Dr Jennifer McManus

Chemistry

Associate Professor
Head of Department

Science Building
1st Floor
2.64
(01) 708 6926

Biography


  • Head of Department, Department of Chemistry (July 2017 - present)
  • Associate Professor, Department of Chemistry (2016 - present)
  • Visiting Scholar, Department of Physics, Harvard University (Feb - April 2016)
  • Assistant Professor/Lecturer, Department of Chemistry (2013-2016)
  • Science Foundation Ireland Stokes Lecturer, Department of Chemistry, Maynooth University (2008-2013)
  • Postdoctoral Associate, Massachusetts Institute of Technology (2005-2008)
  • Postdoctoral Fellow, Department of Physics, University of Fribourg, Switzerland (2004)
  • Visiting Student, Max Planck Institute for Polymer Research, Mainz, Germany (2001)
  • Ph.D., Department of Chemistry, University College Dublin (2003)

Research Interests

Soft Matter and Biophysical Chemistry Group

Research Interests
  • Protein condensation and phase diagrams
  • Self-assembly of soft materials
  • Protein aggregation
  • Mechanical properties of soft materials and biological tissue
  • Bottom up approaches to synthetic biology
  • Membrane protein crystallization

Research Group
  • Sarah Cannon - Senior Technical Officer
  • Mark Grace - Ph.D. student
  • Alessandro Strofaldi - Ph.D. student 
  • Thi Thanh My Nguyen - Ph.D. student  (H2020 ITN - RAMP https://ramp-itn.eu/)
  • Jessica Ames - Ph.D. student  (H2020 ITN - RAMP https://ramp-itn.eu/)
  • Paddy Joyce - Ph.D. student
  • Keith Fenelon - Ph.D. student (SSPC PharM5 https://sspc.ie/)

Group Alumni
  • Judith Mittag, MSc (Res), 2014 (Munich - co-supervised with Prof. Joachim Raedler)
  • Ruth McNamara, PhD 2014
  • Susan James, MSc (Res) 2011, PhD 2015
  • Alice Blumlein, PhD 2016
  • Urszula Migas, PhD 2016
  • Michelle Quinn, PhD 2017
  • Aoife Buggy, PhD 2018 (co-supervised with Dr. Mark Fenelon and Dr. Andre Brodkorb, Teagasc)
  • Lucy Moran, MSc (Res), 2018
  • Arunima Gulati, PhD 2019 (co-supervised with Prof. Tim Guinee and Dr. Mark Fenelon, Teagasc)
  • Judith Mittag, postdoc 2017 - 2018
  • Matthew Jacobs, postdoc 2017 - 2018
  • Stephanie Ortiz Collazos - postdoc 2019

If you are interested in discussing opportunities to join the Soft Matter and Biophysical Chemistry Group as a Ph.D. student or postdoctoral researcher, please email your CV to Dr. Jennifer McManus (jennifer.mcmanus@mu.ie). 


Edited Books

  Year Publication
2019 Protein Self-Assembly - Methods and Protocols
Jennifer J. McManus (Ed.). (2019) Protein Self-Assembly - Methods and Protocols New York: Springer. [DOI] [Details]

Peer Reviewed Journals

  Year Publication
2019 'Using Schematic Models to Understand the Microscopic Basis for Inverted Solubility in γD-Crystallin'
Altan I;Khan AR;James S;Quinn MK;McManus JJ;Charbonneau P; (2019) 'Using Schematic Models to Understand the Microscopic Basis for Inverted Solubility in γD-Crystallin'. Journal of Physical Chemistry B, [DOI] [Details]
2019 'Chemical Modification Alters Protein-Protein Interactions and Can Lead to Lower Protein Solubility'
Michelle K. Quinn, Susan James, Jennifer J. McManus (2019) 'Chemical Modification Alters Protein-Protein Interactions and Can Lead to Lower Protein Solubility'. Journal of Physical Chemistry B, 123 (20):4373-4379 [DOI] [Details]
2019 'Temperature-dependent interactions explain normal and inverted solubility in a gammaD-crystallin mutant'
Amir R. Khan, Susan James, Michelle K. Quinn, Irem Altan, Patrick Charbonneau, Jennifer J. McManus (2019) 'Temperature-dependent interactions explain normal and inverted solubility in a gammaD-crystallin mutant'. Biophysical Journal, [DOI] [Details]
2019 'Dairy cow feeding system alters the characteristics of low-heat skim milk powder and processability of reconstituted skim milk'
Gulati A;Hennessy D;O'Donovan M;McManus JJ;Fenelon MA;Guinee TP; (2019) 'Dairy cow feeding system alters the characteristics of low-heat skim milk powder and processability of reconstituted skim milk'. Journal of Dairy Science, [DOI] [Details]
2019 'Effect of reducing daily herbage allowance during early lactation on composition and processing characteristics of milk from spring-calved herds'
Arunima Gulati, Norann Galvin, Emer Kennedy, Eva Lewis, Jennifer J. McManus, Mark A. Fenelon, Timothey P. Guinee (2019) 'Effect of reducing daily herbage allowance during early lactation on composition and processing characteristics of milk from spring-calved herds'. International Dairy Journal, 92 :69-76 [Details]
2018 'Grazing of dairy cows on pasture versus indoor feeding on total mixed ration: Effects on low-moisture part-skim Mozzarella cheese yield and quality characteristics in mid and late lactation'
Gulati A.;Galvin N.;Hennessy D.;McAuliffe S.;O'Donovan M.;McManus J.;Fenelon M.;Guinee T. (2018) 'Grazing of dairy cows on pasture versus indoor feeding on total mixed ration: Effects on low-moisture part-skim Mozzarella cheese yield and quality characteristics in mid and late lactation'. Journal of Dairy Science, [DOI] [IR Link] [Details]
2018 'Pilot-scale formation of whey protein aggregates determine the stability of heat-treated whey protein solutions-Effect of pH and protein concentration'
Buggy AK;McManus JJ;Brodkorb A;Hogan SA;Fenelon MA; (2018) 'Pilot-scale formation of whey protein aggregates determine the stability of heat-treated whey protein solutions-Effect of pH and protein concentration'. Journal of Dairy Science, [DOI] [Details]
2017 'Protein self-assembly following in situ expression in artificial and mammalian cells'
Migas U.;Quinn M.;McManus J. (2017) 'Protein self-assembly following in situ expression in artificial and mammalian cells'. Integrative Biology, 9 (5):444-450 [DOI] [Details]
2017 'The mechanical properties of individual cell spheroids'
Blumlein A.;Williams N.;McManus J. (2017) 'The mechanical properties of individual cell spheroids'. Scientific Reports, 7 (1) [DOI] [IR Link] [Details]
2017 'Stabilising effect of α-lactalbumin on concentrated infant milk formula emulsions heat treated pre- or post-homogenisation'
Aoife K. Buggy, Jennifer J. McManus, André Brodkorb, Noel Mc Carthy, Mark A. Fenelon (2017) 'Stabilising effect of α-lactalbumin on concentrated infant milk formula emulsions heat treated pre- or post-homogenisation'. Dairy Science and Technology, 96 :845-859 [DOI] [IR Link] [Details]
2017 'Outdoor grazing of dairy cows on pasture versus indoor feeding on total mixed ration: Effects on gross composition and mineral content of milk during lactation'
A. Gulati, N. Galvin, E. Lewis, D. Hennessy, M. O'Donovan, J. J. McManus, M. A. Fenelon, T. P. Guinee (2017) 'Outdoor grazing of dairy cows on pasture versus indoor feeding on total mixed ration: Effects on gross composition and mineral content of milk during lactation'. Journal of Dairy Science, doi.org/10.3168/jds.2017-13338 [DOI] [IR Link] [Details]
2016 'The physics of protein self-assembly'
McManus J.;Charbonneau P.;Zaccarelli E.;Asherie N. (2016) 'The physics of protein self-assembly'. Current Opinion in Colloid and Interface Science, 22 :73-79 [DOI] [IR Link] [Details]
2015 'The self assembly of proteins; Probing patchy protein interactions'
Susan James, Michelle K. Quinn, Jennifer J. McManus (2015) 'The self assembly of proteins; Probing patchy protein interactions'. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 17 :5413-5420 [DOI] [IR Link] [Details]
2015 'Bigel formation via spinodal decomposition of unfolded protein'
Alice Blumlein and Jennifer J. McManus* (2015) 'Bigel formation via spinodal decomposition of unfolded protein'. Journal of Materials Chemistry B, DOI: 10.1039/C5TB00131E [Details]
2015 'How Fluorescent labelling alters the solution behavior of proteins'
Michelle K. Quinn, Nicoletta Gnan, Susan James, Andrea Ninarello, Francesco Sciortino, Emanuela Zaccarelli, Jennifer J. McManus* (2015) 'How Fluorescent labelling alters the solution behavior of proteins'. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, DOI: 10.1039/C5CP04463D [DOI] [IR Link] [Details]
2014 'Adding glycolipid functionality to model membranes - phase behaviour of a synthetic glycolipid in a phospholipid membrane'
Migas, UM;Abbey, L;Velasco-Torrijos, T;McManus, JJ (2014) 'Adding glycolipid functionality to model membranes - phase behaviour of a synthetic glycolipid in a phospholipid membrane'. Soft Matter, 10 :3978-3983 [DOI] [IR Link] [Details]
2014 'Simultaneous measurement of a range of particle sizes during A beta 1-42 fibrillogenesis quantified using fluorescence correlation spectroscopy'
Mittag J.;Milani S.;Walsh D.;Raedler J.;McManus J. (2014) 'Simultaneous measurement of a range of particle sizes during A beta 1-42 fibrillogenesis quantified using fluorescence correlation spectroscopy'. Biochemical and Biophysical Research Communications, 448 (2):195-199 [DOI] [IR Link] [Details]
2013 'Reversible and non-reversible thermal denaturation of lysozyme with varying pH at low ionic strength'
Blumlein Alice, McManus Jennifer J.* (2013) 'Reversible and non-reversible thermal denaturation of lysozyme with varying pH at low ionic strength'. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1834 :2064-2070 [IR Link] [Details]
2013 'Protein corona mediates impact of nanomaterials and slows amyloid beta fibrillation (COVER)'
Mahmoudi M. *, M. P. Monopoli, M. Rezaei, I. Lynch, F. Bertoli, J. J. McManus*, K.A. Dawson* (2013) 'Protein corona mediates impact of nanomaterials and slows amyloid beta fibrillation (COVER)'. CHEMBIOCHEM, 14 :568-572 [IR Link] [Details]
2012 'Differing modes of interaction between monomeric Aβ 1-40 peptides and model lipid membranes: An AFM study'
Sheikh K.;Giordani C.;McManus J.;Hovgaard M.;Jarvis S. (2012) 'Differing modes of interaction between monomeric Aβ 1-40 peptides and model lipid membranes: An AFM study'. Chemistry and Physics of Lipids, 165 (2):142-150 [DOI] [IR Link] [Details]
2012 'Thermal and solution stability of lysozyme in the presence of sucrose, glucose and trehalose'
Susan James and Jennifer J. McManus* (2012) 'Thermal and solution stability of lysozyme in the presence of sucrose, glucose and trehalose'. JOURNAL OF PHYSICAL CHEMISTRY B, 116 :10182-10188 [IR Link] [Details]
2011 'Blowing Bubbles to study living material'
Crosby, Alfred J. and McManus, Jennifer J. (2011) 'Blowing Bubbles to study living material'. PHYSICS TODAY, 64 :62-63 [IR Link] [Details]
2011 'Cavitation rheology of the eye lens (COVER)'
J. Cui, C. Hee-Lee, A. Delbos, J. J. McManus*, A. J. Crosby* (2011) 'Cavitation rheology of the eye lens (COVER)'. SOFT MATTER, 7 :7827-7831 [DOI] [IR Link] [Details]
2010 'Phase behavior of mixtures of human lens proteins Gamma D and Beta B1'
Ying Wang, Aleksey Lomakin, Jennifer J. McManus, Olutayo Ogun, George B. Benedek (2010) 'Phase behavior of mixtures of human lens proteins Gamma D and Beta B1'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, 107 :13282-13287 [IR Link] [Details]
2010 'Cavitation Rheology of the Vitreous: mechanical properties of biological tissue'
Zimberlin, Jessica, Jennifer J. McManus*, Alfred J. Crosby* (2010) 'Cavitation Rheology of the Vitreous: mechanical properties of biological tissue'. SOFT MATTER, 6 :3632-3635 [IR Link] [Details]
2007 'Structure of cholesterol helical ribbons, self-assembling biological springs'
B. Khaykovich, C. Houssain, J. J. McManus, A. Lomakin, D. M. Moncton, G. B. Benedek (2007) 'Structure of cholesterol helical ribbons, self-assembling biological springs'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, 104 :9656-9660 [IR Link] [Details]
2007 'Altered Phase Diagram Due to a Single Point Mutation in Human Gamma D-Crystallin'
J. J. McManus, A. Lomakin, A. Pande, O. Ogun, J. Pande and G.B. Benedek (2007) 'Altered Phase Diagram Due to a Single Point Mutation in Human Gamma D-Crystallin'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, 104 :16856-16861 [IR Link] [Details]
2004 'Observation of a Rectangular Columnar Phase in a DNA-Calcium-Zwitterionic Lipid Complex'
J. J. McManus, J. O. Rädler, K.A. Dawson (2004) 'Observation of a Rectangular Columnar Phase in a DNA-Calcium-Zwitterionic Lipid Complex'. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126 :15966-15967 [IR Link] [Details]
2003 'Phase Behaviour of DPPC in a DNA-Calcium-Zwitterionic Lipid Complex studied by SAXS'
J. J. McManus, J. O. Rädler, K.A. Dawson (2003) 'Phase Behaviour of DPPC in a DNA-Calcium-Zwitterionic Lipid Complex studied by SAXS'. LANGMUIR, 19 :9630-9637 [IR Link] [Details]
2003 'Does Calcium Turn a Zwitterionic Lipid Cationic?'
J. J. McManus , J. O. Rädler, K. A. Dawson (2003) 'Does Calcium Turn a Zwitterionic Lipid Cationic?'. JOURNAL OF PHYSICAL CHEMISTRY B, 107 :9869-9875 [IR Link] [Details]
2001 'A simple and effective separation and purification procedure for DNA fragments using Dodecyltrimethylammonium bromide'
D.M. McLoughlin, J.O’Brien, J. J. McManus, A.V.Gorelov, K.A. Dawson (2001) 'A simple and effective separation and purification procedure for DNA fragments using Dodecyltrimethylammonium bromide'. BIOSEPARATION, 9 :307-313 [Details]
2000 'DNA complexes with cationic surfactant in mixed solvents: the influence of excess surfactant and salt'
D.M. McLoughlin, J. J. McManus, A.V.Gorelov, K.A. Dawson (2000) 'DNA complexes with cationic surfactant in mixed solvents: the influence of excess surfactant and salt'. :186-191 [Details]

Book Chapters

  Year Publication
2019 'Fluorescence Correlation Spectroscopy for Particle Sizing in Highly Concentrated Protein Solutions'
Mittag JJ;Jacobs MR;McManus JJ; (2019) 'Fluorescence Correlation Spectroscopy for Particle Sizing in Highly Concentrated Protein Solutions' In: Protein Self-Assembly - Methods and Protocols. New York: Springer. [DOI] [Details]
2019 'Differential Scanning Calorimetry to Quantify Heat-Induced Aggregation in Concentrated Protein Solutions'
Jacobs MR;Grace M;Blumlein A;McManus JJ; (2019) 'Differential Scanning Calorimetry to Quantify Heat-Induced Aggregation in Concentrated Protein Solutions' In: Protein Self-Assembly - Methods and Protocols. New York: Springer. [DOI] [Details]
2018 'Peptide self-assembly measured using fluorescence correlation spectroscopy'
Mittag J.;Rädler J.;McManus J. (2018) 'Peptide self-assembly measured using fluorescence correlation spectroscopy' In: Nilsson, B. L and Doran T. M (eds). Peptide Self-Assembly. New York, USA: Springer. [DOI] [Details]