Dr Lorna Lopez

Biology, Human Health Institute

Lecturer

Callan
First
2.25
((01)) (474) 7498

Biography

I am a Lecturer/Assistant Professor in Maynooth University. In 2017 I started my own research team with an SFI Starting Investigator Research Grant in Trinity College Dublin investigating the genomic basis of neurodevelopmental disorders and moved to Maynooth in 2020. Since my PhD, I have worked in the field of neuropsychiatric genetics. My research expertise ranges from genomic, proteomic and molecular biological approaches, in family and population-based studies, and always with a focus on understanding the genetic basis of psychiatric disorders and other clinical traits. I have demonstrated scientific success in publishing 65 peer-reviewed publications (ten first author) in international journals (including 25 with an impact factor >10) and in generating external income from Science Foundation Ireland, AXA Research Fund and The Wellcome Trust. I have also demonstrated success in creative research outputs such as a book published in four languages, and leading organisational roles in public events and academic conferences.

Research Interests

I am interested in the genetic basis of neurodevelopmental disorders. My research uses genome sequencing to identify genetic differences in families related to autism, and other neurodevelopmental disorders. We also investigate if genome variation in populations can tell us more about rare genomic variation in neurodevelopmental disorders (UK Biobank) and the underlying genetic links between disorders and human traits (Sleep and ASD, MU SPUR award). 

My previous research published is available here 

I share my research through science communicationpublic patient engagementoutreach and visiting scientists activities.

Books

  Year Publication
2019 Matka aivoihin Värityskirja.
Cotter, D.R., Lopez, L.M., Kelleher, E., Coughlan, H., Cannon, M (2019) Matka aivoihin Värityskirja. Finland: Prometheus. [Details]
2018 Aistear trid an inchinn.
Cotter, D.R., Lopez, L.M., Kelleher, E., Coughlan, H., Cannon, M. (2018) Aistear trid an inchinn. Ireland: Foras na Gaeilge. [Details]
2016 Journey through the Brain.
Cotter, D.R., Lopez, L.M., Kelleher, E., Coughlan, H., Cannon, M. (2016) Journey through the Brain. Dublin: RCSI. [Details]

Peer Reviewed Journals

  Year Publication
2018 'Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits'
Evangelou, Evangelos and Warren, Helen R and Mosen-Ansorena, David and Mifsud, Borbala and Pazoki, Raha and Gao, He and Ntritsos, Georgios and Dimou, Niki and Cabrera, Claudia P and Karaman, Ibrahim and others (2018) 'Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits'. Nature genetics, 50 (10):1412-1425 [full-text] [Details]
2018 'Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case--Control Study of the ALSPAC Longitudinal Birth Cohort'
English, Jane A and Lopez, Lorna M and O�Gorman, Aoife and F\"ocking, Melanie and Hryniewiecka, Magdalena and Scaife, Caitriona and Sabherwal, Sophie and Wynne, Kieran and Dicker, Patrick and Rutten, Bart PF and others (2018) 'Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case--Control Study of the ALSPAC Longitudinal Birth Cohort'. Schizophrenia bulletin, 44 (2):297-306 [full-text] [Details]
2017 'Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk'
Warren, Helen R and Evangelou, Evangelos and Cabrera, Claudia P and Gao, He and Ren, Meixia and Mifsud, Borbala and Ntalla, Ioanna and Surendran, Praveen and Liu, Chunyu and Cook, James P and others (2017) 'Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk'. Nature genetics, 49 (3) [Details]
2017 'Genetic analysis of over one million people identifies 535 novel loci for blood pressure'
Evangelou, Evangelos and Warren, Helen R and Mosen-Ansorena, David and Mifsud, Borbala and Pazoki, Raha and Gao, He and Ntritsos, Georgios and Dimou, Niki and Cabrera, Claudia P and Karaman, Ibrahim and others (2017) 'Genetic analysis of over one million people identifies 535 novel loci for blood pressure'. bioRxiv, [Details]
2017 'Comparison of HapMap and 1000 genomes reference panels in a large-scale genome-wide association study'
De Vries, Paul S and Sabater-Lleal, Maria and Chasman, Daniel I and Trompet, Stella and Ahluwalia, Tarunveer S and Teumer, Alexander and Kleber, Marcus E and Chen, Ming-Huei and Wang, Jie Jin and Attia, John R and others (2017) 'Comparison of HapMap and 1000 genomes reference panels in a large-scale genome-wide association study'. PloS one, 12 (1) [Details]
2017 'Novel genetic loci associated with hippocampal volume'
Hibar, Derrek P and Adams, Hieab HH and Jahanshad, Neda and Chauhan, Ganesh and Stein, Jason L and Hofer, Edith and Renteria, Miguel E and Bis, Joshua C and Arias-Vasquez, Alejandro and Ikram, M Kamran and others (2017) 'Novel genetic loci associated with hippocampal volume'. Nature communications, 8 (1):1-12 [Details]
2017 '126. Altered Complement and Coagulation Cascade in Age 11 Children Precedes to the Onset of Psychotic Disorder'
Cotter, David and English, Jane and Lopez, Lorna and O�Gorman, Aoife and Hryniewiecka, Magdalena and Scaife, Catriona and Sabherwal, Sophie and Wynne, Kieran and Dicker, Patrick and Zammit, Stanley and others (2017) '126. Altered Complement and Coagulation Cascade in Age 11 Children Precedes to the Onset of Psychotic Disorder'. Schizophrenia bulletin, 43 (Suppl 1) [Details]
2016 'Genome-wide association studies identify genetic loci for low von Willebrand factor levels'
Van Loon, Janine and Dehghan, Abbas and Weihong, Tang and Trompet, Stella and McArdle, Wendy L and Asselbergs, Folkert FW and Chen, Ming-Huei and Lopez, Lorna M and Huffman, Jennifer E and Leebeek, Frank WG and others (2016) 'Genome-wide association studies identify genetic loci for low von Willebrand factor levels'. European Journal of Human Genetics, 24 (7):1035-1040 [Details]
2016 'A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration'
De Vries, Paul S and Chasman, Daniel I and Sabater-Lleal, Maria and Chen, Ming-Huei and Huffman, Jennifer E and Steri, Maristella and Tang, Weihong and Teumer, Alexander and Marioni, Riccardo E and Grossmann, Vera and others (2016) 'A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration'. Human molecular genetics, 25 (2):358-370 [Details]
2016 'GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium'
Matteini, Amy M and Tanaka, Toshiko and Karasik, David and Atzmon, Gil and Chou, Wen-Chi and Eicher, John D and Johnson, Andrew D and Arnold, Alice M and Callisaya, Michele L and Davies, Gail and others (2016) 'GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium'. Aging cell, 15 (5):792-800 [Details]
2016 'Differential expression of the inflammation marker IL12p40 in the at-risk mental state for psychosis: a predictor of transition to psychotic disorder?'
F\"ocking, Melanie and Dicker, Patrick and Lopez, Lorna M and Cannon, Mary and Sch\"afer, Miriam R and McGorry, Patrick D and Smesny, Stefan and Cotter, David R and Amminger, G Paul (2016) 'Differential expression of the inflammation marker IL12p40 in the at-risk mental state for psychosis: a predictor of transition to psychotic disorder?'. BMC psychiatry, 16 (1) [Details]
2016 'Novel genetic loci underlying human intracranial volume identified through genome-wide association'
Adams, Hieab HH and Hibar, Derrek P and Chouraki, Vincent and Stein, Jason L and Nyquist, Paul A and Renter\'\ia, Miguel E and Trompet, Stella and Arias-Vasquez, Alejandro and Seshadri, Sudha and Desrivi\`eres, Sylvane and others (2016) 'Novel genetic loci underlying human intracranial volume identified through genome-wide association'. Nature neuroscience, 19 (12) [Details]
2016 'Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept'
Franke, Barbara and Stein, Jason L and Ripke, Stephan and Anttila, Verneri and Hibar, Derrek P and Van Hulzen, Kimm JE and Arias-Vasquez, Alejandro and Smoller, Jordan W and Nichols, Thomas E and Neale, Michael C and others (2016) 'Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept'. Nature neuroscience, 19 (3):420-431 [Details]
2016 'Cannon M1, Sch\afer MR, McGorry PD, Smesny S, Cotter DR, Amminger GP. Differential expression of the inflammation marker IL12p40 in the at-risk mental state for psychosis: a predictor of transition to psychotic disorder'
F\"ocking, M and Dicker, P and Lopez, LM (2016) 'Cannon M1, Sch\afer MR, McGorry PD, Smesny S, Cotter DR, Amminger GP. Differential expression of the inflammation marker IL12p40 in the at-risk mental state for psychosis: a predictor of transition to psychotic disorder'. BMC Psychiatry, 16 (1) [Details]
2015 'Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI'
Verhaaren, Benjamin FJ and Debette, St\'ephanie and Bis, Joshua C and Smith, Jennifer A and Ikram, M Kamran and Adams, Hieab H and Beecham, Ashley H and Rajan, Kumar B and Lopez, Lorna M and Barral, Sandra and others (2015) 'Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI'. Circulation: Cardiovascular Genetics, 8 (2):398-409 [Details]
2015 'Common genetic variants influence human subcortical brain structures'
Hibar, Derrek P and Stein, Jason L and Renteria, Miguel E and Arias-Vasquez, Alejandro and Desrivi\`eres, Sylvane and Jahanshad, Neda and Toro, Roberto and Wittfeld, Katharina and Abramovic, Lucija and Andersson, Micael and others (2015) 'Common genetic variants influence human subcortical brain structures'. Nature, 520 (7546):224-229 [Details]
2015 'Genes from a translational analysis support a multifactorial nature of white matter hyperintensities'
Lopez, Lorna M and Hill, W David and Harris, Sarah E and Valdes Hernandez, Maria and Munoz Maniega, Susana and Bastin, Mark E and Bailey, Emma and Smith, Colin and McBride, Martin and McClure, John and others (2015) 'Genes from a translational analysis support a multifactorial nature of white matter hyperintensities'. Stroke, 46 (2):341-347 [Details]
2015 'Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation'
Soler Artigas, Mar\'\ia and Wain, Louise V and Miller, Suzanne and Kheirallah, Abdul Kader and Huffman, Jennifer E and Ntalla, Ioanna and Shrine, Nick and Obeidat, Ma'en and Trochet, Holly and McArdle, Wendy L and others (2015) 'Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation'. Nature communications, 6 [Details]
2015 'Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia'
F\"ocking, Melanie and Lopez, Lorna M and English, Jane A and Dicker, Patrick and Wolff, A and Brindley, E and Wynne, Kieran and Cagney, Gerard and Cotter, David R (2015) 'Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia'. Molecular psychiatry, 20 (4):424-432 [Details]
2015 'Modulation of genetic associations with serum urate levels by body-mass-index in humans'
Huffman, Jennifer E and Albrecht, Eva and Teumer, Alexander and Mangino, Massimo and Kapur, Karen and Johnson, Toby and Kutalik, Zolt\'an and Pirastu, Nicola and Pistis, Giorgio and Lopez, Lorna M and others (2015) 'Modulation of genetic associations with serum urate levels by body-mass-index in humans'. PloS one, 10 (3) [Details]
2014 'Poster\# T144 INTEGRATED GENOMIC AND PROTEOMIC EVIDENCE FOR THE POSTSYNAPTIC DENSITY IN SCHIZOPHRENIA'
Lopez, Lorna M and English, Jane and Focking, Melanie and Cotter, David (2014) 'Poster\# T144 INTEGRATED GENOMIC AND PROTEOMIC EVIDENCE FOR THE POSTSYNAPTIC DENSITY IN SCHIZOPHRENIA'. Schizophrenia Research, (153) [Details]
2014 'A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing'
Davies, Gail and Harris, Sarah E and Reynolds, Chandra A and Payton, Antony and Knight, Helen M and Liewald, DC and Lopez, Lorna M and Luciano, M and Gow, Alan J and Corley, Janie and others (2014) 'A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing'. Molecular Psychiatry, 19 (1):76-87 [Details]
2014 'Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: comparing meta and megaanalytical approaches for data pooling'
Kochunov, Peter and Jahanshad, Neda and Sprooten, Emma and Nichols, Thomas E and Mandl, Ren\'e C and Almasy, Laura and Booth, Tom and Brouwer, Rachel M and Curran, Joanne E and de Zubicaray, Greig I and others (2014) 'Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: comparing meta and megaanalytical approaches for data pooling'. Neuroimage, 95 :136-150 [Details]
2014 'Genome-wide association analysis identifies six new loci associated with forced vital capacity'
Loth, Daan W and Artigas, Mar\'\ia Soler and Gharib, Sina A and Wain, Louise V and Franceschini, Nora and Koch, Beate and Pottinger, Tess D and Smith, Albert Vernon and Duan, Qing and Oldmeadow, Chris and others (2014) 'Genome-wide association analysis identifies six new loci associated with forced vital capacity'. Nature genetics, 46 (7):669-677 [Details]
2014 'The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data'
Thompson, Paul M and Stein, Jason L and Medland, Sarah E and Hibar, Derrek P and Vasquez, Alejandro Arias and Renteria, Miguel E and Toro, Roberto and Jahanshad, Neda and Schumann, Gunter and Franke, Barbara and others (2014) 'The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data'. Brain imaging and behavior, 8 (2):153-182 [Details]
2014 'No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects'
Baumert, Jens and Huang, Jie and McKnight, Barbara and Sabater-Lleal, Maria and Steri, Maristella and Chu, Audrey Y and Trompet, Stella and Lopez, Lorna M and Fornage, Myriam and Teumer, Alexander and others (2014) 'No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects'. PloS one, 9 (12) [Details]
2014 'The ENIGMA Consortium'
Thompson, Paul M and Stein, Jason L and Medland, Sarah E and Hibar, Derrek P and Vasquez, Alejandro Arias and Renteria, Miguel E and Toro, Roberto and Jahanshad, Neda and Schumann, Gunter and Franke, Barbara and others (2014) 'The ENIGMA Consortium'. Brain Imaging and Behavior, [Details]
2013 'ADRB2, brain white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936'
Lyall, Donald M and Lopez, Lorna M and Bastin, Mark E and Maniega, Susana Munoz and Penke, Lars and Hern\'andez, Maria del C Vald\'es and Royle, Natalie A and Starr, John M and Porteous, David J and Wardlaw, Joanna M and others (2013) 'ADRB2, brain white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936'. Behavior genetics, 43 (1):13-23 [Details]
2013 'Multiethnic meta-analysis of genome-wide association studies in> 100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease'
Sabater-Lleal, Maria and Huang, Jie and Chasman, Daniel and Naitza, Silvia and Dehghan, Abbas and Johnson, Andrew D and Teumer, Alexander and Reiner, Alex P and Folkersen, Lasse and Basu, Saonli and others (2013) 'Multiethnic meta-analysis of genome-wide association studies in> 100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease'. Circulation, 128 (12):1310-1324 [Details]
2013 'Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels'
Thun, Gian Andri and Imboden, Medea and Ferrarotti, Ilaria and Kumar, Ashish and Obeidat, Ma'en and Zorzetto, Michele and Haun, Margot and Curjuric, Ivan and Alves, Alexessander Couto and Jackson, Victoria E and others (2013) 'Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels'. PLoS genetics, 9 (8) [Details]
2013 'Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations'
O'Seaghdha, Conall M and Wu, Hongsheng and Yang, Qiong and Kapur, Karen and Guessous, Idris and Zuber, Annie Mercier and K\"ottgen, Anna and Stoudmann, Candice and Teumer, Alexander and Kutalik, Zolt\'an and others (2013) 'Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations'. PLoS Genet, 9 (9) [Details]
2013 'A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function'
Porcu, Eleonora and Medici, Marco and Pistis, Giorgio and Volpato, Claudia B and Wilson, Scott G and Cappola, Anne R and Bos, Steffan D and Deelen, Joris and den Heijer, Martin and Freathy, Rachel M and others (2013) 'A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function'. PLoS genetics, 9 (2) [Details]
2013 'Genome-wide association analyses identify 18 new loci associated with serum urate concentrations'
K\"ottgen, Anna and Albrecht, Eva and Teumer, Alexander and Vitart, Veronique and Krumsiek, Jan and Hundertmark, Claudia and Pistis, Giorgio and Ruggiero, Daniela and O'Seaghdha, Conall M and Haller, Toomas and others (2013) 'Genome-wide association analyses identify 18 new loci associated with serum urate concentrations'. Nature genetics, 45 (2):145-154 [Details]
2013 'PMCID: PMC3488095'
Curjuric, I and Couto, Alves A and Jackson, VE and Albrecht, E and Ried, JS and Teumer, A and Lopez, LM and Huffman, JE and Enroth, S and Boss\'e (2013) 'PMCID: PMC3488095'. transplantation, 140 (3):362-73 [Details]
2012 'Longevity candidate genes and their association with personality traits in the elderly'
Luciano, Michelle and Lopez, Lorna M and De Moor, Marleen HM and Harris, Sarah E and Davies, Gail and Nutile, Teresa and Krueger, Robert F and Esko, T\~onu and Schlessinger, David and Toshiko, Tanaka and others (2012) 'Longevity candidate genes and their association with personality traits in the elderly'. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 159 (2):192-200 [Details]
2012 'Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease'
Tang, Weihong and Schwienbacher, Christine and Lopez, Lorna M and Ben-Shlomo, Yoav and Oudot-Mellakh, Tiphaine and Johnson, Andrew D and Samani, Nilesh J and Basu, Saonli and G\"ogele, Martin and Davies, Gail and others (2012) 'Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease'. The American Journal of Human Genetics, 91 (1):152-162 [Details]
2012 'Evolutionary conserved longevity genes and human cognitive abilities in elderly cohorts'
Lopez, Lorna M and Harris, Sarah E and Luciano, Michelle and Liewald, Dave and Davies, Gail and Gow, Alan J and Tenesa, Albert and Payton, Antony and Ke, Xiayi and Whalley, Lawrence J and others (2012) 'Evolutionary conserved longevity genes and human cognitive abilities in elderly cohorts'. European journal of human genetics, 20 (3):341-347 [Details]
2012 'Meta-analysis identifies multiple loci associated with kidney function--related traits in east Asian populations'
Okada, Yukinori and Sim, Xueling and Go, Min Jin and Wu, Jer-Yuarn and Gu, Dongfeng and Takeuchi, Fumihiko and Takahashi, Atsushi and Maeda, Shiro and Tsunoda, Tatsuhiko and Chen, Peng and others (2012) 'Meta-analysis identifies multiple loci associated with kidney function--related traits in east Asian populations'. Nature genetics, 44 (8) [Details]
2012 'Identification of common variants associated with human hippocampal and intracranial volumes'
Stein, Jason L and Medland, Sarah E and Vasquez, Alejandro Arias and Hibar, Derrek P and Senstad, Rudy E and Winkler, Anderson M and Toro, Roberto and Appel, Katja and Bartecek, Richard and Bergmann, \Orjan and others (2012) 'Identification of common variants associated with human hippocampal and intracranial volumes'. Nature genetics, 44 (5):552-561 [Details]
2012 'Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways'
Stolk, Lisette and Perry, John RB and Chasman, Daniel I and He, Chunyan and Mangino, Massimo and Sulem, Patrick and Barbalic, Maja and Broer, Linda and Byrne, Enda M and Ernst, Florian and others (2012) 'Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways'. Nature genetics, 44 (3) [Details]
2012 'Common genetic polymorphisms are associated with human hippocampal and intracranial volumes'
Stein, Jason L and Medland, SE and Vasquez, AA and Hibar, DP and Senstad, RE and Winkler, AM and Toro, R and Appel, K and Bartecek, R and Bergmann, \O and others (2012) 'Common genetic polymorphisms are associated with human hippocampal and intracranial volumes'. Nat Genetics, [Details]
2012 'Meta-analysis of genome-wide association studies for personality'
De Moor, Marleen HM and Costa, Paul T and Terracciano, Antonio and Krueger, Robert F and De Geus, Eco JC and Toshiko, Tanaka and Penninx, Brenda WJH and Esko, Tanu and Madden, Pamela AF and Derringer, Jaime and others (2012) 'Meta-analysis of genome-wide association studies for personality'. Molecular psychiatry, 17 (3):337-349 [Details]
2012 'A Genome-wide association study of non-pathological cognitive ageing'
Davies, Gail and Harris, Sarah and Reynolds, Chandra and Payton, Antony and Liewald, David and Lopez, Lorna and Luciano, Michelle and Gow, Alan and Corley, Janie and Henderson, Ross and others (2012) 'A Genome-wide association study of non-pathological cognitive ageing'. Behavior Genetics, 42 (6):927-927 [Details]
2012 'Seventy-five genetic loci influencing the human red blood cell'
Van Der Harst, Pim and Zhang, Weihua and Leach, Irene Mateo and Rendon, Augusto and Verweij, Niek and Sehmi, Joban and Paul, Dirk S and Elling, Ulrich and Allayee, Hooman and Li, Xinzhong and others (2012) 'Seventy-five genetic loci influencing the human red blood cell'. Nature, 492 (7429):369-375 [Details]
2012 'Common variants at 12q14 and 12q24 are associated with hippocampal volume'
Bis, Joshua C and DeCarli, Charles and Smith, Albert Vernon and van der Lijn, Fedde and Crivello, Fabrice and Fornage, Myriam and Debette, Stephanie and Shulman, Joshua M and Schmidt, Helena and Srikanth, Velandai and others (2012) 'Common variants at 12q14 and 12q24 are associated with hippocampal volume'. Nature genetics, 44 (5) [Details]
2012 'A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site'
N\"urnberg, Sylvia T and Rendon, Augusto and Smethurst, Peter A and Paul, Dirk S and Voss, Katrin and Thon, Jonathan N and Lloyd-Jones, Heather and Sambrook, Jennifer G and Tijssen, Marloes R and HaemGen Consortium and others (2012) 'A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site'. Blood, The Journal of the American Society of Hematology, 120 (24):4859-4868 [Details]
2012 'Genetic copy number variation and general cognitive ability'
MacLeod, Andrew K and Davies, Gail and Payton, Antony and Tenesa, Albert and Harris, Sarah E and Liewald, David and Ke, Xiayi and Luciano, Michelle and Lopez, Lorna M and Gow, Alan J and others (2012) 'Genetic copy number variation and general cognitive ability'. PloS one, 7 (12) [Details]
2012 'Evidence of inbreeding depression on human height'
McQuillan, Ruth and Eklund, Niina and Pirastu, Nicola and Kuningas, Maris and McEvoy, Brian P and Esko, T\~onu and Corre, Tanguy and Davies, Gail and Kaakinen, Marika and Lyytik\"ainen, Leo-Pekka and others (2012) 'Evidence of inbreeding depression on human height'. PLoS genetics, 8 (7) [Details]
2012 'Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction'
Wilk, Jemma B and Shrine, Nick RG and Loehr, Laura R and Zhao, Jing Hua and Manichaikul, Ani and Lopez, Lorna M and Smith, Albert Vernon and Heckbert, Susan R and Smolonska, Joanna and Tang, Wenbo and others (2012) 'Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction'. American journal of respiratory and critical care medicine, 186 (7):622-632 [Details]
2012 'Discovery and fine mapping of serum protein loci through transethnic meta-analysis'
Franceschini, Nora and Van Rooij, Frank JA and Prins, Bram P and Feitosa, Mary F and Karakas, Mahir and Eckfeldt, John H and Folsom, Aaron R and Kopp, Jeffrey and Vaez, Ahmad and Andrews, Jeanette S and others (2012) 'Discovery and fine mapping of serum protein loci through transethnic meta-analysis'. The American Journal of Human Genetics, 91 (4):744-753 [Details]
2012 'Genetic contributions to stability and change in intelligence from childhood to old age'
Deary, Ian J and Yang, Jian and Davies, Gail and Harris, Sarah E and Tenesa, Albert and Liewald, David and Luciano, Michelle and Lopez, Lorna M and Gow, Alan J and Corley, Janie and others (2012) 'Genetic contributions to stability and change in intelligence from childhood to old age'. Nature, 482 (7384):212-215 [Details]
2011 'Genetic associations between fibrinogen and cognitive performance in three Scottish cohorts'
Marioni, Riccardo E and Deary, Ian J and Murray, Gordon D and Lowe, Gordon DO and Strachan, Mark WJ and Luciano, Michelle and Houlihan, Lorna M and Gow, Alan J and Harris, Sarah E and Rumley, Ann and others (2011) 'Genetic associations between fibrinogen and cognitive performance in three Scottish cohorts'. Behavior genetics, 41 (5):691-699 [Details]
2011 'Summaries from the XVIII World Congress of Psychiatric Genetics, Athens, Greece, 3--7 October 2010'
Bergen, Sarah E and Balhara, Yatan Pal Singh and Christoforou, Andrea and Cole, James and Degenhardt, Franziska and Dempster, Emma and Fatj\'o-Vilas, Mar and Khedr, Yara and Lopez, Lorna M and Lysenko, Laura and others (2011) 'Summaries from the XVIII World Congress of Psychiatric Genetics, Athens, Greece, 3--7 October 2010'. Psychiatric genetics, 21 (3):136-172 [Details]
2011 'A pilot study of urinary peptides as biomarkers for intelligence in old age'
Lopez, Lorna M and Mullen, William and Z\"urbig, Petra and Harris, Sarah E and Gow, Alan J and Starr, John M and Porteous, David J and Mischak, Harald and Deary, Ian J (2011) 'A pilot study of urinary peptides as biomarkers for intelligence in old age'. Intelligence, 39 (1):46-53 [Details]
2011 'Genetic predictors of fibrin D-dimer levels in healthy adults'
Smith, Nicholas L and Huffman, Jennifer E and Strachan, David P and Huang, Jie and Dehghan, Abbas and Trompet, Stella and Lopez, Lorna M and Shin, So-Youn and Baumert, Jens and Vitart, Veronique and others (2011) 'Genetic predictors of fibrin D-dimer levels in healthy adults'. Circulation, 123 (17):1864-1872 [Details]
2011 'KNG1 Ile581Thr and susceptibility to venous thrombosis'
Morange, Pierre-Emmanuel and Oudot-Mellakh, Tiphaine and Cohen, William and Germain, Marine and Saut, No\'emie and Antoni, Guillemette and Alessi, Marie-Christine and Bertrand, Marion and Dupuy, Anne-Marie and Letenneur, Luc and others (2011) 'KNG1 Ile581Thr and susceptibility to venous thrombosis'. Blood, 117 (13):3692-3694 [Details]
2011 'Genome-wide association studies establish that human intelligence is highly heritable and polygenic'
Davies, Gail and Tenesa, Albert and Payton, Antony and Yang, Jian and Harris, Sarah E and Liewald, David and Ke, Xiayi and Le Hellard, Stephanie and Christoforou, Andrea and Luciano, Michelle and others (2011) 'Genome-wide association studies establish that human intelligence is highly heritable and polygenic'. Molecular psychiatry, 16 (10):996-1005 [Details]
2011 'Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function'
Artigas, Mar\'\ia Soler and Loth, Daan W and Wain, Louise V and Gharib, Sina A and Obeidat, Ma'en and Tang, Wenbo and Zhai, Guangju and Zhao, Jing Hua and Smith, Albert Vernon and Huffman, Jennifer E and others (2011) 'Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function'. Nature genetics, 43 (11) [Details]
2011 'Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure'
Wain, Louise V and Verwoert, Germaine C and O'Reilly, Paul F and Shi, Gang and Johnson, Toby and Johnson, Andrew D and Bochud, Murielle and Rice, Kenneth M and Henneman, Peter and Smith, Albert V and others (2011) 'Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure'. Nature genetics, 43 (10):1005-1011 [Details]
2011 'New gene functions in megakaryopoiesis and platelet formation'
Gieger, Christian and Radhakrishnan, Aparna and Cvejic, Ana and Tang, Weihong and Porcu, Eleonora and Pistis, Giorgio and Serbanovic-Canic, Jovana and Elling, Ulrich and Goodall, Alison H and Labrune, Yann and others (2011) 'New gene functions in megakaryopoiesis and platelet formation'. Nature, 480 (7376):201-208 [Details]
2010 'White matter integrity in the splenium of the corpus callosum is related to successful cognitive aging and partly mediates the protective effect of an ancestral polymorphism in ADRB2'
Penke, Lars and Maniega, Susana Munoz and Houlihan, Lorna M and Murray, Catherine and Gow, Alan J and Clayden, Jonathan D and Bastin, Mark E and Wardlaw, Joanna M and Deary, Ian J (2010) 'White matter integrity in the splenium of the corpus callosum is related to successful cognitive aging and partly mediates the protective effect of an ancestral polymorphism in ADRB2'. Behavior genetics, 40 (2):146-156 [Details]
2010 'Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples'
Marioni, Riccardo E and Deary, Ian J and Murray, Gordon D and Lowe, Gordon DO and Rafnsson, Snorri B and Strachan, Mark WJ and Luciano, Michelle and Houlihan, Lorna M and Gow, Alan J and Harris, Sarah E and others (2010) 'Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples'. Behavior genetics, 40 (1) [Details]
2010 'Association of existing and new candidate genes for anxiety, depression and personality traits in older people'
Luciano, Michelle and Houlihan, Lorna M and Harris, Sarah E and Gow, Alan J and Hayward, Caroline and Starr, John M and Deary, Ian J (2010) 'Association of existing and new candidate genes for anxiety, depression and personality traits in older people'. Behavior Genetics, 40 (4):518-532 [Details]
2010 'Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time'
Houlihan, Lorna M and Davies, Gail and Tenesa, Albert and Harris, Sarah E and Luciano, Michelle and Gow, Alan J and McGhee, Kevin A and Liewald, David C and Porteous, David J and Starr, John M and others (2010) 'Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time'. The American Journal of Human Genetics, 86 (4):626-631 [Details]
2010 'Replication association analysis of S100B and cognitive ageing'
Houlihan, Lorna M and Harris, Sarah E and Deary, Ian J and Starr, John M (2010) 'Replication association analysis of S100B and cognitive ageing'. Psychiatric genetics, 20 (3):133-134 [Details]
2010 'Variation in the uric acid transporter gene (SLC2A9) and memory performance'
Houlihan, Lorna M and Wyatt, Niki D and Harris, Sarah E and Hayward, Caroline and Gow, Alan J and Marioni, Riccardo E and Strachan, Mark WJ and Price, Jackie F and Starr, John M and Wright, Alan F and others (2010) 'Variation in the uric acid transporter gene (SLC2A9) and memory performance'. Human Molecular Genetics, 19 (11):2321-2330 [Details]
2009 'Selected summaries from the XVI World Congress of Psychiatric Genetics, Osaka, Japan, 11--15 October 2008'
Bergen, Sarah and Chen, Jingchun and Dagdan, Elif and Foon, Tee Shiau and Goes, Fernando S and Houlihan, Lorna M and Kloiber, Stefan and Kumar, Ravinesh A and Kuzman, Martina Rojnic and Menke, Andreas and others (2009) 'Selected summaries from the XVI World Congress of Psychiatric Genetics, Osaka, Japan, 11--15 October 2008'. Psychiatric genetics, 19 (5):219-236 [Details]
2009 'A case-control association study and family-based expression analysis of the bipolar disorder candidate gene PI4K2B'
Houlihan, Lorna M and Christoforou, Andrea and Arbuckle, Margaret I and Torrance, Helen S and Anderson, Susan M and Muir, Walter J and Porteous, David J and Blackwood, Douglas H and Evans, Kathryn L (2009) 'A case-control association study and family-based expression analysis of the bipolar disorder candidate gene PI4K2B'. Journal of psychiatric research, 43 (16):1272-1277 [Details]
2009 'ANALYSIS OFPI4KII$\beta$, A CANDIDATE GENE FROM THE BIPOLAR SUSCEPTIBILITY LOCUS ON CHROMOSOME 4P15-16'
Houlihan, L and McLean, M and Thomson, P and Christoforou, A and Morris, S and Anderson, S and Torrance, H and Beekman, J and Muir, W and Porteous, D and others (2009) 'ANALYSIS OFPI4KII$\beta$, A CANDIDATE GENE FROM THE BIPOLAR SUSCEPTIBILITY LOCUS ON CHROMOSOME 4P15-16'. American Journal Of Medical Genetics-A, 138 (1) [Details]
2009 'Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936'
Houlihan, LM and Harris, SE and Luciano, M and Gow, AJ and Starr, JM and Visscher, PM and Deary, IJ (2009) 'Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936'. Genes, Brain and Behavior, 8 (2):238-247 [Details]
2009 'Genetic foundations of human intelligence'
Deary, Ian J and Johnson, Wendy and Houlihan, Lorna M (2009) 'Genetic foundations of human intelligence'. Human genetics, 126 (1):215-232 [Details]
2009 'A functional polymorphism under positive evolutionary selection in ADRB2 is associated with human intelligence with opposite effects in the young and the elderly'
Bochdanovits, Zolt\'an and Gosso, Florencia M and van den Berg, Linda and Rizzu, Patrizia and Polderman, Tinca JC and Pardo, Luba M and Houlihan, Lorna M and Luciano, Michelle and Starr, John M and Harris, Sarah E and others (2009) 'A functional polymorphism under positive evolutionary selection in ADRB2 is associated with human intelligence with opposite effects in the young and the elderly'. Behavior Genetics, 39 (1):15-23 [Details]
2007 'Haplotype analysis and a novel allele-sharing method refines a chromosome 4p locus linked to bipolar affective disorder'
Le Hellard, Stephanie and Lee, Andrew J and Underwood, Sarah and Thomson, Pippa A and Morris, Stewart W and Torrance, Helen S and Anderson, Susan M and Adams, Richard R and Navarro, Pau and Christoforou, Andrea and others (2007) 'Haplotype analysis and a novel allele-sharing method refines a chromosome 4p locus linked to bipolar affective disorder'. Biological psychiatry, 61 (6):797-805 [Details]
2005 'Haplotype and allele sharing analysis of chromosome 4p linked families with bipolar affective disorder'
Evans, K and Hellard, S and Lee, A and Thomson, P and Christoforou, A and Houlihan, L and McLean, M and Wray, N and Muir, W and Blackwood, D and others (2005) 'Haplotype and allele sharing analysis of chromosome 4p linked families with bipolar affective disorder'. American Journal Of Medical Genetics-A, 138 (1):76-77 [Details]

Conference Publications

  Year Publication
2018 Complement Pathway Changes at Age 11 Are Associated with Psychotic Experiences at Age 18 and with Persistence of Psychotic Experiences from Age 11 to Age 18; Evidence from a Nested Case Control Study of the ALSPAC Birth Cohort
Cotter, David and Focking, Melanie and Lewis, Glyn and Lopez, Lorna and English, Jane and Dicker, Pat and Rutten, Bart and Cannon, Mary and Zammit, Stan (2018) Complement Pathway Changes at Age 11 Are Associated with Psychotic Experiences at Age 18 and with Persistence of Psychotic Experiences from Age 11 to Age 18; Evidence from a Nested Case Control Study of the ALSPAC Birth Cohort EARLY INTERVENTION IN PSYCHIATRY , pp.90-90 [Details]
2014 Combining meta-and mega-analytic approaches for multi-site diffusion imaging based genetic studies: From the ENIGMA-DTI working group
Jahanshad, Neda and Kochunov, Peter and Nichols, Thomas E and Sprooten, Emma and Mandl, Ren\'e C and Almasy, Laura and Brouwer, Rachel M and Curran, Joanne E and De Zubicaray, Greig I and Dimitrova, Rali and others (2014) Combining meta-and mega-analytic approaches for multi-site diffusion imaging based genetic studies: From the ENIGMA-DTI working group 2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI) , pp.1234-1238 [Details]
2012 ADRB2, white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936
Lyall, Donald and Lopez, Lorna and Bastin, Mark and Maniega, Susana Munoz and Penke, Lars and Hernandes, Maria del Valdez and Royle, Natalie and Starr, John and Porteous, David and Wardlaw, Joanna and others (2012) ADRB2, white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936 BEHAVIOR GENETICS , pp.949-949 [Details]
2006 Analysis of a phosphoinositol kinase as a candidate bipolar disorder susceptibility gene on chromosome 4p
Houlihan, Lorna M and McLean, Margaret and Muir, Walter J and Porteous, David J and Blackwood, Douglas HR and Evans, Kathryn L (2006) Analysis of a phosphoinositol kinase as a candidate bipolar disorder susceptibility gene on chromosome 4p BIPOLAR DISORDERS , pp.63-64 [Details]
2006 Investigations into a chromosome 4P bipolar disorder susceptibility gene; Allelic expression assays and an association study in PI4K2B
Houlihan, Lorna and Porteous, David J and Blackwood, Douglas HR and Evans, Kathryn L (2006) Investigations into a chromosome 4P bipolar disorder susceptibility gene; Allelic expression assays and an association study in PI4K2B AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS , pp.757-757 [Details]

External Collaborators

  Name Role / Description Country
Professor Louise Gallagher Trinity College Dublin IRELAND
Dr Jane English University College Cork IRELAND
Dr Lisa Meltzer National Jewish Health NORTH & SOUTH AMERICA