Dr Andrew Hogan

Biography
Research Interests
Research Projects
Project | Role | Funding Body / Program | Description | Start Date | End Date | Award (€) | |
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Novel Approach to the Development of Food Products for Pre-Diabetics and Those With Impaired Glucose Tolerance | Co-PI | Enterprise Ireland / Government State Bodies | 01-AUG-18 | 31-JUL-20 | 285000 | ||
Immune dysregulation in Type 1 diabetes. | Principle Investigator | National Children’s Research Centre Crumlin / NCRC / | 09-JUL-18 | 12-JUL-20 | |||
Inflammatory markers of antipsychotic weight gain and cardiometabolic dysfunction in youth mental health disorders | Principle Investigator | National Children’s Research Centre Crumlin / NCRC / | 01-FEB-18 | 30-JAN-21 | |||
Effect of Glucagon like peptide-1 therapy on obesity driven inflammation and co- morbid inflammatory conditions. | Scientific Lead | / Government State Bodies | 01-MAY-15 | 30-APR-18 |
Peer Reviewed Journals
Year | Publication | |
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2011 | 'Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide'
Hogan A.;O'Reilly V.;Dunne M.;Dere R.;Zeng S.;O'Brien C.;Amu S.;Fallon P.;Exley M.;O'Farrelly C.;Zhu X.;Doherty D. (2011) 'Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide'. Journal of Clinical Immunology, 140 (2):196-207 [DOI] [full-text] [Details] |
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2018 | 'Type 1 IFN Induction by Cytosolic Nucleic Acid Is Intact in Neonatal Mononuclear Cells, Contrasting Starkly with Neonatal Hyporesponsiveness to TLR Ligation Due to Independence from Endosome-Mediated IRF3 Activation'
Brennan K;O'Leary BD;Mc Laughlin D;Breen EP;Connolly E;Ali N;O'Driscoll DN;Ozaki E;Mahony R;Mulfaul K;Ryan AM;Ni Chianain A;McHugh A;Molloy EJ;Hogan AE;Paran S;McAuliffe FM;Doyle SL; (2018) 'Type 1 IFN Induction by Cytosolic Nucleic Acid Is Intact in Neonatal Mononuclear Cells, Contrasting Starkly with Neonatal Hyporesponsiveness to TLR Ligation Due to Independence from Endosome-Mediated IRF3 Activation'. Journal of Immunology, [DOI] [full-text] [Details] |
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2017 | 'Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity'
Boulenouar, S;Michelet, X;Duquette, D;Alvarez, D;Hogan, AE;Dold, C;O'Connor, D;Stutte, S;Tavakkoli, A;Winters, D;Exley, MA;O'Shea, D;Brenner, MB;von Andrian, U;Lynch, L (2017) 'Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity'. Immunity, 46 :273-286 [DOI] [full-text] [Details] |
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2017 | 'NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient'
Tobin, LM;Mavinkurve, M;Carolan, E;Kinlen, D;O'Brien, EC;Little, MA;Finlay, DK;Cody, D;Hogan, AE;O'Shea, D (2017) 'NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient'. Jci Insight, 2 [DOI] [full-text] [Details] |
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2017 | 'Preliminary asthma -related outcomes following glucagon - like peptide 1 agonist therapy'
Khan F;Mat A;Hogan A;Kent B;Eigenheer S;Corrigan M;O'Shea D;Butler M; (2017) 'Preliminary asthma -related outcomes following glucagon - like peptide 1 agonist therapy'. QJM - Monthly Journal of the Association of Physicians, [DOI] [full-text] [Details] |
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2016 | 'iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy'
Lynch, L;Hogan, AE;Duquette, D;Lester, C;Banks, A;LeClair, K;Cohen, DE;Ghosh, A;Lu, B;Corrigan, M;Stevanovic, D;Maratos-Flier, E;Drucker, DJ;O'Shea, D;Brenner, M (2016) 'iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy'. Cell Metabolism, 24 :510-519 [DOI] [full-text] [Details] |
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2016 | 'The helminth T2 RNase omega 1 promotes metabolic homeostasis in an IL-33-and group 2 innate lymphoid cell-dependent mechanism'
Hams, E;Bermingham, R;Wurlod, FA;Hogan, AE;O'Shea, D;Preston, RJ;Rodewald, HR;McKenzie, ANJ;Fallon, PG (2016) 'The helminth T2 RNase omega 1 promotes metabolic homeostasis in an IL-33-and group 2 innate lymphoid cell-dependent mechanism'. FASEB Journal, 30 :824-835 [DOI] [full-text] [Details] |
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2015 | 'Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity'
Carolan E.;Tobin L.;Mangan B.;Corrigan M.;Gaoatswe G.;Byrne G.;Geoghegan J.;Cody D.;O'Connell J.;Winter D.;Doherty D.;Lynch L.;O'Shea D.;Hogan A. (2015) 'Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity'. Journal of Immunology, 194 (12):5775-5780 [DOI] [full-text] [Details] |
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2015 | 'Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity'
Gaoatswe, G;Kent, BD;Corrigan, MA;Nolan, G;Hogan, AE;McNicholas, WT;O'Shea, D (2015) 'Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity'. Sleep, 38 :1629-1634 [DOI] [full-text] [Details] |
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2015 | 'Tissue specific regulation of glucocorticoids in severe obesity and the response to significant weight loss following bariatric surgery (BARICORT)'
Woods C.;Corrigan M.;Gathercole L.;Taylor A.;Hughes B.;Gaoatswe G.;Manolopoulos K.;Hogan A.;O'Connell J.;Stewart P.;Tomlinson J.;O'Shea D.;Sherlock M. (2015) 'Tissue specific regulation of glucocorticoids in severe obesity and the response to significant weight loss following bariatric surgery (BARICORT)'. Journal of Clinical Endocrinology and Metabolism, 100 (4):1434-1444 [DOI] [full-text] [Details] |
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2014 | 'The E3 Ubiquitin Ligase Pellino3 Protects against Obesity-Induced Inflammation and Insulin Resistance'
Yang, S;Wang, BW;Humphries, F;Hogan, AE;O'Shea, D;Moynagh, PN (2014) 'The E3 Ubiquitin Ligase Pellino3 Protects against Obesity-Induced Inflammation and Insulin Resistance'. Immunity, 41 :973-987 [DOI] [full-text] [Details] |
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2014 | 'The Impact of Childhood Obesity on Inflammation, Innate Immune Cell Frequency, and Metabolic MicroRNA Expression'
Carolan, E;Hogan, AE;Corrigan, M;Gaotswe, G;O'Connell, J;Foley, N;O'Neill, LA;Cody, D;O'Shea, D (2014) 'The Impact of Childhood Obesity on Inflammation, Innate Immune Cell Frequency, and Metabolic MicroRNA Expression'. Journal of Clinical Endocrinology and Metabolism, 99 :474-478 [DOI] [full-text] [Details] |
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2014 | 'Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus'
Hogan, AE;Gaoatswe, G;Lynch, L;Corrigan, MA;Woods, C;O'Connell, J;O'Shea, D (2014) 'Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus'. Diabetologia, 57 :781-784 [DOI] [full-text] [Details] |
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2013 | 'Cutting edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human Vδ3 T cells'
Mangan B.;Dunne M.;O'Reilly V.;Dunne P.;Exley M.;O'Shea D.;Scotet E.;Hogan A.;Doherty D. (2013) 'Cutting edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human Vδ3 T cells'. Journal of Immunology, 191 (1):30-34 [DOI] [full-text] [Details] |
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2013 | 'Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection'
O'Shea D.;Corrigan M.;Dunne M.;Jackson R.;Woods C.;Gaoatswe G.;Moynagh P.;O'Connell J.;Hogan A. (2013) 'Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection'. International Journal of Obesity, 37 (11):1510-1513 [DOI] [full-text] [Details] |
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2013 | 'Human Invariant NKT Cell Subsets Differentially Promote Differentiation, Antibody Production, and T Cell Stimulation by B Cells In Vitro'
Zeng, SG;Ghnewa, YG;O'Reilly, VP;Lyons, VG;Atzberger, A;Hogan, AE;Exley, MA;Doherty, DG (2013) 'Human Invariant NKT Cell Subsets Differentially Promote Differentiation, Antibody Production, and T Cell Stimulation by B Cells In Vitro'. Journal of Immunology, 191 :1666-1676 [DOI] [full-text] [Details] |
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2012 | 'Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production'
Lynch L.;Nowak M.;Varghese B.;Clark J.;Hogan A.;Toxavidis V.;Balk S.;O'Shea D.;O'Farrelly C.;Exley M. (2012) 'Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production'. Immunity, 37 (3):574-587 [DOI] [full-text] [Details] |
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2012 | 'Correlation between maternal inflammatory markers and fetomaternal adiposity'
Farah N.;Hogan A.;O'Connor N.;Kennelly M.;O'Shea D.;Turner M. (2012) 'Correlation between maternal inflammatory markers and fetomaternal adiposity'. Cytokine, 60 (1):96-99 [DOI] [full-text] [Details] |
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2011 | 'Distinct and overlapping effector functions of expanded human CD4 +, cd8α + and CD4 -CD8α - invariant natural killer T cells'
O'Reilly V.;Zeng S.;Bricard G.;Atzberger A.;Hogan A.;Jackson J.;Feighery C.;Porcelli S.;Doherty D. (2011) 'Distinct and overlapping effector functions of expanded human CD4 +, cd8α + and CD4 -CD8α - invariant natural killer T cells'. PLoS ONE, 6 (12) [DOI] [full-text] [Details] |
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2011 | 'Activation of human invariant natural killer T cells with a thioglycoside analogue of alpha-galactosylceramide'
Hogan, AE;O'Reilly, V;Dunne, MR;Dere, RT;Zeng, SJG;O'Brien, C;Amu, S;Fallon, PG;Exley, MA;O'Farrelly, C;Zhu, XM;Doherty, DG (2011) 'Activation of human invariant natural killer T cells with a thioglycoside analogue of alpha-galactosylceramide'. Journal of Clinical Immunology, 140 :196-207 [DOI] [full-text] [Details] |
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2011 | 'Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis'
Hogan, AE;Tobin, AM;Ahern, T;Corrigan, MA;Gaoatswe, G;Jackson, R;O'Reilly, V;Lynch, L;Doherty, DG;Moynagh, PN;Kirby, B;O'Connell, J;O'Shea, D (2011) 'Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis'. Diabetologia, 54 :2745-2754 [DOI] [full-text] [Details] |
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2011 | 'Tumour Tissue Microenvironment Can Inhibit Dendritic Cell Maturation in Colorectal Cancer'
Michielsen, AJ;Hogan, AE;Marry, J;Tosetto, M;Cox, F;Hyland, JM;Sheahan, KD;O'Donoghue, DP;Mulcahy, HE;Ryan, EJ;O'Sullivan, JN (2011) 'Tumour Tissue Microenvironment Can Inhibit Dendritic Cell Maturation in Colorectal Cancer'. PLoS ONE, 6 [DOI] [full-text] [Details] |
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2011 | 'Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses'
Hogan, AE;Corrigan, MA;O'Reilly, V;Gaoatswe, G;O'Connell, J;Doherty, DG;Lynch, L;O'Shea, D (2011) 'Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses'. Journal of Clinical Immunology, 140 :229-235 [DOI] [full-text] [Details] |
Reviews
Year | Publication | |
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2020 | Interleukin-17 producing mucosal associated invariant T cells - emerging players in chronic inflammatory diseases?.
Pisarska M.M.;Dunne M.R.;O'Shea D.;Hogan A.E. (2020) Interleukin-17 producing mucosal associated invariant T cells - emerging players in chronic inflammatory diseases?. Reviews [DOI] [full-text] [Details] |
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2021 | Mucosal associated invariant t cells in cancer-friend or foe?.
O’neill C.;Cassidy F.C.;O’shea D.;Hogan A.E. (2021) Mucosal associated invariant t cells in cancer-friend or foe?. Reviews [DOI] [full-text] [Details] |