Dr Shirley O'Dea

Biology

Associate Professor
/Co-Director, Avectas

Eolas Building
Third Floor
(01) 474 7300

Biography

Dr. O'Dea (B.Sc., University College Dublin; Ph.D., Dublin City University, 1995) received a Marie Curie Fellowship and a Salvesen Fellowship to work at Edinburgh University (1997-2001) before coming to NUI Maynooth as a Science Foundation Ireland-funded investigator. She was appointed Lecturer in the Biology Department, NUIM in 2005 and Senior Lecturer in 2012. Dr. O'Dea is co-founder, Director and CSO of the spin-out company, Profector Life Sciences (2011).

Book Chapters

  Year Publication
1998 'Primary culture'
O'Sullivan, F., Meleady, P., McBride, S. and Clynes, M. (1998) 'Primary culture' In: Animal Cell Culture Technique; Springer Lab Manual. Springer-Verlag. [Details]
1998 'Isolation, cultivation and differentiation of lung type II epithelial cell'
Meleady, P., O'Sullivan, F., McBride, S. and Clynes, M. (1998) 'Isolation, cultivation and differentiation of lung type II epithelial cell' In: Animal Cell Culture Techniques; Springer Lab Manual. Springer-Verlag. [Details]
1998 'Investigations into cell differentiation using cells in culture'
McBride, S. and Clynes, M. (1998) 'Investigations into cell differentiation using cells in culture' In: Animal Cell Culture Technique; Springer Lab Manual. Springer-Verlag. [Details]
1998 'Cloning animal cells'
McBride, S., Heenan, M. and Clynes M. (1998) 'Cloning animal cells' In: Animal Cell Culture Technique; Springer Lab Manual. Springer-Verlag. [Details]

Peer Reviewed Journals

  Year Publication
2013 'Bone morphogenetic proteins enhance an epithelial-mesenchymal transition in normal airway epithelial cells during restitution of a disrupted epithelium'
McCormack, N., Molloy, E. L., ODea, S. (2013) 'Bone morphogenetic proteins enhance an epithelial-mesenchymal transition in normal airway epithelial cells during restitution of a disrupted epithelium'. RESPIRATORY RESEARCH, 14 [IR Link] [Details]
2013 'IFN-gamma stimulated human umbilical-tissue derived cells potently suppress NK activation and resist NK mediated cytotoxicity in vitro'
Noone, C., Kihm, A., English, K., ODea, S., Mahon, B.P. (2013) 'IFN-gamma stimulated human umbilical-tissue derived cells potently suppress NK activation and resist NK mediated cytotoxicity in vitro'. STEM CELLS AND DEVELOPMENT, 22 [IR Link] [Details]
2012 'Olfactomedin III expression contributes to anoikis-resistance in clonal variants of a human lung squamous carcinoma cell line'
Keenan, J., Joyce, H., Aherne, S., O'Dea, S., Doolan, P., Lynch, V. and Clynes, M. (2012) 'Olfactomedin III expression contributes to anoikis-resistance in clonal variants of a human lung squamous carcinoma cell line'. EXPERIMENTAL CELL RESEARCH, 318 :593-602 [IR Link] [Details]
2011 'Bone morphogenetic protein signalling in airway epithelial cells during regeneration'
Masterson, J.C., Molloy E.L., Gilbert J.L., McCormack N., Adams A., O’Dea S. (2011) 'Bone morphogenetic protein signalling in airway epithelial cells during regeneration'. CELLULAR SIGNALLING, 23 :398-406 [IR Link] [Details]
2009 'Regulation of surfactant protein B gene expression in bone marrow-derived cells'
Field-Corbett, C. English, K. and O'Dea, S. (2009) 'Regulation of surfactant protein B gene expression in bone marrow-derived cells'. STEM CELLS, 27 :662-669 [IR Link] [Details]
2008 'Reducing the false discovery rate in the non-parametric analysis of molecular co-evolution'
Codoer, F.M., ODea, S. and Fares, M.A. (2008) 'Reducing the false discovery rate in the non-parametric analysis of molecular co-evolution'. BMC EVOLUTIONARY BIOLOGY, 8 [IR Link] [Details]
2008 'BMP4 induces an epithelial-mesenchymal transition-like response in adult airway epithelial cells'
Molloy, E.L., Adams, A., Moore, J.B., Masterson, J.C., Madrigal-Estebas, L., Mahon, B.P. and ODea, S. (2008) 'BMP4 induces an epithelial-mesenchymal transition-like response in adult airway epithelial cells'. GROWTH FACTORS, 26 :12-22 [IR Link] [Details]
2008 'Comparative evaluation of viral, non-viral and physical methods of gene delivery to normal and transformed lung epithelial cells'
Gilbert, J.L., Purcell, J., Strappe, P., McCabe, M., OBrien, T. and ODea, S. (2008) 'Comparative evaluation of viral, non-viral and physical methods of gene delivery to normal and transformed lung epithelial cells'. ANTI-CANCER DRUGS, 19 :783-788 [IR Link] [Details]
2007 'Soluble signals from mechanically disrupted lung tissue induce lung-related gene expression in bone marrow-derived cells in vitro'
Field-Corbett, C. and ODea, S. (2007) 'Soluble signals from mechanically disrupted lung tissue induce lung-related gene expression in bone marrow-derived cells in vitro'. STEM CELLS AND DEVELOPMENT, 16 :231-242 [IR Link] [Details]
2007 '5-Bromo-2-deoxyuridine activates DNA damage signaling responses and induces a senescence-like phenotype in p16-null lung cancer cells'
Masterson, J.C. and ODea, S. (2007) '5-Bromo-2-deoxyuridine activates DNA damage signaling responses and induces a senescence-like phenotype in p16-null lung cancer cells'. ANTI-CANCER DRUGS, 18 :1053-1068 [IR Link] [Details]
2004 'p21 Waf1/Cip1 Regulates Proliferation and Apoptosis in Airway Epithelial Cells and Alternative Forms have Altered Binding Activities'
Blundell, R., Harrison, D.J. and O'Dea S. (2004) 'p21 Waf1/Cip1 Regulates Proliferation and Apoptosis in Airway Epithelial Cells and Alternative Forms have Altered Binding Activities'. Experimental Lung Research, 30 :447-464 [IR Link] [Details]
2002 'Absence of p53 in lung epithelial cells favours multinucleation and loss of cell cycle arrest'
Armit, C. J., O'Dea, S., Clarke, A.R. and Harrison, D. J. (2002) 'Absence of p53 in lung epithelial cells favours multinucleation and loss of cell cycle arrest'. BMC CELL BIOLOGY, 3 [IR Link] [Details]
2000 'Characterisation of lectin binding patterns of mouse bronchiolar and rat alveolar epithelial cells in culture'
McBride, S., Tatrai, E., Blundell, R., Kovacikova, Z., Cardozo, L., Adamis, Z., Smith, T. and Harrison, D. (2000) 'Characterisation of lectin binding patterns of mouse bronchiolar and rat alveolar epithelial cells in culture'. Histochemical Journal, 32 :33-40 [IR Link] [Details]
2000 'Gene transfer to adult human lung tissue ex vivo'
McBride, S., Rannie, D. and Harrison, D. (2000) 'Gene transfer to adult human lung tissue ex vivo'. Gene Therapy, 7 :675-678 [IR Link] [Details]
1999 'Bromodeoxyuridine induces keratin protein synthesis at a posttranscriptional level in human lung tumour cell lines'
McBride, S., Walsh, D., Meleady, P., Daly, N. and Clynes, M. (1999) 'Bromodeoxyuridine induces keratin protein synthesis at a posttranscriptional level in human lung tumour cell lines'. DIFFERENTIATION, 64 :185-193 [Details]
1998 'Human lung carcinoma cell line DLKP contains 3 distinct subpopulations with different growth and attachment properties'
McBride, S., .Meleady, P., .Baird, A., .Dinsdale, D. and Clynes, M. (1998) 'Human lung carcinoma cell line DLKP contains 3 distinct subpopulations with different growth and attachment properties'. Tumor Biology, 19 :88-103 [Details]
1996 'Mdr-1 ribozyme-mediated reversal of the multi-drug resistant phenotype in human lung cell lines'
Daly, C., Coyle, S., McBride, S., O'Driscoll, L., Daly, N., Scanlon, K. and Clynes, M. (1996) 'Mdr-1 ribozyme-mediated reversal of the multi-drug resistant phenotype in human lung cell lines'. Cytotechnology, 19 :199-205 [Details]
1995 'Multiple drug resistance in variants of a human lung line exposed to adriamycin and VP-16'
Clynes, M., Heenan, M., McBride, S., Cleary, I., Doherty, G., O'Driscoll, L. and Moran, E. (1995) 'Multiple drug resistance in variants of a human lung line exposed to adriamycin and VP-16'. Journal of Experimental and Clinical Cancer Research, 14 :15-16 [Details]

Conference Contributions

  Year Publication
2005 NUIM Public Speak.
(2005) NUIM Public Speak. [Oral Presentation], Stem Cells: Whats all the fuss about?, NUI Maynooth [Details]
2002 Irish Association for Immunology.
E Lewis, B Mahon and S O'Dea. (2002) Irish Association for Immunology. [Non-Peer Reviewed Published Proceedings], Belfast , 12-SEP-02 - 14-SEP-02 [Details]
2002 British Society for Immunology.
E. Lewis, B. Mahon, DJ Harrison and S. O’Dea (2002) British Society for Immunology. [Non-Peer Reviewed Published Proceedings], Harrogate, UK , 03-DEC-02 - 05-DEC-02 [Details]
2002 British Association for Lung Research.
E Lewis, B Mahon and S O'Dea (2002) British Association for Lung Research. [Non-Peer Reviewed Published Proceedings], Dublin , 28-AUG-02 - 30-AUG-02 [Details]

Book Review

  Year Publication
2013 Regulation of Epithelial to Mesenchymal Transition by Bone Morphogenetic Proteins.
McCormack, N., ODea, S. (2013) Regulation of Epithelial to Mesenchymal Transition by Bone Morphogenetic Proteins. Book Review [DOI] [Details]
2007 Posttranslational truncation of E-cadherin and significance for tumour progression.
Masterson, J and ODea, S. (2007) Posttranslational truncation of E-cadherin and significance for tumour progression. Book Review [Details]
2002 CFTR Gene Transfer to Lung Epithelium - On the Trail of a Target Cell.
O'Dea, S. and Harrison, D.J. (2002) CFTR Gene Transfer to Lung Epithelium - On the Trail of a Target Cell. Book Review [Details]

Thesis

  Year Publication
1995 Regulation of Differentiation Processes in Lung Cancer Cells.
Shirley McBride (1995) Regulation of Differentiation Processes in Lung Cancer Cells. Dublin City University: Thesis [Details]