseases. The overall goal of my research is to further understand how these cells mediate these positive effects and identify their interactions with cells of the immune system to optimise MSC therapy for the treatment of inflammatory disorders.

Peer Reviewed Journals

  Year Publication
2018 'Multipotent Adult Progenitor Cells suppress T cell activation in in vivo models of homeostatic proliferation in a PGE2 dependant manner'
Fiona Carty, Jennifer Corbett, Joao Paulo Monteiro Carvalho Mori Cunha, James L. Reading, Timothy I. Tree, Anthony E. Ting, Samantha R. Stubblefield and Karen English1* (2018) 'Multipotent Adult Progenitor Cells suppress T cell activation in in vivo models of homeostatic proliferation in a PGE2 dependant manner'. Frontiers in Immunology, [DOI] [Details]
2017 'The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents?'
Carty, F;Mahon, BP;English, K (2017) 'The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents?'. Clinical and Experimental Immunology, 188 :1-11 [DOI] [Details]
2016 'Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis-Associated Pathogen Burkholderia cepacia Complex to Lung Epithelial Cells and Protect Mice against Infection'
McClean S;Healy ME;Collins C;Carberry S;O'Shaughnessy L;Dennehy R;Adams Á;Kennelly H;Corbett JM;Carty F;Cahill LA;Callaghan M;English K;Mahon BP;Doyle S;Shinoy M; (2016) 'Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis-Associated Pathogen Burkholderia cepacia Complex to Lung Epithelial Cells and Protect Mice against Infection'. Infection and Immunity, 84 (5) [DOI] [IR Link] [Details]
2016 'Human mesenchymal stromal cells exert HGF dependent cytoprotective effects in a human relevant pre-clinical model of COPD'
Kennelly, H;Mahon, BP;English, K (2016) 'Human mesenchymal stromal cells exert HGF dependent cytoprotective effects in a human relevant pre-clinical model of COPD'. Scientific Reports, 6 [DOI] [Details]
2016 'Hepatocyte Growth Factor Is Required for Mesenchymal Stromal Cell Protection Against Bleomycin-Induced Pulmonary Fibrosis'
Cahill EF;Kennelly H;Carty F;Mahon BP;English K; (2016) 'Hepatocyte Growth Factor Is Required for Mesenchymal Stromal Cell Protection Against Bleomycin-Induced Pulmonary Fibrosis'. Stem cells translational medicine, 5 (10) [DOI] [Details]
2015 'Suppression of IL-7-dependent Effector T-cell Expansion by Multipotent Adult Progenitor Cells and PGE2'
Reading, JL;Vaes, B;Hull, C;Sabbah, S;Hayday, T;Wang, NS;DiPiero, A;Lehman, NA;Taggart, JM;Carty, F;English, K;Pinxteren, J;Deans, R;Ting, AE;Tree, TIM (2015) 'Suppression of IL-7-dependent Effector T-cell Expansion by Multipotent Adult Progenitor Cells and PGE2'. Molecular Therapy, 23 :1783-1793 [DOI] [Details]
2015 'Mesenchymal Stromal Cells Protect Against Caspase 3-Mediated Apoptosis of CD19(+) Peripheral B Cells Through Contact-Dependent Upregulation of VEGF'
Healy, ME;Bergin, R;Mahon, BP;English, K (2015) 'Mesenchymal Stromal Cells Protect Against Caspase 3-Mediated Apoptosis of CD19(+) Peripheral B Cells Through Contact-Dependent Upregulation of VEGF'. Stem Cells and Development, 24 :2391-2402 [DOI] [Details]
2015 'Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells'
Cahill E.;Tobin L.;Carty F.;Mahon B.;English K. (2015) 'Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells'. Stem Cell Research and Therapy, 6 (1) [DOI] [IR Link] [Details]
2014 'Mesenchymal Stromal Cells; Role in Tissue Repair, Drug Discovery and Immune Modulation'
English, K;Mahon, BP;Wood, KJ (2014) 'Mesenchymal Stromal Cells; Role in Tissue Repair, Drug Discovery and Immune Modulation'. Current Drug Delivery, 11 :561-571 [IR Link] [Details]
2013 'Adult mesenchymal stromal cell therapy for inflammatory diseases: How well are we joining the dots?'
Griffin, M.D., Elliman, S.J., Cahill, E., English, K., Ceredig, R. And Ritter, T. (2013) 'Adult mesenchymal stromal cell therapy for inflammatory diseases: How well are we joining the dots?'. Stem Cells, 31 :2033-2041 [Details]
2013 'Mesenchymal Stromal Cells in Transplantation Rejection and Tolerance'
English, K;Wood, KJ (2013) 'Mesenchymal Stromal Cells in Transplantation Rejection and Tolerance'. Cold Spring Harbor perspectives in medicine, 3 [DOI] [Details]
2013 'IFN-gamma stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro'
Noone C.;Kihm A.;English K.;O'Dea S.;Mahon B. (2013) 'IFN-gamma stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro'. Stem Cells and Development, 22 (22):3003-3014 [DOI] [IR Link] [Details]
2013 'Concise review: Adult mesenchymal stromal cell therapy for inflammatory diseases: How well are we joining the dots?'
Griffin, MD;Elliman, SJ;Cahill, E;English, K;Ceredig, R;Ritter, T (2013) 'Concise review: Adult mesenchymal stromal cell therapy for inflammatory diseases: How well are we joining the dots?'. Stem Cells, 31 :2033-2041 [DOI] [Details]
2013 'Human iPSC-derived mesoangioblasts, like their tissue-derived counterparts, suppress T cell proliferation through IDO- and PGE-2-dependent pathways'
Wood K.;Li O.;English K.;Tonlorenzi R.;Cossu G.;Saverio Tedesco F. (2013) 'Human iPSC-derived mesoangioblasts, like their tissue-derived counterparts, suppress T cell proliferation through IDO- and PGE-2-dependent pathways'. F1000 Research, 2 [DOI] [Details]
2013 'Human mesenchymal stem cells suppress donor CD4+T cell proliferation and reduce pathology in a humanized mouse model of acute graft-versus-host disease'
Tobin, LM;Healy, ME;English, K;Mahon, BP (2013) 'Human mesenchymal stem cells suppress donor CD4+T cell proliferation and reduce pathology in a humanized mouse model of acute graft-versus-host disease'. Clinical and Experimental Immunology, 172 :333-348 [DOI] [IR Link] [Details]
2013 'Mesoangioblasts suppress T cell proliferation through IDO and PGE-2-dependent pathways'
English K.;Tonlorenzi R.;Cossu G.;Wood K. (2013) 'Mesoangioblasts suppress T cell proliferation through IDO and PGE-2-dependent pathways'. Stem Cells and Development, 22 (3):512-523 [DOI] [Details]
2013 'Mechanisms of mesenchymal stromal cell immunomodulation. Immunology and Cell Biology'
English, Dr Karen (2013) 'Mechanisms of mesenchymal stromal cell immunomodulation. Immunology and Cell Biology'. Immunology and Cell Biology, 91 :19-26 [DOI] [Details]
2011 'Mesenchymal stem cell inhibition of T-helper 17 cell-differentiation is triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor'
Duffy, MM;Pindjakova, J;Hanley, SA;McCarthy, C;Weidhofer, GA;Sweeney, EM;English, K;Shaw, G;Murphy, JM;Barry, FP;Mahon, BP;Belton, O;Ceredig, R;Griffin, MD (2011) 'Mesenchymal stem cell inhibition of T-helper 17 cell-differentiation is triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor'. European Journal of Immunology, 41 :2840-2851 [DOI] [IR Link] [Details]
2011 'Allogeneic Mesenchymal Stem Cells: Agents of Immune Modulation'
English, K;Mahon, BP (2011) 'Allogeneic Mesenchymal Stem Cells: Agents of Immune Modulation'. Journal of Cellular Biochemistry, 112 :1963-1968 [DOI] [IR Link] [Details]
2010 'Attenuated Bordetella pertussis vaccine strain BPZE1 modulates allergen-induced immunity and prevents allergic pulmonary pathology in a murine model'
Kavanagh, H;Noone, C;Cahill, E;English, K;Locht, C;Mahon, BP (2010) 'Attenuated Bordetella pertussis vaccine strain BPZE1 modulates allergen-induced immunity and prevents allergic pulmonary pathology in a murine model'. Clinical and Experimental Allergy, 40 :933-941 [DOI] [IR Link] [Details]
2009 'Cell contact, prostaglandin E-2 and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4(+)CD25(High)forkhead box P3(+) regulatory T cells'
English, K;Ryan, JM;Tobin, L;Murphy, MJ;Barry, FP;Mahon, BP (2009) 'Cell contact, prostaglandin E-2 and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4(+)CD25(High)forkhead box P3(+) regulatory T cells'. Clinical and Experimental Immunology, 156 :149-160 [DOI] [Details]
2009 'Regulation of Surfactant Protein B Gene Expression in Bone Marrow-Derived Cells'
Field-Corbett, C;English, K;O'Dea, S (2009) 'Regulation of Surfactant Protein B Gene Expression in Bone Marrow-Derived Cells'. Stem Cells, 27 :662-669 [DOI] [Details]
2009 'A Live Attenuated Bordetella pertussis Candidate Vaccine Does Not Cause Disseminating Infection in Gamma Interferon Receptor Knockout Mice'
Skerry, CM;Cassidy, JP;English, K;Feunou-Feunou, P;Locht, C;Mahon, BP (2009) 'A Live Attenuated Bordetella pertussis Candidate Vaccine Does Not Cause Disseminating Infection in Gamma Interferon Receptor Knockout Mice'. CLINICAL AND VACCINE IMMUNOLOGY, 16 :1344-1351 [DOI] [Details]
2008 'Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation'
English, K;Barry, FP;Mahon, BP (2008) 'Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation'. Immunology Letters, 115 :50-58 [DOI] [Details]
2007 'IFN-g and TNF-a differentially regulate immunomodulation by murine mesenchymal stem cells'
English K.;Barry F.;Field-Corbett C.;Mahon B. (2007) 'IFN-g and TNF-a differentially regulate immunomodulation by murine mesenchymal stem cells'. Immunology Letters, 110 (2):91-100 [DOI] [IR Link] [Details]
2006 'Interleukin-10 (IL-10) but not Lipopolysaccharide (LPS) produces increased motor activity and abnormal exploratory patterns while impairing spatial learning in Balb/c mice'
Harvey, D;Smith, R;English, K;Mahon, B;Commins, S (2006) 'Interleukin-10 (IL-10) but not Lipopolysaccharide (LPS) produces increased motor activity and abnormal exploratory patterns while impairing spatial learning in Balb/c mice'. Physiology and Behavior, 87 :842-847 [DOI] [IR Link] [Details]
2006 'Inflammation of the respiratory tract is associated with CCL28 and CCR10 expression in a murine model of allergic asthma'
English K.;Brady C.;Corcoran P.;Cassidy J.;Mahon B. (2006) 'Inflammation of the respiratory tract is associated with CCL28 and CCR10 expression in a murine model of allergic asthma'. Immunology Letters, 103 (2):92-100 [DOI] [Details]

Book Chapters

  Year Publication
2014 'Stem Cell-Based Approach to Immunomodulation'
Wood K.;English K.;Li O. (2014) 'Stem Cell-Based Approach to Immunomodulation' In: Regenerative Medicine Applications in Organ Transplantation. [DOI] [Details]
2013 'Mesenchymal stromal cells in transplantation rejection and tolerance'
English K* and Wood K.J (2013) 'Mesenchymal stromal cells in transplantation rejection and tolerance' In: Transplantation. Cold Spring Harb Perspect Med. 1;3 (5). pii: a015560. [Details]
2013 'Addressing the challenge of autoimmunity in the treatment of diabetes with stem cells'
English K* and Wood K.J (2013) 'Addressing the challenge of autoimmunity in the treatment of diabetes with stem cells' In: The immunological barriers to regenerative medicine. DOI: 10.1007/978-1-4614-5480-9_16. Springer Verlag In Press. [Details]

Conference Contributions

  Year Publication
2010 The Oxford Stem Cell Institute Annual Symposium.
Karen English (2010) The Oxford Stem Cell Institute Annual Symposium. [Oral Presentation], Immunomodulation by mesenchymal stem cells, University of Oxford, June 2010 [Details]
2005 Annual Congress of the British Society of Immunology.
Karen English (2005) Annual Congress of the British Society of Immunology. [Oral Presentation], (Comparative immunology of reproduction) - Allogeneic murine mesenchymal stem cells suppress mitogen induced proliferation of CD4+ T cells, lessons from the fetal allograft, Harrogate, UK Dec 2005 [Details]
2009 Irish Stem Cell Meeting.
Karen English (2009) Irish Stem Cell Meeting. [Oral Presentation], Mesenchymal stem cells and rejection, Trinity College Dublin, March 2009 [Details]
2008 Annual meetings of the Regenerative Medicine Institute (REMEDI).
Karen English (2008) Annual meetings of the Regenerative Medicine Institute (REMEDI). [Conference Organising Committee Member], Mesenchymal stem cell project collaborators, Galway, Ireland April 2005, 2006, 2007, 2008 [Details]
2008 International Society for Cell Therapy – Europe.
Karen English (2008) International Society for Cell Therapy – Europe. [Oral Presentation], Human mesenchymal stem cells induce CD4+CD25HighFoxp3+ regulatory T cells through prostaglandin E2 and transforming growth factor beta 1, Antwerp, Belgium, September 2008 [Details]
2008 RESCUE Society Meeting.
Karen English (2008) RESCUE Society Meeting. [Oral Presentation], Allogeneic human mesenchymal stem cells induce CD4+CD25HighFoxp3+ T cells with suppressor activity through production of prostaglandin E2, transforming growth factor beta 1 and by direct cell contact, Karolinska Institute, Stockholm, Sweeden, October 2008 [Details]
2009 Optistem (EU consortium).
Karen English (2009) Optistem (EU consortium). [Oral Presentation], Mesenchymal stem cells prevent islet allograft rejection, Meeting, Hydra, Greece September 2009 [Details]
2007 Irish Society for Immunology.
Karen English (2007) Irish Society for Immunology. [Oral Presentation], Murine mesenchymal stem cells interfere with dendritic cell migration, maturation and function, DCU, Ireland, September 2007 [Details]
2007 International Immunology Postgraduate Master Class.
Karen English (2007) International Immunology Postgraduate Master Class. [Oral Presentation], Murine mesenchymal stem cells interfere with dendritic cell function and T cell proliferation, NUI Maynooth July 2007 [Details]
2007 2nd UK National Mesenchymal Stem Cell Meeting.
Karen English (2007) 2nd UK National Mesenchymal Stem Cell Meeting. [Oral Presentation], Murine mesenchymal stem cells interfere with dendritic cell migration, maturation and function, York, UK September 2007 [Details]
2007 British Association of Lung Research.
Karen English (2007) British Association of Lung Research. [Oral Presentation], Murine mesenchymal stem cells reduce inflammation in a mouse model of allergic inflammation, NUI Maynooth September 2007 [Details]
2006 Biology And Clinical Applications of Mesenchymal Stem CellsEHA Scientific workshop.
Karen English (2006) Biology And Clinical Applications of Mesenchymal Stem CellsEHA Scientific workshop. [Oral Presentation], Mesenchymal stem cell expression of immunomodulatory factors is regulated by the pro-inflammatory cytokine IFN-, Mandelieu, France October 2006 [Details]
2011 Optistem (EU consortium) Annual Meeting April 2011.
Karen English (2011) Optistem (EU consortium) Annual Meeting April 2011. [Oral Presentation], Human Mesoangioblasts suppress T cell proliferation through IDO and PGE-2 dependent pathways, Loire France [Details]

Book Review

  Year Publication
2011 Allogeneic Mesenchymal Stem Cells-Agents of Immune Deviation. J Cell Biochem.
English K and Mahon BP (2011) Allogeneic Mesenchymal Stem Cells-Agents of Immune Deviation. J Cell Biochem. Book Review [Details]
2011 Immunogenicity of embryonic stem cell-derived progenitors after transplantation.
English K and Wood KJ. (2011) Immunogenicity of embryonic stem cell-derived progenitors after transplantation. Book Review [Details]
2011 Intervertebral Disc Repair: Mesenchymal Stem Cells to the Rescue?.
English, Dr Karen (2011) Intervertebral Disc Repair: Mesenchymal Stem Cells to the Rescue?. Book Review [Details]
2010 Mesenchymal stromal cells; facilitators of successful transplantation?.
English K, French A, Wood KJ. (2010) Mesenchymal stromal cells; facilitators of successful transplantation?. Book Review [Details]
2005 Immunogenicity of adult mesenchymal stem cells: lessons from the fetal allograft.
Barry FP, Murphy JM, English K, Mahon BP (2005) Immunogenicity of adult mesenchymal stem cells: lessons from the fetal allograft. Book Review [Details]

Reviews

  Year Publication
2014 Stem cell transplantation for muscular dystrophy: The challenge of immune response.
Maffioletti S.;Noviello M.;English K.;Tedesco F. (2014) Stem cell transplantation for muscular dystrophy: The challenge of immune response. Reviews [DOI] [Details]
2013 Mesenchymal stromal cells in transplantation rejection and tolerance.
English K.;Wood K. (2013) Mesenchymal stromal cells in transplantation rejection and tolerance. Reviews [DOI] [Details]
2013 Mechanisms of mesenchymal stromal cell immunomodulation.
English K. (2013) Mechanisms of mesenchymal stromal cell immunomodulation. Reviews [DOI] [Details]
2005 Immunogenicity of adult mesenchymal stem cells: Lessons from the fetal allograft.
Barry, FP;Murphy, JM;English, K;Mahon, BP (2005) Immunogenicity of adult mesenchymal stem cells: Lessons from the fetal allograft. NEW ROCHELLE: Reviews [Details]

Note

  Year Publication
2013 Immunomodulation by adult stem cells.
English K. (2013) Immunomodulation by adult stem cells. Note [Details]

Honours and Awards

  Year Title Awarding Body
2008 Top 25 hottest articles” in Immunology Letters by Science Di
2007 Best Postgraduate Oral Presentation, Irish Society of Immu
2012 EFIS/IL Best cited paper award
2007 Dorothy Price Medal, International Postgraduate Master Class
2002 Award for 1st in class, Third year B.Sc. NUI Maynooth
2009 Marie Curie Fellowship Intra-european Fellowship, Oxford.
2011 HRB Translational Medicine Postdoctoral Research Fellowship
2006 NUI Maynooth postgraduate travel grant
2012 Marie Curie Career Integration Grant

Professional Associations

  Association Function From / To
British Society of Immunology /
Irish Society of Immunology /

Recent Postgraduates

  Graduation Student Name University Degree Thesis
2016 Laura Cahill Maynooth University PhD An Investigation of The Effect of Hypoxic Culture on MSC Immunomodulation and Biodistribution in-vivo
2016 Jennifer Corbett Maynooth University PhD Investigation of the Efficacy of a Novel CsA Formulation Alone or in Combination with Cell Therapy in a Humanised Mouse Model of GvHD
2016 Helen Kennelly Maynooth University PhD Investigation of efficacy and mechanisms of action in mesenchymal stromal cell therapy for chronic lung diseases
2015 Marc E. Healy Maynooth University PhD A Delineation of Mesenchymal Stromal Cell Therapeutic Action in New Models of Acute and Chronic Graft versus Host Disease
2018 Aine Adams Maynooth University PhD Development of a humanised mouse model of ovalbumin induced allergy and inflammation as a platform to test functional foods
2017 Fiona Carty Maynooth University PhD Biodistribution and modes of action of Multipoint Adult Progenitor Cell therapy in Murine models of Transplant Rejection

External Collaborators

  Name Role / Description Country
Prof William Gallagher. UCD Imaging Collaborator
.
Bob Deans. Athersys Inc Collaborative research project examining the Multistem cellular therapy in GvHD
Ivan Coulter. Sigmoid Pharma IRC EPS Joint Student PhD Scholar
Catherine Flynn, Consultant Haematologist. St. James's Hospital Clinical Collaborator
Bart Vaes. ReGenesys IRC EPS Joint PhD Student Scholar