Dr Andrew Hogan

Biology, Human Health Institute

Lecturer

Biosciences & Electronic Engineering Building
B2.16
(01) 708 6118

Biography

Dr Andrew Hogan is Principle Investigator with the Metabolic Immunology Research Group.
He completed he undergraduate and post-graduate studies in Maynooth University, before being awarded a Newman Fellowship in Obesity with Prof Donal O'Shea in UCD and St Vincent's Hospital.
In 2012, he was awarded a Research Fellowship from the National Children's Research Centre and established the Childhood Obesity Immunology Group. He has also been a research fellow in the lab of Prof Lydia Lynch in Harvard Medical School. 

The groups research focuses on the impact of Obesity on the immune system and the development of co-morbid diseases such as Type II Diabetes and Cancer. The group has strong clinical partnerships with Prof Donal O'Shea (St Vincent's University Hospital), Prof Declan Cody (Our Lady's Children's Hospital Crumlin) and Dr Anne Marie Tobin (Tallaght Hospital).

Research Interests

Ireland has one of the highest rates of childhood obesity in the world. One in four Irish school-going children are either overweight or obese. These children are at a higher risk of developing cardiovascular, metabolic and cancer related co-morbidities. Furthermore, children who are obese are highly likely to be obese in adulthood. The purpose of our research is to understand how and aim to develop successful interventions to prevent the establishment of overt chronic disease.

The Obesity Immunology research programme aims to do this by investigating (1) how obesity impacts the immune system, driving inflammation and dysregulation, which underpins the development of the aforementioned diseases. (2) Our research also 
focuses on how the immune system regulates metabolism (from insulin signalling to adiposity), better understanding of these processes will allow us to identify new therapeutic strategies for obesity and its associated diseases.

Research Projects

  Project Role Funding Body / Program Description Start Date End Date Award (€)
Novel Approach to the Development of Food Products for Pre-Diabetics and Those With Impaired Glucose Tolerance Co-PI Enterprise Ireland / 01-AUG-18 31-JUL-20
immune dysregulation in Type 1 diabetes. Principle Investigator National Children’s Research Centre Crumlin / NCRC / 09-JUL-18 12-JUL-20
Inflammatory markers of antipsychotic weight gain and cardiometabolic dysfunction in youth mental health disorders Principle Investigator National Children’s Research Centre Crumlin / NCRC / 01-FEB-18 30-JAN-21
Investigating the impact of childhood obesity on innate immune cell function & metabolism and their modulation by Metformin and Glucagon like peptide-1 Principle Investigator / National Children's Research Centre 01-MAY-17 30-MAY-20
Effect of Glucagon like peptide-1 therapy on obesity driven inflammation and co- morbid inflammatory conditions. Scientific Lead / Health Research Board 01-MAY-15 30-APR-18

Peer Reviewed Journals

  Year Publication
2018 'Type 1 IFN Induction by Cytosolic Nucleic Acid Is Intact in Neonatal Mononuclear Cells, Contrasting Starkly with Neonatal Hyporesponsiveness to TLR Ligation Due to Independence from Endosome-Mediated IRF3 Activation'
Brennan K;O'Leary BD;Mc Laughlin D;Breen EP;Connolly E;Ali N;O'Driscoll DN;Ozaki E;Mahony R;Mulfaul K;Ryan AM;Ni Chianain A;McHugh A;Molloy EJ;Hogan AE;Paran S;McAuliffe FM;Doyle SL; (2018) 'Type 1 IFN Induction by Cytosolic Nucleic Acid Is Intact in Neonatal Mononuclear Cells, Contrasting Starkly with Neonatal Hyporesponsiveness to TLR Ligation Due to Independence from Endosome-Mediated IRF3 Activation'. Journal of Immunology, [DOI] [Details]
2017 'Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity'
Boulenouar, S;Michelet, X;Duquette, D;Alvarez, D;Hogan, AE;Dold, C;O'Connor, D;Stutte, S;Tavakkoli, A;Winters, D;Exley, MA;O'Shea, D;Brenner, MB;von Andrian, U;Lynch, L (2017) 'Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity'. Immunity, 46 :273-286 [DOI] [Details]
2017 'NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient'
Tobin, LM;Mavinkurve, M;Carolan, E;Kinlen, D;O'Brien, EC;Little, MA;Finlay, DK;Cody, D;Hogan, AE;O'Shea, D (2017) 'NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient'. Jci Insight, 2 [DOI] [IR Link] [Details]
2017 'Preliminary asthma -related outcomes following glucagon - like peptide 1 agonist therapy'
Khan F;Mat A;Hogan A;Kent B;Eigenheer S;Corrigan M;O'Shea D;Butler M; (2017) 'Preliminary asthma -related outcomes following glucagon - like peptide 1 agonist therapy'. QJM - Monthly Journal of the Association of Physicians, [DOI] [Details]
2016 'iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy'
Lynch, L;Hogan, AE;Duquette, D;Lester, C;Banks, A;LeClair, K;Cohen, DE;Ghosh, A;Lu, B;Corrigan, M;Stevanovic, D;Maratos-Flier, E;Drucker, DJ;O'Shea, D;Brenner, M (2016) 'iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy'. Cell Metabolism, 24 :510-519 [DOI] [Details]
2016 'The helminth T2 RNase omega 1 promotes metabolic homeostasis in an IL-33-and group 2 innate lymphoid cell-dependent mechanism'
Hams, E;Bermingham, R;Wurlod, FA;Hogan, AE;O'Shea, D;Preston, RJ;Rodewald, HR;McKenzie, ANJ;Fallon, PG (2016) 'The helminth T2 RNase omega 1 promotes metabolic homeostasis in an IL-33-and group 2 innate lymphoid cell-dependent mechanism'. FASEB Journal, 30 :824-835 [DOI] [Details]
2015 'Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity'
Carolan E.;Tobin L.;Mangan B.;Corrigan M.;Gaoatswe G.;Byrne G.;Geoghegan J.;Cody D.;O'Connell J.;Winter D.;Doherty D.;Lynch L.;O'Shea D.;Hogan A. (2015) 'Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity'. Journal of Immunology, 194 (12):5775-5780 [DOI] [Details]
2015 'Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity'
Gaoatswe, G;Kent, BD;Corrigan, MA;Nolan, G;Hogan, AE;McNicholas, WT;O'Shea, D (2015) 'Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity'. Sleep, 38 :1629-1634 [DOI] [Details]
2015 'Tissue specific regulation of glucocorticoids in severe obesity and the response to significant weight loss following bariatric surgery (BARICORT)'
Woods C.;Corrigan M.;Gathercole L.;Taylor A.;Hughes B.;Gaoatswe G.;Manolopoulos K.;Hogan A.;O'Connell J.;Stewart P.;Tomlinson J.;O'Shea D.;Sherlock M. (2015) 'Tissue specific regulation of glucocorticoids in severe obesity and the response to significant weight loss following bariatric surgery (BARICORT)'. Journal of Clinical Endocrinology and Metabolism, 100 (4):1434-1444 [DOI] [Details]
2014 'The E3 Ubiquitin Ligase Pellino3 Protects against Obesity-Induced Inflammation and Insulin Resistance'
Yang, S;Wang, BW;Humphries, F;Hogan, AE;O'Shea, D;Moynagh, PN (2014) 'The E3 Ubiquitin Ligase Pellino3 Protects against Obesity-Induced Inflammation and Insulin Resistance'. Immunity, 41 :973-987 [DOI] [Details]
2014 'The Impact of Childhood Obesity on Inflammation, Innate Immune Cell Frequency, and Metabolic MicroRNA Expression'
Carolan, E;Hogan, AE;Corrigan, M;Gaotswe, G;O'Connell, J;Foley, N;O'Neill, LA;Cody, D;O'Shea, D (2014) 'The Impact of Childhood Obesity on Inflammation, Innate Immune Cell Frequency, and Metabolic MicroRNA Expression'. Journal of Clinical Endocrinology and Metabolism, 99 :474-478 [DOI] [Details]
2014 'Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus'
Hogan, AE;Gaoatswe, G;Lynch, L;Corrigan, MA;Woods, C;O'Connell, J;O'Shea, D (2014) 'Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus'. Diabetologia, 57 :781-784 [DOI] [Details]
2013 'Cutting edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human Vδ3 T cells'
Mangan B.;Dunne M.;O'Reilly V.;Dunne P.;Exley M.;O'Shea D.;Scotet E.;Hogan A.;Doherty D. (2013) 'Cutting edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human Vδ3 T cells'. Journal of Immunology, 191 (1):30-34 [DOI] [Details]
2013 'Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection'
O'Shea D.;Corrigan M.;Dunne M.;Jackson R.;Woods C.;Gaoatswe G.;Moynagh P.;O'Connell J.;Hogan A. (2013) 'Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection'. International Journal of Obesity, 37 (11):1510-1513 [DOI] [IR Link] [Details]
2013 'Human Invariant NKT Cell Subsets Differentially Promote Differentiation, Antibody Production, and T Cell Stimulation by B Cells In Vitro'
Zeng, SG;Ghnewa, YG;O'Reilly, VP;Lyons, VG;Atzberger, A;Hogan, AE;Exley, MA;Doherty, DG (2013) 'Human Invariant NKT Cell Subsets Differentially Promote Differentiation, Antibody Production, and T Cell Stimulation by B Cells In Vitro'. Journal of Immunology, 191 :1666-1676 [DOI] [Details]
2012 'Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production'
Lynch L.;Nowak M.;Varghese B.;Clark J.;Hogan A.;Toxavidis V.;Balk S.;O'Shea D.;O'Farrelly C.;Exley M. (2012) 'Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production'. Immunity, 37 (3):574-587 [DOI] [Details]
2012 'Correlation between maternal inflammatory markers and fetomaternal adiposity'
Farah N.;Hogan A.;O'Connor N.;Kennelly M.;O'Shea D.;Turner M. (2012) 'Correlation between maternal inflammatory markers and fetomaternal adiposity'. Cytokine, 60 (1):96-99 [DOI] [Details]
2011 'Distinct and overlapping effector functions of expanded human CD4 +, cd8α + and CD4 -CD8α - invariant natural killer T cells'
O'Reilly V.;Zeng S.;Bricard G.;Atzberger A.;Hogan A.;Jackson J.;Feighery C.;Porcelli S.;Doherty D. (2011) 'Distinct and overlapping effector functions of expanded human CD4 +, cd8α + and CD4 -CD8α - invariant natural killer T cells'. PLoS ONE, 6 (12) [DOI] [Details]
2011 'Activation of human invariant natural killer T cells with a thioglycoside analogue of alpha-galactosylceramide'
Hogan, AE;O'Reilly, V;Dunne, MR;Dere, RT;Zeng, SJG;O'Brien, C;Amu, S;Fallon, PG;Exley, MA;O'Farrelly, C;Zhu, XM;Doherty, DG (2011) 'Activation of human invariant natural killer T cells with a thioglycoside analogue of alpha-galactosylceramide'. Journal of Clinical Immunology, 140 :196-207 [DOI] [IR Link] [Details]
2011 'Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis'
Hogan, AE;Tobin, AM;Ahern, T;Corrigan, MA;Gaoatswe, G;Jackson, R;O'Reilly, V;Lynch, L;Doherty, DG;Moynagh, PN;Kirby, B;O'Connell, J;O'Shea, D (2011) 'Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis'. Diabetologia, 54 :2745-2754 [DOI] [IR Link] [Details]
2011 'Tumour Tissue Microenvironment Can Inhibit Dendritic Cell Maturation in Colorectal Cancer'
Michielsen, AJ;Hogan, AE;Marry, J;Tosetto, M;Cox, F;Hyland, JM;Sheahan, KD;O'Donoghue, DP;Mulcahy, HE;Ryan, EJ;O'Sullivan, JN (2011) 'Tumour Tissue Microenvironment Can Inhibit Dendritic Cell Maturation in Colorectal Cancer'. PLoS ONE, 6 [DOI] [Details]
2011 'Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses'
Hogan, AE;Corrigan, MA;O'Reilly, V;Gaoatswe, G;O'Connell, J;Doherty, DG;Lynch, L;O'Shea, D (2011) 'Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses'. Journal of Clinical Immunology, 140 :229-235 [DOI] [Details]
2007 'CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver'
Kenna, T;O'Brien, M;Hogan, AE;Exley, MA;Porcelli, SA;Hegarty, JE;O'Farrelly, C;Doherty, DG (2007) 'CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver'. Cancer Immunology, Immunotherapy, 56 :563-572 [DOI] [IR Link] [Details]