Prof Paul Moynagh

Biology, Human Health Institute

Professor

Biosciences & Electronic Engineering Facility
B3.15
(01) 708 6105

Biography

Prof. Paul Moynagh obtained his B.A. (Mod) and PhD from Trinity College Dublin. After postdoctoral fellowships he took up a lectureship in UCD Department of Pharmacology in 1995 before becoming founding Head of the UCD School of Biomolecular and Biomedical Science. In 2006 Prof. Moynagh moved to NUI Maynooth where is now Head of the Department of Biology and Director of the Human Health Research Institute. He has published extensively in the area of immunology-related research. In 2009 he was awarded the NUI Centennial Prize for Academic Publishing in Medical and Health Sciences and is the recipient of the 2014 Irish Area Section Biochemical Society (IASBS) Medal. He is a SFI Principal Investigator.  

Book Chapters

  Year Publication
2005 'Toll-like receptor 9 and autoimmunity'
Moynagh, P.N. (2005) 'Toll-like receptor 9 and autoimmunity' In: Molecular Autoimmunity. New York: Kluwer Academic / Plenum Publishers. [Details]
2001 'Methods of detection of the transcription factor NF-ƒÛB in rat hippocampal slices'
Butler, M.P., Moynagh, P.N. and O'Connor, J.J. (2001) 'Methods of detection of the transcription factor NF-ƒÛB in rat hippocampal slices' In: Monitoring Molecules in Neuroscience; Proceedings of the ninth International conference on In Vivo Methods. [Details]
2001 'Assaying IL-8'
Moynagh, P.N. (2001) 'Assaying IL-8' In: Interleukin protocols. Methods in Molecular Medicine. [Details]

Peer Reviewed Journals

  Year Publication
2018 'The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome'
Humphries F.;Bergin R.;Jackson R.;Delagic N.;Wang B.;Yang S.;Dubois A.;Ingram R.;Moynagh P. (2018) 'The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome'. Nature Communications, 9 (1) [DOI] [Details]
2017 'NF-κB signalling is involved in immune-modulation, but not basal functioning, of the mouse suprachiasmatic circadian clock'
O'Keeffe SM;Beynon AL;Davies JS;Moynagh PN;Coogan AN; (2017) 'NF-κB signalling is involved in immune-modulation, but not basal functioning, of the mouse suprachiasmatic circadian clock'. European Journal of Neuroscience, 45 (8) [DOI] [Details]
2017 'Regulatory T cells promote myelin regeneration in the central nervous system'
Dombrowski Y.;O'Hagan T.;DIttmer M.;Penalva R.;Mayoral S.;Bankhead P.;Fleville S.;Eleftheriadis G.;Zhao C.;Naughton M.;Hassan R.;Moffat J.;Falconer J.;Boyd A.;Hamilton P.;Allen I.;Kissenpfennig A.;Moynagh P.;Evergren E.;Perbal B.;Williams A.;Ingram R.;Chan J.;Franklin R.;Fitzgerald D. (2017) 'Regulatory T cells promote myelin regeneration in the central nervous system'. Nature Neuroscience, 20 (5):674-680 [DOI] [Details]
2017 'MyD88 is an essential component of retinoic acid-induced differentiation in human pluripotent embryonal carcinoma cells'
Sulaiman G;Cooke A;Ffrench B;Gasch C;Abdullai OA;O'Connor K;Elbaruni S;Blackshields G;Spillane C;Keegan H;McEneaney V;Knittel R;Rogers A;Jeffery IB;Doyle B;Bates M;d'Adhemar C;Lee MY;Campbell EL;Moynagh PN;Higgins DG;O'Toole S;O'Neill L;O'Leary JJ;Gallagher MF; (2017) 'MyD88 is an essential component of retinoic acid-induced differentiation in human pluripotent embryonal carcinoma cells'. Cell Death and Differentiation, 24 (11) [DOI] [Details]
2017 'Differential modulation of Helicobacter pylori lipopolysaccharide-mediated TLR2 signaling by individual Pellino proteins'
Smith SM;Freeley M;Moynagh PN;Kelleher DP; (2017) 'Differential modulation of Helicobacter pylori lipopolysaccharide-mediated TLR2 signaling by individual Pellino proteins'. Helicobacter, 22 (1) [DOI] [Details]
2016 'Chronic fluoxetine treatment attenuates post-septic affective changes in the mouse'
Anderson, ST;Commins, S;Moynagh, P;Coogan, AN (2016) 'Chronic fluoxetine treatment attenuates post-septic affective changes in the mouse'. BEHAVIOURAL BRAIN RESEARCH, 297 :112-115 [DOI] [Details]
2015 'Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions'
Mellett, M;Atzei, P;Bergin, R;Horgan, A;Floss, T;Wurst, W;Callanan, JJ;Moynagh, PN (2015) 'Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions'. Nature Communications, 6 [DOI] [Details]
2015 'Functional conservation of an ancestral Pellino protein in helminth species'
Cluxton, CD;Caffrey, BE;Kinsella, GK;Moynagh, PN;Fares, MA;Fallon, PG (2015) 'Functional conservation of an ancestral Pellino protein in helminth species'. Scientific Reports, 5 [DOI] [Details]
2015 'Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity'
Humphries F.;Moynagh P. (2015) 'Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity'. Immunological Reviews, 266 (1):93-108 [DOI] [Details]
2014 'Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-κBp50'
Canavan M.;McCarthy C.;Larbi N.;Dowling J.;Collins L.;O'Sullivan F.;Hurley G.;Murphy C.;Quinlan A.;Moloney G.;Darby T.;Macsharry J.;Kagechika H.;Moynagh P.;Melgar S.;Loscher C. (2014) 'Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-κBp50'. Journal of Innate Immunity, 20 (7):675-687 [DOI] [Details]
2014 'Identification of the flagellin glycosylation system in urkholderia cenocepacia and the contribution of glycosylated flagellin to vasion of human innate immune responses'
Hanuszkiewicz A.;Pittock P.;Humphries F.;Moll H.;Rosales A.;Molinaro A.;Moynagh P.;Lajoie G.;Valvano M. (2014) 'Identification of the flagellin glycosylation system in urkholderia cenocepacia and the contribution of glycosylated flagellin to vasion of human innate immune responses'. Journal of Biological Chemistry, 289 (27):19231-19244 [DOI] [Details]
2014 'RIP kinases: key decision makers in cell death and innate immunity'
Humphries F.;Yang S.;Wang B.;Moynagh P. (2014) 'RIP kinases: key decision makers in cell death and innate immunity'. Cell Death and Differentiation, [DOI] [Details]
2014 'Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-kappa Bp50'
Canavan, M;McCarthy, C;Ben Larbi, N;Dowling, JK;Collins, L;O'Sullivan, F;Hurley, G;Murphy, C;Quinlan, A;Moloney, G;Darby, T;MacSharry, J;Kagechika, H;Moynagh, P;Melgar, S;Loscher, CE (2014) 'Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-kappa Bp50'. Journal of Innate Immunity, 20 :675-687 [DOI] [Details]
2014 'The E3 Ubiquitin Ligase Pellino3 Protects against Obesity-Induced Inflammation and Insulin Resistance'
Yang, S;Wang, BW;Humphries, F;Hogan, AE;O'Shea, D;Moynagh, PN (2014) 'The E3 Ubiquitin Ligase Pellino3 Protects against Obesity-Induced Inflammation and Insulin Resistance'. Immunity, 41 :973-987 [DOI] [Details]
2014 'Epstein-Barr Virus Large Tegument Protein BPLF1 Contributes to Innate Immune Evasion through Interference with Toll-Like Receptor Signaling'
van Gent M.;Braem S.;de Jong A.;Delagic N.;Peeters J.;Boer I.;Moynagh P.;Kremmer E.;Wiertz E.;Ovaa H.;Griffin B.;Ressing M. (2014) 'Epstein-Barr Virus Large Tegument Protein BPLF1 Contributes to Innate Immune Evasion through Interference with Toll-Like Receptor Signaling'. PLoS Pathogens, 10 (2) [DOI] [Details]
2013 'Nuclear factor κb2 p52 protein has a role in antiviral immunity through IκB kinase ε-dependent induction of Sp1 protein and interleukin 15'
Doyle S.;Shirey K.;McGettrick A.;Kenny E.;Carpenter S.;Caffrey B.;Gargan S.;Quinn S.;Caamaño J.;Moynagh P.;Vogel S.;Neill L. (2013) 'Nuclear factor κb2 p52 protein has a role in antiviral immunity through IκB kinase ε-dependent induction of Sp1 protein and interleukin 15'. Journal of Biological Chemistry, 288 (35):25066-25075 [DOI] [Details]
2013 'Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α'
Yang S.;Wang B.;Tang L.;Siednienko J.;Callanan J.;Moynagh P. (2013) 'Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α'. Nature Communications, 4 [DOI] [IR Link] [Details]
2013 'Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection'
O'Shea D.;Corrigan M.;Dunne M.;Jackson R.;Woods C.;Gaoatswe G.;Moynagh P.;O'Connell J.;Hogan A. (2013) 'Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection'. International Journal of Obesity, 37 (11):1510-1513 [DOI] [Details]
2013 'Nuclear Factor kappa B2 p52 Protein Has a Role in Antiviral Immunity through I kappa B Kinase epsilon-dependent Induction of Sp1 Protein and Interleukin 15'
Doyle, SL;Shirey, KA;McGettrick, AF;Kenny, EF;Carpenter, S;Caffrey, BE;Gargan, S;Quinn, SR;Caamano, JH;Moynagh, P;Vogel, SN;O'Neill, LA (2013) 'Nuclear Factor kappa B2 p52 Protein Has a Role in Antiviral Immunity through I kappa B Kinase epsilon-dependent Induction of Sp1 Protein and Interleukin 15'. Journal of Biological Chemistry, 288 :25066-25075 [DOI] [Details]
2013 'NFκB2 p52 has a role in antiviral immunity through IKK-dependent induction of Sp1 and IL-15'
Doyle SL, Shirey KA, McGettrick AF, Kenny EF, Carpenter SB, Caffrey BE, Gargan S, Quinn SR, Caamao JH, Moynagh PN, Vogel SN, O'Neill LA. (2013) 'NFκB2 p52 has a role in antiviral immunity through IKK-dependent induction of Sp1 and IL-15'. JOURNAL OF BIOLOGICAL CHEMISTRY, 288 :25066-25075 [IR Link] [Details]
2013 'The Pro-inflammatory Cytokine TNF-alpha Regulates the Activity and Expression of the Serotonin Transporter (SERT) in Astrocytes'
Malynn, S;Campos-Torres, A;Moynagh, P;Haase, J (2013) 'The Pro-inflammatory Cytokine TNF-alpha Regulates the Activity and Expression of the Serotonin Transporter (SERT) in Astrocytes'. Neurochemical Research, 38 :694-704 [DOI] [Details]
2013 'The pro-inflammatory cytokine TNF-α regulates the activity and expression of the serotonin transporter (SERT) in astrocytes'
Malynn S.;Campos-Torres A.;Moynagh P.;Haase J. (2013) 'The pro-inflammatory cytokine TNF-α regulates the activity and expression of the serotonin transporter (SERT) in astrocytes'. Neurochemical Research, 38 (4):694-704 [DOI] [Details]
2012 'The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α'
Downer E.;Clifford E.;Amu S.;Fallon P.;Moynagh P. (2012) 'The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α'. Journal of Biological Chemistry, 287 (30):25440-25453 [DOI] [IR Link] [Details]
2011 'Nuclear factor κB subunits RelB and cRel negatively regulate toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1'
Siednienko J.;Maratha A.;Yang S.;Mitkiewicz M.;Miggin S.;Moynagh P. (2011) 'Nuclear factor κB subunits RelB and cRel negatively regulate toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1'. Journal of Biological Chemistry, 286 (52):44750-44763 [DOI] [Details]
2011 'Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 activation and IFN-β expression: Relevance to therapeutic effects in models of multiple sclerosis'
Downer E.;Clifford E.;Gran B.;Nel H.;Fallon P.;Moynagh P. (2011) 'Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 activation and IFN-β expression: Relevance to therapeutic effects in models of multiple sclerosis'. Journal of Biological Chemistry, 286 (12):10316-10328 [DOI] [IR Link] [Details]
2011 'Nitric oxide affects IL-6 expression in human peripheral blood mononuclear cells involving cGMP-dependent modulation of NF-κB activity'
Siednienko J.;Nowak J.;Moynagh P.;Gorczyca W. (2011) 'Nitric oxide affects IL-6 expression in human peripheral blood mononuclear cells involving cGMP-dependent modulation of NF-κB activity'. Cytokine, 54 (3):282-288 [DOI] [Details]
2011 'Absence of MyD88 Results in Enhanced TLR3-Dependent Phosphorylation of IRF3 and Increased IFN-beta and RANTES Production'
Siednienko, J;Gajanayake, T;Fitzgerald, KA;Moynagh, P;Miggin, SM (2011) 'Absence of MyD88 Results in Enhanced TLR3-Dependent Phosphorylation of IRF3 and Increased IFN-beta and RANTES Production'. Journal of Immunology, 186 :2514-2522 [DOI] [Details]
2011 'Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-β and RANTES production'
Siednienko J.;Gajanayake T.;Fitzgerald K.;Moynagh P.;Miggin S. (2011) 'Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-β and RANTES production'. Journal of Immunology, 186 (4):2514-2522 [DOI] [Details]
2010 'Cactin targets the MHC class III protein IκB-like (IκBL) and inhibits NF-κB and interferon-regulatory factor signaling pathways'
Atzei P.;Gargan S.;Curran N.;Moynagh P. (2010) 'Cactin targets the MHC class III protein IκB-like (IκBL) and inhibits NF-κB and interferon-regulatory factor signaling pathways'. Journal of Biological Chemistry, 285 (47):36804-36817 [DOI] [IR Link] [Details]
2007 'NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1'
Miggin S.;Pålsson-McDermott E.;Dunne A.;Jefferies C.;Pinteaux E.;Banahan K.;Murphy C.;Moynagh P.;Yamamoto M.;Akira S.;Rothwell N.;Golenbock D.;Fitzgerald K.;O'Neill L. (2007) 'NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1'. Proceedings of the National Academy of Sciences of the United States of America, 104 (9):3372-3377 [DOI] [IR Link] [Details]
2007 'NF-kappa B activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1'
Miggin, SM;Palsson-McDermott, E;Dunne, A;Jefferies, C;Pinteaux, E;Banahan, K;Murphy, C;Moynagh, P;Yamamoto, M;Akira, S;Rothwelll, N;Golenbock, D;Fitzgerald, KA;O'Neill, LAJ (2007) 'NF-kappa B activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1'. Proceedings of the National Academy of Sciences of the United States of America, 104 :3372-3377 [DOI] [IR Link] [Details]
2007 'NF-κB activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations'
Sheridan G.;Pickering M.;Twomey C.;Moynagh P.;O'Connor J.;Murphy K. (2007) 'NF-κB activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations'. Learning and Memory, 14 (8):525-532 [DOI] [IR Link] [Details]
2013 'Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-Bp50'
Canavan M, McCarthy C, Larbi NB, Dowling J, Collins L, O'Sullivan F, Hurley G, Murphy C, Quinlan A, Moloney G, Darby T, Macsharry J, Kagechika H, Moynagh P, Melgar S, Loscher CE. (2013) 'Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-Bp50'. INNATE IMMUNITY, PMID:24045337 [DOI] [IR Link] [Details]
2013 'Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection'
O'Shea D, Corrigan M, Dunne MR, Jackson R, Woods C, Gaoatswe G, Moynagh PN, O'Connell J, Hogan AE. (2013) 'Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection'. International Journal of Obesity, doi: 10.1038/ijo.2013.16 [DOI] [IR Link] [Details]
2013 'Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-'
Yang S., Wang B., Tang L., Siednienko J., Callanan J.J. and Moynagh P.N (2013) 'Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-'. NATURE COMMUNICATIONS, 4 [DOI] [IR Link] [Details]
2013 'Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis'
Yang S, Wang B, Humphries F, Jackson R, Healy ME, Bergin R, Aviello G, Hall B, McNamara D, Darby T, Quinlan A, Shanahan F, Melgar S, Fallon PG, Moynagh PN. (2013) 'Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis'. NATURE IMMUNOLOGY, 14 :927-936 [IR Link] [Details]
2013 'The Pro-inflammatory Cytokine TNF-α Regulates the Activity and Expression of the Serotonin Transporter (SERT) in astrocytes'
Malynn, S., Campos-Torres, A., Moynagh, P. And Haase, J (2013) 'The Pro-inflammatory Cytokine TNF-α Regulates the Activity and Expression of the Serotonin Transporter (SERT) in astrocytes'. NEUROCHEMICAL RESEARCH, 38 :694-704 [IR Link] [Details]
2012 'Long-Lasting Effects of Sepsis on Circadian Rhythms in the Mouse'
O’Callaghan, E.K., Anderson, S.T., Moynagh, P.N. and Coogan, A.N. (2012) 'Long-Lasting Effects of Sepsis on Circadian Rhythms in the Mouse'. PLoS ONE, 7 [IR Link] [Details]
2012 'Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia'
Mellett M, Atzei P, Horgan A, Hams E, Floss T, Wurst W, Fallon PG, Moynagh PN. (2012) 'Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia'. Nature Communications, 3 [IR Link] [Details]
2012 'Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons'
Siednienko J, Jackson R, Mellett M, Delagic N, Yang S, Wang B, Tang LS, Callanan JJ, Mahon BP, Moynagh PN. (2012) 'Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons'. Nature Immunology, 13 :1055-1062 [IR Link] [Details]
2012 'The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α'
Downer EJ, Clifford E, Amu S, Fallon PG, Moynagh PN (2012) 'The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α'. JOURNAL OF BIOLOGICAL CHEMISTRY, 287 :25440-25453 [IR Link] [Details]
2011 'A poxviral homolog of the Pellino protein inhibits Toll and Toll-like receptor signalling'
Griffin, B.D., Mellett, M., Campos Torres, A., Kinsella, G.K., Wang, B. and Moynagh, P.N. (2011) 'A poxviral homolog of the Pellino protein inhibits Toll and Toll-like receptor signalling'. EUROPEAN JOURNAL OF IMMUNOLOGY, 41 :798-812 [IR Link] [Details]
2011 'Peli1 (rel)ieves autoimmunity'
Moynagh PN (2011) 'Peli1 (rel)ieves autoimmunity'. Nature Immunology, 12 :927-929 [IR Link] [Details]
2011 'Nitric oxide affects IL-6 expression in human peripheral blood mononuclear cells involving cGMP-dependent modulation of NF-κB activity'
Siednienko J, Nowak J, Moynagh P.N., Gorczyca WA. (2011) 'Nitric oxide affects IL-6 expression in human peripheral blood mononuclear cells involving cGMP-dependent modulation of NF-κB activity'. CYTOKINE, 54 :282-288 [IR Link] [Details]
2011 'Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis'
Hogan AE, Tobin AM, Ahern T, Corrigan MA, Gaoatswe G, Jackson R, O'Reilly V, Lynch L, Doherty DG, Moynagh P.N., Kirby B, O'Connell J, O'Shea D. (2011) 'Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis'. DIABETOLOGIA, 54 :2745-2754 [IR Link] [Details]
2011 'Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and Increased IFN-b and RANTES production'
Siednienko, J., Gajanayake, T., Fitzgerald, K.A., Moynagh, P. and Miggin, S.M. (2011) 'Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and Increased IFN-b and RANTES production'. THE JOURNAL OF IMMUNOLOGY, 186 :2514-2522 [IR Link] [Details]
2011 'The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells'
Hams E, Saunders SP, Cummins EP, O'Connor A, Tambuwala MT, Gallagher WM, Byrne A, Campos-Torres A, Moynagh PN, Jobin C, Taylor CT, Fallon PG. (2011) 'The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells'. Shock, 36 :295-302 [IR Link] [Details]
2011 'Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 (IRF3) activation and IFN-{beta} expression: relevance to therapeutic effects in models of multiple sclerosis'
Downer, E.J., Clifford E., Gran, B., Nel, H.J., Fallon, P.G. and Moynagh, P.N. (2011) 'Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 (IRF3) activation and IFN-{beta} expression: relevance to therapeutic effects in models of multiple sclerosis'. JOURNAL OF BIOLOGICAL CHEMISTRY, 286 :10316-10328 [IR Link] [Details]
2011 'Mal mediates TLR-induced activation of CREB and expression of IL-10'
Mellett,, M., Atzei, P., Jackson, R., O’Neill, L.A.J and Moynagh, P.N (2011) 'Mal mediates TLR-induced activation of CREB and expression of IL-10'. THE JOURNAL OF IMMUNOLOGY, 186 :4925-4935 [IR Link] [Details]
2011 'Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1'
Siednienko J, Maratha A, Yang S, Mitkiewicz M, Miggin SM, Moynagh PN. (2011) 'Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1'. 286(52):44750-63 :44750-44763 [Details]
2010 'Characterisation of expression patterns and functional role of Cactin in early zebrafish development'
Atzei, P., Yang, F., Collery, R., Kennedy, B.N. and Moynagh, P.N. (2010) 'Characterisation of expression patterns and functional role of Cactin in early zebrafish development'. GENE EXPRESSION, 10 :199-206 [IR Link] [Details]
2010 'Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and inhibits NF-kappaB and interferon-regulatory factor signaling pathways'
Atzei, P., Gargan, S., Curran, N. and Moynagh, P.N. (2010) 'Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and inhibits NF-kappaB and interferon-regulatory factor signaling pathways'. 285 :36804-36817 [IR Link] [Details]
2009 'The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling'
Moynagh, P.N. (2009) 'The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling'. TRENDS IN IMMUNOLOGY, 30 :33-42 [IR Link] [Details]
2007 'NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1'
Miggin, S.M., E. Palsson-McDermott, A. Dunne, C. Jefferies, E. Pinteaux, K. Banahan, C. Murphy, P.N. Moynagh, M. Yamamoto, S. Akira, N. Rothwell, D.  Golenbock, K.A. Fitzgerald and L.A. O'Neill (2007) 'NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, 104 :3372-3377 [IR Link] [Details]
2007 'Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning'
O'Sullivan, N.C., P.A. McGettigan, G.K. Sheridan, M. Pickering, L. Conboy, J.J. O'Connor, P.N. Moynagh, D.G. Higgins, C.M. Regan and K.J. Murphy (2007) 'Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning'. JOURNAL OF NEUROCHEMISTRY, 101 :1085-1098 [IR Link] [Details]
2007 'Kinase-active Interleukin-1 Receptor-associated Kinases Promote Polyubiquitination and Degradation of the Pellino Family:  Direct evidence for pellino proteins being ubiquitin-protein isopeptide ligases'
Butler, M.P., J.A. Hanly and P.N. Moynagh (2007) 'Kinase-active Interleukin-1 Receptor-associated Kinases Promote Polyubiquitination and Degradation of the Pellino Family:  Direct evidence for pellino proteins being ubiquitin-protein isopeptide ligases'. JOURNAL OF BIOLOGICAL CHEMISTRY, 282 :29729-29737 [IR Link] [Details]
2007 'NF-kappaB activity in distinct neural subtypes of the rat hippocampus:  Influence of time and GABA antagonism in acute slice preparations'
Sheridan, G.K., M. Pickering, C. Twomey, P.N. Moynagh, J.J. O’Connor and K.J. Murphy (2007) 'NF-kappaB activity in distinct neural subtypes of the rat hippocampus:  Influence of time and GABA antagonism in acute slice preparations'. LEARNING AND MEMORY, 14 :525-532 [IR Link] [Details]
2007 'Evidence for a role for the group I metabotropic glutamate receptor in the inhibitory effect of tumor necrosis factor-alpha on long-term potentiation'
Cumiskey, D., M.P. Butler, P.N. Moynagh and J.J. O'Connor (2007) 'Evidence for a role for the group I metabotropic glutamate receptor in the inhibitory effect of tumor necrosis factor-alpha on long-term potentiation'. BRAIN RESEARCH, 1136 :13-19 [IR Link] [Details]
2006 'In vivo binding of NFkB to the IkBb promoter is insufficient for transcriptional activation'
Griffin, B.D. and Moynagh, P.N. (2006) 'In vivo binding of NFkB to the IkBb promoter is insufficient for transcriptional activation'. BIOCHEMICAL JOURNAL, 400 :115-125 [IR Link] [Details]
2006 'The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling'
Carty, M., Goodbody, R., Schröder, M., Stack, J., Moynagh, P.N. and. Bowie, A.G. (2006) 'The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling'. NATURE IMMUNOLOGY, 7 :1074-1081 [IR Link] [Details]
2006 'Persistent Interleukin-1b Signaling Causes Long Term Activation of NFkB in a Promoter-specific Manner in Human Glial Cells'
Griffin, B.D. and Moynagh, P.N. (2006) 'Persistent Interleukin-1b Signaling Causes Long Term Activation of NFkB in a Promoter-specific Manner in Human Glial Cells'. JOURNAL OF BIOLOGICAL CHEMISTRY, 281 :10316-10326 [IR Link] [Details]
2006 'TNF-alpha is a mediator of the anti-inflammatory response in a human neonatal model of the non-septic shock syndrome'
Hassett, S., Moynagh, P. and Reen, D. (2006) 'TNF-alpha is a mediator of the anti-inflammatory response in a human neonatal model of the non-septic shock syndrome'. PEDIATRIC SURGERY INTERNATIONAL, 22 :24-30 [IR Link] [Details]
2006 'Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity'
Cummins, E.P., Berra, E., Comerford, K.M, Ginouves, A., Fitzgerald, K.T, Seeballuck, F., Godson, C., Nielsen, J.E., Moynagh, P., Pouyssegur J, Taylor CT (2006) 'Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, 103 :18154-18159 [IR Link] [Details]
2005 'The interleukin-1 signalling pathway in astrocytes: a key contributor to inflammation in the brain'
Moynagh, P.N. (2005) 'The interleukin-1 signalling pathway in astrocytes: a key contributor to inflammation in the brain'. JOURNAL OF ANATOMY, 207 :265-269 [IR Link] [Details]
2005 'Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner'
Butler, M.P., Hanly, J.A. and Moynagh, P.N. (2005) 'Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner'. JOURNAL OF BIOLOGICAL CHEMISTRY, 280 :27759-27768 [IR Link] [Details]
2005 'TLR signalling and activation of IRFs: Revisiting old friends from the NF-ƒÛB pathway'
Moynagh, P.N. (2005) 'TLR signalling and activation of IRFs: Revisiting old friends from the NF-ƒÛB pathway'. TRENDS IN IMMUNOLOGY, 26 :469-476 [IR Link] [Details]
2005 'The NF-kB pathway'
Moynagh, P.N. (2005) 'The NF-kB pathway'. JOURNAL OF CELL SCIENCE, 118 :4589-4592 [IR Link] [Details]
2005 'The synthetic cannabinoid R(+)WIN55,212 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid-receptor independent manner'
Curran, N.M., Griffin, B.D., O’Toole, D.,  Brady, K. J., Fitzgerald, S.N. and Moynagh, P.N. (2005) 'The synthetic cannabinoid R(+)WIN55,212 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid-receptor independent manner'. JOURNAL OF BIOLOGICAL CHEMISTRY, 280 :35797-35806 [IR Link] [Details]
2004 'Dissection of tumor-necrosis factor-alpha inhibition of long-term potentiation (LTP) reveals a p38 mitogen-activated protein kinase-dependent mechanism which maps to early-but not late-phase LTP'
Butler, M.P., O’Connor, J.J. and Moynagh, P.N. (2004) 'Dissection of tumor-necrosis factor-alpha inhibition of long-term potentiation (LTP) reveals a p38 mitogen-activated protein kinase-dependent mechanism which maps to early-but not late-phase LTP'. 124 :319-326 [IR Link] [Details]
2004 'The inhibitory effect of tumour necrosis factor on long-term potentiation is attenuated by type 1 metabotropic glutamate receptor blockade'
Cumiskey, D, Butler MP, Moynagh PN & O’Connor JJ. (2004) 'The inhibitory effect of tumour necrosis factor on long-term potentiation is attenuated by type 1 metabotropic glutamate receptor blockade'. JOURNAL OF PHYSIOLOGY, 560P [Details]
2003 'Anti-inflammatory effects of cannabinoid receptor ligands in glial cells'
Curran, N., Brady, KJ., Fitzgerald, S.N. and Moynagh , P.N. (2003) 'Anti-inflammatory effects of cannabinoid receptor ligands in glial cells'. EUROPEAN CYTOKINE NETWORK, 14 [Details]
2003 'Toll-like receptor signalling pathways as key targets for mediating the anti-inflammatory and immunosuppressive effects of glucocorticoids'
Moynagh, P.N. (2003) 'Toll-like receptor signalling pathways as key targets for mediating the anti-inflammatory and immunosuppressive effects of glucocorticoids'. 179 :139-144 [IR Link] [Details]
2003 'Cloning and functional characterisation of human ECSIT'
O’Toole, D, Fitzgerald, S.N. and Moynagh , P.N. (2003) 'Cloning and functional characterisation of human ECSIT'. EUROPEAN CYTOKINE NETWORK, 14 [Details]
2003 'Regulation of Toll-like receptor 4 signalling by A20 zinc finger protein'
O'Reilly, SM and Moynagh, PN. (2003) 'Regulation of Toll-like receptor 4 signalling by A20 zinc finger protein'. Biochemical and Biophysical Research Communications, 303 :586-593 [IR Link] [Details]
2003 'IƒÛBƒÒ: The key to sustained activation of NFƒÛB in glial cells'
Griffin, B.D. and Moynagh, P.N. (2003) 'IƒÛBƒÒ: The key to sustained activation of NFƒÛB in glial cells'. 14 [Details]
2002 'Methods of detection of the transcription factor NF-kappaB in rat hippocampal slices'
Butler, M., Moynagh, P.N. and O’Connor, J. (2002) 'Methods of detection of the transcription factor NF-kappaB in rat hippocampal slices'. Journal of Neuroscience Methods, 119 :185-189 [IR Link] [Details]
2001 'PRISM, a novel mediator of Toll/IL-1 signalling'
Kennedy, E.J. and Moynagh, P.N. (2001) 'PRISM, a novel mediator of Toll/IL-1 signalling'. FASEB JOURNAL, 15 :A209-A209 [Details]
2001 'An Evaluation of the Effects of TNF-Ą on Long term Potentiation in the rat dentate gyrus in vitro'
Butler, M.P., O¡¦Connor, J.J. and Moynagh, P.N. (2001) 'An Evaluation of the Effects of TNF-ƒÑ on Long term Potentiation in the rat dentate gyrus in vitro'. PROCEEDINGS OF THE BRITISH PHARMACOLOGICAL SOCIETY ABSTRACTS, [Details]
2001 'CD40 employs p38 MAP kinase in IgE isotype switching'
Brady, K., Fitzgerald, S., Ingvarsson, S., Borrebaeck CA. and Moynagh, P.N (2001) 'CD40 employs p38 MAP kinase in IgE isotype switching'. Biochemical and Biophysical Research Communications, 289 :276-281 [IR Link] [Details]
2000 'Rapid polarization of Th2 cells during induction of antigen-specific IgE antibodies in vitro'
Akesson, A., Ingvarsson, S., Brady, K., Moynagh, P., Borrebaeck CA. (2000) 'Rapid polarization of Th2 cells during induction of antigen-specific IgE antibodies in vitro'. Clinical and Experimental Allergy, 30 :1298-1306 [IR Link] [Details]
2000 'Regulation of pro-inflammatory gene expression by human Toll'
O’Reilly, S. and Moynagh, P.N. (2000) 'Regulation of pro-inflammatory gene expression by human Toll'. EUROPEAN CYTOKINE NETWORK, 11 [Details]
2000 'Loss of Ikappa B-beta is associated with prolonged NF-kappa B activity in human glial cells'
Bourke, E., Kennedy, E.J. and Moynagh, P.N. (2000) 'Loss of Ikappa B-beta is associated with prolonged NF-kappa B activity in human glial cells'. 275 :39996-40002 [IR Link] [Details]
2000 'Tumour-necrosis-factor-receptor-associated factor 6, NF-kappaB-inducing kinase and IkappaB kinases mediate IgE isotype switching in response to CD40'
Brady, K., Fitzgerald, S., Moynagh, P.N. (2000) 'Tumour-necrosis-factor-receptor-associated factor 6, NF-kappaB-inducing kinase and IkappaB kinases mediate IgE isotype switching in response to CD40'. Biochemical Journal, 350 :735-740 [IR Link] [Details]
1999 'Antiinflammatory effects of glucocorticoids in brain cells, independent of NF-kappa B'
Bourke, E. and  Moynagh, P.N. (1999) 'Antiinflammatory effects of glucocorticoids in brain cells, independent of NF-kappa B'. Journal of Immunology, 163 :2113-2119 [IR Link] [Details]
1998 'Glucocorticoids inhibit expression of adhesion molecules and chemokines in glial cells by a mechanism independent of NFƒÛB'
Bourke, E. and Moynagh, P.N. (1998) 'Glucocorticoids inhibit expression of adhesion molecules and chemokines in glial cells by a mechanism independent of NFƒÛB'. EUROPEAN CYTOKINE NETWORK, 9 [Details]
1998 'p38 MAP kinase mediates the induction of selective IL-1 reponsive genes'
Comerford, K., Gardiner, C. and Moynagh, P.N. (1998) 'p38 MAP kinase mediates the induction of selective IL-1 reponsive genes'. EUROPEAN CYTOKINE NETWORK, 9 [Details]
1997 'Lipid peroxidation is involved in the activation of NF-kappaB by tumor necrosis factor but not interleukin-1 in the human endothelial cell line ECV304. Lack of involvement of H2O2 in NF-kappaB activation by either cytokine in both primary and transformed endothelial cells'
Bowie, AG, Moynagh, P.N. and O'Neill LA. (1997) 'Lipid peroxidation is involved in the activation of NF-kappaB by tumor necrosis factor but not interleukin-1 in the human endothelial cell line ECV304. Lack of involvement of H2O2 in NF-kappaB activation by either cytokine in both primary and transformed endothelial cells'. JOURNAL OF BIOLOGICAL CHEMISTRY, 272 :25941-25950 [IR Link] [Details]

Conference Publications

  Year Publication
2010 mGlR1 inhibition reverses the inhibitory effect of tumour necrosis factor- on long-term potentiation
Cumiskey, D., M.P. Butler, Moynagh, PN, J.J. O'Connor (2010) mGlR1 inhibition reverses the inhibitory effect of tumour necrosis factor- on long-term potentiation Neuroscience 2004 [Details]
2006 Tumour necrosis factor selectively upregulates nuclear factor kappaB expression in hippocampal sub-neuronal populations
Sheridan G., Pickering M., Moynagh P.N., O’Connor J.J. and Murphy K.J. (2006) Tumour necrosis factor selectively upregulates nuclear factor kappaB expression in hippocampal sub-neuronal populations British Journal of Pharmacology Meeting [Details]
2004 IƒÛBƒÒ and temporal regulation of NFƒÛB in glial cells
Griffin, B.D. and Moynagh , P.N. (2004) IƒÛBƒÒ and temporal regulation of NFƒÛB in glial cells Keystone Symposium [Details]

Conference Contributions

  Year Publication
2009 XI World Transplantation Society (TTS) symposium and I European Society for Organ Transplantation.
(2009) XI World Transplantation Society (TTS) symposium and I European Society for Organ Transplantation. [Oral Presentation], Novel insights into negative regulation of inflammatory signalling pathways, Brussels [Details]
2009 Royal College of Surgeons Ireland (RCSI).
(2009) Royal College of Surgeons Ireland (RCSI). [Oral Presentation], Novel regulators of innate immune signalling, [Details]
2008 International Neuroimmunology Symposium.
(2008) International Neuroimmunology Symposium. [Oral Presentation], Molecular Insights into regulation of Neuroinflammation, University College Dublin [Details]

Conference Paper

  Year Publication
2001 An Evaluation of the Role of NF-ƒÛB as a regulator of synaptic plasticity in the rat dentate gyru.
Butler, M.P., O’Connor, J.J. and Moynagh, P.N. (2001) An Evaluation of the Role of NF-ƒÛB as a regulator of synaptic plasticity in the rat dentate gyru. Conference Paper [Details]

Thesis

  Year Publication
1991 Structural Characterization of the Peripheral-Type Benzodiazepine Acceptor .
Paul Moynagh (1991) Structural Characterization of the Peripheral-Type Benzodiazepine Acceptor . Trinity College Dublin: Thesis [Details]