Dr David Fitzpatrick

Biology

Lecturer
Lecturer and PI, Genome Evolution Lab

Callan
1.26
(01) 7086844

Biography

1996 - 2000: NUI Maynooth B.Sc. Biology (Hons).
2000 - 2004: NUI Maynooth PhD Bioinformatics.
2004 - 2005: N.U.I Maynooth. Postdoctoral Researcher.
2005 - 2007: University College Dublin. IRCSET Postdoctoral Fellow.
2007 - 2009: University College Dublin. HRB Postdoctoral Fellow.
2009 - Present: Maynooth University. Lecturer and PI of Genome Evolution Laboratory.


Book Chapters

  Year Publication
2014 'Comparative Genomics and Evolutionary Analyses of Human Fungal Pathogens'
David A Fitzpatrick (2014) 'Comparative Genomics and Evolutionary Analyses of Human Fungal Pathogens' In: Human Pathogenic Fungi: Molecular Biology and Pathogenic Mechanisms. [Details]
2011 'Fungal Genomics'
Fitzpatrick DA and Medina EM (2011) 'Fungal Genomics' In: Fungi: Biology and Applications. John Wiley and Sons. [Details]
2010 'Comparative genomic analysis of pathogenic yeasts and the evolution of virulence'
Fitzpatrick, David A. and Geraldine Butler (2010) 'Comparative genomic analysis of pathogenic yeasts and the evolution of virulence' In: The Yeast Handbook: Pathogenic Yeasts. Berlin: Springer. [Details]
2006 'Chemoreception and Chemoreceptor Genes in Nematodes'
O’Halloran, DM. Fitzpatrick, DA and Burnell, AM. (2006) 'Chemoreception and Chemoreceptor Genes in Nematodes' In: Chemical Communication: from Genes to Ecosystems. Frontis Publishing. [Details]
2006 'A Prokaryotic Phylogenetic Tree: Yes or No?'
McInerney, J.O., Pisani, D., O’Connell, M.J., Fitzpatrick, D.A. and Creevey,C.J. (2006) 'A Prokaryotic Phylogenetic Tree: Yes or No?' In: Towards the Tree of Life: taxonomy and systematics of large and species rich taxa (Systematic Association special volume). CRC Press. [Details]

Peer Reviewed Journals

  Year Publication
2016 'Emergence and evolution of yeast prion and prion-like proteins'
An L, Fitzpatrick D, Harrison PM. (2016) 'Emergence and evolution of yeast prion and prion-like proteins'. BMC EVOLUTIONARY BIOLOGY, 16 [DOI] [IR Link] [Details]
2016 'Antibiotic resistance genes across a wide variety of metagenomes'
Fitzpatrick D, Walsh F (2016) 'Antibiotic resistance genes across a wide variety of metagenomes'. FEMS MICROBIOLOGY ECOLOGY, 2016 Jan 5 [Epub ahead of print] [Details]
2015 'Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus'
Owens RA, O'Keeffe G, Smith EB, Dolan SK, Hammel S, Sheridan KJ, Fitzpatrick DA, Keane TM, Jones GW, Doyle S (2015) 'Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus'. EUKARYOTIC CELL, 14 :941-957 [DOI] [IR Link] [Details]
2015 'A role for the Parkinson’s Disease protein DJ-1 as a chaperone and antioxidant in the anhydrobiotic nematode Panagrolaimus superbus'
Bridget A. Culleton, Patrick Lall, Gemma K. Kinsella, Sean Doyle, John McCaffrey David A.Fitzpatrick and Ann M. Burnell (2015) 'A role for the Parkinson’s Disease protein DJ-1 as a chaperone and antioxidant in the anhydrobiotic nematode Panagrolaimus superbus'. Cell Stress and Chaperones, 20 :121-137 [Details]
2015 'Interplay between Gliotoxin Resistance, Secretion and the Methyl/Methionine Cycle in Aspergillus fumigatus'
Owens RA, O'Keeffe G, Smith EB, Dolan SK, Hammel S, Sheridan KJ, Fitzpatrick DA, Keane TM, Jones GW, Doyle S. (2015) 'Interplay between Gliotoxin Resistance, Secretion and the Methyl/Methionine Cycle in Aspergillus fumigatus'. EUKARYOTIC CELL, EC.00055-15 [IR Link] [Details]
2014 'Regulation of Nonribosomal Peptide Synthesis: bis-Thiomethylation Attenuates Gliotoxin Biosynthesis in Aspergillus fumigatus'
Dolan SK, Owens RA, O'Keeffe G, Hammel S, Fitzpatrick DA, Jones GW, Doyle S (2014) 'Regulation of Nonribosomal Peptide Synthesis: bis-Thiomethylation Attenuates Gliotoxin Biosynthesis in Aspergillus fumigatus'. Chemistry and Biology, 21 :999-1012 [Details]
2014 'RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus'
O'Keeffe G, Hammel S, Owens RA, Keane TM, Fitzpatrick DA, Jones GW, Doyle S. (2014) 'RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus'. BMC GENOMICS, 14 [IR Link] [Details]
2014 'A pluralistic account of homology: adapting the models to the data'
Haggerty, L.S., Jachiet, P.A., Hanage, W.P., Fitzpatrick, D., Lopez, P., O’Connell, M.J., Pisani, D., Wilkinson, M., Bapteste, E., and McInerney, J.O (2014) 'A pluralistic account of homology: adapting the models to the data'. Molecular Biology and Evolution, 31 :501-516 [DOI] [Details]
2014 'Different outcomes for the MYB floral symmetry genes DIVARICATA and RADIALIS during the evolution of derived actinomorphy in Plantago'
Reardon W, Gallagher P, Nolan KM, Wright H, Cardeñosa-Rubio MC, Bragalini C, Lee CS, Fitzpatrick DA, Corcoran K, Wolff K, Nugent JM (2014) 'Different outcomes for the MYB floral symmetry genes DIVARICATA and RADIALIS during the evolution of derived actinomorphy in Plantago'. 202 :716-725 [DOI] [Details]
2014 'Global transcript and phenotypic analysis of yeast cells expressing Ssa1, Ssa2, Ssa3 or Ssa4 as sole source of cytosolic Hsp70-Ssa chaperone activity'
Hasin N., Cusack S.A., Ali S.S., Fitzpatrick D.A., Jones GW. (2014) 'Global transcript and phenotypic analysis of yeast cells expressing Ssa1, Ssa2, Ssa3 or Ssa4 as sole source of cytosolic Hsp70-Ssa chaperone activity'. BMC GENOMICS, 15 [DOI] [IR Link] [Details]
2014 'A pluralistic account of homology: adapting the models to the data'
Haggerty LS, Jachiet PA, Hanage WP, Fitzpatrick D, Lopez P, O'Connell MJ, Pisani D, Wilkinson M, Bapteste E, McInerney JO (2014) 'A pluralistic account of homology: adapting the models to the data'. Molecular Biology and Evolution, 31 :501-516 [Details]
2014 'The evolutionary history of the genes involved in the biosynthesis of the antioxidant ergothioneine'
Jones GW, Doyle S, Fitzpatrick DA (2014) 'The evolutionary history of the genes involved in the biosynthesis of the antioxidant ergothioneine'. Gene, 549 :161-170 [DOI] [Details]
2013 'A comparative study into the molecular evolution of signaling pathway members across olfactory, gustatory, and photo-sensory modalities'
He C, Fitzpatrick DA, O'Halloran DM (2013) 'A comparative study into the molecular evolution of signaling pathway members across olfactory, gustatory, and photo-sensory modalities'. JOURNAL OF GENETICS, 92 :327-334 [IR Link] [Details]
2013 'Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling'
Clarke M, Lohan AJ, Liu B, Lagkouvardos I, Roy S, Zafar N, Bertelli C, Schilde C, Kianianmomeni A, Burglin TR, Frech C, Turcotte B, Kopec KO, Synnott JM, Choo C, Paponov I, Finkler A, Soon Heng Tan C, Hutchins AP, Weinmeier T, Rattei T, Chu JS, Gimenez G, Irimia M, Rigden DJ, Fitzpatrick DA, Lorenzo-Morales J, Bateman A, Chiu CH, Tang P, Hegemann P, Fromm H, Raoult D, Greub G, Miranda-Saavedra D, Chen N, Nash P, Ginger ML, Horn M, Schaap P, Caler L, Loftus B. (2013) 'Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling'. GENOME BIOLOGY, 14 [DOI] [IR Link] [Details]
2013 'Epidemiological and virological investigations of equine influenza outbreaks in Ireland (2010 2012)'
Gildea, S, Fitzpatrick, DA, Cullinane A (2013) 'Epidemiological and virological investigations of equine influenza outbreaks in Ireland (2010 2012)'. INFLUENZA AND OTHER RESPIRATORY VIRUSES, 7 :61-72 [DOI] [IR Link] [Details]
2013 'Genomic and Proteomic Dissection of the Ubiquitous Plant Pathogen, Armillaria mellea: Towards a New Infection Model System'
Collins C, Keane TM, Turner DJ, O'Keeffe G, Fitzpatrick DA, Doyle S. (2013) 'Genomic and Proteomic Dissection of the Ubiquitous Plant Pathogen, Armillaria mellea: Towards a New Infection Model System'. JOURNAL OF PROTEOME RESEARCH, 12 :2552-2570 [DOI] [IR Link] [Details]
2013 'Insight into the family of Na+/Ca2+ exchangers of Caenorhabditis elegans'
Sharma V, He C, Sacca-Schaeffer J, Brzozowski E, Herranz DM, Mendelowitz Z, Fitzpatrick DA, O'Halloran DM. (2013) 'Insight into the family of Na+/Ca2+ exchangers of Caenorhabditis elegans'. GENETICS, 195(2) :611-619 [IR Link] [Details]
2012 'Investigating the Relationship between Topology and Evolution in a Dynamic Nematode Odor Genetic Network'
Fitzpatrick DA, O'Halloran DM (2012) 'Investigating the Relationship between Topology and Evolution in a Dynamic Nematode Odor Genetic Network'. To be added, 2012 [DOI] [IR Link] [Details]
2012 'Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus'
O'Hanlon KA, Margison GP, Hatch A, Fitzpatrick DA, Owens RA, Doyle S, Jones GW. (2012) 'Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus'. NUCLEIC ACIDS RESEARCH, 40 :7806-7820 [DOI] [IR Link] [Details]
2011 'Assessment of Inactivating Stop Codon Mutations in Forty Saccharomyces cerevisiae Strains: Implications for [PSI] Prion- Mediated Phenotypes'
Fitzpatrick DA, O'Brien J, Moran C, Hasin N, Kenny E, Cormican P, Gates A, Morris DW, Jones GW. (2011) 'Assessment of Inactivating Stop Codon Mutations in Forty Saccharomyces cerevisiae Strains: Implications for [PSI] Prion- Mediated Phenotypes'. PLoS ONE, e28684 :1-11 [DOI] [IR Link] [Details]
2011 'Reconstructing the Fungal Tree of Life Using Phylogenomics and a Preliminary Investigation of the Distribution of Yeast Prion-Like Proteins in the Fungal Kingdom'
Medina EM, Jones GW, Fitzpatrick DA. (2011) 'Reconstructing the Fungal Tree of Life Using Phylogenomics and a Preliminary Investigation of the Distribution of Yeast Prion-Like Proteins in the Fungal Kingdom'. 73(3-4) :116-133 [Details]
2011 'The copper regulon of the human fungal pathogen Cryptococcus neoformans H99'
Ding C, Yin J, Tovar EM, Fitzpatrick DA, Higgins DG, Thiele DJ (2011) 'The copper regulon of the human fungal pathogen Cryptococcus neoformans H99'. Molecular Microbiology, 81 :1560-1576 [DOI] [Details]
2011 'Universally distributed single-copy genes indicate a constant rate of horizontal transfer'
Creevey CJ, Doerks T, Fitzpatrick DA, Raes J, Bork P. (2011) 'Universally distributed single-copy genes indicate a constant rate of horizontal transfer'. PLoS ONE, 6 [DOI] [IR Link] [Details]
2010 'Analysis of gene evolution and metabolic pathways using the Candida Gene Order Browser'
Fitzpatrick DA, O'Gaora P, Byrne KP, Butler G (2010) 'Analysis of gene evolution and metabolic pathways using the Candida Gene Order Browser'. BMC GENOMICS, 11 [DOI] [IR Link] [Details]
2009 'What do we get when we make a tree of genomes?'
Haggerty L.S, Martin F.J, Fitzpatrick D.A and McInerney JO (2009) 'What do we get when we make a tree of genomes?'. PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON (BIOLOGY SERIES), [Details]
2009 'Evolution of flower shape in Plantago lanceolata'
Reardon, W., D.A. Fitzpatrick, M.A. Fares and J.M. Nugent (2009) 'Evolution of flower shape in Plantago lanceolata'. PLANT MOLECULAR BIOLOGY, 71 :241-250 [DOI] [Details]
2009 'Lines of evidence for horizontal gene transfer of a phenazine producing operon into multiple bacterial species'
Fitzpatrick D.A (2009) 'Lines of evidence for horizontal gene transfer of a phenazine producing operon into multiple bacterial species'. JOURNAL OF MOLECULAR EVOLUTION, 68 :171-185 [DOI] [Details]
2009 'Novel primers for the amplification of nuclear DNA introns in the entomopathogenic nematode Heterorhabditis bacteriophora and their cross-amplification in seven other Heterorhabditis species'
Regeai, S.O., K.M. Dolan, D.A. Fitzpatrick, J.A. Browne, J.T. Jones and A.M. Burnell, (2009) 'Novel primers for the amplification of nuclear DNA introns in the entomopathogenic nematode Heterorhabditis bacteriophora and their cross-amplification in seven other Heterorhabditis species'. MOLECULAR ECOLOGY NOTES, 9 :421-424 [Details]
2009 'Evolution of pathogenicity and sexual reproduction in eight Candida genomes'
Butler G, Rasmussen MD, Lin MF, Santos MA, Sakthikumar S, Munro CA, Rheinbay E, Grabherr M, Forche A, Reedy JL, Agrafioti I, Arnaud MB, Bates S, Brown AJ, Brunke S, Costanzo MC, Fitzpatrick DA, de Groot PW, Harris D, Hoyer LL, Hube B, Klis FM, Kodira C, Lennard N, Logue ME, Martin R, Neiman AM, Nikolaou E, Quail MA, Quinn J, Santos MC, Schmitzberger FF, Sherlock G, Shah P, Silverstein KA, Skrzypek MS, Soll D, Staggs R, Stansfield I, Stumpf MP, Sudbery PE, Srikantha T, Zeng Q, Berman J, Berriman M, Heitman J, Gow NA, Lorenz MC, Birren BW, Kellis M, Cuomo CA (2009) 'Evolution of pathogenicity and sexual reproduction in eight Candida genomes'. NATURE, 459 :657-662 [DOI] [Details]
2008 'Evidence of recent interkingdom horizontal gene transfer between bacteria and Candida parapsilosis'
Fitzpatrick DA, Logue ME, Butler G. (2008) 'Evidence of recent interkingdom horizontal gene transfer between bacteria and Candida parapsilosis'. BMC EVOLUTIONARY BIOLOGY, 24 [DOI] [IR Link] [Details]
2007 'Evaluation Of Whether Accelerated Protein Evolution In Chordates Has Occurred Before, After Or Simultaneously With Gene Duplication'
Johnston CR, O'Dushlaine C, Fitzpatrick D.A., Edwards RJ, Shields DC (2007) 'Evaluation Of Whether Accelerated Protein Evolution In Chordates Has Occurred Before, After Or Simultaneously With Gene Duplication'. MOLECULAR BIOLOGY AND EVOLUTION, 24 :315-323 [DOI] [Details]
2006 'Multiple Lineage Specific Expansions in the Guanylyl Cyclase Gene Family'
Fitzpatrick, D.A., O'Halloran, D.M. and Burnell, A.M. (2006) 'Multiple Lineage Specific Expansions in the Guanylyl Cyclase Gene Family'. BMC EVOLUTIONARY BIOLOGY, 6 [DOI] [IR Link] [Details]
2006 'Genome Phylogenies Indicate a Meaningful a-Proteobacterial Phylogeny and Support a Grouping of the Mitochondria with the Rickettsiales'
Fitzpatrick, D.A., Creevey, C.J. and McInerney, J.O. (2006) 'Genome Phylogenies Indicate a Meaningful a-Proteobacterial Phylogeny and Support a Grouping of the Mitochondria with the Rickettsiales'. MOLECULAR BIOLOGY AND EVOLUTION, 23 :74-85 [IR Link] [Details]
2006 'A Fungal phylogeny based on 42 complete genomes derived from supertree and combined gene analysis'
Fitzpatrick D.A, Logue ME, Stajich JE, Butler G. (2006) 'A Fungal phylogeny based on 42 complete genomes derived from supertree and combined gene analysis'. BMC EVOLUTIONARY BIOLOGY, 6 [DOI] [IR Link] [Details]
2006 'The Molecular Phylogeny and Functional Significance of a Nematode Specific Clade of Heterotrimeric G-protein α-Subunit Genes'
O'Halloran, D.M., Fitzpatrick, D.A., McCormack, G.P., McInerney, J.O. and Burnell, A.M. (2006) 'The Molecular Phylogeny and Functional Significance of a Nematode Specific Clade of Heterotrimeric G-protein α-Subunit Genes'. JOURNAL OF MOLECULAR EVOLUTION, 63 :87-94 [DOI] [Details]
2005 'The anhydrobiotic potential and molecular phylogenetics of species and strains of Panagrolaimus'
Shannon, A. Browne, JA. Boyd, J. Fitzpatrick, DA and Burnell, AM (2005) 'The anhydrobiotic potential and molecular phylogenetics of species and strains of Panagrolaimus'. JOURNAL OF EXPERIMENTAL BIOLOGY, 208 :2433-2445 [DOI] [IR Link] [Details]
2005 'Evidence of positive Darwinian selection in putative meningococcal vaccine antigens'
Fitzpatrick DA, Creevey CJ and McInerney JO (2005) 'Evidence of positive Darwinian selection in putative meningococcal vaccine antigens'. JOURNAL OF MOLECULAR EVOLUTION, 60 :90-98 [DOI] [IR Link] [Details]
2005 'Evidence of positive Darwinian selection in Omp85, a highly conserved bacterial outer membrane protein essential for cell viability'
Fitzpatrick DA and McInerney JO (2005) 'Evidence of positive Darwinian selection in Omp85, a highly conserved bacterial outer membrane protein essential for cell viability'. JOURNAL OF MOLECULAR EVOLUTION, 60 :268-273 [DOI] [Details]
2004 'A tree-like phylogeny only exists at the tips in the prokaryotes'
Creevey, C. J., Fitzpatrick, D. A., Philip, G. K., Kinsella, R. J., O’Connell, M. J., Pentony, M. M., Travers, S. A., Wilkinson, M. and McInerney, J. O. (2004) 'A tree-like phylogeny only exists at the tips in the prokaryotes'. PROCEEDINGS OF THE ROYAL SOCIETY B, 271 :2551-2558 [DOI] [IR Link] [Details]
2003 'Fatty acid biosynthesis in Mycobacterium tuberculosis: lateral gene transfer, adaptive evolution, and gene duplication'
Kinsella RJ, Fitzpatrick DA, Creevey CJ, McInerney JO (2003) 'Fatty acid biosynthesis in Mycobacterium tuberculosis: lateral gene transfer, adaptive evolution, and gene duplication'. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, 100 :10320-10325 [DOI] [IR Link] [Details]

Book Review

  Year Publication
2012 Horizontal gene transfer in fungi.
Fitzpatrick DA. (2012) Horizontal gene transfer in fungi. Book Review [Details]

Thesis

  Year Publication
2004 A study of selection and recombination in microorganisms and a place for the mitochondrion among the alpha-proteobacteria.
David A Fitzpatrick (2004) A study of selection and recombination in microorganisms and a place for the mitochondrion among the alpha-proteobacteria. NUI Maynooth: Thesis [Details]