Dr Shirley O'Dea

Biology

Associate Professor
Co-Director, Avectas

Eolas Building
Third Floor
(01) 474 7300

Biography

Dr. O'Dea (B.Sc., University College Dublin; Ph.D., Dublin City University, 1995) received a Marie Curie Fellowship and a Salvesen Fellowship to work at Edinburgh University (1997-2001) before coming to Maynooth University as a Science Foundation Ireland-funded investigator. She was appointed Lecturer in the Biology Department, NUIM in 2005 and Associate Professor in 2012. Dr. O'Dea is co-founder of the spin-out company Avectas (www.avectas.com).

Peer Reviewed Journals

  Year Publication
2021 'A novel non-viral delivery method that enables efficient engineering of primary human T cells for ex vivo cell therapy applications'
Kavanagh, H;Dunne, S;Martin, DS;McFadden, E;Gallagher, L;Schwaber, J;Leonard, S;O'Dea, S (2021) 'A novel non-viral delivery method that enables efficient engineering of primary human T cells for ex vivo cell therapy applications'. Cytotherapy, 23 :852-860 [DOI] [Details]
2018 'Delivery of nucleic acids to ex vivo porcine airways using electrospray'
Riddell, P;Gilbert, JL;Molloy, EL;Finnegan, S;Egan, JJ;O'Dea, S (2018) 'Delivery of nucleic acids to ex vivo porcine airways using electrospray'. Experimental Lung Research, 44 :405-416 [DOI] [full-text] [Details]
2018 'A Novel Methodology for Bio-electrospraying Mesenchymal Stem Cells that Maintains Differentiation, Immunomodulatory and Pro-reparative Functions'
McCrea Z.;Arnanthigo Y.;Cryan S.;O’Dea S. (2018) 'A Novel Methodology for Bio-electrospraying Mesenchymal Stem Cells that Maintains Differentiation, Immunomodulatory and Pro-reparative Functions'. Journal of Medical and Biological Engineering, 38 (3):497-513 [DOI] [full-text] [Details]
2017 'Vector-free intracellular delivery by reversible permeabilization'
O'Dea S;Annibaldi V;Gallagher L;Mulholland J;Molloy EL;Breen CJ;Gilbert JL;Martin DS;Maguire M;Curry FR; (2017) 'Vector-free intracellular delivery by reversible permeabilization'. PLoS ONE, 12 (3) [DOI] [full-text] [Details]
2016 'SMAD Signaling in the Airways of Healthy Rhesus Macaques versus Rhesus Macaques with Asthma Highlights a Relationship Between Inflammation and Bone Morphogenetic Proteins'
Lynn TM;Molloy EL;Masterson JC;Glynn SF;Costello RW;Avdalovic MV;Schelegle ES;Miller LA;Hyde DM;O'Dea S; (2016) 'SMAD Signaling in the Airways of Healthy Rhesus Macaques versus Rhesus Macaques with Asthma Highlights a Relationship Between Inflammation and Bone Morphogenetic Proteins'. American Journal of Respiratory Cell and Molecular Biology, 54 (4) [DOI] [full-text] [Details]
2016 'The development of a tissue-engineered tracheobronchial epithelial model using a bilayered collagen-hyaluronate scaffold'
O'Leary C.;Cavanagh B.;Unger R.;Kirkpatrick C.;O'Dea S.;O'Brien F.;Cryan S. (2016) 'The development of a tissue-engineered tracheobronchial epithelial model using a bilayered collagen-hyaluronate scaffold'. Biomaterials, 85 :111-127 [DOI] [full-text] [Details]
2016 'Methodologies for bladder cancer detection with Raman based urine cytology'
Kerr L.;Lynn T.;Cullen I.;Daly P.;Shah N.;O'Dea S.;Malkin A.;Hennelly B. (2016) 'Methodologies for bladder cancer detection with Raman based urine cytology'. Analytical Methods, 8 (25):4991-5000 [DOI] [Details]
2015 'Respiratory Tissue Engineering: Current Status and Opportunities for the Future'
O'Leary C;Gilbert JL;O'Dea S;O'Brien FJ;Cryan SA; (2015) 'Respiratory Tissue Engineering: Current Status and Opportunities for the Future'. Tissue Engineering - Part B: Reviews, 21 (4) [DOI] [Details]
2014 'Anatomy and bronchoscopy of the porcine lung. A model for translational respiratory medicine'
Judge EP;Hughes JM;Egan JJ;Maguire M;Molloy EL;O'Dea S; (2014) 'Anatomy and bronchoscopy of the porcine lung. A model for translational respiratory medicine'. American Journal of Respiratory Cell and Molecular Biology, 51 (3) [DOI] [full-text] [Details]
2013 'IFN-gamma stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro'
Noone C.;Kihm A.;English K.;O'Dea S.;Mahon B. (2013) 'IFN-gamma stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro'. Stem Cells and Development, 22 (22):3003-3014 [DOI] [full-text] [Details]
2013 'Regulation of epithelial to mesenchymal transition by bone morphogenetic proteins'
McCormack N;O'Dea S; (2013) 'Regulation of epithelial to mesenchymal transition by bone morphogenetic proteins'. Cellular Signalling, 25 (12) [DOI] [full-text] [Details]
2013 'Bone morphogenetic proteins enhance an epithelial-mesenchymal transition in normal airway epithelial cells during restitution of a disrupted epithelium'
McCormack, N;Molloy, EL;O'Dea, S (2013) 'Bone morphogenetic proteins enhance an epithelial-mesenchymal transition in normal airway epithelial cells during restitution of a disrupted epithelium'. Respiratory Research, 14 [DOI] [full-text] [Details]
2012 'Olfactomedin III expression contributes to anoikis-resistance in clonal variants of a human lung squamous carcinoma cell line'
Keenan, J;Joyce, H;Aherne, S;O'Dea, S;Doolan, P;Lynch, V;Clynes, M (2012) 'Olfactomedin III expression contributes to anoikis-resistance in clonal variants of a human lung squamous carcinoma cell line'. Experimental Cell Research, 318 :593-602 [DOI] [full-text] [Details]
2011 'Bone morphogenetic protein signalling in airway epithelial cells during regeneration'
Masterson, JC;Molloy, EL;Gilbert, JL;McCormack, N;Adams, A;O'Dea, S (2011) 'Bone morphogenetic protein signalling in airway epithelial cells during regeneration'. Cellular Signalling, 23 :398-406 [DOI] [full-text] [Details]
2009 'Regulation of Surfactant Protein B Gene Expression in Bone Marrow-Derived Cells'
Field-Corbett, C;English, K;O'Dea, S (2009) 'Regulation of Surfactant Protein B Gene Expression in Bone Marrow-Derived Cells'. Stem Cells, 27 :662-669 [DOI] [full-text] [Details]
2008 'BMP4 induces an epithelial-mesenchymal transition-like response in adult airway epithelial cells'
Molloy, EL;Adams, A;Moore, JB;Masterson, JC;Madrigal-Estebas, L;Mahon, BP;O'Dea, S (2008) 'BMP4 induces an epithelial-mesenchymal transition-like response in adult airway epithelial cells'. Growth Factors, 26 :12-22 [DOI] [full-text] [Details]
2008 'Comparative evaluation of viral, nonviral and physical methods of gene delivery to normal and transformed lung epithelial cells'
Gilbert, JL;Purcell, J;Strappe, P;McCabe, M;O'Brien, T;O'Dea, S (2008) 'Comparative evaluation of viral, nonviral and physical methods of gene delivery to normal and transformed lung epithelial cells'. Anti-Cancer Drugs, 19 :783-788 [DOI] [full-text] [Details]
2008 'Reducing the false positive rate in the non-parametric analysis of molecular coevolution'
Codoner, FM;O'Dea, S;Fares, MA (2008) 'Reducing the false positive rate in the non-parametric analysis of molecular coevolution'. BMC Evolutionary Biology, 8 [DOI] [full-text] [Details]
2008 'A possible role for protein synthesis, extracellular signal-regulated kinase, and brain-derived neurotrophic factor in long-term spatial memory retention in the water maze'
McGauran, AMT;Barry, D;Moore, JB;Madsen, D;O'Dea, S;Mahon, BP;Commins, S (2008) 'A possible role for protein synthesis, extracellular signal-regulated kinase, and brain-derived neurotrophic factor in long-term spatial memory retention in the water maze'. Behavioral Neuroscience, 122 :805-815 [DOI] [full-text] [Details]
2007 'Posttranslational truncation of E-cadherin and significance for tumour progression'
Masterson J;O'Dea S; (2007) 'Posttranslational truncation of E-cadherin and significance for tumour progression'. Cells Tissues Organs, 185 (1-3) [DOI] [full-text] [Details]
2007 '5-Bromo-2-deoxyuridine activates DNA damage signaling responses and induces a senescence-like phenotype in p16-null lung cancer cells'
Masterson, J.C. and ODea, S. (2007) '5-Bromo-2-deoxyuridine activates DNA damage signaling responses and induces a senescence-like phenotype in p16-null lung cancer cells'. ANTI-CANCER DRUGS, 18 :1053-1068 [full-text] [Details]
2007 'Soluble signals from mechanically disrupted lung tissue induce lung-related gene expression in bone marrow-derived cells in vitro'
Field-Corbett, C;O'Dea, S (2007) 'Soluble signals from mechanically disrupted lung tissue induce lung-related gene expression in bone marrow-derived cells in vitro'. Stem Cells and Development, 16 :231-241 [DOI] [full-text] [Details]
2004 'P21(Waf1/Cip1) regulates proliferation and apoptosis in airway epithelial cells and alternative forms have altered binding activities'
Blundell, R;Harrison, DJ;O'Dea, S (2004) 'P21(Waf1/Cip1) regulates proliferation and apoptosis in airway epithelial cells and alternative forms have altered binding activities'. Experimental Lung Research, 30 :447-464 [DOI] [full-text] [Details]
2002 'CFTR gene transfer to lung epithelium--on the trail of a target cell'
O'Dea S;Harrison DJ; (2002) 'CFTR gene transfer to lung epithelium--on the trail of a target cell'. Current Gene Therapy, 2 (2) [DOI] [Details]
2002 'Absence of p53 in lung epithelial cells favours multinucleation and loss of cell cycle arrest'
Armit, C. J., O'Dea, S., Clarke, A.R. and Harrison, D. J. (2002) 'Absence of p53 in lung epithelial cells favours multinucleation and loss of cell cycle arrest'. BMC CELL BIOLOGY, 3 [full-text] [Details]
2000 'Characterisation of lectin binding patterns of mouse bronchiolar and rat alveolar epithelial cells in culture'
McBride, S., Tatrai, E., Blundell, R., Kovacikova, Z., Cardozo, L., Adamis, Z., Smith, T. and Harrison, D. (2000) 'Characterisation of lectin binding patterns of mouse bronchiolar and rat alveolar epithelial cells in culture'. Histochemical Journal, 32 :33-40 [full-text] [Details]
2000 'Gene transfer to adult human lung tissue ex vivo'
McBride, S., Rannie, D. and Harrison, D. (2000) 'Gene transfer to adult human lung tissue ex vivo'. Gene Therapy, 7 :675-678 [full-text] [Details]
1999 'Bromodeoxyuridine induces keratin protein synthesis at a posttranscriptional level in human lung tumour cell lines'
McBride, S., Walsh, D., Meleady, P., Daly, N. and Clynes, M. (1999) 'Bromodeoxyuridine induces keratin protein synthesis at a posttranscriptional level in human lung tumour cell lines'. DIFFERENTIATION, 64 :185-193 [full-text] [Details]
1998 'Human lung carcinoma cell line DLKP contains 3 distinct subpopulations with different growth and attachment properties'
McBride, S., .Meleady, P., .Baird, A., .Dinsdale, D. and Clynes, M. (1998) 'Human lung carcinoma cell line DLKP contains 3 distinct subpopulations with different growth and attachment properties'. Tumor Biology, 19 :88-103 [full-text] [Details]
1996 'Mdr-1 ribozyme-mediated reversal of the multi-drug resistant phenotype in human lung cell lines'
Daly, C., Coyle, S., McBride, S., O'Driscoll, L., Daly, N., Scanlon, K. and Clynes, M. (1996) 'Mdr-1 ribozyme-mediated reversal of the multi-drug resistant phenotype in human lung cell lines'. Cytotechnology, 19 :199-205 [full-text] [Details]
1995 'Multiple drug resistance in variants of a human lung line exposed to adriamycin and VP-16'
Clynes, M., Heenan, M., McBride, S., Cleary, I., Doherty, G., O'Driscoll, L. and Moran, E. (1995) 'Multiple drug resistance in variants of a human lung line exposed to adriamycin and VP-16'. Journal of Experimental and Clinical Cancer Research, 14 :15-16 [full-text] [Details]

Book Chapters

  Year Publication
1998 'Primary culture'
O'Sullivan, F., Meleady, P., McBride, S. and Clynes, M. (1998) 'Primary culture' In: Animal Cell Culture Technique; Springer Lab Manual. Springer-Verlag. [Details]
1998 'Isolation, cultivation and differentiation of lung type II epithelial cells'
Meleady, P., O'Sullivan, F., McBride, S. and Clynes, M. (1998) 'Isolation, cultivation and differentiation of lung type II epithelial cells' In: Animal Cell Culture Techniques; Springer Lab Manual. Berlin, Germany: Springer-Verlag. [Details]
1998 'Investigations into cell differentiation using cells in culture'
McBride, S. and Clynes, M. (1998) 'Investigations into cell differentiation using cells in culture' In: Animal Cell Culture Technique; Springer Lab Manual. Springer-Verlag. [Details]
1998 'Cloning animal cells'
McBride, S., Heenan, M. and Clynes M. (1998) 'Cloning animal cells' In: Animal Cell Culture Technique; Springer Lab Manual. Springer-Verlag. [Details]

Conference Hosted

  Year Publication
2012 Emerging Treatments for Lung Diseases: Progress, Challenges and Opportunities from an Irish Perspective.
Shirley O'Dea (2012) Emerging Treatments for Lung Diseases: Progress, Challenges and Opportunities from an Irish Perspective. Conference Hosted [Details]
2007 Gene and Stem Cell Therapies for Lung Diseases.
Shirley O'Dea (2007) Gene and Stem Cell Therapies for Lung Diseases. Conference Hosted [Details]

Honours and Awards

  Year Title Awarding Body
2021 Biotech Company of the Year - Avectas Pharma Industry Awards
2019 BioScience Laboratory of the Year - Avectas Irish Laboratory Awards
2019 Innovation of the Year - Spraybase Melt Electrospinning - Avectas Irish Laboratory Awards
2014 Annual Commercialisation Award Maynooth University
1999 Salveson Trust Fellowship Salveson Trust, UK
1997 Marie Curie Fellowship European Union

Professional Associations

  Association Function From / To
International Society for Cell and Gene Therapy Member /